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Pagina personale di Fabrizio RONCAGLIA

Dipartimento di Scienze Chimiche e Geologiche
Dipartimento di Scienze Chimiche e Geologiche - Sede Dipartimento di Scienze Chimiche e Geologiche

Clark, Andrew J; Curran, Dennis P.; Fox, David J.; Ghelfi, Franco; Guy, Collette S.; Hay, Benjamin; James, Natalie; Phillips, Jessica M.; Roncaglia, Fabrizio; Sellars, Philip B.; Wilson, Paul; Zhang, Hanmo ( 2016 ) - Axially Chiral Enamides: Substituent Effects, Rotation Barriers, and Implications for their Cyclization Reactions - JOURNAL OF ORGANIC CHEMISTRY - n. volume 81 - pp. da 5547 a 5565 ISSN: 0022-3263 [Articolo in rivista (262) - Articolo su rivista]
Abstract

The barrier to rotation around the N-alkenyl bond of 38 N-alkenyl-N-alkylacetamide derivatives was measured (ΔG∞ rotation varied between <8.0 and 31.0 kcal mol-1). The most important factor in controlling the rate of rotation was the level of alkene substitution, followed by the size of the nitrogen substituent and, finally, the size of the acyl substituent. Tertiary enamides with four alkenyl substituents exhibited half-lives for rotation between 5.5 days and 99 years at 298 K, sufficient to isolate enantiomerically enriched atropisomers. The radical cyclizations of a subset of N-alkenyl-N-benzyl-α-haloacetamides exhibiting relatively high barriers to rotation round the N-alkenyl bond (ΔG∞ rotation >20 kcal mol-1) were studied to determine the regiochemistry of cyclization. Those with high barriers (>27 kcal mol-1) did not lead to cyclization, but those with lower values produced highly functionalized γ-lactams via a 5-endo-trig radical-polar crossover process that was terminated by reduction, an unusual cyclopropanation sequence, or trapping with H2O, depending upon the reaction conditions. Because elevated temperatures were necessary for cyclization, this precluded study of the asymmetric transfer in the reaction of individual atropisomers. However, enantiomerically enriched atropsiomeric enamides should be regarded as potential asymmetric building blocks for reactions that can be accomplished at room temperature.

Isse, Abdirisak A.; Ghelfi, Franco; Roncaglia, Fabrizio; Gennaro, Armando; Visona, Giulia ( 2015 ) - Electrochemical Approach to Copper-Catalyzed Reversed Atom Transfer Radical Cyclization - ADVANCED SYNTHESIS & CATALYSIS - n. volume 357 - pp. da 782 a 792 ISSN: 1615-4150 [Articolo in rivista (262) - Articolo su rivista]
Abstract

Electrochemically mediated atom transfer radical cyclization (eATRC) has been developed as an easy and clean method allowing the synthesis of halogenated cyclic compounds. This method has been successfully applied to the copper-catalyzed atom transfer radical cyclization of some N-allyl-alpha,alpha-dichloroamides in acetonitrile (CH3CN) using a copper complex with tris(2-pyridylmethyl)amine (TPMA) with a metal loading of 1%. The catalyst is introduced as [Cu(II)TPMA](2+) and is activated and continuously regenerated to its active copper(I) form by reduction at a platinum (Pt) electrode. During the ATRC process a new copper(II) complex, namely, [ClCu(II)TPMA](+), whose reduction potential is ca. 0.350 V more negative than that of the starting [Cu(II)TPMA](2+), is formed. Therefore, the choice of the applied potential is critical and should be done taking care that all copper(II) species are reduced to copper(I). The compounds undergo very high conversions (79-100%) in a few hours of electrolysis, producing a cyclic gamma-lactam (yield 60-98%) as a mixture of two isomers, with a good cis-diastereoselectivity [dr (cis/trans) = 59/41-83/17]. [Cu(II)PMDE-TA](2+) (PMDETA= N, N, N',N '',N ''-pentamethyldiethylenetriamine) which is much cheaper, albeit less reactive than [Cu(II)TPMA](2+), was also investigated but the results were not satisfactory.

