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Roberto LONARDI

Ricercatore Universitario
Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze sede Policlinico


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Pubblicazioni

2021 - Health-related quality of life outcomes and hospitalization length of stay after micro-fragmented autologous adipose tissue injection in minor amputations for diabetic foot ulceration (MiFrAADiF Trial): Results from a randomized controlled single-center clinical trial [Articolo su rivista]
Gennai, S.; Leone, N.; Covic, T.; Migliari, M.; Lonardi, R.; Silingardi, R.
abstract

Background: The diabetic foot ulcer (DFU) is a high prevalence complication that significantly impairs the health-related quality of life (HRQoL) and is characterized by prolonged hospital length of stay (LOS). The impact of the micro-fragmented autologous adipose tissue injection at the minor amputation wound in the case of DFU (MiFrAADiF) on HRQoL and LOS compared to the standard care has not been determined yet. Methods: This was a two-arm, 6-month, individually-randomized controlled single-center clinical trial. A 1:1 randomization to local injection of autologous micro-fragmented adipose tissue (treatment group; N.=57) or standard clinical care (control group; N.=57) was performed. The primary objective was the HRQoL. The secondary endpoint was the LOS. HRQoL was assessed with the Medical Outcomes Study 36-item Short-Form Health Survey which provides 2 scores focused on physical (PCS) and mental functioning (MCS). The trial was registered in ClinicalTrials.gov (NCT03276312). Results: The type of treatment (P=0.009) and the time elapsed since surgery (P=0.0000) demonstrated a significant improvement on PCS. The MCS improvements resulted in a non-significant association with treatment (P=0.21). The time elapsed since surgery showed a significant influence on the MCS (P=0.0000). The mean LOS was 16.2 days and 24.4 days for the treatment and the control group respectively (P=0.025). Conclusions: The MiFrAADiF Trial demonstrated a significant improvement in terms of physical HRQoL and a significant reduction of the hospital length of stay after injection of micro-fragmented autologous adipose tissue in diabetic patients' minor amputations wound.


2019 - Autologous micro-fragmented adipose tissue for the treatment of diabetic foot minor amputations: A randomized controlled single-center clinical trial (MiFrAADiF) [Articolo su rivista]
Lonardi, R.; Leone, N.; Gennai, S.; Trevisi Borsari, G.; Covic, T.; Silingardi, R.
abstract

Background: The diabetic foot ulcer (DFU) is one of the most prevalent complications of diabetes mellitus and often develops severe effects that can lead to amputation. A non-healing "minor" amputation often precedes a major amputation resulting in a negative impact on the function and quality of life of the patients. Stem cell-based therapies have emerged as a promising option to improve healing, and the adipose tissue is an abundant and easy to access source. The injection of autologous micro-fragmented adipose tissue at the amputation stump of a diabetic population undergoing a lower limb minor amputation was evaluated and compared with the standard care. Methods: In this randomized controlled trial with two arms (parallel assignment) and no masking, 114 patients undergoing a lower limb minor amputation were randomized to standard of care or to micro-fragmented adipose tissue injection prepared using a minimal manipulation technique (Lipogems®) in a closed system. Clinical outcomes were determined monthly up to 6 months. Primary endpoint of the study was the evaluation of the healing rate and time after the minor amputation. Secondary endpoints included the assessment of safety, feasibility, technical success, relapse rate, skin tropism, and intensity of pain. Results: At 6 months, 80% of the micro-fragmented adipose tissue-treated feet healed and 20% failed as compared with the control group where 46% healed and 54% failed (p = 0.0064). No treatment-related adverse events nor relapses were documented, and technical success was achieved in all cases. The skin tropism was improved in the treatment group, and the pain scale did not differ between the two groups. Conclusion: The results of this randomized controlled trial suggest that the local injection of autologous micro-fragmented adipose tissue is a safe and valid therapeutic option able to improve healing rate following minor amputations of irreversible DFU. The technique overcomes several stem cell therapy-related criticisms and its potential in wound care should be better evaluated and the therapeutic indications could be expanded. Trial registration: ClinicalTrials.gov number: NCT03276312. Date of registration: September 8, 2017 (retrospectively registered).


