Gian Maria CAVALLINI - personale UniMoRe

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Gian Maria CAVALLINI

Professore Associato
Dipartimento Chirurgico, Medico, Odontoiatrico e di Scienze Morfologiche con interesse Trapiantologico, Oncologico e di Medicina Rigenerativa

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Pubblicazioni

2023 - Malarial retinopathy in a preschool child: A case report with long-term paediatric and ophthamological follow-up [Articolo su rivista]
Lazzerini, A.; Sforza, F.; Fornasari, E.; Mastropasqua, R.; Bergonzini, P.; Iughetti, L.; Cavallini, G. M.
abstract

Aim: To report a paediatric case of retinopathy-positive cerebral malaria, emphasizing the clinical significance of long-term neurological and ophthalmological follow-up (5,5 years). Case report: After a recent journey in Ghana, a 17-month-old African female child was admitted at the Paediatric Emergency Room with fever and vomiting. Blood smear confirmed a Plasmodium Falciparum parasitaemia. Iv quinine was promptly administered, but after a few hours, the child developed generalized seizures, requiring benzodiazepine therapy and assisted ventilation for severe desaturation. Brain imaging (CT and MRI), lumbar puncture and several electroencephalograms showed data compatible with cerebral involvement of malaria. Schepens ophthalmoscopy and Ret-Cam pictures acquisition revealed macular haemorrhages in the left eye with central whitening and bilateral capillary abnormalities, typical signs of malarial retinopathy. Antimalarial therapy and iv Levetiracetam allowed neurological improvement. Eleven days after the admission, the child was discharged, showing no neurological symptoms and with an improved EEG signal, a normalized fundus oculi and brain imaging. Neurological and ophthalmological long-term follow-up were conducted: EEG controls didn’t reveal abnormalities and the complete ophthalmological assessment showed a regular visual acuity and fundus oculi, as well as a normal SD-OCT and electrophysiologic testing. Conclusion: Cerebral malaria is a severe complication, characterized by a high fatality rate and challenging diagnosis. A helpful instrument for diagnostic and prognostic evaluation is the ophthalmological detection of malarial retinopathy and its monitoring over time. In our patient the long term visual follow-up didn’t reveal any adverse outcome.

2022 - Aqueous Humor Analysis in Overlapping Clinical Diagnosis of Cytomegalovirus and Rubella Virus Anterior Uveitis [Articolo su rivista]
Gozzi, F.; Belloni, L.; Aldigeri, R.; Gentile, P.; Mastrofilippo, V.; De Simone, L.; Bolletta, E.; Alessandrello, F.; Bonacini, M.; Croci, S.; Zerbini, A.; Cavallini, G. M.; Salvarani, C.; Cimino, L.
abstract

Background and Objectives: A cross-sectional single-center study was conducted to investigate the etiology in hypertensive anterior uveitis whose clinical features are not fully distinctive from cytomegalovirus or from rubella virus and to demonstrate the possible coexistence of both these viruses in causing anterior uveitis. Materials and Methods: The clinical charts of a cohort of patients with hypertensive viral anterior uveitis of uncertain origin consecutively seen in a single center from 2019 to 2022 were retrospectively reviewed; data on the clinical features, aqueous polymerase chain reaction, and antibody response to cytomegalovirus and rubella virus were collected. Results: Forty-three eyes of as many subjects with viral anterior uveitis of uncertain origin were included. Thirty-two patients had an aqueous polymerase chain reaction or antibody index positive to cytomegalovirus only, while 11 cases had an aqueous antibody response to both cytomegalovirus and rubella virus. This latter overlapping group had a statistically significant higher rate of hypochromia and anterior vitritis (p-value: 0.02 and < 0.001, respectively). Conclusions: The simultaneous presence of intraocular antibodies against cytomegalovirus and rubella virus could redefine the differential diagnosis of hypertensive viral anterior uveitis, demonstrating a possible "converged" immune pathway consisting in a variety of stimuli.

2022 - Beneficial Effects of Polydeoxyribonucleotide (PDRN) in an In Vitro Model of Fuchs Endothelial Corneal Dystrophy [Articolo su rivista]
Ceravolo, I.; Mannino, F.; Irrera, N.; Minutoli, L.; Arcoraci, V.; Altavilla, D.; Cavallini, G. M.; Guarini, S.; Squadrito, F.; Pallio, G.
abstract

Fuchs endothelial corneal dystrophy (FECD) is a bilateral, hereditary syndrome characterized by progressive irreversible injury in the corneal endothelium; it is the most frequent cause for corneal transplantation worldwide. Oxidative stress induces the apoptosis of corneal endothelial cells (CECs), and has a crucial function in FECD pathogenesis. The stimulation of the adenosine A2A receptor (A2Ar) inhibits oxidative stress, reduces inflammation and modulates apoptosis. Poly-deoxyribonucleotide (PDRN) is a registered drug that acts through adenosine A2Ar. Thus, the goal of this study was to assess the effect of PDRN in an in vitro FECD model. Human Corneal Endothelial Cells (IHCE) were challenged with H2O2 (200 µM) alone or in combination with PDRN (100 µg/mL), PDRN plus ZM241385 (1 µM) as an A2Ar antagonist, and CGS21680 (1 µM) as a well-known A2Ar agonist. H2O2 reduced the cells’ viability and increased the expression of the pro-inflammatory markers NF-κB, IL-6, IL-1β, and TNF-α; by contrast, it decreased the expression of the anti-inflammatory IL-10. Moreover, the pro-apoptotic genes Bax, Caspase-3 and Caspase-8 were concurrently upregulated with a decrease of Bcl-2 expression. PDRN and CGS21680 reverted the negative effects of H2O2. Co-incubation with ZM241385 abolished the effects of PDRN, indicating that A2Ar is involved in the mode of action of PDRN. These data suggest that PDRN defends IHCE cells against H2O2-induced damage, potentially as a result of its antioxidant, anti-inflammatory and antiapoptotic properties, suggesting that PDRN could be used as an FECD therapy.

2022 - Could different aqueous humor and plasma cytokine profiles help differentiate between ocular sarcoidosis and ocular tuberculosis? [Articolo su rivista]
De Simone, L.; Bonacini, M.; Aldigeri, R.; Alessandrello, F.; Mastrofilippo, V.; Gozzi, F.; Bolletta, E.; Adani, C.; Zerbini, A.; Cavallini, G. M.; Fontana, L.; Salvarani, C.; Croci, S.; Cimino, L.
abstract

Objective and design: A cross-sectional single-center study was conducted to assess cytokine levels in aqueous humor (AH) and plasma of three different uveitis entities: definite ocular sarcoidosis (OS), definite OS associated with QuantiFERON®-TB Gold test positivity (Q + OS) and presumed tubercular uveitis (TBU). Subjects: Thirty-two patients (15 OS, 5 Q + OS, 12 TBU) were included. Methods: Quantification of selected cytokines was performed on blood and AH samples collected before starting any treatment. Statistical analysis was conducted using the Kruskal–Wallis test, the Mann–Whitney or Fisher test and the Principal Component Analysis (PCA). Results: IL-6, IL-8 and IP-10 levels were higher in AH samples than in peripheral blood. In AH samples, BLC, IL-8 and IP-10 were significantly higher in definite OS than in presumptive TBU. There were no statistically significant differences in terms of cytokine levels between Q + OS and presumptive TBU. PCA showed a similar cytokine pattern in the latter two groups (IFNγ, IL-15, IL-2, IP-10, MIG), while the prevalent expression of BLC, IL-10 and MIP-3 α was seen in definite OS. Conclusions: The different AH and plasma cytokine profiles observed in OS compared to Q + OS and TBU may help to differentiate OS from TBU in overlapping clinical phenotypes of granulomatous uveitis (Q + OS).

2022 - Evaluation of the impact of cataract surgery on cognitive function in very elderly patients: a prospective, observational study [Articolo su rivista]
Verdina, T.; Stiro, F.; Bruni, F.; Spedicato, G. A.; Mastropasqua, R.; Cavallini, G. M.
abstract

Aim: To evaluate the impact of cataract surgery on cognitive function in very elderly patients (≥ 85 years). Methods: A prospective, nonrandomized, comparative study of very elderly patients (≥ 85 years), and elderly patients (≥ 65 < 85 years) scheduled for first time cataract surgery. Cognitive function, quality of life (QoL), best corrected visual acuity (BCVA), endothelial cell count (ECC), and central corneal thickness (CCT) were assessed at 90 days before surgery (T0), at surgery (T1), and at 30 (T2) and 90 days (T3) after surgery. Macular thickness (MT) was evaluated at T2. Six-item cognitive impairment test (6CIT) was used to evaluate cognitive function while the Catquest-9SF test was used to assess QoL. The confusion assessment method (CAM) was used to evaluate the presence of delirium episodes at within 48 h from T1. Results: A total of 78 patients (very elderly n = 24, elderly n = 54) were enrolled; average age 80.3 ± 6.2 years old. Significant improvements for cognitive function, BCVA, QoL (p < 0.01) during the observational period were observed among the cohort. A greater improvement in cognitive function was observed in the very elderly patients between T1 and T2 (p = 0.02), while there was no difference in BCVA and QoL between the groups. There were no significant differences in ECC and CCT changes between the groups. No delirium episodes or significant macular abnormalities were registered. Conclusions: Cataract surgery in very elderly patients seems to offer a greater improvement in cognitive function as compared to elderly patients, and it is associated with a significant improvement in QoL, without any incidence of postoperative delirium.

2021 - Acute transient macular detachment after uneventful cataract surgery in a highly myopic eye [Articolo su rivista]
Verdina, T.; Caporossi, T.; Cavallini, G. M.; Mastropasqua, R.
abstract

Purpose: We report a case of a highly myopic patient who presented a serous macular detachment at 24 hours after uncomplicated cataract surgery. Observations: Surprisingly, after six days from surgery, a reabsorption of the detachment was noticed and the macular area returned to be anatomically normal without any surgical intervention. This early postoperative complication could be caused by changes in the vitreoretinal interface and ocular fluid dynamics or to a rupture of blood-retinal barriers due to postoperative inflammation. Conclusions and importance: Our case reports on the occurrence of an early transient macular detachment after uneventful cataract surgery in a highly myopic eye. This finding suggests the importance of an OCT-based control in the immediate postoperative hours.

2021 - Clinical and genetic findings in italian patients with sector retinitis pigmentosa [Articolo su rivista]
Verdina, T.; Greenstein, V. C.; Tsang, S. H.; Murro, V.; Mucciolo, D. P.; Passerini, I.; Mastropasqua, R.; Cavallini, G. M.; Virgili, G.; Giansanti, F.; Sodi, A.
abstract

Purpose: To describe clinical and genetic features in a series of Italian patients with sector retinitis pigmentosa (sector RP). Methods: Fifteen patients with sector RP were selected from the database of Hereditary Retinal Degenerations Refer-ring Center of Careggi Hospital (Florence, Italy). Eleven patients from five independent pedigrees underwent genetic analysis with next-generation sequencing (NGS) confirmed with Sanger sequencing. The diagnosis of sector RP was based on the detection of topographically limited retinal abnormalities consistent with corresponding sectorial visual field defects. Best-corrected visual acuity (BCVA), fundus color pictures as well as fundus autofluorescence (FAF), spectral domain-optical coherence tomography (SD-OCT), full-field electroretinography (ERG), and 30–2 Humphrey visual field (VF) data were retrospectively collected and analyzed. Results: For the 30 eyes, the mean BCVA was 0.05 ± 0.13 logMAR, and the mean refractive error was −0.52 ± 1.89 D. The inferior retina was the most affected sector (86.7%), and the VF defect corresponded to the affected sector. FAF showed a demarcation line of increased autofluorescence between the healthy and affected retina, corresponding on SD-OCT to an interruption of the ellipsoid zone (EZ) band in the diseased retina. Dark-adapted ERG amplitudes were decreased in comparison to normative values. In five unrelated families, the sector RP phenotype was associated with sequence variants in the RHO gene. The same mutation c.568G>A p.(Asp190Asn) was found in nine patients of four families. Conclusions: Typical sector RP is a mild form of RP characterized by preserved visual acuity with limited retinal involvement and, generally, a more favorable prognosis than other forms of RP.

2021 - Limited or complete vitrectomy for erm? [Articolo su rivista]
Forlini, M.; Date, P.; D'Eliseo, D.; Rossini, P.; Bratu, A.; Volinia, A.; Neri, G.; Verdina, T.; Carbotti, M. R.; Cavallini, G. M.; Sborgia, L.; Galeone, A.; Imburgia, A.; Mularoni, A.; Meduri, A.
abstract

2021 - Subthreshold micropulse yellow laser for the management of refractory cystoid macular edema consequent to complicated cataract surgery [Articolo su rivista]
Verdina, T.; Ferrari, C.; Valerio, E.; Brombin, A.; Lazzerini, A.; Mastropasqua, R.; Cavallini, G. M.
abstract

Purpose: To report the safety and efficacy of subthreshold micropulse yellow laser of 577 nm for a complex case of refractory pseudophakic cystoid macular edema. Methods: A retrospective chart review of an interventional case report of three subthreshold micropulse yellow laser interventions for refractory pseudophakic cystoid macular edema. Patient: A 77-year-old healthy female underwent pseudoexfoliative cataract surgery complicated by posterior capsule rupture and sulcus intraocular lens implantation. After 3 months, she required a scleral fixation of the same lens, due to a lack of capsular support and decentration of the intraocular lens. One month later, she experienced a severe pseudophakic cystoid macular edema (foveal thickness of 399 µm and best-corrected visual acuity of 20/80 Snellen). The condition was refractory to conventional treatments prior to subthreshold micropulse yellow laser interventions, including non-steroidal anti-inflammatory eye drops, topical steroids, oral indomethacin and three sub-Tenon’s triamcinolone injections, attempted over a 14-month period. Results: Subthreshold micropulse yellow laser treatment was performed and immediate resolution was achieved and maintained for 2 months. Two cases of edema relapse were observed at 3 months from initial laser treatment and again at 4 months from the second laser treatment. Final patient’s follow-up at 6 months from the third laser treatment evidenced the absence of edema, improved visual acuity (foveal thickness of 265 µm/best-corrected visual acuity of 20/30 Snellen) and the absence of complications. Conclusions: Subthreshold micropulse yellow laser seems to be a safe and effective treatment for short-term resolution of refractory pseudophakic cystoid macular edema after complicated cataract surgery and represents a useful alternative to expensive and invasive therapies. A trend towards a longer duration of edema resolution with every subthreshold micropulse yellow laser repetition was observed.

2021 - Why should you stay one night? Prospective observational study of enhanced recovery in elderly patients [Articolo su rivista]
Melegari, G.; Albertini, G.; Romani, A.; Malaguti, S.; Traccitto, F.; Giuliani, E.; Cavallini, G. M.; Bertellini, E.; Barbieri, A.
abstract

Background: Delirium is a severe condition that can arise in many contexts during hospitalization. The aim of this research was to measure the incidence of postoperative delirium in patients aged 75 years or older, with the exclusion of those with preexisting neurocognitive disorders (NCD), who underwent fast-track, moderate surgery. Methods: We conducted a prospective cohort study with patients ≥ 75 years of age who were eligible for fast-track, moderate surgery, without severe dementia, with a planned hospitalization of 24 h and with a physical status varying from very fit to vulnerable. The 4-item confusion assessment method (CAM4) was used to measure delirium. Results: Of the 209 eligible patients, 195 subjects were enrolled in the study. The percentage of the population with a CAM4 score above 0 before surgery was 2.56%; after surgery, the percentage was 10.25%; and on the following day, the percentage was 4.61%. There was a statistically significant difference in the CAM4 scores between immediately after surgery and at 24 h after surgery (p = 0.0172). Conclusion: The data from this study support an enhanced recovery approach for elderly patients, in which after a minor surgical procedure with anaesthesia, a recovery period of one night in the hospital can contribute to normalizing the CAM4 score and reducing the incidence of delirium. Graphic abstract: [Figure not available: see fulltext.]