Roncaglia, Fabrizio; Ghelfi, Franco; Felluga, Fulvia; Poppi, Valentina ( 2014 ) - Simultaneous deprotection-oxidation of cyclic hemiacetals: A fine ending for a Ueno-Stork ATRC to dichloro-γ-lactones - TETRAHEDRON LETTERS - n. volume 55 - pp. da 2865 a 2868 ISSN: 0040-4039 [Articolo in rivista (262) - Articolo su rivista]
Abstract

Recently we found that a copper catalysed Ueno–Stork cyclization can be a very useful means for the expedient synthesis of dichloro-gamma-lactones, but, to take advantage of this step, the method still lacks of an efficient and selective follow-up. This Letter describes our progress in that field, unveiling the use of a supported and recyclable Cr(VI) catalyst for the simultaneous deprotection and oxidation of cyclic dichloro hemiacetals.

A. J. Clark; A. Cornia; F. Felluga; A. Gennaro; F. Ghelfi; A. A. Isse; M. C. Menziani; F. Muniz-Miranda; F. Roncaglia; D. Spinelli ( 2014 ) - Arylsulfonyl Groups: The Best Cyclization Auxiliaries for the Preparation of ATRC γ-Lactams can be Acidolytically Removed - EUROPEAN JOURNAL OF ORGANIC CHEMISTRY - n. volume / - pp. da 6734 a 6745 ISSN: 1099-0690 [Articolo in rivista (262) - Articolo su rivista]
Abstract

The N-arylsulfonyl group, which is the best and most useful cyclization auxiliary for the transition-metal-catalyzed atom transfer radical cyclization (ATRC) of N-allyl-α-polychloroamides, can be effectively removed from the target γ-lactams by using H2SO4–HOAc, without impairing the halogen functions. The reaction involves H+ attack on the aromatic moiety, and is strongly responsive to the electronic properties of the substituent bound to the aromatic ring: electron-donating groups, such as methyl or methoxy are, in fact, required for efficient “deprotection”. The N-p-nitrophenylsulfonyl cyclization auxiliary, in contrast to all the other sulfonyl groups tested, proved to be unsuitable for the ATRC, owing to a side reductive transposition that halts the redox cycle.

Franco Bellesia;Andrew J. Clark;Fulvia Felluga;Armando Gennaro;Abdirisak A. Isse;Fabrizio Roncaglia;Franco Ghelfi ( 2013 ) - Efficient and Green Route to γ-Lactams by Copper-Catalysed Reversed Atom Transfer Radical Cyclisation of α-Polychloro-N-allylamides, using a Low Load of Metal (0.5 mol%) - ADVANCED SYNTHESIS & CATALYSIS - n. volume 355 - pp. da 1649 a 1660 ISSN: 1615-4150 [Articolo in rivista (262) - Articolo su rivista]
Abstract

The cyclisation of N-allyl-N-substituteda- polychloroamides is efficiently obtained through a copper-catalysed activators regenerated by electron transfer–atom transfer radical cyclisation process, with a metal load of only 0.5 mol%. The redox catalyst is introduced in its inactive form as copper( II) chloride/[nitrogen ligand] complex, and continuously regenerated to the active copper(I) chloride/[ nitrogen ligand] species by ascorbic acid. To preserve the catalyst integrity, the hydrochloric acid, released after each regeneration cycle, has been quenched by carbonate. The choice of the solvent is critical, the best performance being observed in ethyl acetate-ethanol (3:1).

Franco Bellesia; Seoung-ryoung Choi; Fulvia Felluga; Giuliano Fiscaletti; Franco Ghelfi; Maria Cristina Menziani; Andrew F. Parsons; C. Dale Poulter; Fabrizio Roncaglia; Massimo Sabbatini; Domenico Spinelli ( 2013 ) - Novel Route to Chaetomellic Acid A and Analogues: Serendipitous Discovery of a more Competent FTase Inhibitor - BIOORGANIC & MEDICINAL CHEMISTRY - n. volume 21 - pp. da 348 a 358 ISSN: 1464-3391 [Articolo in rivista (262) - Articolo su rivista]
Abstract

A new practical route to chaetomellic acid A (ACA), based on the copper catalysed radical cyclization (RC) of (Z)-3-(2,2-dichloropropanoyl)-2-pentadecylidene-1,3-thiazinane, is described. Remarkably, the process entailed: (i) a one-pot preparation of the intermediate N-a-perchloroacyl-2-(Z)-alkyliden-1,3-thiazinanes starting from N-(3-hydroxypropyl)palmitamide, (ii) a two step smooth transformation of the RC products into ACA and (iii) only one intermediate chromatographic purification step. The method offers a versatile approach to the preparation of ACA analogues, through the synthesis of an intermediate maleic anhydride with a vinylic group at the end of the aliphatic tail, a function that can be transformed through a thiol–ene coupling. Serendipitously, the disodium salt of 2-(9-(butylthio)nonyl)-3-methylmaleic acid, that we prepared as a representative sulfurated ACA analogue, was a more competent FTase inhibitor than ACA. This behaviour was analysed by a molecular docking study.