2018 - Standard “off-the-shelf” multibranched thoracoabdominal endograft in urgent and elective patients with single and staged procedures in a multicenter experience [Articolo su rivista]
Silingardi, Roberto; Gennai, Stefano; Leone, Nicola; Gargiulo, Mauro; Faggioli, Gianluca; Cao, Piergiorgio; Verzini, Fabio; Ippoliti, Arnaldo; Tusini, Nicola; Ricci, Carmelo; Antonello, Michele; Chiesa, Roberto; Marone, Enrico Maria; Mangialardi, Nicola; Speziale, Francesco; Veraldi, Gian Franco; Bonardelli, Stefano; Marcheselli, Luigi; Lonardi, Roberto; Saitta, Giuseppe; Lauricella, Antonio; Ferrer, Ciro; Simonte, Gioele; Pratesi, Giovanni; Fontana, Antonio; Lucatelli, Pierleone; Dall'Antonia, Alberto; Bertoglio, Luca; Ronchey, Sonia; Mansour, Wassim; Mezzetto, Luca; Cuomo, Raffaele
abstract

Objective: The objective of this study was to assess immediate and midterm outcomes for urgent/emergent and elective patients with thoracoabdominal aortic aneurysms (TAAAs) treated with the first commercially available “off-the-shelf” multibranched endograft for endovascular aneurysm repair, with a single-step or a staged surgical approach. Methods: A multicenter, nonrandomized, retrospective study was conducted of TAAA patients grouped by urgent/emergent and elective treatment with multibranched endograft for endovascular aneurysm repair at 13 Italian centers from November 2012 to August 2016. Urgent/emergent repair was classified as rupture in 16%, impending rupture in 9%, pain in 53%, or a maximum TAAA diameter ≥80 mm in 22%. Study end points were technical success, mortality, spinal cord ischemia, target visceral vessel (TVV) patency, and procedure-related reinterventions at 30 days and at follow-up. Results: Seventy-three patients (274 TVVs) were enrolled. Treatment was performed in elective (n = 41 [56%]) or urgent/emergent (n = 32 [44%]) settings, according to a single-step (n = 30 [41%]) or staged (n = 43 [59%]) approach. Technical success was 92%. Mortality within 30 days was 4% (n = 3 urgent/emergent patients) due to myocardial infarction. Spinal cord ischemia was recorded in two patients (3%; elective group). The primary patency of TVVs was 99% (three renal branch occlusions). Procedure-related reinterventions were required in five cases (7%). At least one adverse event from any cause ≤30 days was registered in 42% (n = 31). At a median follow-up of 18 months (range, 1-43 months), eight (11%) deaths (elective vs urgent/emergent, 2% vs 22%; P =.018), three (1%) cases of branch occlusion or stenosis, and five (7%) reinterventions were recorded. A survival of 88% (standard error [SE], 4%), 86% (SE, 4%), and 82% (SE, 5%) was evidenced at 12, 24, and 36 months, respectively. Urgent/emergent repair and female gender were identified as independent risk factors for all-cause mortality (P <.001 and P =.015, respectively), and the staged approach was identified as protective (P =.026). Freedom from reintervention was 86% (SE, 4%) and 83% (SE, 5%) at 12 and 24 months. Conclusions: The first off-the-shelf multibranched endograft seems safe in both urgent/emergent and elective settings. The staged surgical approach appears to positively influence overall survival. This unique device and its operators will usher in a new treatment paradigm for TAAA repair.