2020 - An international collaborative evaluation of central serous chorioretinopathy: different therapeutic approaches and review of literature. The European Vitreoretinal Society central serous chorioretinopathy study [Articolo su rivista]
Romano, M. R.; Parolini, B.; Allegrini, D.; Mickalewska, Z.; Adelman, R.; Bonovas, S.; Bopp, S.; Citirik, M.; Tekin, K.; Fiser, I.; Boon, C. J. F.; Van, D.; Donvito, G.; Gungel, H.; Ozdogan Erkul, S.; Unsal, E.; Osmanbasoglu, O.; Dincer, N.; Ercalik, N. Y.; Yenerel, N. M.; Amar, J. -P.; Ennemoser, A.; Besozzi, G.; Sallam, A. A. B.; Ellabban, A. A.; Chang, W.; Eandi, C. M.; Demir, M.; Lee, J.; Pak, K.; Arrevola, L.; Sloka, A.; Morawski, K.; Kulig - Stochmal, A.; Romanowska - Dixon, B.; Striebe, N. -A.; Feltgen, N.; Hoerauf, H.; Inan, U. U.; Tanev, I.; Dyrda, A.; Schuler, A.; Lucke, K.; Brix, A.; Pape, S.; Kusserow-Napp, C.; Loo, P. A.; Kanra, A. Y.; Ardagil Akcakaya, A.; Ari Yaylali, S.; Bae, S. H.; Kim, H. K.; Kim, S. J.; Han, J. R.; Nam, W. H.; Odrobina, D.; Lavaque, E.; Bertelli, E.; Coser, S.; Ziemssen, F.; Forlini, M.; Benatti, C.; Cavallini, G. M.; Stefanickova, J.; Berrod, J. -P.; Saksonov, S.; Lytvinchuk, L.; Moussa, M.; Stefaniotou, M.; Christodoulou, E.; Zayed, M. A.; Oz, O.; Tassinari, P.; Koch, P.; Declercq, C.; Johnston, R.; Rusnak, S.; Penas, S.; Ozdek, S.; Ucgul, Y.; Cisiecki, S.; Dziegielewski, K.; Klimczak, D.; Michalewska, Z.; Michalewski, J.; Nawrocka, Z.; Nawrocki, J.; Ornafel, K.; Pikulski, Z.; Maciej, M.; Acar, N.; Elshafei, M. M.; Hamon, F.; Soyeur, R.; Badat, I.; Brousseau, B.; Hermouet, E.; Peiretti, E.; Lee, J. -H.; Ferreira, N.; Yoon, H. -S.; Alkhars, W. I.; Dudani, A.; Minu, R.; Telang, O.; Morepatil, V. G.; Furtado, M. J.; Jo, Y. -J.; Piccolino, F. C.; Finzi, A.
abstract

Purpose: To study and compare the efficacy of different therapeutic options for the treatment of central serous chorioretinopathy (CSCR). Methods: This is a nonrandomized, international multicentre study on 1719 patients (1861 eyes) diagnosed with CSCR, from 63 centres (24 countries). Reported data included different methods of treatment and both results of diagnostic examinations [fluorescein angiography and/or optical coherent tomography (OCT)] and best-corrected visual acuity (BCVA) before and after therapy. The duration of observation had a mean of 11 months but was extended in a minority of cases up to 7 years. The aim of this study is to evaluate the efficacy of the different therapeutic options of CSCR in terms of both visual (BCVA) and anatomic (OCT) improvement. Results: One thousand seven hundred nineteen patients (1861 eyes) diagnosed with CSCR were included. Treatments performed were nonsteroidal anti-inflammatory eye drops, laser photocoagulation, micropulse diode laser photocoagulation, photodynamic therapy (PDT; Standard PDT, Reduced-dose PDT, Reduced-fluence PDT), intravitreal (IVT) antivascular endothelial growth factor injection (VEGF), observation and other treatments. The list of the OTHERS included both combinations of the main proposed treatments or a variety of other treatments such as eplerenone, spironolactone, acetazolamide, beta-blockers, anti-anxiety drugs, aspirin, folic acid, methotrexate, statins, vitis vinifera extract medication and pars plana vitrectomy. The majority of the patients were men with a prevalence of 77%. The odds ratio (OR) showed a partial or complete resolution of fluid on OCT with any treatment as compared with observation. In univariate analysis, the anatomical result (improvement in subretinal fluid using OCT at 1 month) was favoured by age <60 years (p < 0.005), no previous observation (p < 0.0002), duration less than 3 months (p < 0.0001), absence of CSCR in the fellow eye (p = 0.04), leakage outside of the arcade (p = 0.05) and fluid height >500 μm (p = 0.03). The OR for obtaining partial or complete resolution showed that anti-VEGF and eyedrops were not statistically significant; whereas PDT (8.5), thermal laser (11.3) and micropulse laser (8.9) lead to better anatomical results with less variability. In univariate analysis, the functional result at 1 month was favoured by first episode (p = 0.04), height of subretinal fluid >500 μm (p < 0.0001) and short duration of observation (p = 0.02). Finally, there was no statistically significant difference among the treatments at 12 months. Conclusion: Spontaneous resolution has been described in a high percentage of patients. Laser (micropulse and thermal) and PDT seem to lead to significant early anatomical improvement; however, there is little change beyond the first month of treatment. The real visual benefit needs further clarification.

2020 - Association of Ultrapure Citicoline, Homotaurine and Vitamin e in the Management of Normotensive Glaucoma: A Case Report [Articolo su rivista]
Verdina, T.; Verdina, T.; Passarelli, N.; Carlini, A.; Chemello, F.; Mastropasqua, R.; Cavallini, G. M.
abstract

Normal tension glaucoma (NTG) remains a therapeutic challenge for the ophthalmologist since there are no effective therapies as the main therapeutic target, i.e., the intraocular pressure (IOP) increase, is missed. We report on the effectiveness of two neuroprotective molecules (ultrapure citicoline plus homotaurine), in combination with a topical hypotensive approach, in the management of NTG in a long-term follow-up (30 months). A 38-year-old Caucasian woman with no significant medical history and a diagnosis of NTG, after an extensive 30-month treatment with oral dietary supplement containing ultrapure citicoline 500 mg, homotaurine 50 mg and vitamin E once per day and topical glaucoma medication (brimonidine + brinzolamide drops twice per day), presented a significantly improved automated 24-2 visual field with a controlled tonometric measurement associated with a stabilization of retinal fiber layer and ganglion cells at OCT examination with patient satisfaction. This finding suggests that ultrapure citicoline together with homotaurine and vitamin E, through a synergistic neuroprotective effect, could be a promising approach in the management of NTG.

2020 - Biofeedback Low Vision Rehabilitation with Retimax Vision Trainer in Patients with Advanced Age-related Macular Degeneration: A Pilot Study [Articolo su rivista]
Verdina, T.; Piaggi, S.; Peschiera, R.; Russolillo, V.; Ferraro, V.; Chester, J.; Mastropasqua, R.; Cavallini, G. M.
abstract

Purpose: To evaluate the effectiveness of Visual Evoked Potential (VEP) biofeedback rehabilitation in selected low vision patients with advanced age-related macular degeneration (AMD). Design: Retrospective observational cohort study. Methods: Patients affected by advanced AMD, central macular atrophy with unstable fixation and best corrected visual acuity (BCVA) between 20/100 and 20/320 were considered. Selected patients underwent fundus photography and microperimetry with fixation analysis for the selected eye (highest BCVA). Ten consecutive training sessions of 10 min each were performed twice a week in the selected eye with Retimax Vision Trainer (CSO, Florence). BCVA, reading acuity and reading speed, contrast sensitivity, fixation, retinal sensitivity and quality of life questionnaire (VFQ-25) were evaluated at baseline and 7 days following the final session. Results: Significant improvements in terms of BCVA [p = .011], reading speed [p = .007], VFQ-25 score [p = .007], retinal sensitivity [p = .021] and fixation stability in the central 2° and 4° [p = .048; p = .037] post-treatment were observed for the 9 patients enrolled, with insignificant improvements observed in reading acuity and contrast sensitivity [p = .335; p = .291]. Conclusions: Preliminary results support VEP biofeedback rehabilitation improvements for visual function and quality of life in advanced AMD patients with low vision.

2020 - Correction: One week of levofloxacin plus dexamethasone eye drops for cataract surgery: an innovative and rational therapeutic strategy (Eye, (2020), 10.1038/s41433-020-0869-1) [Articolo su rivista]
Bandello, F.; Coassin, M.; Di Zazzo, A.; Rizzo, S.; Biagini, I.; Pozdeyeva, N.; Sinitsyn, M.; Verzin, A.; De Rosa, P.; Calabro, F.; Avitabile, T.; Bonfiglio, V.; Fasce, F.; Barraquer, R.; Mateu, J. L.; Kohnen, T.; Carnovali, M.; Malyugin, B.; Aragona, P.; Arvedi, P.; Cagini, C.; Caretti, L.; Cavallini, G. M.; Cillino, S.; Figini, I.; Franco, L. M.; La Mantia, A.; Laborante, A.; Lanzetta, P.; Marcigaglia, M.; Mariotti, C.; Martini, E.; Mastropasqua, L.; Morselli, S.; Passani, F.; Pece, A.; Pertile, G.; Pioppo, A.; Pirondini, C.; Prantera, M.; Rapisarda, A.; Romano, M. R.; Scarpa, G.; Schiano-Lomoriello, D.; Scorcia, V.; Scuderi, G.; Semeraro, F.; Spedale, F.; Staurenghi, G.; Tognetto, D.; Tosi, M.; Trabucchi, G.; Trivella, F.; Villani, E.; Vento, A.; Vinciguerra, P.; Alio, J. L.; Alfonso Sanchez, J. F.; Montiel, F. A.; Lorenz, K.; Panova, I.; Eremina, A.; Ciprandi, G.
abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

2020 - Efficacy of biofeedback rehabilitation based on visual evoked potentials analysis in patients with advanced age-related macular degeneration [Articolo su rivista]
Verdina, T.; Piaggi, S.; Ferraro, V.; Russolillo, V.; Peschiera, R.; Chester, J.; Mastropasqua, R.; Cavallini, G. M.
abstract

Age-related macular degeneration (AMD) is a progressive and degenerative disorder of the macula. In advanced stages, it is characterized by the formation of areas of geographic atrophy or fibrous scars in the central macula, which determines irreversible loss of central vision. These patients can benefit from visual rehabilitation programmes with acoustic "biofeedback" mechanisms that can instruct the patient to move fixation from the central degenerated macular area to an adjacent healthy area, with a reorganization of the primary visual cortex. In this prospective, comparative, non-randomized study we evaluated the efficacy of visual rehabilitation with an innovative acoustic biofeedback training system based on visual evoked potentials (VEP) real-time examination (Retimax Vision Trainer, CSO, Florence), in a series of patients with advanced AMD compared to a control group. Patients undergoing training were subjected to ten consecutive visual training sessions of 10min each, performed twice a week. Patients in the control group did not receive any training. VEP biofeedback rehabilitation seems to improve visual acuity, reading performances, contrast sensitivity, retinal fixation and sensitivity and quality of life in AMD patients.

2020 - Evaluation of the Morphology of Ganglion Cell Complex and Functional Outcomes after Internal Limiting Membrane Peeling with Macular Abrasion in Idiopathic Macular Hole [Articolo su rivista]
Imburgia, A.; Date, P.; Mularoni, A.; Cavallini, G. M.; Mastropasqua, R.; Forlini, M.
abstract

Aim. This study aims to evaluate the morphology of ganglion cell complex (GCC) along with functional outcomes in patients undergoing vitrectomy with ILM peeling and macular abrasion with Tano diamond dusted membrane scrapers (DDMS) for three different stages of the idiopathic macular hole (IMH). Methods. This retrospective study was conducted between April 2019 and December 2019. 33 patients with IMH were included and divided into three groups: Stage I, stage II, and stage IV. All patients were subjected to vitrectomy with ILM peeling. Gentle and vigorous macular abrasion was additionally performed for stage II and stage IV patients, respectively. The best-corrected visual acuity (BCVA), GCC thickness (measured by spectral domain-optical coherence tomography (SD-OCT)), and photopic contrast sensitivity (Rodenstock CV 900 Chart Panel) were determined before surgery and at 1- A nd 3-month follow-ups. Results. Closure of MH was achieved in all the patients. The difference between the preoperative and one- A nd three-month postoperative values of BCVA was statistically significant in the three groups (P<0.01). Contrast sensitivity progressively improved in all patients and was statistically significant (P<0.01). The reduction in GCC thickness during follow-up was 34%-42% of the preoperative measurements. On comparing the mean GCC thickness of the operated and healthy eyes, it was not statistically significant in stage I patients. However, the same when done in stage II and IV was statistically significant with P value < 0.05 and P<0.01, respectively. Conclusion. Combining ILM peeling with macular abrasion in advanced stages of MH may facilitate its closure without significantly affecting the functional outcome.

2020 - Limited Vitrectomy versus Complete Vitrectomy for Epiretinal Membranes: A Comparative Multicenter Trial [Articolo su rivista]
Forlini, M.; Date, P.; D'Eliseo, D.; Rossini, P.; Bratu, A.; Volinia, A.; Neri, G.; Verdina, T.; Carbotti, M. R.; Cavallini, G. M.; Sborgia, L.; Galeone, A.; Imburgia, A.; Mularoni, A.; Meduri, A.
abstract

Purpose. To evaluate whether limited vitrectomy is as effective as complete vitrectomy in eyes with epiretinal membrane (ERM) and to compare the surgical times and rates of complications. Methods. In this multicentre European study, data of eyes with ERM that underwent vitrectomy from January 2017 to July 2018 were analyzed retrospectively. In the limited vitrectomy group, a posterior vitreous detachment (PVD) was induced up till the equator as opposed to complete PVD induction till the vitreous base in the comparison group. Incidence of iatrogenic retinal breaks, retinal detachment, surgical time, and visual outcomes were compared between groups. Results. We included 139 eyes in the analysis with a mean age being 72.2 ± 6.9 years. In this, sixty-five eyes (47%) underwent limited vitrectomy and 74 eyes (53%) underwent complete vitrectomy. Iatrogenic retinal tears were seen in both groups (5% in limited vitrectomy versus 7% in complete vitrectomy, p=0.49). Retinal detachment occurred in 2 eyes in the limited vitrectomy group (3%) compared to none in the complete vitrectomy group (p=0.22). Best-corrected visual acuity (BCVA) and central macular thickness improved significantly with no intergroup differences (p=0.18). Surgical time was significantly shorter in the limited vitrectomy group with 91% surgeries taking less than 1 hour compared to 71% in the complete vitrectomy group (p<0.001). Conclusion. A limited vitrectomy is a time-efficient and effective surgical procedure for removal of epiretinal membrane with no additional complications.

2020 - Long-Term Evaluation of Capsulotomy Shape and Posterior Capsule Opacification after Low-Energy Bimanual Femtosecond Laser-Assisted Cataract Surgery [Articolo su rivista]
Verdina, T.; Peppoloni, C.; Barbieri, L.; Carbotti, M. R.; Battaglia, B.; Mastropasqua, R.; Cavallini, G. M.
abstract

Purpose. To evaluate capsulotomy shape and posterior capsule opacification (PCO) during an 18-month follow-up for bimanual femtosecond laser-assisted cataract surgery (FLACS). Methods. 74 eyes operated by a well-trained surgeon with bimanual FLACS technique using low-energy LDV Z8 (Ziemer Ophthalmic Systems AG, Port, Switzerland) were included in the study. The follow-up period was 18 ± 2 months. Another 91 eyes, which underwent standard bimanual microincision cataract surgery (B-MICS), served as a control group. In all cases, a BunnyLens AF (Hanita Lenses, Israel) intraocular lens was implanted in the bag. A digital image of the capsule with slit-lamp retroillumination was performed in all patients at 18 months of follow-up. Image analysis software (ImageJ) was used to evaluate the shape of the capsulotomy in terms of diameter, area, and circularity. PCO score was evaluated using EPCO 2000 software. Best corrected visual acuity (BCVA) and endothelial cell count (ECC) were evaluated before and after surgery at 1 and 18 ± 2 months. Results. At 18 months, mean capsulotomy diameter was 5.34 ± 0.21 mm while capsulorhexis was 5.87 ± 0.37 mm (p<0.001) and the deviation area from baseline was 1.13 ± 1.76 mm2 in FLACS and 2.67 ± 1.69 mm2 in B-MICS (p<0.001). Capsulotomy circularity was 0.94 ± 0.04 while capsulorhexis was 0.83 ± 0.07 (p<0.001). EPCO score was 0.050 ± 0.081 in the FLACS group and 0.122 ± 0.239 in the B-MICS group (p=0.03). The mean BCVA improvement was significant in both groups, without a significant difference at 18 months. We noticed a statistically significant difference in endothelial cell loss at 18 months (FLACS 12.4% and B-MICS 18.1%; p=0.017). Conclusions. Bimanual FLACS is a safe and effective technique, as determined in a long-term follow-up. Capsulotomy shape presented higher stability and circularity in the FLACS group over the 18-month observation period. FLACS resulted in lower PCO scores and endothelial cell loss at 18 months in comparison to B-MICS standard technique.