A. Cornia; F. Felluga; V. Frenna; F. Ghelfi; A. F. Parsons; M. Pattarozzi; F. Roncaglia; D. Spinelli ( 2012 ) - CuCl catalyzed radical cyclisation of N-alpha-perchloroacyl-ketene-N,S-acetals: a new way to prepare disubstituted maleic anhydrides - TETRAHEDRON - n. volume 68 - pp. da 5863 a 5881 ISSN: 0040-4020 [Articolo in rivista (262) - Articolo su rivista]
Abstract

The copper catalyzed radical cyclization (RC) of N-α-perchloroacyl cyclic ketene-N,X(X = O, NR, S)-acetals was studied. While the RC of N-acyl ketene-N,O-acetals was unsuccessful, the 5-endo cyclization provided much better results, with the following order of cyclization efficiency: hexa-atomic cyclic ketene-N,NR-acetals < penta-atomic cyclic ketene-N,S-acetals < hexa-atomic cyclic ketene-N,S-acetals. Invariably the catalytic cycle begins with the formation of a carbamoyl methyl radical. This leads to a cascade of reactions, including a radical polar crossover step, which ends with the formation of the maleimide nucleus, or precursors of this. Products from the RC of the hexa-atomic cyclic ketene-N,S-acetals, were efficiently transformed into disubstituted maleic anhydrides.

F. Roncaglia; A. F. Parsons; F. Bellesia; F. Ghelfi ( 2011 ) - Acetic Anhydride/Et3N/DMAP: An Effective Acetylating System for Hemiacetals - SYNTHETIC COMMUNICATIONS - n. volume 41 - pp. da 1175 a 1180 ISSN: 0039-7911 [Articolo in rivista (262) - Articolo su rivista]
Abstract

The selective and efficient acetylation of the hemiacetal hydroxyl in the equilibrium mixture between RCl2C(OAll)OH and AllOH/RCl2CHO was achieved using the acylating system Ac2O/Et3N/dimethylaminopyridine (DMAP).

M. Pattarozzi; F. Roncaglia; V. Giangiordano; P. Davoli; F. Prati; F. Ghelfi. ( 2010 ) - 'Ligand-free-like' CuCl-catalyzed atom transfer radical cyclization of N-substituted N-allyl polychloroamides to γ-lactams. - SYNTHESIS - n. volume - - pp. da 694 a 700 ISSN: 0039-7881 [Articolo in rivista (262) - Articolo su rivista]
Abstract

Atom transfer radical cyclization (ATRC) of N-alkyl N-allyl dichloroamides to γ-lactams, catalyzed by 'naked' CuCl, worked efficiently in DMF, whereas, when the same dichloroamides were N-sulfonylated, DMF needed to be replaced by acetonitrile. The outcome of the cycloisomerization with N-substituted N-allyl trichloroacetamides was less affected by solvent choice, although for an effective reaction to occur, the solvent had to dissolve the cuprous salt. Catalyst loading ranged between 5 and 20 mol%.

Ghelfi, Franco; Pattarozzi, Mariella; Roncaglia, Fabrizio; Giangiordano, Valerio; Parsons, A. F. ( 2010 ) - Expedient Synthesis, on Large Scale, of Aliphatic Chaetomellic Anhydrides from N-Allyl-2,2-dichlorocarboxyamides - SYNTHETIC COMMUNICATIONS - n. volume 40 - pp. da 1040 a 1051 ISSN: 0039-7911 [Articolo in rivista (262) - Articolo su rivista]
Abstract

Chaetomellic anhydride A and an analog (with two addnl. carbons) were obtained, on a preparative scale, starting from amides derived from the acylation of 2-(2-propenylamino)pyridine with 2,2-dichloropalmitic or 2,2-dichlorostearic acid. An alternative approach, in which the Me substituent of the target anhydride is introduced by the carboxylic acid reactant and the long aliph. chain is added through the allylamino moiety, proved unviable.

