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Gaetano MARVERTI

Professore Associato
Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze sede ex-Sc. Biomediche


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Pubblicazioni

2024 - Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation [Articolo su rivista]
Marverti, Gaetano; Moschella, Maria Gaetana; Belardo, Alice; Lamesta, Michele; Mercanile, Giada; Tagliazucchi, Lorenzo; Aiello, Daniele; Venturelli, Alberto; Illuminati, Davide; Guerrini, Remo; Losi, Lorena; Ponterini, Glauco; Costi, Maria Paola; D'Arca, Domenico
abstract


2024 - Integrating MS proteomics in the Medicinal Chemistry pipeline as powerful tool to overcome drug resistance issues in colorectal cancer [Abstract in Atti di Convegno]
Tagliazucchi, Lorenzo; Piazzi, Manuela; D'Arca, Domenico; Marverti, Gaetano; Moschella, MARIA GAETANA; Bedeschi, Martina; Tesei, Anna; Passardi, Alessandro; Costi, M Paola
abstract


2024 - MS Proteomics And Biochemical Characterization Of Thymidylate Synthase Dimer Destabilizer E7 To Halt Colorectal Carcinoma [Abstract in Atti di Convegno]
Tagliazucchi, Lorenzo; DI PERSIO, Sara; Moschella, MARIA GAETANA; Malpezzi, Giulia; Aiello, Daniele; Saporito, Giulia; Bedeschi, Martina; Tesei, Anna; Passardi, Alessandro; Marverti, Gaetano; Venturelli, Alberto; D’Arca, Domenico; Costi, Maria Paola
abstract


2024 - Precision medicine through proteomics studies in drug resistant colorectal cancer [Abstract in Atti di Convegno]
Costi, Maria Paola; Piazzi, Manuela; Tagliazucchi, Lorenzo; Marverti, Gaetano; D’Arca, Domenico; Moschella, MARIA GAETANA; Losi, Lorena; Bedeschi, Martina; Tesei, Anna; Passardi, Alessandro
abstract


2023 - Dabrafenib-Panobinostat Salt: Improving Dissolution Rate and Inhibition of BRAF Melanoma Cells [Articolo su rivista]
Rai, Sunil; Marverti, Gaetano; Gunnam, Anilkumar; Allu, Suryanarayana; Nangia, Ashwini
abstract


2023 - Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma [Abstract in Atti di Convegno]
Tagliazucchi, Lorenzo; Malpezzi, Giulia; Aiello, Daniele; Zappaterra, Dana; Elisi, GIAN MARCO; Venturelli, Alberto; Moschella, MARIA GAETANA; D'Arca, Domenico; Marverti, Gaetano; Lopresti, Ludovica; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Ponterini, Glauco; Costi, Maria Paola
abstract


2023 - Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles [Abstract in Atti di Convegno]
Aiello, Daniele; Malpezzi, Giulia; Tagliazucchi, Lorenzo; Moschella, MARIA GAETANA; Giulia, Saporito; Venturelli, Alberto; Gluaco, Ponterini; D'Arca, Domenico; Marverti, Gaetano; Federico, Falchi; Costi, Maria Paola
abstract


2023 - Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma [Articolo su rivista]
D'Arca, Domenico; Severi, Leda; Ferrari, Stefania; Dozza, Luca; Marverti, Gaetano; Magni, Fulvio; Chinello, Clizia; Pagani, Lisa; Tagliazucchi, Lorenzo; Villani, Marco; D'Addese, Gianluca; Piga, Isabella; Conteduca, Vincenza; Rossi, Lorena; Gurioli, Giorgia; De Giorgi, Ugo; Losi, Lorena; Costi, Maria Paola
abstract


2023 - Targeting the Interplay of Independent Cellular Pathways and Immunity: A Challenge in Cancer Immunotherapy [Articolo su rivista]
Lauriola, Angela; Davalli, Pierpaola; Marverti, Gaetano; Santi, Spartaco; Caporali, Andrea; D’Arca, Domenico
abstract


2023 - design, synthesis and biological evaluation of novel YAP:TEAD complex disruptors for thetreatment of colorectal cancer [Relazione in Atti di Convegno]
Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Elisi, GIAN MARCO; Mor, Marco; Moschella, MARIA GAETANA; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
abstract


2022 - A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties [Poster]
Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Moschella, MARIA GAETANA; Aiello, Daniele; Lopresti, Ludovica; Pozzi, Cecilia; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
abstract