2020 - Multifocal electroretinographic responses in sector retinitis pigmentosa [Articolo su rivista]
Giambene, B.; Verdina, T.; Pennino, M.; Fabbrucci, M.; Cavallini, G. M.; Menchini, U.
abstract

Headings: Multifocal electroretinography (mfERG) may be useful in the management of sector retinitis pigmentosa (SRP). Aim: To compare multifocal electroretinographic responses in SRP, generalised retinitis pigmentosa (GRP), and healthy controls. Methods: Eighteen patients with SRP, twelve with GRP, and fifteen controls were included in the study. All participants underwent: complete ophthalmological examination, Humphrey visual field testing, full-field ERG, and mfERG. The mean P1 amplitude, the implicit time (IT), and the mapping of the local responses were evaluated. Results: The mean P1 amplitude was higher in the SRPs than in GRPs (p < 0.001), while it did not differ between SRPs and controls (p = 0.913). In the SRPs, the P1 amplitude in pathologic areas was higher than in the GRPs (p < 0.001). In normal areas, this parameter did not differ from the controls (p = 0.499). Moreover, in the SRPs, no differences in the P1 amplitude and the IT between pigmented and non-pigmented areas were found. Conclusion: In the present study, the mfERG examination displayed significant differences between sector and generalised RP, showing normal values in sector RP even in pigmented areas. Considering the patients included in this study, SRP seems to represent a favourable variant of the disease, characterised by a limited retinal involvement and apparently mild functional damage. It is still unclear how these results can be extended to other forms of SRP.

2020 - One week of levofloxacin plus dexamethasone eye drops for cataract surgery: an innovative and rational therapeutic strategy [Articolo su rivista]
Bandello, F.; Coassin, M.; Di Zazzo, A.; Rizzo, S.; Biagini, I.; Pozdeyeva, N.; Sinitsyn, M.; Verzin, A.; De Rosa, P.; Calabro, F.; Avitabile, T.; Bonfiglio, V.; Fasce, F.; Barraquer, R.; Mateu, J. L.; Khonen, T.; Carnovali, M.; Malyugin, B.; Aragona, P.; Arvedi, P.; Cagini, C.; Caretti, L.; Cavallini, G. M.; Cillino, S.; Figini, I.; Franco, L. M.; La Mantia, A.; Laborante, A.; Lanzetta, P.; Marcigaglia, M.; Mariotti, C.; Martini, E.; Mastropasqua, L.; Morselli, S.; Passani, F.; Pece, A.; Pertile, G.; Pioppo, A.; Pirondini, C.; Prantera, M.; Rapisarda, A.; Romano, M. R.; Scarpa, G.; Schiano-Lomoriello, D.; Scorcia, V.; Scuderi, G.; Semeraro, F.; Spedale, F.; Staurenghi, G.; Tognetto, D.; Tosi, M.; Trabucchi, G.; Trivella, F.; Villani, E.; Vento, A.; Vinciguerra, P.; Alio, J. L.; Alfonso Sanchez, J. F.; Montiel, F. A.; Lorenz, K.; Panova, I.; Eremina, A.; Ciprandi, G.
abstract

Background: Cataract surgery is the most common operation performed worldwide. A fixed topical corticosteroid-antibiotic combination is usually prescribed in clinical practice for 2 or more weeks to treat post surgical inflammation and prevent infection. However, this protracted schedule may increase the incidence of corticosteroid-related adverse events and notably promote antibiotic resistance. Methods: This International, multicentre, randomized, blinded-assessor, parallel-group clinical study evaluated the non-inferiority of 1-week levofloxacin/dexamethasone eye drops, followed by 1-week dexamethasone alone, vs. 2-week gold-standard tobramycin/dexamethasone (one drop QID for all schedules) to prevent and treat ocular inflammation and prevent infection after uncomplicated cataract surgery. Non-inferiority was defined as the lower limit of the 95% confidence interval (CI) around a treatment difference >–10%. The study randomized 808 patients enrolled in 53 centres (Italy, Germany, Spain and Russia). The primary endpoint was the proportion of patients without anterior chamber inflammation on day 15 defined as the end of treatment. Endophthalmitis was the key secondary endpoint. This study is registered with EudraCT code: 2018-000286-36. Results: After the end of treatment, 95.2% of the patients in the test arm vs. 94.9% of the control arm had no signs of inflammation in the anterior chamber (difference between proportions of patients = 0.028; 95% CI: −0.0275/0.0331). No case of endophthalmitis was reported. No statistically significant difference was evident in any of the other secondary endpoints. Both treatments were well tolerated. Conclusions: Non-inferiority of the new short pharmacological strategy was proven. One week of levofloxacin/dexamethasone prevents infection, ensures complete control of inflammation in almost all patients and may contain antibiotic resistance.

2020 - The Role of Subthreshold Micropulse Yellow Laser as an Alternative Option for the Treatment of Refractory Postoperative Cystoid Macular Edema [Articolo su rivista]
Verdina, Tommaso; D'Aloisio, Rossella; Lazzerini, Andrea; Ferrari, Cecilia; Valerio, Edoardo; Mastropasqua, Rodolfo; Cavallini, Gian Maria
abstract

To evaluate the efficacy and the safety of subthreshold micropulse yellow laser (SMYL) in the treatment of chronic postoperative cystoid macular edema (PCME), which is refractory to standard therapies.

2019 - Bimanual femtosecond laser-assisted cataract surgery compared to standard bimanual phacoemulsification: A case-control study [Articolo su rivista]
Cavallini, Gian Maria; Fornasari, Elisa; De Maria, Michele; Lazzerini, Andrea; Campi, Luca; Verdina, Tommaso
abstract

To evaluate the efficacy and safety of bimanual, low-energy femtosecond laser-assisted cataract surgery with 1.4-mm microincisions compared to standard bimanual phacoemulsification (bimanual microincision cataract surgery).

2019 - Clinical Management of Acinic Cell Carcinoma of the Lacrimal Gland [Articolo su rivista]
Anesi, A.; Negrello, S.; Lucchetti, D.; Pollastri, G.; Trevisiol, L.; Badiali, L.; Lazzerini, A.; Cavallini, G. M.; Chiarini, L.
abstract

To report a case of acinic cell carcinoma occurred in the lacrimal gland. A 59-year-old man was admitted because of sudden blurring of vision, progressive proptosis of the left eye, and mild double vision in left and down directions of the gaze (Hess-Lancaster test). His medical history detailed controlled bilateral keratoconus and open angle glaucoma. On examination, the best corrected visual acuity decreased from 8/20 till 1/50 in one week. There was a swelling of the left upper eyelid. A hard and tender mass was palpated in the superior temporal left orbit. Ultrasound scan showed an extraconal solid mass, situated in the superior lateral corner of the orbit. Computed tomography and magnetic resonance imaging (MRI) revealed a mass of two centimeters in diameter, with round well-defined outline, within the lacrimal gland. We per-formed an enucleoresection of the mass, via a coronal approach and a lateral orbitotomy by a piezosurgical device. The lesion appeared nodular, brownish, measuring about 2 × 1.5 cm. Histopathological findings were consistent with acinic cell carcinoma with a microcystic, focally papillary-cystic growth of pattern. Follow-up MRI outcomes led to removal of the residual lacrimal gland for suspicion of recurrence. No tumor recurrences where detected at 7-year follow-up.

2019 - Evaluation of macular pigment optical density following femtosecond laser-assisted cataract surgery [Articolo su rivista]
Verdina, T.; Date, P.; Benatti, C.; Lazzerini, A.; Fornasari, E.; De Maria, M.; Pellacani, E.; Forlini, M.; Cavallini, G. M.
abstract

Background: To evaluate macular pigment optical density (MPOD) after bimanual femtosecond laser-assisted cataract surgery (FLACS) compared to standard bimanual phacoemulsiﬁcation (B-MICS). Methods: Aprospective, casematched, comparative cohort study conducted at theInstitute of Ophthalmology, University of Modena and Reggio Emilia (Italy); 30 eyes under wentbimanual FLACS with low-energy Ziemer LDV Z8 (FLACS) and 30 underwent B-MICS standard technique (B-MICS). All interventions were conducted by the same expert surgeon. MPOD using the Macular Pigment Screener II (MPS II) was evaluated at baseline, 7 and 30 days after surgery. As secondary outcomes, we considered best corrected visual acuity (BCVA) and central macular thickness (CMT) obtained using optical coherence tomography. Results: In all cases, a BunnyLens AF IOL was safely implanted in the capsular bag through a1.4 mm incision. We found asigniﬁcant reductionin MPOD in both groups at 7 and 30 days; 0.16 ±0.14 and 0.10±0.12 (FLACS) and 0.18±0.13 and 0.15±0.14 (B-MICS), respectively (P<0.05). However, there was no signiﬁcant difference between the two groups at either 7 (P=0.52) or 30 days (P=0.18). BCVA improved signiﬁcantly in both groups and CMT increased in both groups (P<0.001, P<0.001, respectively). BCVA and CMT were similar between the groups with a signiﬁcant difference in CMT in favor of the FLACS group at 30 days (P=0.017). Conclusions: MPOD was reduced in both groups without any signiﬁcant difference between the FLACS and B-MICS cataract interventions. FLACS is associated with a signiﬁcantly higher increase of macular thickness at 30 days compared to B-MICS.

2019 - Femtosecond laser-assisted cataract surgery with bimanual technique: learning curve for an experienced cataract surgeon [Articolo su rivista]
Cavallini, Gian Maria; Verdina, Tommaso; de Maria, Michele; Fornasari, Elisa; Volpini, Elisa; Campi, Luca
abstract

Purpose: To describe the intraoperative complications and the learning curve of microincision cataract surgery assisted by femtosecond laser (FLACS) with bimanual technique performed by an experienced surgeon. Methods: It is a prospective, observational, comparative case series. A total of 120 eyes which underwent bimanual FLACS by the same experienced surgeon during his first experience were included in the study; we considered the first 60 cases as Group A and the second 60 cases as Group B. In both groups, only nuclear sclerosis of grade 2 or 3 was included; an intraocular lens was implanted through a 1.4-mm incision. Best-corrected visual acuity (BCVA), surgically induced astigmatism (SIA), central corneal thickness and endothelial cell loss (ECL) were evaluated before and at 1 and 3 months after surgery. Intraoperative parameters, and intra- and post-operative complications were recorded. Results: In Group A, we had femtosecond laser-related minor complications in 11 cases (18.3%) and post-operative complications in 2 cases (3.3%); in Group B, we recorded 2 cases (3.3%) of femtosecond laser-related minor complications with no post-operative complications. Mean effective phaco time (EPT) was 5.32 Â± 3.68 s in Group A and 4.34 Â± 2.39 s in Group B with a significant difference (p = 0.046). We recorded a significant mean BCVA improvement at 3 months in both groups (p < 0.05) and no significant SIA nor corneal pachymetry changes in the two groups during the follow-up (p > 0.05). Finally, we found significant ECL in both groups with a significant difference between the two groups (p = 0.042). Conclusions: FLACS with bimanual technique and low-energy LDV Z8 is associated with a necessary initial learning curve. After the first adjustments in the surgical technique, this technology seems to be safe and effective with rapid visual recovery and it helps surgeons to standardize the crucial steps of cataract surgery.

2019 - Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer’s Disease in Transgenic Mice at Different Ages [Articolo su rivista]
Vandini, Eleonora; Ottani, Alessandra; Zaffe, Davide; Calevro, Anita; Canalini, Fabrizio; Cavallini, Gian Maria; Rossi, Rosario; Guarini, Salvatore; Giuliani, Daniela
abstract

Abstract Backgroud: Alzheimer disease is an age-related severe neurodegenerative pathology. The level of the third endogenous gas, hydrogen sulfide (H2S), is decreased in the brain of Alzheimer’s disease (AD) patients compared with the brain of the age-matched normal individuals; also, plasma H2S levels are negatively correlated with the severity of AD. Recently, we have demonstrated that systemic H2S injections are neuroprotective in an early phase of preclinical AD. Objectives: This study focuses on the possible neuroprotection of a chronic treatment with an H2S donor and sulfurous water (rich of H2S) in a severe transgenic 3×Tg-AD mice model. Method: 3×Tg-AD mice at 2 different ages (6 and 12 months) were daily treated intraperitoneally with an H2S donor and sulfurous water (rich of H2S) for 3 months consecutively. We investigated the cognitive ability, brain morphological alterations, amyloid/tau cascade, excitotoxic, inflammatory and apoptotic responses. Results: Three months of treatments with H2S significantly protected against impairment in learning and memory in a severe 3×Tg-AD mice model, at both ages studied, and reduced the size of Amyloid β plaques with preservation of the morphological picture. This neuroprotection appeared mainly in the cortex and hippocampus, associated with reduction in activity of c-jun N-terminal kinases, extracellular signal-regulated kinases and p38, which have an established role not only in the phosphorylation of tau protein but also in the inflammatory and excitotoxic response. Conclusion: Our findings indicate that appropriate treatments with various sources of H2S, might represent an innovative approach to counteract early and severe AD progression in humans.

2019 - Reply [Articolo su rivista]
Date, Purva; Forlini, Matteo; Ferrari, Tommaso Micelli; Dʼeliseo, Domenico; Cavallini, Gian Maria
abstract

We thank Drs. Kumawat and Chawla1 for their interest and insightful comments on our study titled “Comparative analysis of retinal reattachment surgery with or without internal limiting membrane peeling to prevent postoperative macular pucker.”2 First, the authors mention in their introducing comments that many other factors are responsible for epiretinal membrane (ERM) formation including duration of retinal detachment, proliferative vitreoretinopathy (PVR), number of retinal breaks, size of retinal breaks, and postoperative anti-inﬂammatory treatment, etc. We entirely agree with the authors and have hence performed a regression analysis to see the confounding inﬂuence of factors (with sufﬁcient numbers in our data set) such as PVR and presence of giant retinal tears on ERM formation in our series. Yet, the authors have commented that these issues have not been addressed. In our opinion, ERM is an extension of the PVR process, and irrespective of the underlying cause, advance PVR grade C2 or more has risk of developing ERM, also internal limiting membrane (ILM) peeling can be extremely challenging in a detached retina with extensive PVR, so we have excluded them from our study. Reliability of preoperative optical coherence tomography for macular thickness and morphology in RD depends on conﬁguration of detached retina, PVR changes, and media opacities. Considering these facts, it was not possible to evaluate preoperative optical coherence tomography ﬁndings in all the cases. In our study, we have deﬁned the presence of ERM on optical coherence tomography even if it did not affect visual acuity and may not have been obvious on slit-lamp biomicroscopy. Functional outcome in terms of visually signiﬁcant ERM during the follow-up (visual acuity less than 0.5 log MAR) developed in four of seven eyes in ILM peeling group and 18 of 25 eyes of non–ILM-peeling group. In our article, we have already enumerated various complications and retinal structural changes after ILM peeling. It is clearly mentioned that we do not report any such complications in our study. Finally, the authors conclude by saying that larger prospective randomized controlled trials studying morphological and functional changes may be needed before we practice ILM peeling in all retinal detachment surgeries which echoes the concluding remarks of our original publication verbatim

2018 - Anterior Capsule of the Lens: Comparison of Morphological Properties and Apoptosis Induction following FLACS and Standard Phacoemulsification Surgery [Articolo su rivista]
Pisciotta, Alessandra; De Maria, Michele; Verdina, Tommaso; Fornasari, Elisa; De Pol, Anto; Cavallini, Gian Maria
abstract

Purpose. Comparative evaluation of morphological features of anterior capsules and apoptosis induction in epithelial cells after femtosecond laser-assisted cataract surgery (FLACS) and standard phacoemulsification surgery. Methods. Group 1: 30 FLACS anterior capsulotomies and Group 2: 30 manual anterior continuous curvilinear capsulorhexes. All patients were operated on by the same experienced surgeon. Morphological features of the anterior capsules and apoptosis induction in epithelial cells were evaluated. Results. All patients revealed a significant mean best-corrected visual acuity (BCVA) improvement 3 months after surgery, and no major intraoperative nor postoperative complications occurred. The capsular epithelium appeared to be preserved in both groups. Scanning electron microscopy analysis revealed irregular saw-tooth shaped edges in capsules from Group 1 whereas capsules from Group 2 showed regular and smooth edges. A statistically significant higher expression of the downstream apoptotic effector cleaved caspase 3 was observed in Group 1. Conclusions. The saw-tooth appearance was likely due to the progressive sequence of laser pulses on the capsule. The low energy/high frequency properties of the laser pulse, combined with an overlapped pulse pattern, resulted in highly continuous morphology of capsule edges. The higher apoptosis induction in FLACS group might be due to photodisruption-dependent plasma generation and formation of cavitation bubbles.

