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CARLA PEZZUOLI
COLLABORATORE DI RICERCA
Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze sede ex-Sc. Biomediche
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Pubblicazioni
2024
- Ketogenic interventions in Autosomal Dominant Polycystic Kidney Disease: A comprehensive review of current evidence
[Articolo su rivista]
Pezzuoli, Carla; Biagini, Giuseppe; Magistroni, Riccardo
abstract
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder characterized
by the development and enlargement of multiple kidney cysts, leading to progressive kidney
function decline. To date, Tolvaptan, the only approved treatment for this condition, is able to slow
down the loss of annual kidney function without stopping the progression of the disease. Furthermore,
this therapy is approved only for patients with rapid disease progression and its compliance
is problematic because of the drug’s impact on quality of life. The recent literature suggests that
cystic cells are subject to several metabolic dysregulations, particularly in the glucose pathway, and
mitochondrial abnormalities, leading to decreased oxidative phosphorylation and impaired fatty
acid oxidation. This finding paved the way for new lines of research targeting potential therapeutic
interventions for ADPKD. In particular, this review highlights the latest studies on the use of ketosis,
through ketogenic dietary interventions (daily calorie restriction, intermittent fasting, time-restricted
feeding, ketogenic diets, and exogenous ketosis), as a potential strategy for patients with ADPKD,
and the possible involvement of microbiota in the ketogenic interventions’ effect.
2024
- The key role of public health in renovating Italian biomedical doctoral programs
[Articolo su rivista]
Palandri, Lucia; Urbano, Teresa; Pezzuoli, Carla; Miselli, Francesca; Caraffi, Riccardo; Filippini, Tommaso; Bargellini, Annalisa; Righi, Elena; Mazzi, Davide; Vigezzi, Giacomo Pietro; Odone, Anna; Marmiroli, Sandra; Boriani, Giuseppe; Vinceti, Marco
abstract
Background: A key renovation of doctoral programs is currently ongoing in Italy. Public health and its competencies may play a pivotal role in high-level training to scientific research, including interdisciplinary and methodological abilities. Methods: As a case study, we used the ongoing renovation of the Clinical and Experimental Medicine doctoral program at the University of Modena and Reggio Emilia. We focused on how the program is designed to meet national requirements as well as students' needs, thus improving educational standards for scientific research in the biomedical field, and on the specific contribution of public health and epidemiology in such an effort. Results: The renovation process of doctoral programs in Italy, with specific reference to the biomedical field, focuses on epidemiologic-statistical methodology, ethics, language and communication skills, and open science from an interdisciplinary and international perspective. In the specific context of the doctoral program assessed in the study and from a broader perspective, public health appears to play a key role, taking advantage of most recent methodological advancements, and contributing to the renovation of the learning process and its systematic quality monitoring. Conclusions: From a comparative assessment of this case study and Italian legislation, the key role of public health has emerged in the renovation process of doctoral programs in the biomedical field.
2023
- #5187 GREASE II: A PHASE II RANDOMIZED, 24-MONTH, PARALLEL-GROUP, SUPERIORITY STUDY TO EVALUATE THE EFFICACY OF A KETOGENIC DIET IN ADPKD PATIENTS
[Abstract in Rivista]
Pezzuoli, Carla; Testa, Francesca; Giovanella, Silvia; Ligabue, Giulia; Marchiò, Maddalena; Biagini, Giuseppe; Magistroni, Riccardo
abstract
2021
- Comparison between four mid-term dietary patterns to be used in postmenopausal women
[Abstract in Rivista]
Pezzuoli, C.; Zonta, G.; Meraglia, F.; Spinella, P.; Tikhonoff, V.
abstract
2021
- Menopause as determinant of fatty liver index at population level
[Articolo su rivista]
Meraglia, F.; Pezzuoli, C.; Anesi, S.; Bindolo, M. C.; Toniazzo, S.; Spinella, P.; Tikhonoff, V.
abstract
2021
- Study protocol car-predime (cardiovascular prevention with diet in menopause): preliminary report
[Abstract in Rivista]
Meraglia, F.; Pezzuoli, C.; Anesi, S.; Bindolo, M. C.; Toniazzo, S.; Spinella, P.; Tikhonoff, V.
abstract