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Daniele RADI
Personale tecnico amministrativo
Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto
Referente informatico
Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto
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Pubblicazioni
2019
- A regional audit system for stillbirth: A way to better understand the phenomenon
[Articolo su rivista]
Po, G.; Monari, F.; Zanni, F.; Grandi, G.; Lupi, C.; Facchinetti, F.; Mancini, L.; Lugli, L.; Lanzoni, C.; Sgarbi, L.; Chiossi, C.; Ricchieri, F.; Roberta, C.; Contiero, R.; Garani, G.; Pedriali, M.; Rossi, S.; Fini, S.; Di Bartolo, M.; Radi, D.; Vancini, A.; Donati, A.; Guadalupi, E.; Righetti, F.; Salerno, A.; Cocchi, G.; Morandi, R.; Gabrielli, L.; Graziano, C.; Seri, M.; Caprara, G.; Mario, S. N. C.; Fantuz, F.; Ferlini, F.; Righi, E.; Silvestrini, D.; Foschi, F.; Fieni, S.; Frusca, T.; Ferretti, A.; Galli, L.; Magnani, C.; Silini, E.; Balduzzi, L.; Bellini, M.; Rodolfi, A. M.; Sgarabotto, M. P.; Fragni, G.; Comitini, G.; Bonasoni, M. P.; Fioroni, L.; Rozzi, C.; Tuzio, A.; Vito, I.; Mammoliti, P.; De Ambrosi, E.; Ricci, M.; Bandini, A.; Belosi, C.; Muratori, C.; Zago, S.; Turci, A.; Vitarelli, M.
abstract
Background: Implementation of high-quality national audits for perinatal mortality are needed to improve the registration of all perinatal deaths and the identification of the causes of death. This study aims to evaluate the implementation of a Regional Audit System for Stillbirth in Emilia-Romagna Region, Italy. Methods: For each stillbirth (≥ 22 weeks of gestation, ≥ 500 g) occurred between January 1, 2014 to December 1, 2016 (n = 332), the same diagnostic workup was performed and a clinical record with data about mother and stillborn was completed. Every case was discussed in a multidisciplinary local audit to assess both the cause of death (ReCoDe classification) and the quality of care. Data were reviewed by the Regional Audit Group. Stillbirth rates, causes of death and the quality of care were established for each case. Results: Total stillbirth rate was 3.09 per 1000 births (332/107,528). Late stillbirth rate was 2.3 per 1000 (251/107,087). Sixteen stillbirths were not registered by the Regional Birth Register. The most prevalent cause of death was placental disorder (33.3%), followed by fetal (17.6%), cord (14.2%) and maternal disorders (7.6%). Unexplained cases were 14%. Compared to local audits, the regional group attributed different causes of death in 17% of cases. At multivariate analysis, infections were associated with early stillbirths (OR 3.38, CI95% 1.62-7.03) and intrapartum cases (OR 6.64, CI95% 2.61-17.02). Placental disorders were related to growth restriction (OR 1.89, CI95% 1.06-3.36) and were more frequent before term (OR 1.86, CI95% 1.11-3.15). Stillbirths judged possibly/probably preventable with a different management (10.9%) occurred more frequently in non-Italian women and were mainly related to maternal disorders (OR 6.64, CI95% 2.61-17.02). Conclusions: Regional Audit System for Stillbirth improves the registration of stillbirth and allows to define the causes of death. Moreover, sub-optimal care was recognized, allowing to identify populations which could benefit from preventive measures.
2012
- Nitric Oxide concentration in endometrial washing throughout the menstrual cycle
[Articolo su rivista]
S., Giulini; M. M., Carbone; LA MARCA, Antonio; A., Tirelli; Radi, Daniele; Volpe, Annibale
abstract
PURPOSE: Nitric oxide (NO) intrauterine production has been shown to have an important role in the reproductive system in females. The objective of the present study was to evaluate NO concentration in endometrial washing throughout the menstrual cycle. METHODS: Observational study at Institute of Obstetrics and Gynecology, Mother-Infant Department, University Hospital. The study included 40 healthy fertile women, aged 21-40, with regular menstrual cycle, undergoing endometrial washing by hydrosonography for the assessment of NO concentration. RESULTS: Nitric oxide concentration in endometrial washing were low in early to mid proliferative phase (4.73 ± 1.57 mcM/L), but significantly higher (p < 0.05) in late proliferative phase (7.30 ± 3.37 mcM/L) early secretory phase (8.05 ± 1.97 mcM/L) and late secretory phase (8.69 ± 4.12 mcM/L) of menstrual cycle. CONCLUSIONS: Endometrial washing by hydrosonography is a simple, minimally invasive, and effective tool to use in the evaluation of cyclical NO intrauterine production. Nitric oxide concentrations increased during the late proliferative and secretory phase of menstrual cycle.
