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MAURIZIO COPPINI

CULTORE DELLA MATERIA
Dipartimento Chirurgico, Medico, Odontoiatrico e di Scienze Morfologiche con interesse Trapiantologico, Oncologico e di Medicina Rigenerativa

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Pubblicazioni

2022 - HIV and syphilis: incidence rate of co-infection and syphilis re-infection in a cohort of newly diagnosed HIV patients [Articolo su rivista]
DI Tullio, Francesca; Mandel, Victor D; Cuomo, Gianluca; Coppini, Maurizio; Guaraldi, Giovanni; Mussini, Cristina; Pellacani, Giovanni; Borghi, Vanni
abstract

Syphilis represents a major public health concern disproportionately affecting HIV positive patients and in many cases both infections are newly diagnosed at the same time. To date, limited studies are available on syphilis incidence in patients with a new HIV diagnosis.

2019 - Collaboration experience between Dermatology Unit and Infectious Disease Clinic in Modena: optimization strategies for HIV, hepatitis and syphilis screening tests [Relazione in Atti di Convegno]
DI TULLIO, Francesca; Mandel, Victor Desmond; Coppini, Maurizio; Mussini, Cristina; Borghi, Vanni; Pellacani, Giovanni
abstract

Introduction Screening tests for HIV, HBV, HCV and syphilis are very important to detect and treat these infections at an early stage and prevent their diffusion inside communities. Sexually Transmitted Diseases Ambulatory of Dermatology Unit (STDs-DU) and “Test & Counselling” Ambulatory of Infectious Disease Clinic (T&C-IDC) in Modena began collaboration in 2010 and adopted a common diagnostic serological profile since 2013. Objective The main aim of the study was to analyse the results of screening tests performed in the STDs-DU and T&C-IDC, comparing the results obtained after the adoption of the shared protocol with the previous period. The secondary objective was to evaluate the efficacy of our collaboration in term of number of new diagnoses and linkage to care. Materials and Methods Consecutive patients referred to the STDs-DU and T&C-IDC from January 2010 to December 2016, with at least one performed screening test for HIV, HBV, HCV and syphilis were enrolled. Referral of patients with a new infection was obtained by capture-recapture methods in hospital databases. Results During the seven-years observation we collected 13117 admittances for 9154 patients. We observed a significant increase in the number of screening tests (p<0.001) and ratio between tests and admissions (p=0.002). 644 (7.0%) people with at least one infection were diagnosed. Among these, the most common was syphilis (41.9%), followed by HBV (25.7%), HCV (21.4%) and HIV (10.9%). Syphilis and HCV occurred predominantly in Italians (72.5% and 81.1%) and males (75.7% and 75.5%), while foreign-born (85.5%) mainly harboured HBV infection. HIV diagnosis was detected more frequently among males (67.1%) with a similar proportion between Italians and foreign-born. 543 out of 644 (84.3%) patients were linked to care. Conclusions The cooperation between STDs-DU and T&C-IDC has proven to work well increasing the diagnosis over the time and obtaining good results in linkage to care.

2019 - Optimization strategies for HIV, hepatitis and syphilis testing in Infectious Disease Clinic and Dermatology Unit of Modena: 7-year results of collaboration experience [Articolo su rivista]
Mandel, Victor Desmond; Di Tullio, Francesca; Rugge, Walter; Coppini, Maurizio; Mussini, Cristina; Pellacani, Giovanni; Borghi, Vanni
abstract