Pattarozzi, Mariella; Roncaglia, Fabrizio; Accorsi, L.; Parsons, A. F.; Ghelfi, Franco ( 2010 ) - Functional rearrangement of 3-Cl or 3,3-diCl-γ-lactams bearing a secondary 1-chloroalkyl substituent at C-4 - TETRAHEDRON - n. volume 66 - pp. da 1357 a 1364 ISSN: 0040-4020 [Articolo in rivista (262) - Articolo su rivista]
Abstract

The study of the reaction with MeONa/MeOH of chlorinated , prepd. from the atom transfer radical cyclization of N-allyl-α-perchloroamides, has been extended to the case of substrates carrying an exo halogen atom on a branched carbon. Only with secondary exo C-Cl groups, that are not located on a fused ring, does the functional rearrangement follow the typical transformation route, which with trichloro-lactams can proceed further to give 4-alkylidene derivs. From a practical point of view, the outcome of the reaction with di- or trichloro N-cinnamylamides is synthetically valuable, affording the 5-methoxy-1H-pyrrol-2(5H)-one or 3-benzylidenepyrrolidine-2,5-dione, resp., in good to excellent yield.

Felluga, F.; Ghelfi, Franco; Pitacco, G.; Roncaglia, Fabrizio; Valentin, E.; Venneri, C. D. ( 2010 ) - Esterase-mediated synthesis of optically active GABA analogues containing a stereogenic all-carbon quaternary carbon atom. - TETRAHEDRON-ASYMMETRY - n. volume 21 - pp. da 2183 a 2191 ISSN: 0957-4166 [Articolo in rivista (262) - Articolo su rivista]
Abstract

Esterase from Horse Liver (HLAP) was able to hydrolyze a series of linear and cyclic b,b-dialkyl-c-nitroesters, in spite of the well-known reluctance of hydrolytic enzymes to recognize and transform hindered substrates, such as those possessing a stereogenic quaternary carbon atom next to the reaction site. The resulting optically active c-nitroesters gave access to optically active b,b-disubstituted c-aminoacids as well as a,a-disubstituted succinic acids, both being biologically relevant compounds.

F. Ghelfi; F. Roncaglia; M. Pattarozzi; V. Giangiordano; G. Petrillo; F. Sancassan; A. F. Parsons. ( 2009 ) - Atom transfer radical cyclization of O-allyl-2,2-dichlorohemiacetal acetates: an expedient method to dichloro-gamma-lactones. - TETRAHEDRON - n. volume 65 - pp. da 10323 a 10333 ISSN: 0040-4020 [Articolo in rivista (262) - Articolo su rivista]
Abstract

3-Alkyl-3-chloro-4-chloromethyl--lactones were synthesized in acceptable yields, exploiting the CuCl-N,N,N’,N”,N”-pentamethyldiethylenetriamine catalyzed atom transfer radical cyclization (ATRC) of O-allyl-2,2-dichlorohemiacetal acetates, starting materials easily prepared from 2,2-dichloroaldehydes. The oxidation of the intermediate dichloro-2-acetoxytetrahydrofurans was completed in a two step, one-pot procedure: hydrolysis to gamma-lactol and final oxidation to lactone with the Jones’ reagent.

F. Roncaglia; C. V. Stevens; F. Ghelfi; M. Van der Steen; M. Pattarozzi; L. De Buyck ( 2009 ) - A new synthetic route to Tyromycin A and its analogue from renewable resources - TETRAHEDRON - n. volume 65 - pp. da 1481 a 1487 ISSN: 0040-4020 [Articolo in rivista (262) - Articolo su rivista]
Abstract

The synthesis of tyromycin A and that of the non-natural lower homologue, involving as featuring stepsa transition metal catalyzed atom transfer radical cyclization and a functional rearrangement of thepolyhalogenated 2-pyrrolidinones thus obtained, are described. Both routes use 10-undecenoic acid,a renewable source from castor oil, as starting material for the preparation of the pivotal intermediatesa,a,a0,a0-tetrachlorodicarboxylic acids.