2017 - Anatomical fixation with unibody endografts: procedural duration, fluoroscopy time, use of contrast medium [Capitolo/Saggio]
Lonardi, Roberto; Catldi, Valentina; Sorbello, Stefania; Cuccì, Antonietta; Munari, Elisa
abstract


2017 - Does stem cell therapy induce myocardial neoangiogenesis? Histological evaluation in an ischemia/reperfusion animal model [Articolo su rivista]
Pennella, Sonia; Bonetti, L. R.; Migaldi, Mario; Manenti, Antonio; Lonardi, Roberto; Giuliani, Enrico; Barbieri, Alberto; Farinetti, Alberto; Mattioli, Anna Vittoria
abstract

Background: In an experimental model in the rabbit, a myocardial ischemia-reperfusion injury was obtained. Subsequently, the effects of homologous bone marrow stem cell (BMSC) administration were studied. Methods: In 21 New Zealand adult rabbits, ischemia/reperfusion damage was induced by temporary occlusion of the anterior descending coronary artery. Homologous BMSCs were isolated, cultured and re-suspended for injection at the level of the ischemic zone. We evaluated the proangiogenetic effect of intramyocardial injections of BMSC at the peri-infarcted area. Histological evaluations were made after 20 days from the surgical procedure. Results: In rabbits treated with intramyocardial BMSC administration, we demonstrated histologically capillary neoangiogenesis, without signs of tissue immunological reaction or of generation of new myocardial cells. On the contrary, only minimal neovascular supply was detected in rabbits treated with intravenous administration of BMSC. Only typical signs of ischemic myocardium injury were observed in the control group. Conclusion: These observations suggest that the effect of direct BMSC administration in ischemic myocardium could promote a capillary neoangiogenesis, which helps to prevent ischemic myocardial damage.


2013 - Surgical approach to intramyocardial administration of bone marrow stem cells in an animal model. [Articolo su rivista]
Farinetti, Alberto; Lonardi, Roberto; Barbieri, Alberto; Giuliani, Enrico; Pennella, Sonia; Pozza, M; Saviano, Massimo; Manenti, Antonio; Mattioli, Anna Vittoria
abstract

Abstract AIM: The aim of the study was to evaluate the surgical approach to intramyocardial (i.m.) injection of Bone Marrow Stem Cells (BMSCs) in a pre-clinical model and its complications. MATERIAL OF STUDY: In New Zealand rabbits an ischemia reperfusion injury lasting 20 min was induced by temporary ligation of anterior descending coronary artery during cardiac surgical procedure. Homologous BMSCs were isolated from the posterior iliac crest, cultured and re-suspended for injection. BMSC were injected at the peri-infarcted area and side effects were evaluated. A control group with myocardial infarction was treated with i.m. injections of saline, to evaluate possible side effects of injection. Comparison of ventricular premature contractions (VPC), ventricular tachycardia and ventricular fibrillation were recorded during surgery and after 7 and 21 days. RESULTS: Seven rabbits developed intractable ventricular fibrillation during the experimental protocol, three during coronary ligation but before cell injections and four following i.m. injections. At day 7, hourly PVC were more frequent in the groups of animals that received i.m. injections of BMSCs (132 +/- 19 beats) compared to saline injections. (54 +/- 14). CONCLUSIONS: Intramyocardial injections of BMSCs induced an electrical instability as shown by a high number of PVC as compared with intramyocardial injections of saline.


2012 - Analysis of pro-arrhythmic effects induced by different routes of administration of bone marrow stem cells [Articolo su rivista]
Mattioli, Anna Vittoria; Lonardi, Roberto; Giuliani, Enrico; Barbieri, Alberto; S., Pennella; Farinetti, Alberto
abstract

Bone Marrow Stem Cells,Intramyocardial injections,Ischemia/Reperfusion,Pre-Clinical Study,QT interval


2012 - Neodymium: YAG laser treatment of lower leg telangiectasia: a new minimally invasive approach. [Articolo su rivista]
Iannitti, T; Lonardi, Roberto; Rottigni, V; Palmieri, Beniamino
abstract