Background: Screening tests for human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis infections performed in at-risk population show a higher number of positive tests compared to those carried out in the general population. 'Test & Counselling' Ambulatory of Infectious Disease Clinic (T&C-IDC) and Sexually Transmitted Diseases Ambulatory of Dermatology Unit (STDs-DU) of Modena began collaboration in 2010 and adopted a common diagnostic serological profile since 2013. Objectives: The main objective was to analyse the number of screening tests performed in the T&C-IDC and STDs-DU, comparing the results obtained after the adoption of the shared protocol with the previous period. The secondary aim was to evaluate the linkage to care of newly diagnosed patients. Methods: Consecutive patients referred to the T&C-IDC and STDs-DU from January 2010 to December 2016, with at least one performed screening test for HIV, HBV, HCV and syphilis were enrolled. Referral of patients with a new infection was obtained by capture-recapture methods in hospital databases. Results: During the 7-year observation, we collected 13 117 admittances for 9154 patients. A significant increase in the number of screening tests (P < 0.001) and ratio between tests and admissions (P = 0.002) was observed. A total of 644 (7.0%) people with at least one infection were diagnosed. Among these, the most common was syphilis (41.9%), followed by HBV (25.7%), HCV (21.4%) and HIV (10.9%). Syphilis occurred predominantly in Italians (72.5%) and males (75.7%), as like as HCV, while foreign-born (85.5%) mainly harboured HBV infection. HIV diagnosis was detected more frequently among males (67.1%) with a similar proportion between Italians and foreign-born. Five hundred and forty-three out of 644 (84.3%) patients were linked to care. Conclusion: The collaboration between T&C-IDC and STDs-DU has proven to work well increasing the diagnosis over the time and obtaining good results in linkage to care.

2018 - Optimization strategies for HIV, hepatitis and syphilis testing in Infectious Disease Clinic and Dermatology Unit of Modena: seven-years results of collaboration experience [Poster]
DI TULLIO, Francesca; Mandel, Victor Desmond; Coppini, Maurizio; Mussini, Cristina; Borghi, Vanni; Pellacani, Giovanni
abstract

Introduction: Human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis infections modify the epidemiology and presentation of each other. Screening tests are very important for detection of sexually transmitted infections (STIs), for treating them at an early stage and prevent the diffusion inside communities. “Test & Counselling” Ambulatory of Infectious Disease Clinic (T&C-IDC) and Sexually Transmitted Diseases Ambulatory of Dermatology Unit (STDs-DU) of the Azienda Ospedaliero-Universitaria Policlinico of Modena began collaboration in 2010 and adopted a common diagnostic profile since 2013. The main objective was to analyse the results of screening tests performed in the T&C-IDC and STDs-DU during the study period in order to identify early HIV, HBV, HCV and syphilis infections. The secondary objective was to evaluate the efficacy of our collaboration in term of number of new STIs diagnoses and linkage to care. Material and Methods: Consecutive patients referred to the T&C-IDC and STDs-DU from January 2010 to December 2016, with at least one performed screening test for HIV, HBV, HCV and syphilis were enrolled. Demographic and laboratory data were acquired from each patient. Linkage to care of positive patients was obtained through a join of different outpatient clinical databases. Results: During the seven-years observation we collected 13117 admittances for 9154 patients. Median age was 35.1 years ± 12.6 and foreign-born population represents 29% of the tested people. People who resulted positive for at least one screening test increased during the study period. A total of 668 infections were detected in 644 patients. Discussion: The agreement between T&C-IDC and STDs-DU has proven to work well increasing the diagnosis over the time and obtaining a good results in linkage to care, which allows to patients with positive screening test to be sent to the pertinent Clinic for further investigations and therapeutic management.

2017 - New imaging tools for an old disease: Secondary syphilis [Articolo su rivista]
Guardoli, Davide; Reggiani, Camilla; Ciardo, Silvana; Coppini, Maurizio; Cesinaro, Anna Maria; Piana, Simonetta; Pellacani, Giovanni; Longo, Caterina
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2017 - Optimization strategies for HIV, syphilis and hepatitis testings in infectious disease and dermatology clinics: preliminary results of Modena collaboration experience [Poster]
DI TULLIO, Francesca; Mandel, Victor Desmond; Coppini, Maurizio; Pellacani, Giovanni; Mussini, Cristina; Borghi, Vanni
abstract