2022 - Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth [Articolo su rivista]
Costantino, Luca; Ferrari, Stefania; Santucci, Matteo; MH Salo-Ahen, Outi; Carosati, Emanuele; Franchini, Silvia; Lauriola, Angela; Pozzi, Cecilia; Trande, Matteo; Gozzi, Gaia; Saxena, Puneet; Cannazza, Giuseppe; Losi, Lorena; Cardinale, Daniela; Venturelli, Alberto; Quotadamo, Antonio; Linciano, Pasquale; Tagliazucchi, Lorenzo; Moschella, MARIA GAETANA; Guerrini, Remo; Pacifico, Salvatore; Luciani, Rosaria; Genovese, Filippo; Henrich, Stefan; Alboni, Silvia; Santarem, Nuno; CORDEIRO DA SILVA, Anabela; Giovannetti, Elisa; J Peters, Godefridus; Pinton, Paolo; Rimessi, Alessandro; Cruciani, Gabriele; M Stroud, Robert; C Wade, Rebecca; Mangani, Stefano; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
abstract


2022 - Development of a sensitive biochemical tool to assess the expression levels of recombinant ectopic proteins in in vitro engineered cellular systems [Abstract in Atti di Convegno]
Moschella, Mg; Marverti, G; Cassanelli, Valentina; Venuti, Federica; Tagliazucchi, L; Costi, Mp; D’Arca., D
abstract


2022 - Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library [Articolo su rivista]
Lauriola, A.; Uliassi, E.; Santucci, M.; Bolognesi, M. L.; Mor, M.; Scalvini, L.; Elisi, G. M.; Gozzi, G.; Tagliazucchi, L.; Marverti, G.; Ferrari, S.; Losi, L.; D'Arca, D.; Costi, M. P.
abstract


2022 - LC-MS serum proteomics reveals a panel of proteins prognostic of positive responsiveness to bevacizumab therapy in late-stages ovarian cancer patients [Abstract in Atti di Convegno]
Tagliazucchi, Lorenzo; Moschella, MARIA GAETANA; D'Addese, Gianluca; Califano, Daniela; Arenare, Laura; Mezzanzanico, Delia; Chinello, Clizia; Magni, Fulvio; Villani, Marco; Losi, Lorena; Marverti, Gaetano; D'Arca, Domenico; Chiodini, Paolo; Pignata, Sandro; Costi, Maria Paola
abstract


2022 - Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase [Abstract in Atti di Convegno]
Aiello, Daniele; Ascione, Cristian; Tagliazucchi, Lorenzo; Malpezzi, Giulia; Cassanelli, Valentina; Ponterini, Glauco; D'Arca, Domenico; Marverti, Gaetano; Moschella, MARIA GAETANA; Falchi, Federico; Venturelli, Alberto; Costi, Maria Paola
abstract


2022 - Targeting the dimer-monomer equilibrium of thymidylate synthase, to accelerate protein degradation and cancer cell growth inhibition [Abstract in Atti di Convegno]
Costi, Maria Paola; Venturelli, A; Ponterini, G; Pozzi, C; Wade, Rebecca; Giovannetti, E; Rimessi, A; Tagliazucchi, L; Moschella, M; Marverti, G; D’Arca, D
abstract


2022 - Telomere Dysfunction Is Associated with Altered {DNA} Organization in Trichoplein/Tchp/Mitostatin ({TpMs}) Depleted Cells [Articolo su rivista]
Lauriola, Angela; Davalli, Pierpaola; Marverti, Gaetano; Caporali, Andrea; Mai, Sabine; D'Arca, Domenico
abstract


2021 - Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme [Relazione in Atti di Convegno]
Tagliazucchi, Lorenzo; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
abstract


2021 - Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth [Poster]
Tagliazucchi, Lorenzo; Malpezzi, Giulia; Pozzi, Cecilia; Lopresti, Ludovica; Venturelli, Alberto; D'Arca, Domenico; Marverti, Gaetano; Cecconi, Ciro; Ponterini, Glauco; Costi, Maria Paola
abstract


2021 - Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting [Articolo su rivista]
Marverti, Gaetano; Marraccini, Chiara; Martello, Andrea; D'Arca, Domenico; Pacifico, Salvatore; Guerrini, Remo; Spyrakis, Francesca; Gozzi, Gaia; Lauriola, Angela; Santucci, Matteo; Cannazza, Giuseppe; Tagliazucchi, Lorenzo; Cazzato, Addolorata Stefania; Losi, Lorena; Ferrari, Stefania; Ponterini, Glauco; Costi, Maria P
abstract


2021 - Structural bases for the synergistic inhibition of human thymidylate synthase and ovarian cancer cell growth by drug combinations [Articolo su rivista]
Pozzi, C.; Santucci, M.; Marverti, G.; D'arca, D.; Tagliazucchi, L.; Ferrari, S.; Gozzi, G.; Losi, L.; Tassone, G.; Mangani, S.; Ponterini, G.; Costi, M. P.
abstract