The aim of this study was to validate the safety and effectiveness of a new therapeutic procedure for the treatment of lower leg telangiectasia without clinical vein insufficiency. A group of 20 healthy women aged between 24 and 47 years (mean±sem 37.05 ± 1.47) with lower leg telangiectasia without clinical vein insufficiency, previously investigated by echo colour Doppler sonography, were recruited and were treated with neodymium:YAG laser (mean±sem 2.5 ± 0.11 sessions). Good or excellent results were obtained in 16 patients and the improvements were statistically significant (p < 0.01). Out of the 20 patients, 16 were satisfied with the procedure. We strongly support laser treatment of lower leg telangiectasia since it allows injection of chemicals to be avoided, and changes the stromal microarchitecture rearranging the fibroblast network into a more resistant pattern reducing the likelihood of relapse.


2012 - Ventricular Arrhythmias Following Intramyocardial Injections of Bone Marrow Stem Cells: an Animal Model. [Abstract in Rivista]
Mattioli, Anna Vittoria; Lonardi, Roberto; Pennella, Sonia; E., Giuliani; Farinetti, Alberto
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2011 - Aderenza alle linee guida nell'uso dell'aspirina in pazienti con precedente emorragia e malattie cardiovascolari [Abstract in Rivista]
Pennella, S.; Farinetti, Alberto; Lonardi, R.; Giuliani, E.; Tazzioli, Giovanni; Mattioli, Anna Vittoria
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2011 - Ecocolordoppler [Capitolo/Saggio]
Lonardi, Roberto; S., Aiello; T., Curti
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2011 - Inquadramento diagnostico nella sindrome post-flebitica [Capitolo/Saggio]
Lonardi, Roberto; T., Curti
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2011 - Pro-arrhythmic effects of intramiyocardial administration of mesenchymal bone marrow stem cells: a pre-clinical study [Abstract in Rivista]
Mattioli, Anna Vittoria; Lonardi, Roberto; E., Giuliani; S., Pennella; Farinetti, Alberto
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2011 - Relationship between ventricular arrhythmias and prologed QT time duration after intramyocardial administration of bone marrow stem cells. [Abstract in Rivista]
Mattioli, Anna Vittoria; Pennella, S.; Lonardi, R.; Giuliani, E.; Barbieri, Alberto; Farinetti, A.
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2010 - Aderenza alle linee guida nell'uso dell'aspirina in pazienti con precedente emorragia e malattie cardiovascolari [Abstract in Rivista]
S., Pennella; Farinetti, Alberto; Lonardi, Roberto; E., Giuliani; M., Davoli; Tazzioli, Giovanni; Mattioli, Anna Vittoria
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2010 - Cardiac arrhythmias after intramyocardial administration of mesenchymal bone marrow stem cells in acute myocardial infarction [Abstract in Atti di Convegno]
Mattioli, Anna Vittoria; Farinetti, Alberto; Lonardi, Roberto; Enrico, Giuliani; Sonia, Pennella; Losi, Lorena; Barbieri, Alberto
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2010 - Dieta Mediterranea e Antiossidanti: differenze di genere in pazienti con fibrillazione atriale. [Abstract in Rivista]
S., Pennella; Farinetti, Alberto; Pedrazzi, Patrizia; C., Miloro; Lonardi, Roberto; Mattioli, Anna Vittoria
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2010 - EuroSCORE and 4Ts score could predict thrombotic complications after cardiac surgery [Abstract in Atti di Convegno]
Mattioli, Anna Vittoria; Farinetti, A.; Barbieri, Alberto; Lonardi, R.; Pennella, S.; Ambrosio, G.
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2010 - Low adherence to guidelines in aspirin use in patients with previous minor bleeding and cardiovascular disease [Abstract in Rivista]
Mattioli, Anna Vittoria; S., Pennella; Lonardi, Roberto; Tazzioli, Giovanni; Farinetti, Alberto
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2010 - Recurrences of stroke in patients with atrial septal aneurysm and patent foramen ovale : long-term follow-up [Abstract in Rivista]
Mattioli, Anna Vittoria; S., Pennella; Farinetti, Alberto; Lonardi, Roberto
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2010 - Valutazione del danno vascolare periferico a livello carotideo in pazienti con anticorpi eparina-indotti:follow-up ad un anno [Abstract in Rivista]
S., Pennella; Farinetti, Alberto; Lonardi, Roberto; Mattioli, Anna Vittoria
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2010 - Ventricular Arrhythmias after intramyocardial administration of mesenchymal bone marrow stem cells in acute myocardial infarction: an animal model. [Abstract in Rivista]
Mattioli, Anna Vittoria; Farinetti, Alberto; Lonardi, Roberto; E., Giuliani; S., Pennella
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2009 - Anticorpi anti eparina/PF4 e placche carotidee: studio mediante Doppler e follow-up ad un anno [Abstract in Atti di Convegno]
U., Carletti; Farinetti, Alberto; Lonardi, Roberto; L., Bonetti; Mattioli, Anna Vittoria
abstract