Background: HIV and sexually transmitted diseases (STDs) screening tests are usually offered in many Italian health institutions. These tests are very important for detection of HIV and STDs, for treating them at an early stage and for prevention of diffusion inside communities. Generally, HIV test is the only screening exam performed in Infectious Disease Clinic (IDC). Increased collaboration between IDC and STDs Centre using the same approach to test sexually transmitted infections could implement the number of new diagnoses. In the Azienda Ospedaliero-Universitaria (AOU) of Modena, the IDC and STDs Centre of Dermatology Clinic began a strict collaboration and adopted a common diagnostic profile including HIV, syphilis, HBV and HCV screening tests since 2013. The aim of the study was to observe the results of a seven-years collaboration in term of number of new HIV and STDs diagnoses. Material & Methods: Consecutive patients who underwent at least 1 screening test for HIV, syphilis, HBV and HCV from January 2010 to September 2016 in IDC or STDs Centre were included. Demographical data were electronically recorded in clinical databases. “Linkage to care” was obtained through a capture and recapture method using Modena HIV surveillance System and Modena HIV clinic databases. Results: During the study period 10675 admittances related to 8623 patients, who carried out at least 1 screening test, were registered in the centres. They were mainly male (68.2%). Median age was 33 years-old (IQR 26-43). Foreigners represented 26.5% of tested people. Since 2013 an increasing number of admittances was observed (1343 accesses in 2010 and 1901 in 2015). HBV, HCV and syphilis tests increased in IDC after 2013 as well as HIV tests in STDs Centre (Figure 1). A total of 700 people were positive for at least 1 screening test: 71 with HIV infection (2016 incidence rate 1.4%), 314 with syphilis (2016 incidence rate 1.3%), 182 with HCV infection (2016 incidence rate 1.64%) and 161 with HBV infection (2016 incidence rate 3.8%). The number of HIV and HBV positive tests increased in the last 2 years but the trend was statistically significant only for HIV (p<0.001). 57% of HIV new infections were observed in Italian men, while 82% of new HBV infections were detected in young foreigners. During the study period the number of new syphilis infections showed a reduction (p<0.001) while HCV positive tests were changeless (p=0.245). 87.6% of new infections were found be linked in care in AOU of Modena. Conclusion: The agreement between IDC and STDs Centre has proven to work well increasing the diagnosis over the time and obtaining a good results in “linkage to care”, which allows to patients with positive screening test to be sent to the pertinent Clinic for further investigations and therapeutical management.

2013 - E-FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes in vitro. [Articolo su rivista]
Dallaglio, Katiuscia; Marconi, Alessandra; Truzzi, Francesca; Lotti, Roberta; Palazzo, Elisabetta; Petrachi, Tiziana; Saltari, Annalisa; Coppini, Maurizio; Pincelli, Carlo
abstract

Epidermal fatty acid-binding protein (E-FABP) is a lipid carrier, originally discovered in human epidermis. We show that E-FABP is almost exclusively expressed in postmitotic (PM) keratinocytes, corresponding to its localization in the highest suprabasal layers, while it is barely expressed in keratinocyte stem cells (KSC) and transit amplifying (TA) keratinocytes. Transfection of normal human keratinocytes with recombinant (r) E-FABP induces overexpression of K10 and involucrin. On the other hand, E-FABP inhibition by siRNA downregulates K10 and involucrin expression in normal keratinocytes through NF-κB and JNK signalling pathways. E-FABP is highly expressed in psoriatic epidermis, and it is mainly localized in stratum spinosum. Psoriatic PM keratinocytes overexpress E-FABP as compared to the same population in normal epidermis. E-FABP inhibition in psoriatic keratinocytes markedly reduces differentiation, while it upregulates psoriatic markers such as survivin and K16. However, under high-calcium conditions, E-FABP silencing downregulates K10 and involucrin, while survivin and K16 expression is completely abolished. These data strongly indicate that E-FABP plays an important role in keratinocyte differentiation. Moreover, E-FABP modulates differentiation in psoriatic keratinocytes.