Pattarozzi, Mariella; Ghelfi, Franco; Roncaglia, Fabrizio; Pagnoni, Ugo Maria; Parsons, A. F. ( 2009 ) - Synthesis of the disubstituted maleic anhydride frame using a novel tandem radical-polar reaction - SYNLETT - n. volume 00 - pp. da 2172 a 2176 ISSN: 0936-5214 [Articolo in rivista (262) - Articolo su rivista]
Abstract

An unreported 5-endo-trig atom transfer radical cyclization of cyclic N--dichloroacyl-ketene-N,S-acetals, which evolves as a tandem radical-polar process, is described. The reaction, which is carried out in the presence of a Cu(I) complex catalyst (10 mol%) and an inorganic base (i.e. carbonate), can be exploited as the key step for a novel, short and versatile synthesis of the 3,4-disubstituted maleic anhydride nucleus.

F. Ghelfi; M. Pattarozzi; F. Roncaglia; A.F. Parsons; F. Felluga; U.M. Pagnoni; E. Valentin; A. Mucci; F. Bellesia ( 2008 ) - Preparation of the Maleic Anhydride Nucleus from Dichloro γ-Lactams: Focus on the Role of the N-Substituent in the Functional Rearrangement and in the Hydrolytic Steps - SYNTHESIS - n. volume 19 - pp. da 3131 a 3141 ISSN: 0039-7881 [Articolo in rivista (262) - Articolo su rivista]
Abstract

The preparation of the 3,4-dialkyl-substituted maleic anhydride nucleus, through the functional rearrangement of dichloro γ-lactams, allowed the comparison of various N-substituents in the functional rearrangement step. The 2-pyridyl group proved to be the most appropriate N-substituent for the hydrolysis of the 5-methoxy-1,5-dihydro-2H-pyrrol-2-one intermediate into the 5-hydroxy adduct, and for the hydrolysis of the maleimide nucleus into the maleic anhydride. The oxidation of the 5-hydroxy-1,5-dihydro-2H-pyrrol-2-one into the corresponding maleimide was achieved with manganese(IV) oxide.

M. Van der Steen; C.V. Stevens; Y. Eeckhout; L. De Buyck; F. Ghelfi; F. Roncaglia ( 2008 ) - Undecylenic acid: a valuable renewable Building Block on route to Tyromycin A derivatives - EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY - n. volume 110 - pp. da 846 a 852 ISSN: 1438-9312 [Articolo in rivista (262) - Articolo su rivista]
Abstract

A key intermediate for the synthesis of Tyromycin A, a C-20 tetrachlorodicarboxylic acid, was produced in six steps starting with a dimerisation of methyl 10-undecenoate which was obtained from a renewable resource, e.g. castor oil. The acyloin condensation product was then oxidised, transformed to the diene, followed by ozonisation, chlorination and finally oxidation to the corresponding tetrachlorodicarboxylic acid.

C. FORZATO; G. FURLAN; F. GHELFI; P. NITTI; G. PITACCO; F. RONCAGLIA; E. VALENTIN ( 2007 ) - Lipase-catalysed deacetylation of botryodiplodin acetate (PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND, OX5 1GB ) - TETRAHEDRON-ASYMMETRY - n. volume 18 - pp. da 447 a 450 ISSN: 0957-4166 [Articolo in rivista (262) - Articolo su rivista]
Abstract

Enantioselective deacetylation of -(±)-botryodiplodin acetate was successfully accomplished by means of Lipase PS to afford -(+)-botryodiplodin and -(+)-botryodiplodin acetate with high enantiomeric excesses. Enzyme-mediated transesterification of the acetylated molecule with n-butanol as well as its hydrolysis in several organic solvents are also reported. The CD spectra of -(+)-botryodiplodin and -(+)-botryodiplodin acetate are also presented.

F. FELLUGA; F. GHELFI; UM PAGNONI; AF PARSONS; M. PATTAROZZI; F. RONCAGLIA; E. VALENTIN ( 2007 ) - A novel short approach to (Z)-pulchellalactam through Transition-Metal-Catalized Atom-Transfer Radical Cyclization of 1-isopropylprop-2-enyl dichloroacetate - SYNTHESIS - n. volume 00 - pp. da 1882 a 1886 ISSN: 0039-7881 [Articolo in rivista (262) - Articolo su rivista]
Abstract

A new five-step route to the CD45 protein tyrosine phosphatase inhibitor (Z)-pulchellalactam is presented. Key steps are the CuCl-bipyridine catalysed atom transfer radical cyclization of an appropriate allyl ,-dichloroacetate and the subsequent dehydrochlorination/prototropic rearrangement of the resulting dichlorolactone.