Premesse.L’eparina è un farmaco ampiamente usato nelle patologie cardiache. La somministrazione di eparina non frazionata può indurre la comparsa di una reazione avversa su base autoimmune nota come trombocitopenia eparina indotta (HIT). La HIT è caratterizzata da trombocitopenia e trombosi paradossa che può colpire sia il sistema venoso che quello arterioso. I pazienti (paz) che sviluppano HIT presentano una trombocitopenia con riduzione della conta piastrinica >50% del valore basale, complicanze tromboemboliche e presenza di anticorpi anti eparina/PF4 nel siero.Nel presente studio abbiamo valutato la presenza di placche carotidee in una popolazione di paz trattati con eparina non frazionata in rapporto agli anticorpi anti eparina/PF4.


2009 - Endo-perivenous laser procedures for teleangectasias treatment. [Articolo su rivista]
Lonardi, Roberto; A., Crippa; F., Zini; L., Tessari
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2009 - Intake di antiossidanti e aderenza alla dieta mediterranea influenzano il rischio di fibrillazione atriale. [Abstract in Rivista]
Mattioli, Anna Vittoria; Farinetti, Alberto; C., Miloro; Pedrazzi, Patrizia; Lonardi, Roberto; Mattioli, Giorgio
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2009 - Multidisciplinary chronic leg ulcers service in Modena: data anaysis. [Articolo su rivista]
Lonardi, Roberto; Curti, Tiziano; F., Neri; D., Olezzi; Giannetti, Alberto; Magnoni, Cristina
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2009 - Recidiva di stroke in pazienti con aneurisma del setto interatriale e patent foramen ovale: influenza della terapia. [Abstract in Rivista]
Mattioli, Anna Vittoria; Farinetti, Alberto; Lonardi, Roberto; U., Carletti; C., Miloro; Mattioli, Giorgio
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2009 - Ventricular Arrhythmias After Intramyocardial Administration of Mesenchymal Bone Marrow Stem Cells in Acute Myocardial Infarction: An Animal Model [Abstract in Rivista]
Mattioli, Anna Vittoria; Farinetti, Alberto; Lonardi, Roberto; Losi, Lorena; Barbieri, Alberto; Enrico, Giuliani; Mattioli, Giorgio
abstract

Background. Mesenchymal bone marrow derived cells (MSCs) have been shown to home to injured tissue and produce growth factors that aid angiogenesis. We aim to evaluate ventricular premature contractions (VPCs) and mechanical properties of cardiomyocytes after MSC transplantation using the micro-electrical mechanical systems (MEMS) Technology; these tiny microchips implanted in the heart may be used to monitor heart physiology. Methods. An acute myocardial infarction was induced by ligation of anterior coronary artery in New Zealand rabbits, weighting >3 kg (10 min of ischemia followed by reperfusion). MSCs were isolated, cultured and re-suspended in saline for injection. Injections were done at the peri-infarcted areas, in 5 rabbits we injected MSC whereas in 5 control rabbits we injected saline (to evaluate pro-angiogenic effect of intramyocardial injections i.m.). An arrhythmias recorder was located on the animal and the ECG was recorded for 7 days. Animals were sacrificed and histological and morphological analysis was performed.