2013 - Perché un’improvvisa caduta di capelli merita un’accurata e completa visita dermatologica? [Poster]
Mandel, Victor Desmond; Ferrari, Chiara; AL JALBOUT, Samer; Coppini, Maurizio; Lasagni, Claudia; Pellacani, Giovanni
abstract

Il lupus eritematoso è una patologia sistemica autoimmune ad andamento cronico recidivante, caratterizzata da un ampio spettro clinico, che varia da una forma a coinvolgimento sistemico a una esclusivamente cutanea. Presentiamo il caso di una donna di colore di 42 anni con importante disagio psicologico dovuto a un rapido diradamento al cuoio capelluto. All’esame obiettivo si rilevava la presenza di due ampie aree di alopecia cicatriziale in sede parietale e occipitale. La diagnosi differenziale di alopecia cicatriziale al cuoio capelluto comprende principalmente lichen planus pilaris, lupus eritematoso discoide, follicolite decalvante e alopecia di Brocq. Ad una più approfondita valutazione clinica si riscontravano chiazze ipercromiche nella conca auricolare e lesioni infiltrate ipercheratosiche con ulcerazione centrale localizzate ai gomiti e in regione retro-auricolare. L’insieme di tali reperti clinici deponeva per lupus eritematoso discoide. Tale diagnosi veniva confermata dal quadro istologico e dalla presenza di depositi granulari di IgG alla giunzione dermo-epidermica evidenziati con l’immunofluorescenza diretta. Questo caso testimonia l’importanza di un accurato esame obiettivo dermatologico al fine di un corretto approccio clinico. Nello specifico, l’orientamento diagnostico veniva suggerito dalla concomitanza di tipiche lesioni al corpo e al cuoio capelluto.

2012 - Total body skin examination for skin cancer screening in patients with focused symptoms [Articolo su rivista]
Argenziano, G; Zalaudek, I; Hofmann Wellenhof, R; Bakos, Rm; Bergman, W; Blum, A; Broganelli, P; Cabo, H; Caltagirone, F; Catricalà, C; Coppini, Maurizio; Dewes, L; Francia, Mg; Garrone, A; Turk, Bg; Ghigliotti, G; Giacomel, J; Gourhant, Jy; Hlavin, G; Kukutsch, N; Lipari, D; Melchionda, G; Ozdemir, F; Pellacani, Giovanni; Pellicano, R; Puig, S; Scalvenzi, M; Sortino Rachou, Am; Virgili, Ar; Kittler, H.
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2005 - Una nuova associazione di calcipotriolo e betametasone dipropionato per il trattamento topico della psoriasi: esperienza clinica [Articolo su rivista]
Giannetti, Alberto; Coppini, Maurizio; A., Baggio
abstract

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2004 - Differences between non-national and indigenous patients with sexually transmitted infections in Italy and insight into the control of sexually transmitted infections [Articolo su rivista]
M., Giuliani; B., Suligoi; M., Affronti; F., Amerio; L., Andreassi; G., Angelini; M., Aricò; A., Barba; P., Battarra; E., Beconcini; B., Benvegnù; P., Biggio; F., Bonfigli; T., Cainelli; P., Calandra; E., Calzolari; D., Camisa; Coppini, Maurizio; F., Cottoni; A., D'Antuono; A., Di Carlo; P., Donofrio; G., Gaddoni; G., Galbiati; M., Gatti; S., Graifemberghi; S., Geraci; B., Guerra; V., Ingordo; G., Landi; M. A., Latino; N., Licci; A., Locatelli; M., Menegatti; G., Moise; A., Mossini; M., Norat; E., Nunzi; F., Perino; L., Priano; E., Provenzano; P., Puiatti; A., Rafanelli; F., Ricciuti; G., Righini; C., Sabbatini; D., Simonetto; G., Tarantini; F., Urbani; L., Vittone; G., Zuccati
abstract