2021 - Structural insight into YAP-TEAD4 protein-protein interactions as target for cancer treatment [Abstract in Atti di Convegno]
Lopresti, Ludovica; Pozzi, Cecilia; Tagliazucchi, L; D’Arca, D; Marverti, G; Costi, Mp; Mangani, Stefano
abstract


2020 - A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells [Articolo su rivista]
Marverti, Gaetano; Gozzi, Gaia; Maretti, Eleonora; Lauriola, Angela; Severi, Leda; Sacchetti, Francesca; Losi, Lorena; Pacifico, Salvatore; Ferrari, Stefania; Ponterini, Glauco; Leo, Eliana Grazia; Costi, Maria Paola; D'Arca, Domenico
abstract


2020 - Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells [Articolo su rivista]
Lauriola, Angela; Martello, Andrea; Fantini, Sebastian; Marverti, Gaetano; Zanocco-Marani, Tommaso; Davalli, Pierpaola; Guardavaccaro, Daniele; Mai, Sabine; Caporali, Andrea; D’Arca, Domenico
abstract


2020 - Structural, Hirshfeld surface and in vitro cytotoxicity evaluation of five new N-aryl-N’-alkoxycarbonyl thiocarbamide derivatives. [Articolo su rivista]
Pandey, Sunil K.; Pratap, Seema; Rai, Sunil K.; Marverti, Gaetano
abstract


2020 - Synthesis, characterisation, Hirshfeld surface and in vitro cytotoxicity evaluation of new N-aryl-N0-Alkoxycarbonyl thiocarbamide derivatives. [Articolo su rivista]
Pandey, Sunil K.; Pratap, Seema; Rai, Sunil K.; Marverti, Gaetano; Kaur, Manpreet; P. Jasinski., Jerry
abstract


2019 - Copper (I) complexes based on novel N, N'-disubstituted thiocarbamides: Synthesis, spectroscopic, in vitro cytotoxicity, DNA damage and G0/G1 cell cycle arrest studies [Articolo su rivista]
Pandey, S. K.; Pratap, S.; Pokharia, S.; Mishra, H.; Marverti, G.; Kaur, M.; Jasinski, J. P.
abstract


2019 - Copper (I) complexes of N-(2/4 methoxy/2-chloro-4-nitro) phenyl-N’ (methoxycarbonyl) thiocarbamides as potential anticancer agents: Synthesis, crystal structure, in vitro cytotoxicity and DNA damage studies. [Articolo su rivista]
Pandey, Sunil K.; Singh, Durga P.; Pratap, Seema; Marverti, Gaetano; J. Butcher., R.
abstract


2019 - Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth [Articolo su rivista]
Pacifico, Salvatore; Santucci, Matteo; Luciani, Rosaria; Saxena, Puneet; Linciano, Pasquale; Ponterini, Glauco; Lauriola, Angela; D'Arca, Domenico; Marverti, Gaetano; Guerrini, Remo; Costi, Maria Paola
abstract


2019 - Experimental and theoretical exploration of molecular structure and anticancer properties of two N, N′–disubstituted thiocarbamide derivatives [Articolo su rivista]
Pandey, Sunil K.; Pratap, Seema; Tiwari, Manish K.; Marverti, Gaetano; Jasinski, Jerry P.
abstract


2019 - Exploring the biological activity of a library of 1,2,5-Oxadiazole derivatives endowed with antiproliferative activity [Articolo su rivista]
Gelain, A; Mori, M; Meneghetti, F; Porta, F; Basile, L; Marverti, G; Asai, A; Hyeraci, M; García-Argáez, An; Via, Ld; Guccione, S; Villa, S
abstract


2019 - Synthesis, characterization, Hirshfeld surface, cytotoxicity, DNA damage and cell cycle arrest studies of N, N-diphenyl-N'-(biphenyl-4- carbonyl/4-chlorobenzoyl) thiocarbamides [Articolo su rivista]
K Pandey, Sunil; K Rai, Sunil; Marverti, Gaetano; Kaur, Manpreet; P Jasinski, Jerry; Pratap, Seema
abstract


2019 - Synthesis, spectroscopic, crystal structure and in vitro cytotoxicity studies of N-thiophenoyl-N'-substituted phenyl thiocarbamide derivatives [Articolo su rivista]
Pandey, Sunil K.; Pratap, Seema; Marverti, Gaetano; Kaur, Manpreet; Jasinski, Jerry P.
abstract


2019 - The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines [Articolo su rivista]
Marverti, G.; Gozzi, G.; Lauriola, A.; Ponterini, G.; Belluti, S.; Imbriano, C.; Costi, M. P.; D’Arca, D.
abstract