2018 - Human dental pulp stem cells expressing STRO-1, c-kit and CD34 markers in peripheral nerve regeneration [Articolo su rivista]
Carnevale, Gianluca; Pisciotta, Alessandra; Riccio, Massimo; Bertoni, Laura; DE BIASI, Sara; Gibellini, Lara; Zordani, Alessio; Cavallini, Gian Maria; LA SALA, Giovanni Battista; Bruzzesi, Giacomo; Ferrari, Adriano; Cossarizza, Andrea; DE POL, Anto
abstract

Peripheral nerve injuries are a commonly encountered clinical problem and often result in long-term functional defects. The application of stem cells able to differentiate in Schwann cell-like cells in vitro and in vivo, could represent an attractive therapeutic approach for the treatment of nerve injuries. Further, stem cells sources sharing the same embryological origin as Schwann cells might be considered a suitable tool. The aim of this study was to demonstrate the ability of a neuroectodermal subpopulation of human STRO-1(+) /c-Kit(+) /CD34(+) DPSCs, expressing P75(NTR) , nestin and SOX-10, to differentiate into Schwann cell-like cells in vitro and to promote axonal regeneration in vivo, which led to functional recovery as measured by sustained gait improvement, in animal rat model of peripheral nerve injury. Transplanted human dental pulp stem cells (hDPSCs) engrafted into sciatic nerve defect, as revealed by the positive staining against human nuclei, showed the expression of typical Schwann cells markers, S100b and, noteworthy, a significant number of myelinated axons was detected. Moreover, hDPSCs promoted axonal regeneration from proximal to distal stumps 1 month after transplantation. This study demonstrates that STRO-1(+) /c-Kit(+) /CD34(+) hDPSCs, associated with neural crest derivation, represent a promising source of stem cells for the treatment of demyelinating disorders and might provide a valid alternative tool for future clinical applications to achieve functional recovery after injury or peripheral neuropathies besides minimizing ethical issues. Copyright © 2016 John Wiley & Sons, Ltd.

2018 - Postoperative diffuse opacification of a hydrophilic acrylic intraocular lens: analysis of an explant [Articolo su rivista]
Cavallini, Gian Maria; Volante, Veronica; Campi, Luca; De Maria, Michele; Fornasari, Elisa; Urso, Giancarlo
abstract

Purpose: We describe the clinicopathological and ultrastructural features of an opaque single-piece hydrophilic acrylic intraocular lens (IOL) explanted from a patient. Method: The main outcome of this report is the documentation of calcium deposits confirmed by surface analysis. The decrease in visual acuity was due to the opacification of the IOL. The opacification involved both the optic plate and the haptics. Results: The analysis at the scansion electron microscope revealed that the opacity was caused by the deposition of calcium and phosphate within the lens optic and haptics. Conclusion: This is the first case about the opacification of an Oculentis L-313. The opacification was characterized by calcium and phosphate deposition probably due to a morphological alteration of the posterior surface of the IOL.

2018 - Prophylactic ILM peeling: When, why, how? [Articolo su rivista]
Forlini, M.; Date, P.; Ferrari, L. M.; Lorusso, M.; Lecce, G.; Verdina, T.; Neri, G.; Benatti, C.; Rossini, P.; Bratu, A.; D'Eliseo, D.; Ferrari, T. M.; Cavallini, G. M.
abstract

2018 - Reply [Articolo su rivista]
Forlini, M.; Date, P.; Micelli Ferrari, T.; D'Eliseo, D.; Cavallini, G. M.
abstract

2017 - Bimanual microincision cataract surgery with implantation of the new Incise (R) MJ14 intraocular lens through a 1.4 mm incision [Articolo su rivista]
Cavallini, Gm; Verdina, T; De Maria, M; Fornasari, E; Torlai, G; Volante, V; Donati, S; Cagini, C.; DE MARIA, Michele
abstract

AIM: To analyze the visual outcomes and the posterior capsule opacification (PCO) with the new Incise (R) MJ14 intraocular lens (IOL) implanted through a 1.4 mm clear corneal incision (CCI) in patients who underwent bimanual microincision cataract surgery (B-MICS).METHODS: Eighty eyes which underwent cataract surgery using B-MICS technique performed by the same experienced surgeon were included in the study: 40 eyes were implanted with an Incise (R) MJ14 IOL through a 1.4 mm CCI (group A) without enlargement of the main CCI, while 40 eyes were implanted with an Akreos (R) MI60 IOL with enlargement of the main CCI to 1.8 mm (group B). Best corrected visual acuity (BCVA), astigmatism and endothelial cell loss were evaluated before and after surgery at 7, 30d and 6mo. Anterior segment-optical coherence tomography (AS-OCT) of CCI was performed at 1, 3, 7, 30d, 6 and 18mo. PCO incidence was evaluated at 18mo using EPCO 2000 Software.RESULTS: Mean BCVA improvement and endothelial cell loss were statistically significant at 18mo in both groups with no difference between the two groups; no statistically significant difference in surgically induced astigmatism (SIA) was noticed in the two groups. At AS-OCT the only significant alterations in the CCI were endothelial gaping and local detachment of Descemet's membrane at 1 and 7d after surgery; no statistically significant alterations were found at 1, 6 and 18mo. PCO score at 18mo was 0.03 +/- 0.07 for group A and 0.08 +/- 0.18 for group B (P=0.11) with no sign of central optic plate invasion in both groups.CONCLUSION: The implant of the new Incise (R) MJ14 IOL through a 1.4 mm CCI and B-MICS technique appeared to be a safe and effective procedure with rapid visual recovery. PCO rate resulted very low and the CCI presented few morphological alterations which were only detectable in the first days postoperatively and achieved fast corneal healing during the long-term follow-up.

2017 - COMPARATIVE ANALYSIS OF RETINAL REATTACHMENT SURGERY WITH OR WITHOUT INTERNAL LIMITING MEMBRANE PEELING TO PREVENT POSTOPERATIVE MACULAR PUCKER [Articolo su rivista]
Forlini, Matteo; Date, Purva; Ferrari, Luisa Micelli; Lorusso, Massimo; Lecce, Gabriella; Verdina, Tommaso; Neri, Giovanni; Benatti, Caterina; Rossini, Paolo; Bratu, Adriana; Dê¼eliseo, Domenico; Ferrari, Tommaso Micelli; Cavallini, Gian Maria
abstract

PURPOSE:: To determine whether internal limiting membrane (ILM) peeling during pars plana vitrectomy for rhegmatogenous retinal detachment reduces the incidence of epiretinal membrane (ERM) formation. METHODS:: In this retrospective study, preoperative, intraoperative, and postoperative data from all eyes undergoing pars plana vitrectomy for rhegmatogenous retinal detachment between January 2007 and December 2013 was analyzed. All cases with at least 1-year of follow-up were included. Data collection included vision, intraoperative complications, occurrence of ERM, and spectral domain optical coherence tomography characteristics. The OCTs were retrieved for all eyes and were graded by a single masked grader. RESULTS:: Out of 159 eyes recruited, ILM peeling was done in 78 eyes (49%). Overall occurrence of ERM was 20%. Seven eyes (9%) in ILM peeling group and 25 eyes in the non-ILM peeling group (31%) showed ERM (P = 0.001). Postoperative vision was significantly better in eyes that had ILM peeling (0.48 Â± 0.4 logarithm of the minimum angle of resolution [20/63] vs. 0.77 Â± 0.6 logarithm of the minimum angle of resolution [20/125], P = 0.003). In multivariable models adjusting for type of tamponade, ILM peeling reduced the likelihood of ERM formation by 75% (P = 0.01). CONCLUSION:: Internal limiting membrane peeling during pars plana vitrectomy for rhegmatogenous retinal detachment significantly reduces ERM formation in the postoperative period and is associated with better visual and anatomical outcomes.

2017 - MODIFICATION of ADJUSTABLE MACULAR BUCKLING with 29-G CHANDELIER LIGHT for OPTIMAL POSITIONING in HIGHLY MYOPIC EYES with MACULAR HOLE [Articolo su rivista]
Forlini, Matteo; Szkaradek, Maå‚gorzata; Rejdak, Robert; Bratu, Adriana; Rossini, Paolo; D'Eliseo, Domenico; Forlini, Cesare; Cavallini, Gian Maria
abstract

Purpose: To evaluate the efficacy of the modification of Adjustable Macular Buckling device in the treatment of myopic macular hole retinal detachment with posterior staphyloma. Methods: Four consecutive patients suffering from myopic macular detachment with macular hole were treated using the macular buckling procedure. An Adjustable Macular Buckling device was used in all four cases and was modified using a 29-gauge optical fiber to illuminate its macular plate. Results: Optical coherence tomography showed successful retinal reattachment and closure of the macular hole after the buckling procedure. The macular plate of the buckling device was properly positioned in all four patients. No complications were observed. Conclusion: The modification of the macular buckling device improves the accuracy of its positioning by illuminating its macular plate.

2017 - Multimodal analysis of the Preferred Retinal Location and the Transition Zone in patients with Stargardt Disease [Articolo su rivista]
Verdina, Tommaso; Greenstein, Vivienne C.; Sodi, Andrea; Tsang, Stephen H.; Burke, Tomas R.; Passerini, Ilaria; Allikmets, Rando; Virgili, Gianni; Cavallini, Gian Maria; Rizzo, Stanislao
abstract

Purpose: The purpose of our study was to investigate morpho-functional features of the preferred retinal location (PRL) and the transition zone (TZ) in a series of patients with recessive Stargardt disease (STGD1). Methods: Fifty-two STGD1 patients with at least one ABCA4 mutation, atrophy of the central macula (MA) and an eccentric PRL were recruited for the study. Microperimetry, fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT) were performed. The location and stability of the PRL along with the associated FAF pattern and visual sensitivities were determined and compared to the underlying retinal structure. Results: The mean visual sensitivity of the PRLs for the 52 eyes was 10.76 +/- 3.70 dB. For the majority of eyes, PRLs were associated with intact ellipsoid zone (EZ) bands and qualitatively normal FAF patterns. In 17 eyes (32.7%) the eccentric PRL was located at the edge of the MA. In 35 eyes (67.3%) it was located at varying distances from the border of the MA with a TZ between the PRL and the MA. The TZ was associated with decreased sensitivity values (5.92 +/- 4.69 dB) compared to PRLs (p<0.05), with absence/disruption of the EZ band and abnormal FAF patterns (hyper or hypo-autofluorescence). Conclusions: In STGD1 eccentric PRLs are located away from the border of MA and associated with intact EZ bands and normal FAF. The TZ is characterized by structural and functional abnormalities. The results of multimodal imaging of the PRL and TZ suggest a possible sequence of retinal and functional changes with disease progression that may help in the planning of future therapies; RPE dysfunction appears to be the primary event leading to photoreceptor degeneration and then to RPE loss.

2017 - Multiple beneficial effects of melanocortin MC4 receptor agonists in experimental neurodegenerative disorders: Therapeutic perspectives [Articolo su rivista]
Giuliani, Daniela; Ottani, Alessandra; Neri, Laura; Zaffe, Davide; Grieco, Paolo; Jochem, Jerzy; Cavallini, Gian Maria; Catania, Anna; Guarini, Salvatore
abstract

Melanocortin peptides induce neuroprotection in acute and chronic experimental neurodegenerative conditions. Melanocortins likewise counteract systemic responses to brain injuries. Furthermore, they promote neurogenesis by activating critical signaling pathways. Melanocortin-induced long-lasting improvement in synaptic activity and neurological performance, including learning and memory, sensory-motor orientation and coordinated limb use, has been consistently observed in experimental models of acute and chronic neurodegeneration. Evidence indicates that the neuroprotective and neurogenic effects of melanocortins, as well as the protection against systemic responses to a brain injury, are mediated by brain melanocortin 4 (MC4) receptors, through an involvement of the vagus nerve. Here we discuss the targets and mechanisms underlying the multiple beneficial effects recently observed in animal models of neurodegeneration. We comment on the potential clinical usefulness of melanocortin MC4 receptor agonists as neuroprotective and neuroregenerative agents in ischemic stroke, subarachnoid hemorrhage, traumatic brain injury, spinal cord injury, and Alzheimer's disease.

2017 - Rigenerazione della cornea. Dalla scoperta all'approvazione di un prodotto medicinale di terapia avanzata contenente cellule staminali in Europa [Capitolo/Saggio]
Pellegrini, G; Lambiase, Andrea; Macaluso, C; Pocobelli, A; Vinciguerra, P; Cavallini, Gm; Ducange, Pietro; Rama, P
abstract

2017 - Studio sugli infortuni oculari professionali nel territorio di Modena e Provincia. [Abstract in Atti di Convegno]
Dall’Olio, E; Clo', Elena; Sernesi, Mv; Gualdi, Eugenia; Gobba, F; Cavallini, G.
abstract

Studio sugli infortuni oculari professionali nel territorio di Modena e Provincia.

2017 - Work-related eye injuries: A relevant health problem. main epidemiological data from a highly-industrialized area of northern Italy [Articolo su rivista]
Gobba, Fabriziomaria; Dall'Olio, Enrico; Modenese, Alberto; DE MARIA, Michele; Campi, Luca; Cavallini, Gian Maria
abstract

The province of Modena is one of the most industrialized areas of Northern Italy. The medical records of the Ophthalmological Emergency Department (OED) of Modena University Hospital were studied: there were 13, 470 OED accesses in 2014 and in 754 cases that an occupational eye injury occurred. The frequency of work-related eye injuries (3â °) was lower compared to other published studies, but the absolute number is still relevant, showing the need for more adequate prevention, especially in metal work, construction work, and agriculture, where the worst prognoses were observed. Intervention programs must be implemented as early as possible in the working life, considering that the frequency in younger workers is about double that of the oldest age class (3.5â °vs. 1.8â °), and special attention should also be given to foreigners, who have a 50% higher injury risk. Furthermore, the planning of specific interventions for eye-injured workers may be useful, considering that a previous injury does not appear to encourage the adoption of preventive interventions, and a subgroup of eye-injured workers have a potential risk for new injuries. Finally, the data presented here indicates how OED records, integrated with specific occupational information, can be applied for studies on work-related eye injuries.

2016 - Dexamethasone Disodium Phosphate Penetration Into the Human Aqueous Humor After Topical Application [Articolo su rivista]
Cagini, Carlo; Cometa, Francesco; Torroni, Giovanni; Pellegrino, Adriana; Pellegrino, Roberto; Cavallini, Gian Maria
abstract

Purpose: To study the amount of steroids that is found in the aqueous humor after topical administration of dexamethasone solution eye-drops and dexamethasone suspension eye-drops. Materials and methods: One hundred seventeen consecutive patients of both genders 18 years or older, candidates for cataract surgery were randomly assigned to one of three groups. Fifty-one patients (group A) received a single instillation of a suspension containing tobramicin 0.3% mg/ml + dexamethasone 0.1% mg/ml; 56 patients (group B) received a single instillation of a solution containing tobramicin 0.3% mg/ml + dexamethasone 0.1% mg/ml; 10 patients (group C), control group, did not receive any drops. Samples were taken immediately before surgery from the anterior chamber and dexamethasone levels were measured using gas chromatography/mass spectrometry. Results: The mean dexamethasone concentrations were 0.56 μM (min 0.00, max 3.25) in group A and 0.15 μM (min 0.00, max 2.93) in group B. Dexamethasone was not detected in samples from group C. Conclusions: Dexamethasone suspension gives concentrations of steroids in the aqueous humor approximately three times higher than with dexamethasone solution drops.