Background: To determine the health needs non-nationals, informationon disease occurrence is fundamental.Goals: The goal of this study was to assess the clinical and behavioralcharacteristics of non-Italians with a new sexually transmittedinfection (STI).Methods: Data were taken from Italy’s National STI SurveillanceSystem (1991–1999).Results: Of the 61,798 STI cases reported from January 1991 toDecember 1999, 6847 (11.2%) were diagnosed among non-Italians,47.1% of whom were Africans. Being a non-Italian patient with an STIwas associated with male gender (adjusted odds ratio [AOR], 1.19;95% confidence interval [CI], 1.11–1.27), youngest age (AOR, 1.71;95% CI, 1.43–2.04), no formal education (AOR, 20.25; 95% CI, 17.51–23.42), and having contracted the STI abroad (AOR, 13.98; 95% CI,12.59 –15.54). The HIV-1 prevalence among non-Italian patients withSTIs was 5.5% (95% CI, 4.9–6.2), with large differences by continentof origin. The highest prevalence was found among European injectingdrug users (54.1%; 95% CI, 37.1–70.1), South American homosexualmen (41.6%; 95% CI, 32.0 –51.8), and heterosexuals from Sub-SaharanAfrica (8.9%; 95% CI, 7.2–10.8).Conclusions: Non-Italian patients with STIs seem to consist mainlyof migrants, and STI transmission patterns differ from those amongItalians; this information is important for developing targeted STIprevention effort

2002 - Associazione di melanoma e vitiligine: a proposito di un caso. [Articolo su rivista]
Coppini, Maurizio; A., Scarabello; A., Martella
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2002 - Calcipotriolo lozione nella psoriasi del cuoio capelluto: studio controllato 1 appl./die verso 2 appl./die [Articolo su rivista]
Giannetti, Alberto; Coppini, Maurizio; B., Giannotti; P., Carli; G., Landi; C., Stinchi; A., Pazzaglia; M., Lombardo; G., Micali; M. L., Musumeci; P., Amerio; B., Guidi; L., Andreassi; P., Calandra; R., Cucchia; A., Franchi; R., De Laurentis
abstract

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2002 - MST e Immigrazione: la situazione nel 2002. [Articolo su rivista]
Coppini, Maurizio; B., Suligoi
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1999 - Clinical trial of the efficacy and safety of oral etretinate withcalcipotriol cream compared with etretinate alone inmoderate-severe psoriasis [Articolo su rivista]
Giannetti, Alberto; Coppini, Maurizio; M. G., Bertazzoni; A., Califano; E., Altieri; A., Pazzaglia; M., Lega; M., Lombardo; C., Pelfini; C. V., Fornasa; G., Rabbiosi; M., Cespa
abstract

Background The aim of this clinical trial was to assess the efficacy and safety of calcipotriol cream associated with oraletretinate compared with etretinate alone in the treatment of moderate-severe psoriasis.Methods This controlled multicenter trial, within patients (hemiparts), enrolled 86 in- or out-patients (62 males, 24 females),mean (LSD) age 57.1 5 14.2 years, with psoriasis vulgaris on both sides of the body, and mean (LSE) baseline PASI score(Psoriasis Area and Severity Index) 30.7 ? 0.9. All patients took oral etretinate 50 mg/day and applied calcipotriol cream (50kg/g) on one half of their body twice a day. Treatment was continued for 9 weeks, and patients were seen every 3 weeks.Results At the end of the first 3 weeks the PASI score indicated a significant clinical difference between the two sides of thebody (P < 0,001, ANOVA), with a reduction of 50.7% in the score for the calcipotriol-treated half, compared with a 39%reduction for the untreated half. By the 9th week of treatment the PASI score was 81.4% lower on the treated half, and 70.3% onthe untreated side (P < 0.001, ANOVA).Conclusions These findings suggest that patients with moderate-severe psoriasis might benefit from treatment with etretinateplus calcipotriol, with the aim of achieving a faster response and an overall smaller total dose of etretinate.

1998 - Primary cutaneous nocardiosis [Articolo su rivista]
M., Folgaresi; G., Ferdani; Coppini, Maurizio; Pincelli, Carlo
abstract

A 37-year-old patient with systemic lupus erythematosus, who had been treated with oral corticosteroids for 10 years, developed primary cutaneous nocardiosis. Brown-violaceous, suppurative nodules and plaques arose on her right leg. Cultures of multiple biopsies on blood agar medium grew Nocardia. The patient received 500 mg of imipenem three times a day which resulted in complete regression of the lesions within two months. No relapse was observed 6 months later.