2018 - Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth [Articolo su rivista]
Saxena, Puneet; Severi, Leda; Santucci, Matteo; Taddia, Laura; Ferrari, Stefania; Luciani, Rosaria; Marverti, Gaetano; Marraccini, Chiara; Tondi, Donatella; Mor, Marco; Laura, Scalvini; Vitiello, Simone; Losi, Lorena; Fonda, Sergio; Pacifico, Salvatore; Guerrini, Remo; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
abstract


2018 - Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth [Articolo su rivista]
Ferrari, Stefania; Severi, Leda; Cecilia, Pozzi; Quotadamo, Antonio; Ponterini, Glauco; Losi, Lorena; Marverti, Gaetano; Costi, Maria Paola
abstract


2018 - Monodentate Coordination of N, N′-Disubstituted Thiocarbamide Ligands: Syntheses, Structural Analyses, In Vitro Cytotoxicity and DNA Damage Studies of Cu(I) Complexes [Articolo su rivista]
Pandey, Sunil K.; Singh, Durga P.; Marverti, Gaetano; Butcher, R. J.; Pratap, Seema
abstract


2018 - Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer [Articolo su rivista]
Severi, Leda; Losi, Lorena; Fonda, Sergio; Taddia, Laura; Gozzi, Gaia; Marverti, Gaetano; Magni, Fulvio; Chinello, Clizia; Stella, Martina; Sheouli, Jalid; Braicu, Elena I.; Genovese, Filippo; Lauriola, Angela; Marraccini, Chiara; Gualandi, Alessandra; D'Arca, Domenico; Ferrari, Stefania; Costi, Maria P.
abstract


2018 - Repurposing of drugs targeting yap-tead functions [Articolo su rivista]
Elisi, Gian Marco; Santucci, Matteo; D’Arca, Domenico; Lauriola, Angela; Marverti, Gaetano; Losi, Lorena; Scalvini, Laura; Bolognesi, Maria Laura; Mor, Marco; Costi, Maria Paola
abstract


2018 - Synthesis, molecular structure exploration and in vitro cytotoxicity screening of five novel N, N′- disubstituted thiocarbamide derivatives [Articolo su rivista]
Pandey, Sunil K.; Pratap, Seema; Gozzi, Gaia; Marverti, Gaetano; Butcher, R. J.
abstract


2018 - Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies [Articolo su rivista]
Davalli, Pierpaola; Marverti, Gaetano; Lauriola, Angela; D’Arca, Domenico
abstract


2018 - pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells [Articolo su rivista]
Sacchetti, Francesca; Marverti, Gaetano; D’Arca, Domenico; Severi, Leda; Maretti, Eleonora; Iannuccelli, Valentina; Pacifico, Salvatore; Ponterini, Glauco; Costi, Maria Paola; Leo, Eliana
abstract


2017 - Heat shock protein 90 and serine/threonine kinase B-Raf inhibitors have overlapping chemical space [Articolo su rivista]
Anighoro, A.; Pinzi, Luca; Marverti, Gaetano; Bajorath, J; Rastelli, Giulio
abstract


2016 - Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology [Articolo su rivista]
Ponterini, Glauco; Martello, Andrea; Pavesi, Giorgia; Lauriola, Angela; Luciani, Rosaria; Santucci, Matteo; Pela', Michela; Gozzi, Gaia; Pacifico, Salvatore; Guerrini, Remo; Marverti, Gaetano; Costi, Maria Paola; D'Arca, Domenico
abstract


2016 - Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase [Articolo su rivista]
Luciani, Rosaria; Saxena, Puneet; Surade, Sachin; Santucci, Matteo; Venturelli, Alberto; Borsari, Chiara; Marverti, Gaetano; Ponterini, Glauco; Ferrari, Stefania; Blundell, Tom L; Costi, Maria Paola
abstract


2015 - ANTICANCER DRUGS [Brevetto]
Costantino, Luca; Costi, Maria Paola; Ponterini, Glauco; Marverti, Gaetano; Franchini, Silvia; Tondi, Donatella; D'Arca, Domenico; Ferrari, Stefania; Luciani, Rosaria; Venturelli, Alberto; Sammak, Susan; Lauriola, Angela; Gozzi, Gaia
abstract


2015 - Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance [Articolo su rivista]
Taddia, Laura; D'Arca, Domenico; Ferrari, Stefania; Marraccini, Chiara; Severi, Leda; Ponterini, Glauco; Assaraf, Yahuda G.; Marverti, Gaetano; Costi, Maria Paola
abstract