F. Bellesia; C. Danieli; L. De Buyck; R. Galeazzi; F. Ghelfi;A. Mucci; M. Orena; U. M. Pagnoni; A. F. Parsons; F. Roncaglia ( 2006 ) - A short approach to chaetomellic anhydride A from2,2-dichloropalmitic acid: elucidation of the mechanism governingthe functional rearrangement of the chlorinatedpyrrolidin-2-one intermediate - TETRAHEDRON - n. volume 62 - pp. da 746 a 757 ISSN: 0040-4020 [Articolo in rivista (262) - Articolo su rivista]
Abstract

Chaetomellic anhydride A was efficiently attained in three steps, starting from 2,2-dichloropalmitic acid and 2-(3-chloro-2-propenylamino)pyridine. Atom transfer radical cyclisation selectively formed the cis-stereoisomer of the trichloropyrrolidin-2-one, which underwent a stereospecific functional rearrangement to form a substituted maleimide. The choice of 2-pyridyl, as ‘cyclisation auxiliary’ in the atom transfer radical cyclisation step, proved beneficial for hydrolysis of the maleimide to form the desired anhydride.

L. DE BUYCK; C. FORZATO; F. GHELFI; A. MUCCI; P. NITTI; UM PAGNONI; AF PARSONS; G. PITACCO; F. RONCAGLIA ( 2006 ) - A new and effective route to (+/-)-botryodiplodin and (+/-)-epi-botryodiplodin acetates using a halogen atom transfer Ueno-Stork cyclization - TETRAHEDRON LETTERS - n. volume 47 - pp. da 7759 a 7762 ISSN: 0040-4039 [Articolo in rivista (262) - Articolo su rivista]
Abstract

(+/-)-Botryodiplodin and (+/-)-epi-botryodiplodin acetates were prepared in good yields following a practical four step route. The method, for the construction of the strategic tetrahydrofuran ring, hinged on an unprecedented halogen atom transfer Ueno-Stork cyclization of an O-allyl alpha,alpha-dihalohemiacetal acetate, catalyzed by the redox complex CuCl/N,N,N ',N '',N ''-pentamethyldiethylenetriamine. (c) 2006 Elsevier Ltd. All rights reserved.

F. Roncaglia; L. De Buyck; F. Bellesia; C. Forzato; F. Ghelfi; L. Goldoni; A. Mucci; U. M. Pagnoni; A. F. Parsons; E. Valentin ( 2005 ) - Sintesi della (+/-)-Botriodiplodina e della sua forma Epi attraverso una ciclizzazione di Ueno-Stork a trasferimento di atomo ( III Meeting Prin 2003-2004 - - 12-13 ottobre 2005) ( - III Meeting Prin 2003-2004 ) (.. .. ITA ) - n. volume unico [Abstract in Atti di convegno (274) - Abstract in Atti di Convegno]
Abstract

E' riportata la sintesi della (+/-)-botriodiplodina e della sua forma Epi attraverso una ciclizzazione di Ueno-Stork a trasferimento di atomo

L. De Buyck; F. Ghelfi; A. Mucci; U. M. Pagnoni; A. F. Parsons; A. Pinetti; F. Roncaglia ( 2005 ) - Studio di una via più versatile per la preparazione di nuclei 2,5-furandionici disostituiti ( III Meeting Prin 2003-2004 - - 12-13 ottobre 2005) ( - III Meeting Prin 2003-2004 ) (.. .. ITA ) - n. volume unico [Abstract in Atti di convegno (274) - Abstract in Atti di Convegno]
Abstract

Si riporta lo studio di una via più versatile per la preparazione di nuclei 2,5-furandionici disostituiti

F. Roncaglia; L. De Buyck; F. Bellesia; C. Forzato; F. Ghelfi; L. Goldoni; A. Mucci; U. M. Pagnoni; A. F. Parsons; E. Valentin ( 2005 ) - Nuova sintesi della (+/-)-Botriodiplodina attraverso ciclizzazione di Ueno-Stork a trasferimento di atomo ( 5° Sigma Aldrich Young Chemists Symposium - - 10-12 ottobre 2005) ( - 5° Sigma Aldrich Young Chemists Symposium ) (SAYCS Riccione ITA ) - n. volume unico [Abstract in Atti di convegno (274) - Abstract in Atti di Convegno]
Abstract

E' presentata una nuova sintesi della (+/-)-Botriodiplodina attraverso ciclizzazione di Ueno-Stork a trasferimento di atomo