1998 - Sentinel surveillance of sexually transmitted diseases in Italy. [Articolo su rivista]
M., Giuliani; B., Suligoi; F., Amerio; L., Andreassi; R., Filotico; M., Aricò; A., Barba; P., Battarra; E., Beconcini; B., Benvegnù; P., Biggio; F., Bonfigli; T., Cainelli; P., Calandra; E., Calzolari; Coppini, Maurizio; F., Cottoni; A., D'Antuono; P., Donofrio; G., Gaddoni; G., Galbiati; M., Gatti; G., Gentili; S., Graifemberghi; B., Guerra; G., Landi; M. A., Latino; N., Licci; A., Locatelli; G., Moise; A., Mossini; M., Norat; F., Perino; L., Priano; E., Provenzano; P., Puiatti; A., Rafanelli; F., Ricciuti; G., Righini; C., Sabbatini; D., Simonetto; G., Tarantini; F., Urbani; L., Vittone; G., Zuccati
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1990 - Use of recent technologies in Chlamydia trachomatis diagnosis: utility and different applications [Articolo su rivista]
Messi, Patrizia; C. A., Provvisionato; Coppini, Maurizio; L., Piccinini
abstract

The authors report the results obtained usin "in situ" hybridization and immunoperoxidase assay to identify Chlamydia trachomatis in samples of man affected by non-gonococcal urethritis

1989 - Hereditary adenomatosis of the colon and rectum: clinical features of 8 families from Northern Italy [Articolo su rivista]
PONZ DE LEON, Maurizio; R. Sassatelli G., Zanghieri; C., Sacchetti; Roncucci, Luca; A., Scalmati; G., Bertoni; R., Conigliaro; M. G., Mortilla; C., Rombaldi; C., Pedrazzoli; R., Prati; P., Landi; Coppini, Maurizio; A., Ascari
abstract

Adenomatosis coli (or familial polyposis of the large bowel) and related syndromes are relatively rare diseases characterized by an autosomal dominant mode of inheritance. In these diseases, the entire colorectal mucosa is covered by hundreds (often innumerable) polyps of various dimensions. In addition, several extracolonic abnormalities have been reported. In the present study, we describe the clinical features of eight families from northern Italy fulfilling the diagnostic criteria of adenomatosis coli. Information was available on 123 unaffected and 30 affected family members. The most relevant findings of the study can be summarized as follows. 1) Gene frequency was calculated to be between 1:7,300 and 1:19,000. Segregation ratio in affected branches was 0.57, with a gene penetrance of nearly 60% and a male:female ratio of 1.73. 2) Extracolonic manifestations were present in all families and in 15 of 30 affected patients, the most frequent being cutaneous cysts and retinal lesions. No case fulfilling the classical criteria of Gardner syndrome was observed. 3) When the diagnosis of adenomatosis followed the appearance of symptoms, colorectal cancer had usually already developed, whereas no malignant changes were observed in individuals diagnosed in the asymptomatic stage. When colectomy with ileorectal anastomosis was the treatment of choice, polyps tended to recur in the rectal stump, and long-term endoscopic follow-up was necessary. In conclusion, adenomatosis coli may account for a definite proportion of colorectal neoplasms observed in the general population. Taking into consideration the genetic base of the disease, it follows that individuals at risk should be closely monitored for several years. Moreover, clinical investigations should not be limited to the large bowel, but should be extended to the skin, upper digestive tract, fundus oculi, bones, and probably other organs.

1989 - Heterosexual Transmission Of The Human Immunodeficiency Virus - A Seroepidemiological Study [Articolo su rivista]
B., De Rienzo; N., Mongiardo; F., Pellegrino; Coppini, Maurizio; G., Lami; G., Zanchetta; V., Borghi; I., Cocchi; F., Squadrini; Giannetti, Alberto
abstract