2015 - N-(naphthyl)-N′-(methoxy carbonyl)thiocarbamide and its Cu(I) complex: synthesis, spectroscopic, X-ray, DFT andin vitrocytotoxicity study [Articolo su rivista]
Singh, Durga P.; Pratap, Seema; Pandey, Sunil K.; Butcher, Ray J.; Marverti, Gaetano
abstract


2014 - Internalization and stability of a thymidylate synthase peptide inhibitor in ovarian cancer cells [Articolo su rivista]
Cannazza, Giuseppe; Cazzato, ADDOLORATA STEFANIA; Marraccini, Chiara; Pavesi, Giorgia; Pirondi, Silvia; R., Guerrini; M., Pelà; Frassineti, Chiara; Ferrari, Stefania; Marverti, Gaetano; Ponterini, Glauco; Costi, Maria Paola
abstract


2014 - Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides [Articolo su rivista]
Genovese, Filippo; A., Gualandi; L., Taddia; Marverti, Gaetano; S., Pirondi; C., Marraccini; P., Perco; M., Pelà; R., Guerrini; M. R., Amoroso; F., Esposito; A., Martello; Ponterini, Glauco; D'Arca, Domenico; Costi, Maria Paola
abstract


2014 - Optimization of Peptides That Target Human Thymidylate Synthase to Inhibit Ovarian Cancer Cell Growth [Articolo su rivista]
M., Pelà; Saxena, Puneet; Luciani, Rosaria; Santucci, Matteo; Ferrari, Stefania; Marverti, Gaetano; Marraccini, Chiara; Martello, Andrea; Pirondi, Silvia; Genovese, Filippo; S., Salvadori; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola; R., Guerrini
abstract


2014 - Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer [Brevetto]
Costi, Maria Paola; Ferrari, Stefania; Venturelli, Alberto; Ponterini, Glauco; Cardinale, Daniela; Marverti, Gaetano
abstract


2014 - Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer-US8916679 “B2 - Granted patent as second publication”. [Brevetto]
Costi, Maria Paola; Marverti, Gaetano; Cardinale, Daniela; Venturelli, Alberto; Ferrari, Stefania; Ponterini, Glauco
abstract


2013 - A proteomic approach to investigate the mechanism of action of anticancer peptides [Relazione in Atti di Convegno]
Genovese, Filippo; Gualandi, Alessandra; Taddia, Laura; Caselli, Monica; Ponterini, Glauco; Ferrari, Stefania; Marverti, Gaetano; R., Guerrini; M., Pela'; Pavesi, Giorgia; C., Trapella; Costi, Maria Paola
abstract


2013 - Chairperson EUTROC- Mayo Conference-Berlin - Preliminary characterization of pharmacodynamic biomarkers for LR-peptide growth inhibition of ovarian cancer (OC) cell models. [Altro]
Costi, Maria Paola; Amoroso, MARIA ROSARIA; Marverti, Gaetano; Genovese, Filippo
abstract


2013 - Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-IIα by bis-DemethoxyCurcumin in cancer cells [Articolo su rivista]
Belluti, Silvia; Basile, Valentina; Benatti, Paolo; Ferrari, Erika; Marverti, Gaetano; Imbriano, Carol
abstract


2013 - Invited lecture to 18th World Congress on Advances in Oncology and 16th International Symposium on Molecular Medicine 10-12 October, 2013, Creta Maris, Hersonissos, Crete, Greece [Relazione in Atti di Convegno]
Genovese, Filippo; Gualandi, Alessandra; Marverti, Gaetano; Taddia, Laura; Glauco, Ponterini; Pirondi, Silvia; Pela', Michela; Pavesi, Giorgia; Costi, Maria Paola
abstract


2013 - Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells [Articolo su rivista]
Marverti, Gaetano; Ligabue, A; Lombardi, P; Ferrari, Stefania; Monti, Maria Giuseppina; Frassineti, Chiara; Costi, Maria Paola
abstract


2013 - PTEROATE-PEPTIDE BIOCONJUGATE TARGETING THE FOLATE RECEPTOR IN HUMAN OVARIAN CANCER CELL LINES: TRANSPORT AND MECHANISM OF ACTION. [Abstract in Rivista]
Costi, Maria Paola; Marverti, Gaetano; Pirondi, Silvia; Martello, Andrea; D'Arca, Domenico; Pela', Michela; Guerrini, R.; Marraccini, Chiara
abstract


2013 - Translational repression of thymidylate synthase by targeting its mRNA [Articolo su rivista]
D., Garg; A. V., Beribisky; Ponterini, Glauco; Ligabue, Alessio; Marverti, Gaetano; Martello, Andrea; Costi, Maria Paola; M., Sattler; R. C., Wade
abstract