2016 - From discovery to approval of an advanced therapy medicinal product-containing stem cells, in the EU [Articolo su rivista]
Pellegrini, Graziella; Lambiase, Alessandro; Macaluso, Claudio; Pocobelli, Augusto; Deng, Sophie; Cavallini, Gian Maria; Esteki, Roza; Rama, Paolo
abstract

In 1997, the human corneal epithelium was reconstructed in vitro and transplanted on patients. Later, it became a routine treatment, before regulations considered advanced therapy medicinal products and drugs on the same lines. Manufacturing, before and after good manufacturing practice setting, was established in different facilities and the clinical application in several hospitals. Advanced therapy medicinal products, including stem cells, are unique products with different challenges than other drugs: some uncertainties, in addition to benefit, cannot be avoided. This review will focus on all recent developments in the stem cell based corneal therapy.

2016 - Long-term follow-up for bimanual microincision cataract surgery: Comparison of results obtained by surgeons in training and experienced surgeons [Articolo su rivista]
Cavallini, Gian Maria; Verdina, Tommaso; Forlini, Matteo; Volante, Veronica; DE MARIA, Michele; Torlai, Giulio; Benatti, Caterina; Delvecchio, Giancarlo
abstract

Purpose: To determine the efficacy of bimanual microincision cataract surgery (B-MICS) performed by surgeons in training, evaluating clinical results, posterior capsule opacification (PCO) incidence, and clear corneal incision (CCI) architecture in a long-term follow-up and comparing results with those obtained by experienced surgeons. Patients and methods: Eighty eyes of 62 patients operated on by three surgeons in training who used B-MICS technique for the first time were included in the study (Group A). Eighty eyes of 59 patients who underwent B-MICS by three experienced surgeons were included as a control group (Group B). Best corrected visual acuity, astigmatism, corneal pachymetry, and endothelial cell count were evaluated before surgery and at 1 month and 18 months after surgery. Anterior segment optical coherence tomography images were obtained to study the morphology of CCIs. PCO incidence was evaluated using EPCO2000 software. Results: Out of 160 surgeries included in the study, mean best-corrected visual acuity improvement at 18 months was 0.343±0.246 logMAR for Group A, and 0.388±0.175 logMAR for Group B, respectively. We found no statistically significant induced astigmatism nor corneal pachymetry changes in either group, while we noticed a statistically significant endothelial cell loss postoperatively in both groups (P < 0.05). In Group A, mean PCO score was 0.163±0.196, while for Group B, it was 0.057±0.132 (P=0.0025). Mean length and inclination of the CCIs for Group A and Group B were, respectively, 1,358±175 µm and 1,437±256 µm and 141.8°±6.4° and 148.7°±5.1°. As regards corneal architecture in the 320 CCIs considered, we found posterior wound retractions and endothelial gaps, respectively, 9.8% and 11.6% for Group A and 7.8% and 10.8% for Group B. Conclusion: B-MICS performed by surgeons in training is an effective surgical technique even when assessed after a long-term follow-up. PCO incidence resulted in being higher for less experienced surgeons. Corneal incisions were shorter and less angled in surgeons in training in comparison with results obtained by expert surgeons.

2016 - Unravelling the Complexity of Inherited Retinal Dystrophies Molecular Testing: Added Value of Targeted Next-Generation Sequencing [Articolo su rivista]
Bernardis, Isabella; Chiesi, Laura; Tenedini, Elena; Artuso, Lucia; Percesepe, Antonio; Artusi, Valentina; Simone, Maria Luisa; Manfredini, Rossella; Camparini, Monica; Rinaldi, Chiara; Ciardella, Antonio; Graziano, Claudio; Balducci, Nicole; Tranchina, Antonia; Cavallini, Gian Maria; Pietrangelo, Antonello; Marigo, Valeria; Tagliafico, Enrico
abstract

To assess the clinical utility of targeted Next-Generation Sequencing (NGS) for the diagnosis of Inherited Retinal Dystrophies (IRDs), a total of 109 subjects were enrolled in the study, including 88 IRD affected probands and 21 healthy relatives. Clinical diagnoses included Retinitis Pigmentosa (RP), Leber Congenital Amaurosis (LCA), Stargardt Disease (STGD), Best Macular Dystrophy (BMD), Usher Syndrome (USH), and other IRDs with undefined clinical diagnosis. Participants underwent a complete ophthalmologic examination followed by genetic counseling. A custom AmpliSeq� panel of 72 IRD-related genes was designed for the analysis and tested using Ion semiconductor Next-Generation Sequencing (NGS). Potential disease-causing mutations were identified in 59.1% of probands, comprising mutations in 16 genes. The highest diagnostic yields were achieved for BMD, LCA, USH, and STGD patients, whereas RP confirmed its high genetic heterogeneity. Causative mutations were identified in 17.6% of probands with undefined diagnosis. Revision of the initial diagnosis was performed for 9.6% of genetically diagnosed patients. This study demonstrates that NGS represents a comprehensive cost-effective approach for IRDs molecular diagnosis. The identification of the genetic alterations underlying the phenotype enabled the clinicians to achieve a more accurate diagnosis. The results emphasize the importance of molecular diagnosis coupled with clinic information to unravel the extensive phenotypic heterogeneity of these diseases.

2015 - A Next Generation Sequencing amplicon-based strategy to explore Inherited Retinal Degeneration complexity [Abstract in Atti di Convegno]
Artusi, Valentina; Chiesi, Laura; Bernardis, Isabella; Tenedini, Elena; Artuso, Lucia; Cavallini, Gian Maria; Percesepe, Antonio; Marigo, Valeria; Tagliafico, Enrico
abstract

Inherited Retinal Degeneration (IRD) are a group of eye disorders, characterized by photoreceptors degeneration which include: Retinitis Pigmentosa, Stargardt disease, Usher Syndrome and Leber congenital amaurosis. The high genetic heterogeneity, the incompleteness of disease specific databases and the elevated number of genes involved in IRD, often hamper the correct molecular diagnosis and patients stratification. To clarify IRD molecular profile, we used a next Generation Sequencing (NGS) strategy and designed a custom AmpliSeq panel (Life Technologies), containing the coding sequences of 72 disease related genes, for a total of 1649 amplicons. An in-house bioinformatic pipeline was optimized to filter synonymous variants and polymorphism and to annotate variants with prediction algorithm (dbNSFP) and disease specific databases (LOVD eye diseases, Retina International, RPGR database). A cohort of 40 samples was selected (29 patients, 11 healthy relatives). They underwent a complete ophthalmologic examination (visual acuity, anterior segment and fundus examination, ERG and/or EOG, OCT), as well as a genetic counselling. Possibly causative mutations were detected in 62% patients (n=18). We found mutations in 8 genes. The most recurrent gene was mutated in 38% (n=7) of patients. The remaining seven genes harboured lower frequencies with just one or two patients mutated. Overall, seven genes were inherited with an autosomal recessive pattern and one gene was X-linked. Of note, less than 21% of variants have been already described in specific databases. These preliminary results highlight the need to further explore the molecular complexity and heterogeneity of RD in order to translate these analyses into clinical practice.

2015 - Long-term analysis of IOL stability of the Lewis technique for scleral fixation [Articolo su rivista]
Cavallini, Gian Maria; Volante, V.; De Maria, Michele; Torlai, Giulio; Forlini, Matteo; Chiesi, Laura; Campi, L.; Cagini, C.
abstract

PURPOSE: To demonstrate that in case of absence of capsular support intraocular lens (IOL) scleral fixation is both effective and stable over years. METHODS: A total of 13 eyes from 13 patients who underwent an IOL scleral fixation according to Lewis suturing technique between January 2001 and December 2008 were studied. Patients underwent a complete ophthalmologic evaluation. The IOL stability was assessed using slit-lamp and anterior segment optical coherence tomography (AS-OCT) examination. The IOL stability was evaluated in terms of centration and tilting. All the knots were photographed and their integrity assessed. RESULTS: Follow-up was 60-129 months. Eleven knots appeared evident and undamaged, 6 knots were eroded, and 9 knots were not detectable. All IOLs were stable in the sulcus. Two patients presented a slight decentration of the IOL at the slit-lamp examination, while the AS-OCT demonstrated slight tilting of the lenses in 4 patients. CONCLUSIONS: The Lewis technique for IOL scleral fixation is an optimal surgical technique in case of absence of capsular support. No IOL luxation in the vitreous chamber has been reported; only 2 of the 10 patients with at least one eroded knot presented a minimal decentration of the lens with no influence on visual acuity. Although knot erosion is not an uncommon occurrence, IOL remains stable in the long term, probably due to a fibrotic process around the suture, and the IOL haptics, which prevent IOL dislocation.

2015 - Long-term follow-up of retropupillary iris-claw intraocular lens implantation: A retrospective analysis Cataract and refractive surgery [Articolo su rivista]
Forlini, Matteo; Soliman, Wael; Bratu, Adriana; Rossini, Paolo; Cavallini, Gian Maria; Forlini, Cesare
abstract

Background: The ideal intraocular lens in cases of aphakia without capsular support is debated. Choices include anterior chamber lenses, iris- or scleral-sutured lenses, and iris-claw lenses. Our aim was to report our long-term evaluation of the use of retropupillary implantation of the Artisan iris-claw intraocular lens (RPICIOL) in several aphakic conditions without capsular support. Methods: A retrospective analysis of consecutive 320 eyes of 320 patients (222 males and 98 females) without capsular support in which we performed RPICIOL implantation in post-traumatic aphakia (141 eyes, group 1), post-cataract surgery aphakia (122 eyes, group 2), and in cases in which penetrating keratoplasty was associated with vitrectomy (57 eyes, group 3). Either anterior or posterior vitrectomy procedures were performed with 20-, 23-, or 25-gauge techniques for different associated anterior or posterior segment indications. We reviewed the refractive outcome, anatomical outcome, long-term stability of the implants, and possible long-term complications. Results: The mean patient age was 59.7 years (range, 16-84 years) in group 1; 60.1 years (range, 14-76 years) in group 2; and 65.8 years (range, 25-71.5 years) in group 3. The mean follow-up time was 5.3 years (range, 1 month to 8 years). At the end of the follow-up period, the mean post-operative best-corrected LogMAR visual acuity was 0.6 (range, perception of light to 0.3) in group 1; 0.3 (range, 0.5-0.1) in group 2; and 0.6 (range, hand movement to 0.2) in group 3. Disenclavation of RPICIOLs occurred in three cases because of slippage of one of the iris-claw haptics and spontaneous complete posterior dislocation occurred in one case. One case presented with retinal detachment, and no cases of uveitis were observed. Eight cases complained of chronic dull pain, and severe iridodonesis was seen in five cases. One case of post-operative macular edema was observed without post-operative increase in the mean intraocular pressure. There was no statistically different change in the endothelial cell density (cells/mm2) at the end of the follow-up period. Conclusions: RPICIOL for secondary implantations is a valid alternative strategy to scleral-fixated or angle-supported IOL implantation.

2015 - Macular buckling for retinal detachment in highly myopic eyes with macular hole: Use of a modified macular buckle improved precision and allowed optimal positioning [Articolo su rivista]
Forlini, M.; Szkaradek, M.; Rejdak, R.; Bratu, A.; Rossini, P.; Forlini, C.; Cavallini, G. M.
abstract

2015 - Results and complications of surgeons-in-training learning bimanual microincision cataract surgery [Articolo su rivista]
Cavallini, Gian Maria; Volante, Veronica; Verdina, Tommaso; Forlini, Matteo; Bigliardi, MARIA CHIARA; DE MARIA, Michele; Torlai, Giulio; Delvecchio, Giancarlo
abstract

PURPOSE: To evaluate visual outcomes and complications of bimanual microincision cataract surgery performed by surgeons in training. SETTING: Institute of Ophthalmology, University of Modena and Reggio Emilia, Modena, Italy. DESIGN: Prospective case series. METHODS: The corrected distance visual acuity (CDVA), astigmatism, corneal pachymetry, and endothelial cell count were evaluated before and 7 and 30 days after bimanual MICS performed by surgeons in training. Intraoperative and postoperative complications were also recorded. RESULTS: Three surgeons in training performed bimanual MICS in 150 eyes of 131 patients. There were 18 intraoperative complications (12.0%) (10 iris traumas [6.6%]; 4 capsule ruptures without vitreous loss [2.7%]; 3 capsule ruptures with vitreous loss [2.0%]; 1 intraocular lens [IOL] implantation in the sulcus due to zonular laxity [0.7%]). There were 5 postoperative complications (3.3%) (2 iris prolapses [1.3%]; 1 IOL loop malposition [0.7%]; 1 narrowing of anterior chamber [0.7%]; 1 capsulorhexis phimosis [0.7%]). Thirty days postoperatively, the mean CDVA improvement was 0.53 ± 0.20 (Snellen decimal) (P < .05), the mean decrease in astigmatism was 0.09 ± 0.54 diopter (P = .29), and the mean increase in corneal pachymetry was 7.42 ± 22.01 μm (P = .12). There was statistically significant endothelial cell loss (mean 496.50 ± 469.66 cells/mm(2)) (P < .05). CONCLUSIONS: Bimanual MICS performed by surgeons in training was safe and effective. Visual outcomes and complication rates were similar to those reported for coaxial cataract surgery performed by surgeons in training.

2015 - Studio sugli infortuni oculari professionali in Provincia di Modena. [Abstract in Atti di Convegno]
Dall’Olio, E; Clò, E; Gobba, F; Sernesi, Mv; Gualdi, E; De Maria, M; Cavallini, G.
abstract

Studio sugli infortuni oculari professionali in Provincia di Modena. Atti del 78° Congresso Nazionale SIMLII.

2014 - B-MICS Bimanual Micro Incision Cataract Surgery [Monografia/Trattato scientifico]
Cavallini, Gian Maria
abstract

Lo sviluppo tecnologico ha portato all’introduzione di facoemulsificatori in grado di emettere energie sempre più controllabili e sicure. Così pure le ricerche sui materiali hanno portato all’introduzione di lenti intraoculari particolarmente resistenti così da poter essere inserite attraverso un’incisione da 1.4 mm senza essere costretti ad eseguire ulteriori allargamenti o altre incisioni. Il risultato clinico per il paziente è l’assoluta assenza di astigmatismo indotto, la ridotta reazione infiammatoria postoperatoria ed un più rapido recupero funzionale.

2014 - Bilateral posterior scleritis as a presenting manifestation of giant cell arteritis: A case report [Articolo su rivista]
Cavallini, Gian Maria; Volante, Veronica; Bigliardi, MARIA CHIARA; Mascia, Maria Teresa; Forlini, Matteo
abstract

Posterior scleritis is a rare and frequently misdiagnosed form of ocular inflammation that may be either idiopathic or associated with various systemic diseases. The systemic associations1 are similar to those observed in anterior scleritis and include rheumatoid arthritis, Wegener granulomatosis, systemic lupus erythematosus, systemic vasculitis, relapsing polychondritis, sarcoidosis, and other autoimmune diseases. Moreover, it may occur in isolation or associated with either anterior scleritis or anterior uveitis. Giant cell arteritis (GCA) is a systemic immune-mediated vasculitis that affects medium-sized and large arteries. GCA has a wide spectrum of clinical features related to both systemic inflammation and ischemia. The most common symptoms are headache, scalp tenderness, jaw claudication, and systemic manifestations (fever, weight loss, anorexia, and malaise). Ophthalmologic symptoms are common manifestations of GCA and may occur alone, without other symptoms of GCA. Arteritic anterior ischemic optic neuropathy (AAION) is the most common ophthalmologic manifestation. Other ocular manifestations are central or branch retinal artery occlusion and diplopia that results from ischemia of extraocular muscles or ocular motor nerves.2 A few other reports about the association of GCA with scleritis have appeared in the literature.3, 4 and 5 We report a case of bilateral posterior scleritis that was diagnosed in association with GCA.