2006 - Complicanze e risultati del trattamento endovascolare [Capitolo/Saggio]
Coppi, Gioachino; Moratto, R.; Silingardi, R.; Giovannoni, M.; Ragazzi, G.; Lonardi, Roberto; Rametta, F.
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2006 - Ipertensione nefro-vascolare: Complicanze e risultati del trattamento endovascolare. [Monografia/Trattato scientifico]
Coppi, Gioachino; Moratto, R.; Silingardi, R.; Giovannoni, M.; Ragazzi, G.; Lonardi, Roberto; Rametta, F.
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2006 - La procedura laser endovenosa. [Articolo su rivista]
Lonardi, Roberto; G., Ragazzi; Coppi, Gioachino
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2005 - Anatomia chirurgica delle arterie della caviglia e del piede [Capitolo/Saggio]
Lonardi, Roberto; A., Rumolo; I., Polverini; V., Melita
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2005 - Effects of Sildenafil on Sleep-Related Erections and on Penile Response to Intra-cavernous Injection of PGE1 in normal man [Relazione in Atti di Convegno]
Lonardi, Roberto; A. R. M., Granata; A., Fontana; C., Carani; G., Coppi
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2005 - Endovenous Radiofrequency Obliteration of Great Saphenous Vein [Relazione in Atti di Convegno]
G., Ragazzi; Lonardi, Roberto; M., Bessone; F., Benassi; G., Coppi
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2005 - Stratificazione del rischio cardiologico nel paziente chirurgico. [Capitolo/Saggio]
A., Rumolo; A., Barbieri; M., Gargiulo; Lonardi, Roberto; I., Polverini; F., Benassi; A., Stella
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2004 - Cryopreserved femoral arterial allograft for hemodialysis access. [Articolo su rivista]
M., Gargiulo; A., Stella; I., Polverini; L., Lucchi; M., Buzzi; M., Bessone; A., Rumolo; Lonardi, Roberto; L., Stipo; M., Mirelli; R., Conte
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2004 - Limitations of cardiac risk stratification in vascular surgery. [Articolo su rivista]
A., Rumolo; M., Gargiulo; I., Polverini; Barbieri, Alberto; F., Bursi; Lonardi, Roberto; R., Corradi; Modena, Maria Grazia
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2004 - Trattamento endovascolare dell'endofibrosi iliaca in ciclista professionista [Abstract in Atti di Convegno]
M., Bessone; M., Gargiulo; Lonardi, Roberto; F., Maioli; A., Stella
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2002 - Monitoraggio intra e post-operatorio nella valutazione dei by-pass estremi nei diabetici. [Capitolo/Saggio]
A., Stella; M., Gargiulo; A., Rumolo; F., Benassi Franciosi; Lonardi, Roberto
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2002 - Scelta e valutazione del monitoraggio nelle ricostruzioni femoro-distali. [Capitolo/Saggio]
M., Gargiulo; A., Stella; A., Rumolo; F., Benassi Franciosi; Lonardi, Roberto; V., Melita
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2001 - Identikit del paziente flebopatico: nostra esperienza nel progetto flebo 2000 [Articolo su rivista]
A., Stella; M., Gargiulo; A., Rumolo; V., Melita; Lonardi, Roberto
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2000 - Endovenous management of saphenous vein reflux. Reflux management study group. [Articolo su rivista]
Lonardi, Roberto
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2000 - Filtri cavali. [Articolo su rivista]
A., Stella; M., Gargiulo; Lonardi, Roberto; A., Rumolo
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1999 - Clinical outcome and its predictors in 1560 patients with critical leg ischaemia. [Articolo su rivista]
Lonardi, Roberto
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1997 - Hematoma of the rectus abdominis as a complication of anticoagulant therapy with subcutaneously administered heparin calcium [Ematoma del muscolo retto addominale quale complicanza della terapia anticoagulante con eparina calcica s.c.] [Articolo su rivista]
A., Cavezzi; G., Ragazzi; Lonardi, Roberto; G., Tuscano
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1997 - Long-term mortality and its predictors in patients with critical leg ischaemia. [Articolo su rivista]
Lonardi, Roberto
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1997 - Rapporto i.c.a.i. Storia e risultati di una strategia di ricerca epidemiologica e strumentale. [Articolo su rivista]
Lonardi, Roberto
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1996 - A prospective epidemiological survery of the natural history of chronic critical leg ischaemia. [Articolo su rivista]
Lonardi, Roberto
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1996 - La terapia chirurgica delle sindromi dello stretto toracico superiore. [Capitolo/Saggio]
G., Tuscano; Lonardi, Roberto; L., Manzoni; A., Francescone
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1996 - Monitoraggio delle erezioni correlate al sonno nella valutazione delle componenti psicogena ed organica dell’inadeguatezza sessuale maschile comparsa dopo intervento chirurgico per neoplasia colon-rettale [Abstract in Atti di Convegno]
Granata, Antonio R. M.; Rochira, Vincenzo; Raffaella, Mantovani; Beniamino, Coppa; Antonio, Balestrieri; Lonardi, Roberto
abstract