2012 - Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells. [Articolo su rivista]
Marverti, Gaetano; Guaitoli, Giambattista; Ligabue, Alessio; Frassineti, Chiara; Monti, Maria Giuseppina; P., Lombardi; Costi, Maria Paola
abstract


2012 - Folate Receptor Expression and Folate Receptor Targeted Chemotherapy in Cisplatin-sensitive and – resistant Human cancer cell lines Marverti G.a, Pirondi S.a, MarracciniC.a, Frassineti C.a, Helleman J.b, Berns E.M.J.J. b, and Costi, M.P. cThe 4th International Symposium on Folate Receptors and Transporters Cozumel, Mexico October 7 - 11, 2012 [Poster]
Marverti, Gaetano; Pirondi, Silvia; Marraccini, Chiara; Frassineti, Chiara; Costi, Maria Paola
abstract


2012 - Inhibitor of Ovarian Cancer Cells growth by Virtual Screening: A New Thiazole Derivative Targeting Human Thymidylate Synthase [Articolo su rivista]
Emanuele, Carosati; Anna, Tochowicz; Marverti, Gaetano; Giambattista, Guaitoli; Paolo, Benedetti; Ferrari, Stefania; Robert M., Stroud; Janet Sue Finer, Moore; Luciani, Rosaria; Davide, Farina; Gabriele, Cruciani; Costi, Maria Paola
abstract


2012 - Proteomic Approach to the Detection of the Mechanism of Action of Anticancer Peptides [Abstract in Rivista]
Genovese, Filippo; Gualandi, Alessandra; Taddia, Laura; Caselli, Monica; Ponterini, Glauco; Marverti, Gaetano; Pirondi, Silvia; R., Guerrini; M., Pela'; Pavesi, Giorgia; C., Trapella; Costi, Maria Paola
abstract


2012 - Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression [Articolo su rivista]
Ligabue, Alessio; Marverti, Gaetano; Liebl, Ursula; Myllykallio, Hannu
abstract


2011 - Characterization of the cell growth inhibitory effects of a novel DNA-intercalating bipyridyl-thiourea-Pt(II) complex in cisplatin-sensitive and-resistant human ovarian cancer cells [Articolo su rivista]
Marverti, Gaetano; Ligabue, Alessio; Montanari, Monica; Guerrieri, Davide; M., Cusumano; M. L., Di Pietro; L., Troiano; DI VONO, Elena; S., Iotti; G., Farruggia; F., Wolf; Monti, Maria Giuseppina; Frassineti, Chiara
abstract


2011 - Erratum: Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 34 (E542-E549) DOI: 10.1073/pnas.1104829108) [Articolo su rivista]
Cardinale, D.; Guaitoli, G.; Tondi, D.; Luciani, R.; Henrich, S.; Salo-Ahen, O. M. H.; Ferrari, S.; Marverti, G.; Guerrieri, D.; Ligabue, A.; Frassineti, C.; Pozzi, C.; Mangani, S.; Fessas, D.; Guerrini, R.; Ponterini, G.; Wade, R. C.; Costi, M. P.
abstract


2011 - Newly synthesized curcumin derivatives: crosstalk between chemico-physical properties and biological activity. [Articolo su rivista]
Ferrari, Erika; Francesca, Pignedoli; Imbriano, Carol; Marverti, Gaetano; Valentina, Basile; Ettore, Venturi; Saladini, Monica
abstract


2011 - Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase [Articolo su rivista]
Cardinale, Daniela; Guaitoli, Giambattista; Tondi, Donatella; Luciani, Rosaria; S., Henrich; O. M. H., Salo Ahen; Ferrari, Stefania; Marverti, Gaetano; Guerrieri, Davide; Ligabue, Alessio; Frassineti, Chiara; C., Pozzi; S., Mangani; D., Fessas; R., Guerrini; Ponterini, Glauco; R. C., Wade; Costi, Maria Paola
abstract


2010 - Ligand-Based Virtual Screening and ADME-Tox Guided Approach to Identify Triazolo-quinoxalines as Folate Cycle Inhibitors. [Articolo su rivista]
E., Carosati; G., Sforna; M., Pippi; Marverti, Gaetano; Ligabue, Alessio; Guerrieri, Davide; S., Piras; Guaitoli, Giambattista; Luciani, Rosaria; Costi, Maria Paola; G., Cruciani
abstract


2010 - Spermidine/spermine N1-acetyltranferasemodulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistanthuman ovarian cancer cell lines [Articolo su rivista]
Marverti, Gaetano; Ligabue, Alessio; Guerrieri, Davide; Paglietti, G; Piras, S; Costi, Maria Paola; Farina, Davide Salvatore Francesco; Frassineti, Chiara; Monti, Maria Giuseppina; Moruzzi, Maria Stella
abstract