2014 - Chemical injury treated with autologous limbal epithelial stem cell transplantation and subconjunctival bevacizumab [Articolo su rivista]
Cavallini, Gian Maria; Pellegrini, Graziella; Volante, Veronica; Ducange, Pietro; DE MARIA, Michele; Torlai, Giulio; Benatti, Caterina; Forlini, Matteo
abstract

Limbal stem cell (LSC) deficiency leads to corneal opacity due to a conjunctivalization of the corneal surface. LSC transplantation, which can be followed by corneal keratoplasty, is an effective procedure to restore corneal transparency; however, a common cause of failure of this procedure is neovascularization (NV).

2014 - Endoscopic Cyclophotocoagulation for Refractory Glaucoma After OOKP [Articolo su rivista]
Forlini, M.; Adabache-Guel, T.; Bratu, A.; Rossini, P.; Cavallini, G. M.; Forlini, C.
abstract

2014 - Endoscopic cyclophotocoagulation in refractory glaucoma after osteo-odonto-keratoprosthesis in Stevens-Johnson syndrome: a case report [Articolo su rivista]
Forlini, Matteo; Adabache Guel, Tania; Bratu, Adriana; Rossini, Paolo; Mingaine, Mpekethu Sam; Cavallini, Gian Maria; Forlini, Cesare
abstract

To report successful treatment of refractive glaucoma in a patient submitted to osteo-odonto-keratoprosthesis surgery for Stevens-Johnson syndrome.

2014 - Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways [Articolo su rivista]
Giuliani, Daniela; A., Bitto; M., Galantucci; Zaffe, Davide; Ottani, Alessandra; N., Irrera; L., Neri; Cavallini, Gian Maria; D., Altavilla; A. R., Botticelli; F., Squadrito; Guarini, Salvatore
abstract

Besides specific triggering causes, Alzheimer's disease (AD) involves pathophysiological pathways that are common to acute and chronic neurodegenerative disorders. Melanocortins induce neuroprotection in experimental acute neurodegenerative conditions, and low melanocortin levels have been found in occasional studies performed in AD-type dementia patients. Here we investigated the possible neuroprotective role of melanocortins in a chronic neurodegenerative disorder, AD, by using 12-week-old (at the start of the study) triple-transgenic (3xTg-AD) mice harboring human transgenes APP(Swe), PS1(M146V), and tau(P301L). Treatment of 3xTg-AD mice, once daily until the end of the study (30 weeks of age), with the melanocortin analog [Nle(4),D-Phe(7)]-alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) reduced cerebral cortex/hippocampus phosphorylation/level of all AD-related biomarkers investigated (mediators of amyloid/tau cascade, oxidative/nitrosative stress, inflammation, apoptosis), decreased neuronal loss, induced over-expression of the synaptic activity-dependent gene Zif268, and improved cognitive functions, relative to saline-treated 3xTg-AD mice. Pharmacological blockade of melanocortin MC4 receptors prevented all neuroprotective effects of NDP-alpha-MSH. Our study identifies, for the first time, a class of drugs, MC4 receptor-stimulating melanocortins, that are able to counteract the progression of experimental AD by targeting pathophysiological mechanisms up- and down-stream of beta-amyloid and tau. These data could have important clinical implications. (C) 2014 Elsevier Inc. All rights reserved.

2013 - Akreos Adapt AO Intraocular Lens Opacification: A Case Report. [Articolo su rivista]
Forlini, Matteo; Orabona, Gd; Bratu, Ai; Rossini, P; Cavallini, Gian Maria; Forlini, C.
abstract

A 79-year-old hyperglycemic patient was referred to the 'Santa Maria delle Croci' Hospital, Ravenna, Italy. He presented with visual impairment in the right eye. Four years ago, he had had an uneventful cataract surgery in the right eye. We observed an opacification of the intraocular lens (IOL) causing significant visual disturbance. The IOL was exchanged. Unfortunately, pathologic analysis was not performed. Patient-related factors such as hyperglycemia and hypertension might have been responsible for the opacification. To our knowledge, there is only one previous report of opacification of the Akreos Adapt AO IOL.

2013 - Clinical risk management in eye outpatient surgery: a new surgical safety checklist for cataract surgery and intravitreal anti-VEGF injection [Articolo su rivista]
Cavallini, Gian Maria; Campi, Luca; DE MARIA, Michele; Forlini, Matteo
abstract

Abstract BACKGROUND: A database study to test a new model of surgical safety checklist for eye surgery in the outpatient operating room, especially for cataract surgery and intravitreal anti-VEGF injections. METHODS: WHO Surgical Safety Checklist analysis, and changes to obtain a customized surgical safety checklist for eye surgery. Testing of the new checklist in the outpatient operating room of the Institute of Ophthalmology, University of Modena during a period of 4 months (January-April 2011). All cataract surgery and intravitreal anti-VEGF operations were included in the study, and controlled by the new surgical safety checklist. The percentage of answers to each safety check was calculated to obtain an estimate of adherence to our new checklist. RESULT: Eight hundred and forty nine procedures (390 cataract, 452 anti-VEGF injections, seven combined surgery) were analyzed. The study showed a high level of adherence to the majority of the safety checks in the checklist. Important differences were identified in consent confirmation (correct confirmation in 99.76 %, no confirmation in 0.24 %), surgical site marking (correct marking in 99.29 %, no marking in 0.71 %), patient cooperation during operation (95.17 % of patients were cooperative, 4.83 % of patients were uncooperative), adherence to antibiotic prophylaxis (correct prophylaxis in 93.17 %, no prophylaxis in 6.83 %), critical situation during surgical procedures (no critical situation in 91.76 %, critical situation in 8.24 %) CONCLUSION: The study showed a high level of adherence to the checklist. A surgical safety checklist could improve the management of an eye surgery operating room.

2013 - In vitro differentiation into insulin-producing β-cells of stem cells isolated from human amniotic fluid and dental pulp. [Articolo su rivista]
Carnevale, Gianluca; Riccio, Massimo; Pisciotta, Alessandra; Beretti, Francesca; Maraldi, Tullia; Zavatti, Manuela; Cavallini, Gian Maria; LA SALA, Giovanni Battista; Ferrari, Adriano; DE POL, Anto
abstract

AIM: To investigate the ability of human amniotic fluid stem cells and human dental pulp stem cells to differentiate into insulin-producing cells. METHODS: Human amniotic fluid stem cells and human dental pulp stem cells were induced to differentiate into pancreatic β-cells by a multistep protocol. Islet-like structures were assessed in differentiated human amniotic fluid stem cells and human dental pulp stem cells after 21 days of culture by dithizone staining. Pancreatic and duodenal homebox-1, insulin and Glut-2 expression were detected by immunofluorescence and confocal microscopy. Insulin secreted from differentiated cells was tested with SELDI-TOF MS and by enzyme-linked immunosorbent assay. RESULTS: Human amniotic fluid stem cells and human dental pulp stem cells, after 7 days of differentiation started to form islet-like structures that became evident after 14 days of induction. SELDI-TOF MS analysis, revealed the presence of insulin in the media of differentiated cells at day 14, further confirmed by enzyme-linked immunosorbent assay after 7, 14 and 21 days. Both stem cell types expressed, after differentiation, pancreatic and duodenal homebox-1, insulin and Glut-2 and were positively stained by dithizone. Either the cytosol to nucleus translocation of pancreatic and duodenal homebox-1, either the expression of insulin, are regulated by glucose concentration changes. Day 21 islet-like structures derived from both human amniotic fluid stem cells and human dental pulp stem cell release insulin in a glucose-dependent manner. CONCLUSION: The present study demonstrates the ability of human amniotic fluid stem cells and human dental pulp stem cell to differentiate into insulin-producing cells, offering a non-pancreatic, low-invasive source of cells for islet regeneration.

2013 - Simultaneous correction of post-traumatic aphakia and aniridia with the use of artificial iris and IOL implantation [Articolo su rivista]
Forlini, C.; Forlini, M.; Cavallini, G. M.
abstract

2013 - Simultaneous correction of post-traumatic aphakia and aniridia with the use of artificial iris and IOL implantation [Articolo su rivista]
Forlini, Cesare; Forlini, Matteo; Rejdak, Robert; Prokopiuk, Agata; Levkina, Oxana; Bratu, Adriana; Rossini, Paolo; Cagampang, Perfecto R; Cavallini, Gian Maria
abstract

Abstract BACKGROUND: Combined post-traumatic aniridia and aphakia demand extensive and complex reconstructive surgery. We present our approach for simultaneous correction of this surgical situation with the use of the ArtificialIris (Dr. Schmidt Intraocularlinsen GmbH, Germany) with a foldable acrylic IOL Lentis L-313 (Oculentis, GmbH, Germany) sutured to its surface. The novelty (our first operation was on June 2010) of this surgical technique is based on the combined use of foldable (with closed haptics) IOL and Artificialiris to correct post-traumatic aniridia and aphakia. METHODS: Four consecutive cases of combined post-traumatic lesions of iris and lens, corrected with complex device ArtificialIris and foldable IOL. In two cases, the compound implant was sutured to the sclera in sulcus during the penetrating keratoplasty; in another case, it was positioned through a corneal incision of about 5.0 mm with transscleral fixation, and in one patient with preserved capsular support and possibility of IOL in-the-bag implantation the ArtificialIris was placed in sulcus sutureless through a clear corneal tunnel. RESULTS: Maximal follow-up was 6 months. The complex device was placed firmly fixed within the sulcus, including in the eye implanted without sutures, and showed a stable and centered position without any tilt or torque. CONCLUSION: Management of post-traumatic aniridia combined with aphakia by haptic fixation of a foldable acrylic IOL on a foldable iris prosthesis appears to be a promising approach which gives the surgeon the possibility to correct a complex lesion with one procedure, which is less traumatic and faster. Existence of foldable materials, both iris and IOL, permits relatively small corneal incisions (4.0-5.0 mm). Moreover, the custom-tailored iris prosthesis gives a perfect aesthetic result.

2013 - Successful treatment of Fusarium keratitis after photo refractive keratectomy. [Articolo su rivista]
Cavallini, Gian Maria; Ducange, Pietro; Volante, Veronica; Benatti, Caterina
abstract

A 39-year-old woman presented to our hospital with a history of photorefractive keratectomy (PRK), performed two weeks prior; slit-lamp examination revealed diffuse conjunctival congestion, corneal ulcer and stromal infiltration. After 5 days of antifungal and antibacteric treatment, the infiltrate progressively increased so that a therapeutic penetrating keratoplasty was necessary. The microbiological analyses revealed the presence of fungal filaments. Twenty days after surgery the patient had recurrent fungal infiltrate in the donor cornea with wound dehiscence. We performed a second penetrating keratoplasty. With the matrix-assisted-laser-desorption-ionization-time-of-flight analysis (MALDI-TOF) we identified a Fusarium solani. Intravenous amphothericine B, a combination of intracameral and intrastromal voriconazole and intracameral amphotericine B were administered. After 6 months from the last surgery the infection was eradicated. The management of fungal keratitis after PRK depends on many factors: In our experience, a prompt keratoplasty and the use of intracameral antifungal medication proved to be very effective.

2012 - Apprendimento della tecnica B-MICS nella chirurgia della cataratta: risultati e complicanze [Altro]
V., Volante; M. C., Bigliardi; M. E., Bosi; Cavallini, Gian Maria
abstract

Ad oggi inoltre, per nostra conoscenza, non è stato condotto uno studio che mirasse a valutare l’incidenza di complicanze durante la fase di training della B-MICS; abbiamo pertanto valutare l’apprendimento della tecnica B-MICS da parte di un chirurgo in formazione, considerando le principali complicanze intra e postoperatorie verificatesi durante la curva di apprendimento di tale tecnica chirurgica. Sono stati poi valutati i risultati postoperatori in termini di acuità visiva, di astigmatismo, di spessore corneale e conta endoteliale.

2012 - CLEAR CORNEAL INCISIONS IN B-MICS CATARACT SURGERY: THE LONG-TERM WOUND HEALING ARCHITECTURE [Articolo su rivista]
Cavallini, Gian Maria; L., Campi; G., Torlai; M., Forlini; E., Fornasari
abstract

Abstract: PURPOSE: To evaluate the B-MICS clear corneal incision architectural features in the longtermusing Anterior Segment OCT.DESIGN: Case series.SETTING: Institute of Ophthalmology, University of Modena, Italy.METHODS: 52 eyes from 33 patients who underwent uneventful B-MICS cataract extraction in theprevious 2-16 months were examined through AS-OCT. Images were analyzed measuring cornealthickness, incision length, incision angle, prevalence of epithelial or endothelial gaping, misalignment,Descemet's membrane detachment and posterior wound retraction (PWR).RESULTS: The mean incision length and incision angle were respectively 1427.91 μm and 31.19° forthe right hand, 1440.63 μm and 31.54° for the left hand. 1474.13 μm and 31.27° in temporal incisions,1394.41 μm and 31.46° in nasal CCIs. PWR was the only architectural feature we found, its prevalencewas 7.10% at 2-3 months, 31.8% at 4-11 months, 33.3% over 12 months. 53% of PWR were in 1.8 mmCCIs, 47% in 1.4 mm CCIs. Mean PWR length was 74.4 ± 23.81 μm, the mean percentage of woundretraction relative to the CCI length was 5.28%. The mean BCVA in eyes with PWR was 9.93/10 ± 0.23.CONCLUSION: B-MICS surgical technique is not related to particular morphological features of CCIs, theenlargement from 1.4 to 1.8 mm of one incision or its construction with either the dominant or thenon-dominant hand is not distinguishable in the long-term wound architecture. The PWR is the onlyarchitectural feature we found in our postoperative intervals, but its prevalence seems substantiallylower than in other surgical techniques.

2012 - Human serum promotes osteogenic differentiation of Human Dental Pulp Stem Cells in vitro and in vivo. [Articolo su rivista]
Pisciotta, Alessandra; Riccio, Massimo; Carnevale, Gianluca; Beretti, Francesca; Gibellini, Lara; Maraldi, Tullia; Cavallini, Gian Maria; Ferrari, Adriano; Bruzzesi, G; DE POL, Anto
abstract

Human dental pulp is a promising alternative source of stem cells for cell-based tissue engineering in regenerative medicine, for the easily recruitment with low invasivity for the patient and for the self-renewal and differentiation potential of cells. So far, in vitro culture of mesenchymal stem cells is usually based on supplementing culture and differentiation media with foetal calf serum (FCS). FCS is known to contain a great quantity of growth factors, and thus to promote cell attachment on plastic surface as well as expansion and differentiation. Nevertheless, FCS as an animal origin supplement may represent a potential means for disease transmission besides leading to a xenogenic immune response. Therefore, a significant interest is focused on investigating alternative supplements, in order to obtain a sufficient cell number for clinical application, avoiding the inconvenients of FCS use. In our study we have demonstrated that human serum (HS) is a suitable alternative to FCS, indeed its addition to culture medium induces a high hDPSCs proliferation rate and improves the in vitro osteogenic differentiation. Furthermore, hDPSCs-collagen constructs, pre-differentiated with HS-medium in vitro for 10 days, when implanted in immunocompromised rats, are able to restore critical size parietal bone defects. Therefore these data indicate that HS is a valid substitute for FCS to culture and differentiate in vitro hDPSCs in order to obtain a successful bone regeneration in vivo.