Monitoring of sleep-related erections in the assessment of psychogenic and organic components of male sexual inadequacy appearance after surgery for colorectal cancer might distinguish organic from psychogenic erectile dysfunction.


1996 - Preventing pulmonary embolism using venous caval filter in elderly patients [Articolo su rivista]
Cavezzi, A; Sabatini, D; Lonardi, Roberto; Hussein, H; Sfrappini, M; Infriccioli, P.
abstract

A survey of the venous caval filter implantations is presented, carried out during the last 10 years at the Modena Institute of Surgical Pathologies. Out of a total of 92 cases, 49 patients were older than 65 years (on average 72.95 years). The complication-free surgical procedures and the low number of minor complications having occurred during the follow up of 1 to 10 years suggest a more extensive use of the caval filters in elderly patients.


1996 - Rationale and methodology of the i.c.a.i. study, a randomised clinical trial of alprostadil in the treatment of chronic critical leg ischaemia. [Articolo su rivista]
Lonardi, Roberto
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1995 - An attempt to improve the reliability of the penile response to intracavernosal injection of prostaglandin E1 [Abstract in Atti di Convegno]
Granata, Antonio R. M.; Rochira, Vincenzo; Raffaella, Mantovani; Lonardi, Roberto; Antonio, Balestrieri; Carani, Cesare
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The association of oral propranolol and intracavernosal PGE1 was tested as a potential way for reinforcing and increase the penile response to PGE1 in term of a better quality of erection.


1993 - Il posizionamento di filtri cavali nella prevenzione dell'embolia polmonare. [Articolo su rivista]
Lonardi, Roberto; A., Cavezzi; H., Hassan; G., Tuscano
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1991 - La sindrome dello stretto toracico superiore. [Capitolo/Saggio]
G., Tuscano; G., Veronesi; Lonardi, Roberto
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1991 - La sindrome dello stretto toracico superiore: clinica [Capitolo/Saggio]
G., Tuscano; G., Veronesi; Lonardi, Roberto
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1982 - La profondoplastica: indicazioni e risultati [Capitolo/Saggio]
G., Tuscano; O., Maleti; G., Roncaglia; E., Ricchi; Lonardi, Roberto
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