2009 - Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells [Articolo su rivista]
Marverti, Gaetano; Ligabue, Alessio; G., Paglietti; P., Corona; S., Piras; G., Vitale; Guerrieri, Davide; Luciani, Rosaria; Costi, Maria Paola; Frassineti, Chiara; Moruzzi, Maria Stella
abstract


2009 - Development of new metal-chelating multi target drus derived from Curcumin [Relazione in Atti di Convegno]
Ferrari, Erika; Pignedoli, Francesca; Lazzari, Sandra; Imbriano, Carol; Marverti, Gaetano; Saladini, Monica
abstract


2009 - Synthesis, cytotoxic and combined cDDP activity of new stable curcumin derivatives [Articolo su rivista]
Ferrari, Erika; Lazzari, Sandra; Marverti, Gaetano; Pignedoli, Francesca; Ferdinando, Spagnolo; Saladini, Monica
abstract


2008 - Collateral sensitivity to novel folate cycle inhibitors enhances cisplatin effectiveness against human ovarian cancer cells. [Abstract in Atti di Convegno]
Marverti, Gaetano; Ligabue, Alessio; Guerrieri, Davide; Costi, Maria Paola; G., Paglietti; Frassineti, Chiara; Moruzzi, Maria Stella
abstract


2008 - SSAT modulation by putative regulators of folate cycle enzymes expression in cisplatin-sensitive and –resistant human ovarian cancer cell lines. [Abstract in Atti di Convegno]
Marverti, G.; Ligabue, A.; Costi, M. P.; Lombardi, P.; Guerrieri, D.; Frassineti, C.; Monti, M. G.; Moruzzi, M. S.
abstract


2008 - Studies on the anti-proliferative effects of novel DNA-intercalating bipyridyl-thiourea-Pt(II) complexes against cisplatin-sensitive and -resistant human ovarian cancer cells [Articolo su rivista]
Marverti, Gaetano; Matteo, Cusumano; Ligabue, Alessio; Maria Letizia Di, Pietro; Pasquale Antonio, Vainiglia; Ferrari, Angela; Bergomi, Margherita; Maria Stella, Moruzzi; Frassineti, Chiara
abstract


2008 - Synthesis, chemical and biological studies on new Fe3þ-glycosilated b-diketo complexes for the treatment of iron deficiency [Articolo su rivista]
Beatrice, Arezzini; Marco, Ferrali; Ferrari, Erika; Frassineti, Chiara; Lazzari, Sandra; Marverti, Gaetano; Ferdinando, Spagnolo; Saladini, Monica
abstract


2007 - 1H, 13C, 195Pt NMR study on platinum(II) interaction with sulphur containing Amadori compounds [Articolo su rivista]
Ferrari, Erika; Grandi, Romano; Lazzari, Sandra; Marverti, Gaetano; Rossi, Cecilia; Saladini, Monica
abstract


2006 - Glucosyl curcuminoid derivatives: Fe(III) and Ga(III) chelating agents with anti-cancer properties [Relazione in Atti di Convegno]
Ferrari, Erika; Frassineti, Chiara; Lazzari, Sandra; Marverti, Gaetano; Grandi, Romano; Saladini, Monica
abstract


2006 - Glucosyl curcuminoid derivatives: Fe(III) and Ga(III) chelating agents with anti-cancer properties [Relazione in Atti di Convegno]
Ferrari, Erika; Frassineti, Chiara; Lazzari, Sandra; Marverti, Gaetano; Grandi, Romano; Saladini, Monica
abstract


2005 - Spermidine/spermine N1-acetyltransferase transient over-expression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin [Articolo su rivista]
Marverti, Gaetano; Monti, Maria Giuseppina; Pegg, A. E.; Mccloskey, D. E.; Bettuzzi, S; Ligabue, Alessio; Caporali, A; D'Arca, Domenico; Moruzzi, Maria Stella
abstract


2004 - Cisplatin-resistance modulates the effect of protein synthesis inhibitors on spermidine/spermine N-1-acetyltransferase expression [Articolo su rivista]
Marverti, Gaetano; Monti, Maria Giuseppina; Bettuzzi, Saverio; A., Caporali; Astancolle, Serenella; Moruzzi, Maria Stella
abstract


2004 - Polyamine depletion switches the form of 2-deoxy-D-ribose-induced cell death from apoptosis to necrosis in HL-60 cells. [Articolo su rivista]
Monti, Maria Giuseppina; Ghiaroni, Stefania; Marverti, Gaetano; Montanari, Monica; Moruzzi, Maria Stella
abstract