The transmission of the human immunodeficiency virus (HIV) was studied in 647 subjects who presented no apparent risk factors for the infection other than having had promiscuous heterosexual relations, heterosexual relations with people with an elevated risk of infection, or heterosexual relations with people infected by human immunodeficiency virus. Thirty subjects were found to be seropositive for anti-human immunodeficiency virus antibodies. The elevated risk factors included being the habitual partner of a person at risk of infection or of a person who was infected by human immunodeficiency virus, or being the partner of a patient with acquired immunodeficiency syndrome. The transmission of the virus was verified in 13 of 284 subjects (4.57%) who had had heterosexual intercourse three or more times with persons at risk and in 16 of 101 subjects (15.84%) who had had heterosexual intercourse three or more times with persons who were seropositive for human immunodeficiency virus antibodies. No significant correlation between human immunodeficiency virus infection and a history of sexually transmitted infections, nor between human immunodeficiency virus infection and female subjects was found. These data suggest that the epidemic of acquired immunodeficiency syndrome can also spread through heterosexual relations, even if the possibility of becoming infected in this way seems at the moment limited to particular risk behaviors.

1986 - Phenytoin-Treatment Of Rdeb Vegetans [Articolo su rivista]
Pini, Luigi Alberto; G., Girolomoni; Coppini, Maurizio; Pincelli, Carlo
abstract

To assess the potential short- and long-term efficacy of phenytoin in treating recessive dystrophic epidermolysis bullosa (RDEB), we treated a patiens with therapeutic doses of oral phenytoin (blood level, 8 to 10 micrograms/mL) for an 10 moths period During this tretament we recorded a percentage decrease in blistering of the skin over 50% This report suggest that phenytoin seems to have therapeutic efficacy in RDEB.

1985 - Enzymatic techniques in the direct assay of urinary metabolites in psoriatic patients [Articolo su rivista]
Monzani, Agar; Coppini, Dino; Coppini, Maurizio; Plessi, Maria
abstract

Urinary contents of acetic acid, citric acid, D-gluconic acid, L-lactic acid, L-malic acid weree detremined in a series of psoriatic patients by an enzymatic technique directly applied to the urine. The results demonstrate that in the urine of psoriatic patients there is a more or less significant variation in the level of the metabolites.

1984 - Definition of health education. Current status of Italian legislation. Structures foreseen by the law [Articolo su rivista]
Coppini, Maurizio; Pincelli, Carlo
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1984 - Determination of serum ferritin in porphyria cutanea tarda. A reliable sign of hepatic siderosis [Articolo su rivista]
P., Gibertini; Rocchi, Emilio; Pietrangelo, Antonello; Coppini, Maurizio; E., Ventura; Cassanelli, M
abstract

Some parameters of iron metabolism in 26 patients with porphyria cutanea tarda (PCT) which is often associated with mild iron overload and hepatic siderosis, are studied. Serum iron, percent transferrin saturation and ferritin were pathologically increased. Statistical comparisons were performed between PCT patients and healthy controls, liver disease patients (cirrhosis, chronic active hepatitis) and patients with associated liver siderosis (alcoholic cirrhosis, cirrhosis and chronic active hepatitis in thalassemia). Ferritin levels are higher in patients with porphyria than in healthy controls (p less than 0,001) and in patients without liver siderosis (p less than 0,001). No statistical difference is observed between patients with porphyria and patients with siderosis. A significant decrease in ferritin levels is registered after venesection therapy. The conclusion is drawn that serum ferritin increase in PCT is related to hepatic iron store amounts rather than hepatic necrosis. It is assumed that ferritin follow-up during phlebotomy therapy and also during remission is useful to indicate the exhaustion or an early replenishment of hepatic iron stores.

1983 - Litiuria e zincuria nella psoriasi [Articolo su rivista]
Monzani, Agar; Coppini, Maurizio; Parenti, Carlo; Plessi, Maria; Coppini, Dino
abstract

Sono state deteminate mediante AAS le variazioni dei livelli urinari di litio e di zinco in una serie di 60 pazienti affetti da psoriasi. I risultati ottenuti permettono di ampliare la casistica su litiuria e zincuria, consentendo lo studio dei reciproci rapporti.

1982 - Psoriasis and lithium carbonate. Apropos of 2 clinical cases [Articolo su rivista]
Pincelli, Carlo; Coppini, Maurizio; M., Zucchi; M., Zanini
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