2012 - LA GESTIONE DEL RISCHIO NELLA CHIRURGIA OCULARE AMBULATORIALE [Altro]
L., Campi; M., De Maria; Cavallini, Gian Maria
abstract

Il nostro studio in accordo con la letteratura internazionale, sostiene che la SSC può ridurre le complicanze operatorie. Tuttavia il reale impatto della checklist dipende dalla volontà e dalla convinzione nell’implementazione di tale strumento nelle strutture sanitarie [18].Il nostro studio ci ha dato l’opportunità di iniziare la “cultura del rischio” nella nostra clinica, essendo sicuri del fatto che la checklist è un valido strumento per gestire i numerosi rischi cui i pazienti vanno incontro quando si sottopongono alla chirurgia oculare.Inoltre, è assolutamente evidente che la nostra clinica ha un elevato livello di sicurezza, date le ottime risposte ottenute in ogni singolo SC della checklist. Il nostro studio ha evidenziato risultati preliminari e parziali. Focalizzandoci in questa fase esclusivamente sulla forma della checklist e su una sua prova diretta in sala, lo step successivo sarà quello di valutare le complicanze cliniche riscontrate nei pazienti della nostra casistica. Sarà interessante confrontare le complicanze di un gruppo di pazienti trattati sotto il controllo della checklist con un gruppo simile trattato senza il controllo della checklist. Questo permetterà di ottenere un valore quantitativo circa la riduzione del rischio per pazienti che devono sottoporsi a chirurgia della cataratta o iniezioni intravitreali di anti-VEGF.In futuro, continuare ad utilizzare la checklist sarà fondamentale: sarà utile applicare ulteriori modifiche per adattare la checklist ad altri tipi di chirurgia oculare come la chirurgia vitreo-retinica. Si tratta di tipologie chirurgiche estremamente complesse e differenti rispetto alla chirurgia in regime ambulatoriale.Uno studio di RCA potrà indentificare le cause radice che hanno determinato la comparsa delle complicanze e verificare in quale fase di tutta la procedura esse abbiano agito, identificando il punto debole della procedura. Sarebbe utile proporre una checklist per individuare gli High-risk patient (pazienti ad alto rischio) che si sottopongono alla chirurgia della cataratta [19-20]; inoltre questo tipo di checklist potrebbe essere utilizzata per scegliere i pazienti adatti per i chirurghi in training, riducendo quindi i rischi ed aumentando le opportunità di apprendimento nella nostra clinica [21].Infine, sarebbe interessante coinvolgere altre realtà oculistiche sia regionali, sia italiane per ottenere una casistica tanto ampia da proporre uno studio di metanalisi sull’argomento, per analizzare su larga scala gli outcomes della checklist.

2012 - La gestione del rischio nella chirurgia oculare [Altro]
Cavallini, Gian Maria; L., Campi; M., De Maria; M., Forlini
abstract

2012 - Le IOL multifocali: quando no? [Altro]
Cavallini, Gian Maria; S., Pelloni; E., Fornasari; M., Forlini
abstract

Le IOL multifocali: quando no? studio sui benefici delle IOL mutlifocali ed analisi dei casi clinici in cui è consigliabile l'impianto di lenti multifocali.

2012 - Learning B-MICS in cataract surgery: results and complications [Altro]
V., Volante; M. C., Bigliardi; M. E., Bosi; Cavallini, Gian Maria
abstract

TITLE: Learning B-MICS in cataract surgery: results and complicationsPURPOSE: To evaluate complications and outcomes of bimanual microphacoemulsification performed by a surgeon in training.SETTING: Institute of Ophthalmology, University of Modena and Reggio Emilia, Modena, Italy.METHODS: A prospective study about the first 42 eyes of 38 patients underwent cataract surgery performed by the same surgeon in training, using for the first time bimanual microphacoemulsification thecnique (B-MICS), under expert surgeon supervision. Intra and postoperative complications and intraoperative parameters were recorded. Preoperative and postoperative parameters evaluated were visual acuity, astigmatism, corneal pachymetry and endothelial cell count.RESULTS: Of 42 cataract surgery, there were 5 cases of iris trauma (11,9%), one of which (2,38%) with postoperative iris prolaps, 2 cases of capsular rupture without vitreous loss (4,76%), 2 cases of posterior capsular rupture with vitreous loss (4,46%), 1 case of IOL implantation in the sulcus because zonular marked laxity (2,38%), 1 IOL’s loop malposition (2,38%). After surgery visual acuity improved, both at 7 and 30 days (p<0.001). There was also, a statistically significant endothelial cell loss between pre and postoperative phase, reduction that is statistically significant at both 7 that 30 days from the surgery (p <0.001 and p=0.002). There was no statistically significant difference between pre and postoperative astigmatism, and corneal thikness (p>0.05). Instead, there was a statistically significant increase in astigmatism after 7 days in complicated cases (vitreous loss, capsular tear or capsular weakness, p=0,017), in contrast with uncomplicated cases. CONCLUSIONS: Complication rates are similar to that reported in literature about cataract surgery performed by surgeon in training with traditional phacoemulsification technique. B-MICS is a good and safe technique even performed by surgeon in training.

2012 - STUDIO MORFOLOGICO-FUNZIONALE DELLA CAPSULORESSI E DELLE MICROINCISIONI IN OCCHI OPERATI DI CATARATTA CON TECNICA B-MICS [Altro]
Cavallini, Gian Maria; G., Torlai; L., Campi; E., Fornasari; M., Forlini
abstract

SCOPO: Valutare gli aspetti morfologici-strutturali delle incisioni e della capsuloressi in pazienti sottoposti ad intervento di asportazione di cataratta con tecnica B-MICS (bimanual micro incision cataract surgery) in rapporto ai risultati clinici ottenuti.MATERIALI E METODI: È stata analizzata, presso la Struttura Complessa di Oftalmologia dell’Università di Modena e Reggio Emilia, una serie aperta di 80 occhi di 48 pazienti operati di cataratta con tecnica B-MICS dopo 3-6 mesi dall’intervento.I pazienti sono stati sottoposti ad una fotografia del segmento anteriore alla lampada a fessura per evidenziare la linea di ressi e sono stati suddivisi in 3 gruppi in base al diametro della capsuloressi: piccola (< 6,00 mm), media (= 6,00 mm) e grande (> 6,00 mm). Inoltre si sono sottoposti a studio con OCT del segmento anteriore (Nidek RS3000) per valutare l’architettura delle microincisioni di accesso corneale, comparando le incisioni secondo due modalità: mano destra vs. mano sinistra del chirurgo ed incisioni sul versante nasale vs. incisioni temporali.RISULTATI: L’analisi della capsuloressi è stata possibile in 59 occhi: 14 con capsuloressi piccole, 21 medie, 24 grandi; l’acuità visiva media nel gruppo di pazienti con ressi grande era di 9,71/10 ± 0,06, con correzione di 0.00 ± 0,68 diottrie; nel gruppo con ressi media era di 9,6/10 ± 0,09 con correzione di - 0,08 ± 0,66 diottrie; nel gruppo con ressi piccola era di 9,75/10 ±0,09 con correzione di -0,16 ± 0,48 diottrie.Lo studio delle microincisioni mediante OCT del segmento anteriore è stato eseguito in 52 occhi. Nel confronto mano destra (dominante) e mano sinistra (non dominante) i valori per la mano destra sono stati: 709,75 μm di spessore corneale, 1427,91 μm di lunghezza dell’incisione e 31, 19° di angolo rispetto alla tangente corneale, i valori per la mano sinistra sono stati: 724,56 μm di spessore corneale, 1440,63 μm di lunghezza dell’incisione e 31,54° di angolo rispetto alla tangente corneale. Nel confronto tra incisioni nasali e temporali i valori per le incisioni nasali sono stati: 710, 35 μm di spessore corneale, 1394,41 μm di lunghezza dell’incisione e 31,46° di angolo rispetto alla tangente corneale, i valori per l’incisione temporale sono stati: 723,96 μm di spessore corneale, 1474,13 μm di lunghezza dell’incisione e 31,27° di angolo rispetto la tangente corneale.CONCLUSIONI: L’acuità visiva dei pazienti non mostra una differenza significativa nei tre diversi gruppi dimensionali di capsuloressi: il diametro della ressi eseguita non appare quindi un fattore determinante per il raggiungimento di una acuità visiva ottimale.Per quanto riguarda le microincisioni, non emergono differenze statisticamente significative nella loro struttura confrontando quelle eseguite con la mano dominante con quelle eseguite con la mano non dominante, né emerge una differenza statisticamente significativa nella struttura fra le incisioni nasali rispetto a quelle temporali.

2012 - STUDIO MORFOLOGICO-FUNZIONALE DELLE MICROINCISIONI E DELLA CAPSULORESSI IN OCCHI OPERATI DI CATARATTA CON TECNICA B-MICS [Altro]
Cavallini, Gian Maria; G., Torlai; L., Campi; M., Forlini; E., Fornasari
abstract

OUTCOME PRIMARI dello studio sono stati:1.Analizzare la struttura delle MICROINCISIONI, valutandone l’architettura a distanza di tempo dall’intervento, quindi in una condizione stabilizzata. L’obiettivo che ci siamo posti è di valutare se le incisioni effettuate con chirurgia bimanuale presentino caratteristiche morfologiche distintive. 2.Analizzare le caratteristiche dimensionali della CAPSULORESSI, quali la sua ampiezza e i suoi diametri rispetto alla IOL impiantata, ponendoci come quesito se queste caratteristiche abbiano una correlazione o influiscano sulla acuità visiva finale del paziente.OUTCOME SECONDARIO è stato: Abbiamo analizzato la prevalenza, la morfologia e l’effetto sull’outcome visivo finale dei pazienti, della PWR, che è un elemento di riscontro comune a questa distanza di tempo dall’intervento, come sostenuto in un articolo di L. Wang in cui la prevalenza di PWR è stata calcolata in incisioni di 2.65-2.7 mm

2012 - The protease inhibitor atazanavir triggers autophagy and mitophagy in human preadipocytes [Articolo su rivista]
Gibellini, Lara; DE BIASI, Sara; Pinti, Marcello; Nasi, Milena; Riccio, Massimo; Carnevale, Gianluca; Cavallini, Gian Maria; F. J., Sala De Oyanguren; J. E., O’Connor; Mussini, Cristina; DE POL, Anto; Cossarizza, Andrea
abstract

Background: The association betweenHAARTand lipodystrophy iswell established, but lipodystrophy pathogenesis is still poorly understood. Drugs, and in particular protease inhibitors, accumulate in adipose tissue affecting adipocyte physiology and gene expression by several mechanisms. Recent studies have identified autophagy as another process affected by these classes of drugs, but no studies have been performed in adipose cells. Methods: SW872 preadipocytic human cell line was used to evaluate changes induced by amprenavir (APV), ritonavir (RTV), or atazanavir (ATV), all used at 10–200mmol/l. A subline was stably transfected with murine stem cell virus (pMSCV)-enhanced green fluorescent protein (EGFP)-LC3 plasmid (to obtain a fluorescent LC3 protein) and treated with ATV at different doses. The distribution of LC3 and the colocalization of mitochondria, lysosome, and autophagosome were assessed by confocal microscopy. Transmission electron microscopy of ATV-treated cells was also performed. The cellular content of lysosomes was assessed using Lysotracker Green; apoptosis was evaluated by annexin V/propidium iodide staining, and mitochondrial superoxide anion (mtO2-) was analyzed by mitoSOX red. Lysosomes, apoptosis, and mtO2 - were studied by flow cytometry and multispectral imaging flow cytometry. Results: In SW872 cells, RTV caused massive apoptosis, more than autophagy, whereas APV was almost ineffective. ATV induced both apoptosis (high doses) and autophagy (low doses). ATV-treated cells displayed LC3-specific punctae, suggesting the formation of autophagosomes that enclosed mitochondria, as revealed by electron microscopy. At low doses, ATV promoted mitochondrial superoxide generation, whereas at high doses, it induced mitochondrial membrane depolarization. Conclusion: Autophagy/mitophagy can be considered a mechanism triggered by ATV in SW872 preadipocytes.

2011 - Capitolo 53 "Complications of Pharmacotherapy" [Capitolo/Saggio]
M., Forlini; Cavallini, Gian Maria; L., Campi; V., Morales Canton; P., Rossini; A., Bratu; C., Forlini; G., Di Stefano
abstract

Pharmacological therapy of ocular diseases comprises a vast variety of drug classes available for use in treating the many different pathological situations, including antibiotics and antivirals, fibrinolytic molecules (tPA), new generation antiedema drugs (triamcinolone acetonide) and antivascular endothelial grow factor (antiVEGF) agents for the treatment of neovascular and exudative diseases of the retina.

2011 - Cionni's modified capsular tension ring in traumatic cataract [Altro]
Cavallini, Gian Maria; C., Benatti; M., Forlini
abstract

Cionni's modified capsular tension ring in traumatic cataract

2011 - Gestione delle complicanze con B-MICS [Altro]
M., Forlini; Cavallini, Gian Maria; M. C., Bigliardi
abstract

Studio sulla gestione delle complicanze con B-MICS

2011 - Incisione per microfacoemulsificazione bimanuale [Altro]
Cavallini, Gian Maria; M., Forlini; M. C., Bigliardi
abstract

Incisione per microfacoemulsificazione bimanuale

2011 - Le causticazioni corneali da agenti chimici [Altro]
Cavallini, Gian Maria; P., Ducange; M., Forlini
abstract

Le causticazioni corneali da agenti chimici

2010 - B-MICS technique for cataract surgery in complex cases [Abstract in Atti di Convegno]
Cavallini, Gian Maria; S., Pelloni; M., Forlini
abstract

B-MICS technique for cataract surgery in complex cases

2010 - Microfaemulsificazione bimanuale [Altro]
Cavallini, Gian Maria; S., Pelloni; M., Forlini
abstract

Dissertazione sulla tecnica chirurgica di microfaemulsificazione bimanuale (B-MICS)

2010 - New life after PK and cosmetic IOL implantation in trauma cases [Altro]
M., Forlini; B., Foscarini; Cavallini, Gian Maria
abstract

New life after PK and cosmetic IOL implantation in trauma cases

2009 - Bimanual microphaco versus coaxial miniphaco. [Capitolo/Saggio]
Cavallini, Gian Maria; Campi, L; Masini, C; Pelloni, S.
abstract

2009 - Bottle Cork Injury to the Eye [Capitolo/Saggio]
Cavallini, Gian Maria; Forlini, M; Masini, C; Campi, L; Pelloni, S.
abstract

2009 - Bottle cork and cap injury to the eye: A review of 34 cases [Articolo su rivista]
Cavallini, Gian Maria; Martini, A; Campi, L; Forlini, M.
abstract

AIM: To describe our series of bottle cork and cap injuries to the eye in order to report the visual impairment and clinical outcomes observed in 34 cases over an 8-year period. METHODS: Retrospective review of the database of the Ophthalmology Institute of Modena from January 1999 to September 2007. All patients presented with closed-globe injury according to Kuhn et al.'s classification. All the cases were caused by sparkling wine: white in 24 cases and red in ten cases. RESULTS: The incidence varied between six and two cases a year (average 3.89). Bottle cork and cap injuries represent 11% of all injuries admitted to our department in the period considered in our series. In details: nine patients recovered totally, 22 patients recovered partially, three patients had a severe visual outcome (

2009 - Cataract development in a young patient with lathosterolosis: A clinicopathologic case report [Articolo su rivista]
Cavallini, Gm; Masini, C; Chiesi, C; Campi, L; Rivasi, Francesco; Ferrari, P.
abstract

PURPOSE: To report a unique case of cataract in a young patient with lathosterolosis, a singular defect of cholesterol biosynthesis, and to report the clinical results and histopathologic findings after cataract surgery. METHODS: A 7-year-old patient with lathosterolosis, a rare defect of cholesterol biosynthesis, presented with a complex phenotype, including severe mental retardation, liver disease, multiple congenital anomalies, and bilateral posterior subcapsular cataracts. After a severe metabolic decompensation, a worsening in the lens opacity of the left eye occurred. The authors thus performed cataract surgery and made a histopathologic analysis of aspirated lenticular samples. The following examinations were performed at 1 day, 1 week, 3 months, 6 months, 12 months, and 24 months: refraction, biomicroscopy, and fundus evaluation. Visual acuity was not assessable due to lack of patient collaboration. The postoperative follow-up period was 24 months. RESULTS: Histopathologic findings on lenticular fragments revealed the presence of fibers disposed in a honeycomb, samples with homogeneous eosinophilic lens fibers, and other fragments characterized by bulgy elements referable to cortical fibers with degenerative characteristics. After surgery, biomicroscopic evaluation revealed no significant inflammation and good intraocular lens centration at the various control visits. No intraoperative or postoperative complications occurred. No posterior capsule opacification occurred 2 years after surgery. CONCLUSIONS: Lathosterolosis may lead to dysmetabolic cataract development; this unique case of cataract in such a patient has been successfully managed with surgery. Clinical results were excellent, and no complications occurred either intra- or postoperatively.

2009 - Comparison between two different microincision IOLs for the development of PCO. [Abstract in Atti di Convegno]
S., Pelloni; C., Masini; Cavallini, Gian Maria; L., Campi
abstract

Comparison between two different microincision IOLs for the development of PCO.