2001 - Differential induction of spermidine/spermine N1-acetyltransferase activity in cisplatin-sensitive and -resistant ovarian cancer cells in response to N1,N12-bis (ethyl)spermine involves transcriptional and post-transcriptional regulation. [Articolo su rivista]
Marverti, Gaetano; Bettuzzi, S.; Astancolle, Serenella; Pinna, C.; Monti, Maria Giuseppina; Moruzzi, Maria Stella
abstract


1999 - 2-Deoxy-D-ribose-induced apoptosis in HL-60 cells is associated with the cell cycle progression by spermidine [Articolo su rivista]
Monti, Maria Giuseppina; S., Ghiaroni; D., Barbieri; C., Franceschi; Marverti, Gaetano; Moruzzi, Maria Stella
abstract


1999 - Differential induction of spermidine/spermine N1-acetyltransferase in cisplatin-sensitive and -resistant human breast cancer cells by N1, N12-bis(ethyl)spermine. [Capitolo/Saggio]
Marverti, Gaetano; G., Monti; M. G., Piccinini; And, Moruzzi; M., S.
abstract


1998 - N-1,N-12-bis(ethyl)spermine effect on growth of cis-diamminedichloroplatinum(II)-sensitive and -resistant human ovarian-carcinoma cell lines [Articolo su rivista]
Marverti, Gaetano; Piccinini, Giorgio; S., Ghiaroni; D., Barbieri; Quaglino, Daniela; Moruzzi, Maria Stella
abstract


1998 - Polyamine depletion protects HL-60 cells from 2-deoxy-D-ribose-induced apoptosis. [Articolo su rivista]
Monti, Maria Giuseppina; Ghiaroni, S.; Pernecco, Laura Rosa; Barbieri, D.; Marverti, Gaetano; Franceschi, Claudio
abstract


1997 - Modulation of cis-diamminedichloroplatinum(II) accumulation and cytotoxicity by spermine in sensitive and resistant human ovarian carcinoma cells. [Articolo su rivista]
Marverti, Gaetano; P. A., Andrews; Piccinini, Giorgio; S., Ghiaroni; D., Barbieri; Moruzzi, Maria Stella
abstract


1996 - Inhibition of cell growth by accumulated spermine is associated with a transient alteration of cell cycle progression [Articolo su rivista]
Monti, M. G.; Pernecco, L.; Manfredini, R.; Frassineti, C.; Barbieri, D.; Marverti, G.; Ghiaroni, S.
abstract


1996 - Stimulation of cis-diamminedichloroplatinum(II) accumulation by modulation of passive permeability with genistein: an altered responce in accumulation-defective resistant cells. [Articolo su rivista]
Marverti, Gaetano; P. A., Andrews
abstract


1995 - The effect of spermine on calcium requirement for protein kinase C association with phospholipid vesicles. [Articolo su rivista]
Moruzzi, Maria Stella; Marverti, Gaetano; Piccinini, Giorgio; Frassineti, Chiara; Monti, Maria Giuseppina
abstract


1994 - Effect of spermine on irreversible insertion of protein kinase C into phospholipid vesicles. [Relazione in Atti di Convegno]
Moruzzi, M. S; Marverti, Gaetano; Piccinini, G; Pernecco, L; Monti, M. G.
abstract


1994 - Spermine protects protein kinase C from phospholipid-induced inactivation [Articolo su rivista]
Monti, Maria Giuseppina; S., Ghiaroni; Marverti, Gaetano; G., Piccinini; L., Pernecco; Moruzzi, Maria Stella
abstract


1993 - Effect of Spermine on Membrane-Associated and Membrane-Inserted Forms of Protein Kinase C [Articolo su rivista]
Moruzzi, Maria Stella; Marverti, Gaetano; G., Piccinini; Frassineti, Chiara; Monti, Maria Giuseppina
abstract


1993 - Relationship Between Spermine and Calcium on the Activation Process of Protein Kinase C. [Articolo su rivista]
Moruzzi, Maria Stella; Marverti, Gaetano; Piccinini, Giorgio; Frassineti, Chiara; Monti, Maria Giuseppina
abstract


1991 - Effetto delle poliammine sulla regolazione della proteina cinasi C. [Relazione in Atti di Convegno]
Moruzzi, M. S; Piccinini, G; Marverti, Gaetano; Monti, M. G.
abstract


1990 - Effect of spermine on association of protein kinase C with phospholipid vesicles. [Articolo su rivista]
Moruzzi, Maria Stella; Monti, Maria Giuseppina; Piccinini, G; Marverti, Gaetano; Tadolini, B.
abstract