2010
- Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART).
[Articolo su rivista]
Marca, A. L.; G., Sighinolfi; Radi, Daniele; C., Argento; E., Baraldi; A. C., Artenisio; G., Stabile; Volpe, Annibale
abstract
BACKGROUND: In women, anti-Müllerian hormone (AMH) levels may represent the ovarian follicular pool and could be a useful marker of ovarian reserve. The clinical application of AMH measurement has been proposed in the prediction of quantitative and qualitative aspects in assisted reproductive technologies (ART). In men AMH is secreted in both the serum and seminal fluid. Its measurement may be useful in clinical evaluation of the infertile male. METHODS: The PubMed database was systematically searched for studies published until the end of January 2009, search criteria relevant to AMH, ovarian reserve, ovarian response to gonadotrophin stimulation, spermatogenesis and azoospermia were used. RESULTS: AMH seems to be a better marker in predicting ovarian response to controlled ovarian stimulation than age of the patient, FSH, estradiol and inhibin B. A similar performance for AMH and antral follicular count has been reported. In clinical practice, AMH measurement may be useful in the prediction of poor response and cycle cancellation and also of hyper-response and ovarian hyperstimulation syndrome. In the male, the wide overlap of AMH values between controls and infertile men precludes this hormone from being a useful marker of spermatogenesis. CONCLUSIONS: As AMH may permit the identification of both the extremes of ovarian stimulation, a possible role for its measurement may be in the individualization of treatment strategies in order to reduce the clinical risk of ART along with optimized treatment burden. It is fundamental to clarify the cost/benefit of its use in ovarian reserve testing. Regarding the role of AMH in the evaluation of infertile men, AMH as single marker of spermatogenesis does not seem to reach a satisfactory clinical utility.
1987
- PROOPIOMELANOCORTIN-RELATED PEPTIDES IN FETOPLACENTAL STRUCTURES THROUGHOUT PREGNANCY
[Articolo su rivista]
Facchinetti, Fabio; A. E., Panerai; F., Petraglia; Radi, Daniele; T., Setti; A. R., Storchi; A. R., Genazzani
abstract
This study evaluates the presence of proopiomelanocortin(POMO).related peptides
in four embryos and eight fetal pituitaries starting from 5 to 25 weeks of pregnancy. .Moreover,
fetal membranes (amnion and chorion) were also investigated.
Freshly collected samples were boiled in acetic acid to destroy enzymes, homogenized and aub-
mitted to high performance liquid chromatography (linear gradient from 25 to 40% acetonitrile in
0.01 M HOI, in 15', 1.5 ml/min), The collected fractions were tested for the presence of p.lipotrophin
(p.LPH), p.endorphin(p.EP), y.endorphin(y.EP) through: RIAs.
p.EP and p•LPH were detected from 7 weeks of pregnancy while y.EP appeared later. Only
the cephalic portion of the embryos contained the peptides where p.LPH predominates while no
immunoreactivity was detected in the rostral one.
In the fetal pituitary there is a progressive increase of y.EP according to the gestational age and
both p.EP and p.LPH showed a trend toward constancy in the 15- 25 week range.
Amnion and chorion contai n a significant amount of the three peptìdes. Their ontogenesis starts
earlìerthan in the embryo; p.LPH or p.EP were detected at 5 weeks of pregnancy. In both tissues
p.EP was higher in the first than in the second trimester.
These data demonstrate a different pattern of POMO ontogeny and processing betweeri the con-
ceptus and his environment. This suggests that the POMQ•related opiod system of the fetus and of
fetal adnexes are independent of each other, possibly subserving to different functions,
1986
- OPIOID-PEPTIDES IN EMBRYO AND FETUS
[Articolo su rivista]
Storchi, Ar; Radi, Daniele; Petraglia, F; Facchinetti, Fabio
abstract
OPIOID-PEPTIDES IN EMBRYO AND FETUS