2009 - Dismetabolic Cataracts. [Capitolo/Saggio]
Cavallini, Gian Maria; Masini, C; Campi, L; Chiesi, Carlo; Pelloni, S.
abstract

2009 - Evaluation of refraction in a statistically significant sample: changes according to age and strabismus [Articolo su rivista]
Chiesi, C; Chiesi, L; Cavallini, Gian Maria
abstract

PURPOSE: To assess possible refractive changes according to age and strabismus in a statistically significant cohort. METHODS: A population-based sample of 12,534 subjects 0.5 to 20 years old, examined between 2004 and 2006, was tested. Each subject received a complete orthoptic examination, including spherocylindrical streak retinoscopy in cycloplegia. Patients were divided into those with orthophoria (7,784) and those with strabismus (4,750), and the latter group was further divided into those with esodeviation (3,026) and those with exodeviation (1,724). A statistical analysis of the spherical equivalent, astigmatism, and anisometropia was performed with an independent samples t test or one-way analysis of variance. RESULTS: The percentage of patients with a mean spherical equivalent within +/- 1 and +/- 2 standard deviations was greater than 68% and 95%, respectively. The mean spherical equivalent of the total sample was 1.62 diopters (D) (+/- 2.88). The mean spherical equivalent was 1.10 +/- 2.94 D in the orthophoria group, 3.22 +/- 2.29 D in the esodeviation group, and 1.13 +/- 2.50 D in the exodeviation group (one-way analysis of variance; P = .000). Age-related changes in the mean spherical equivalent showed a clear and steady myopic shift, reaching mean myopic refraction at 12 to 14 years in both the total sample and the orthophoria and exodeviation groups. It assumed a more constant trend, with no myopic swing, in the esodeviation group (P = .000). Mean astigmatism was less in patients with less than 1.00 D anisometropia (0.83 +/- 0.92 D) than in those with 1.00 D or greater anisometropia (1.42 +/- 1.18 D) (t test; P = .0001). CONCLUSION: Both the age-related trend in the spherical equivalent and the high hyperopic values of the distribution peak in patients with esodeviation confirm the importance of the hypermetropic refractive component. The statistically significantly higher incidence of astigmatism in patients with 1.00 D or greater ametropia highlights its incidence in amblyopia. Copyright 2009, SLACK Incorporated.

2009 - External ophthalmomyiasis by Oestrus ovis larvae diagnosed in a Papanicolaou-stained conjunctival smear. [Articolo su rivista]
Rivasi, Francesco; Campi, L; Cavallini, Gm; Pampiglione, S.
abstract

Human ophthalmomyiasis is an eye infection associated with the larvae of certain flies of the Order Diptera (Insecta). This parasitic infection is classified as internal, orbital or external in relation to the location of the larvae.1 External ophthalmomyiasis is caused by species of a number of families, which include Oestrus ovis. This species, also called 'sheep bot fly', is a parasite specific to ovines and can only incidentally affect man. Adult Oestrus ovis females normally project their larvae into the muzzle of sheep while flying. In humans, the face and particularly the eyes are affected, these larvae being responsible for most cases of human external ophthalmomyiasis.2,3 In sheep, the larvae climb into the nasal passages reaching the frontal sinuses. After a few months, they detach and complete their life cycle in the soil from which the adult emerges at the next favourable season. The cycle ends in the human host as the parasite dies after a few days or weeks. While the infection is uncommon and reported only sporadically in Northern Italy, shepherds, farmers and people living in rural areas where sheep are bred are particularly affected.4,5 The larva, a millimetre in length and equipped with two oral hooks and numerous rows of tiny spines, irritates the conjunctival layer provoking an acute foreign body sensation, photophobia, blepharospasm, a watery to mucopurulent discharge, a sometimes painful chemosis with oedema of the eyelids.2,4 The prognosis is normally benign. Careful conjunctival examination can demonstrate the typical larvae. We report a human case of this infection, which occurred in Northern Italy and was diagnosed by cytological examination of a Papanicolaou-stained conjunctival smear.

2009 - Facoemulsificazione bimanuale: vantaggi e svantaggi [Altro]
Cavallini, Gian Maria; S., Pelloni
abstract

Valutazione dei vantaggi e svantaggi della facoemulsificazione bimanuale.

2009 - Le chirurgie innovative: quali quando, take home message. [Altro]
Cavallini, Gian Maria; S., Pelloni; C., Masini
abstract

Suggerimenti circa l'utilizzo delle chirurgie innovative nella cataratta.

2009 - Nuove tecniche di facoemulsificazione. [Altro]
Cavallini, Gian Maria; S., Pelloni; C., Masini
abstract

Descrizione dell nuove tecniche di facoemulsificazione.

2008 - Accuracy of Intraocular Lens Power Calculation in Bimanual Microphacoemulsification. [Capitolo/Saggio]
Cavallini, Gian Maria; Campi, L; Neri, G.
abstract

2008 - B-MICS Versus C-MICS. Which method is better? [Recensione in Rivista]
Cavallini, Gian Maria; L., Campi; C., Masini; S., Pelloni
abstract

B-MICS Versus C-MICS. Which method is better?The article is about benefits of bimanual micro incision cataract surgery compared with coaxial technique.

2008 - B-MICS con le macchine di ultima generazione. [Altro]
Cavallini, Gian Maria
abstract

Valutazione dei risultati clinici della B-MICS con le macchine di ultima generazione.

2008 - B-MICS e C-MICS [Altro]
Cavallini, Gian Maria
abstract

Confronto tra gli outcomes clinici e chirurgici tra B-MICS e C-MICS

2008 - B-MICS versus C-MICS. Which method is better? [Altro]
Cavallini, Gian Maria; L., Campi; C., Masini; S., Pelloni
abstract

Comparison between B-MICS versus C-MICS.

2008 - Bimanual microfacoemulsification with the Sovereign Whitestar, the Signature Whitestar and the Stellaris platforms: a comparative clinical trial. [Abstract in Atti di Convegno]
Cavallini, Gian Maria; S., Pelloni; M., Masini
abstract

Bimanual microfacoemulsification with the Sovereign Whitestar, the Signature Whitestar and the Stellaris platforms: a comparative clinical trial

2008 - Bimanual microphaco versus coaxial miniphaco. [Capitolo/Saggio]
Cavallini, Gian Maria; Campi, L; Masini, C; Pelloni, S.
abstract

2008 - Capsulorhexis phimosis after bimanual microphacoemulsification and in-the-bag implantation of the Akreos MI60 intraocular lens [Articolo su rivista]
Cavallini, Gian Maria; C., Masini; L., Campi; S., Pelloni
abstract

An 80-year-old woman with corticonuclear cataract had cataract extraction by bimanual microphacoemulsification and in-the-bag implantation of the Akreos MI60 (Bausch & Lomb) intraocular lens (IOL). After 6 months, a complete capsulorhexis phimosis developed and surgery was performed to open and reduce the phimosis, with complete functional recovery. In the fellow pseudophakic eye, an acrylic hydrophobic Acri.Smart 48S (Acri.Tec) IOL had been implanted without complications. We conclude that a capsulorhexis phimosis may occur a few months after uneventful cataract surgery and in-the-bag implantation of the Akreos MI60 IOL.

2008 - Chirurgia della cataratta nella retinopatia diabetica. [Altro]
Cavallini, Gian Maria; L., Campi; V., Volante; A., Pupino; C., Masini; S., Pelloni
abstract

Chirurgia della cataratta nella retinopatia diabetica.

2008 - Clinical evidence for key benefits of 1.8 mm MICS. [Altro]
Cavallini, Gian Maria
abstract

Valutation of clinical evidence for key benefits of 1.8 mm MICS.

2008 - ESPERIENZA CON LA LENTE INTRAOCULARE AKREOS MI60. STUDIO MULTICENTRICO ITALIANO [Altro]
Cavallini, Gian Maria; V., Orfeo; L., Zeppa; P. M., Fantaguzzi; Gruppo Italiano studio LIO, Mi60
abstract

Obiettivi: valutare l’efficacia e la sicurezza della lente intraoculare (LIO) da microincisione Akreos MI60. Materiali e metodi: in uno studio multicentrico eseguito in 4 centri italiani, 130 occhi di pazienti con cataratta senile reclutati in modo consecutivo, sono stati impiantati con LIO Akreos MI60 nel corso di intervento di estrazione di cataratta con tecnica bimanuale o coassiale di microfacoemulsificazione. L’acuità visiva (AV), la centratura della LIO e gli Eventi Avversi (EA) sono stati monitorati durante follow-up (FU) a 1 settimana, a 1 e a 3 mesi. Obbiettivi primari sono stati l’AV ad alto e basso contrasto e la Sensibilità al Contrasto (CS) in condizioni fotopiche (F) e mesopiche (M) a 3 mesi di FU. Risultati: dati preliminari relativi a 30 pazienti riportano una Best Corrected VA ad alto contrasto di 0.05 ± 0.11 e di 0.21 ± 0.09 a basso contrasto (Log Mar). Le curve di CS sono nei limiti di normalità sia in condizioni F che in condizioni M. Non si riportano Eventi Avversi intra e post-operatori. Conclusioni: nella casistica analizzata, la lente Akreos MI60 ha dimostrato sicurezza e facile impiantabilità nel sacco capsulare e ottima efficacia nel recupero della funzione visiva.

2008 - Facoemulsificazione con minincisione bimanuale . [Altro]
Cavallini, Gian Maria; C., Masini; S., Pelloni
abstract

Descrizione della facoemulsificazione con minincisione bimanuale .

2008 - IOL asferiche, IOL toriche [Altro]
Cavallini, Gian Maria
abstract

Valutazione delle differenze, vantaggi e svantaggi delle IOL asferiche e delle IOL toriche.

2008 - Le lenti intraoculari dislocate in camera vitrea. [Altro]
Cavallini, Gian Maria
abstract

Gestione dlle lenti intraoculari dislocate in camera vitrea.

2008 - MICS bimanuale [Altro]
S., Pelloni; Cavallini, Gian Maria
abstract

Descrizione della tecnica B-MICS.

2008 - MICS phaco machines: how far have they come? A review of some of the latest technologies [Recensione in Rivista]
Cavallini, Gian Maria; Cristina, Masini; Luca, Campi; Simone, Pelloni
abstract

2008 - MICS phaco machines: how far have they come? A review of some of the latest technology [Articolo su rivista]
Cavallini, Gian Maria; C., Masini; L., Campi; S., Pelloni
abstract

Following the initial insight of Dr Amar Agarwal,1 microincision cataract surgery (MICS) has been undergoing a steady evolution regarding new technologies, the aim being to optimize the capabilities of this minimally invasive technique. We describe below how new instruments and technologies have now been developed to manage the main problems of fluidics and ultrasound — factors that had particularly plagued those surgeons who practiced bimanual MICS.

2008 - MICS: LATEST TECHNOLOGIES AND TECHNIQUES [Altro]
A., Franchini; A., Caporossi; G., Alessio; Cavallini, Gian Maria; R., Mencucci; S., Morselli; F., Passani; D., Tognetto
abstract

Sinossi: il corso tratterà le più importanti novità per la facoemulsificazione sia per quel che riguarda i software che le tecniche chirurgiche. Soprattutto verrà discusso come sfruttare al meglio le caratteristiche del proprio facoemulsificatore per adattarle alle nuove tecniche di microincisione bimanuale e coassiale. Obiettivo: partendo dalle peculiariarità di ogni software e dalle necessità di gestione della fluidica e della energia tipiche di ognuna delle più innovative tecniche chirurgiche, i partecipanti potranno affrontare qualsiasi tipo di cataratta con i settaggi, i software e le tecniche più adeguate. Inoltre chi vorrà acquistare una nuova piattaforma potrà farlo in base a quelle che sono le sue esigenze e le tecniche con cui si vuole cimentare.

2008 - Microincision IOLs go head-to-head Study compares Akreos MI60 with the Acri.Smart 48S lens [Recensione in Rivista]
Cavallini, Gian Maria; Luca, Campi; Cristina, Masini; Simone, Pelloni
abstract

2008 - Microincision IOLs go head-to-head. Study compares Akreos MI60 with Acri.Smart 48S lens. [Articolo su rivista]
Cavallini, Gian Maria; L., Campi; C., Masini; S., Pelloni
abstract

Nowadays, cataract surgery not only has a therapeutic purpose, which is to substitute an opaque lens with a transparent IOL, but it also has a refractive aim; to correct previous refractive defects in order to eliminate the use of spectacles. The need for a good postoperative visual acuity and a fast functional recovery has lead cataract surgery to become more and more micro-invasive in nature so that surgical trauma is reduced, a faster recovery and good, time-stable visual results are achieved.1 The achievement of this goal has been realized, thanks to the improvement of surgical techniques, in the form of microcoaxial phacoemulsification and bimanual microphacoemulsification,2 which now allow the almost complete reduction of surgically induced astigmatism.

2008 - New Technologies in Bimanual microphacoemulsification. [Capitolo/Saggio]
Cavallini, Gian Maria; Masini, C; Campi, L; Pupino, A; Pelloni, S.
abstract

2008 - Strumenti chirurgici: suggerimenti per la transizione. [Altro]
Cavallini, Gian Maria
abstract

Suggerimenti per la transizione in B-MICS e suoi strumenti chirurgici.

2007 - Bimanual microphacoemulsification and Acri.Smart intraocular lens implantation combined with vitreoretinal surgery [Articolo su rivista]
Cavallini, Gian Maria; A., Pupino; C., Masini; L., Campi; S., Pelloni
abstract

PURPOSE: To assess the efficacy and safety of bimanual microphacoemulsification combined with vitrectomy in eyes with clinically evident cataract and vitreoretinal pathology. SETTING: Institute of Ophthalmology of the University of Modena and Reggio Emilia, Modena, Italy. METHODS: This prospective case series comprised 19 consecutive patients with clinically significant cataract who were scheduled for vitrectomy. Bimanual microphacoemulsification was performed, and an Acri.Smart 46 S hydrophobic acrylic intraocular lens (IOL) with a 6.0 mm optic (Acri.Tec, Inc.) was implanted in the capsular bag. Immediately after, standard 3-port vitrectomy was performed. RESULTS: The prevailing vitreoretinal pathology was retinal detachment, with 1 case of macular pucker and 1 case of macular hole. In all cases, the IOL was implanted in the capsular bag. There were no intraoperative complications during the cataract surgery or vitrectomy. Follow-up 1, 15, 30, 90, and 180 days after surgery showed significant visual recovery in all cases. The mean endothelial loss was 10.05% +/- 2.01% (SO). In 3 cases that had tamponade with heavy silicone oil, progressive posterior capsule opacification occurred 6 months after surgery. CONCLUSIONS: Bimanual microphacoemulsification combined with vitrectomy was effective and sate. The microincisions and 19-gauge instruments provided excellent chamber resistance that simplified surgical maneuvers in eyes that might have a distorted fundus reflection and increased zonular laxity. The Acri.Smart 46 S IOL, which can be injected through a 2.0 mm incision, provided good fundus visibility during vitrectomy and good maneuverability up to the extreme periphery without resulting in glare or distracting reflections for the surgeon.

2007 - Bimanual microphacoemulsification versus coaxial miniphacoemulsification: Prospective study [Articolo su rivista]
Cavallini, Gian Maria; L., Campi; C., Masini; S., Pelloni; A., Pupino
abstract

PURPOSE: To compare the outcomes of bimanual microphacoemulsification and coaxial miniphacoemulsification and assess the potential advantages of the former over the latter. SETTING: Institute of Ophthalmology, University of Modena, Modena, Italy. METHODS: In a controlled prospective clinical trial, 100 eyes of 50 patients with nuclear or corticonuclear cataract of grade 2 to 4 on the Lens Opacities Classification System III had phacoemulsification. Fifty eyes were randomized to have surgery by the bimanual technique and 50, by the coaxial technique. All surgeries were performed by the same surgeon using the same machine (Sovereign WhiteStar, American Medical Optics). In all cases, the incision was made superiorly in clear cornea and a hydrophobic acrylic flexible intraocular lens (Acri.Smart 48 S, Acri.Tec) was implanted. Intraoperative parameters were mean phacoemulsification time, total phacoemulsification percentage, effective phacoemulsification time (EPT), total volume of balanced salt solution (BSS) used, total surgical time, and final size of the corneal incision. Postoperative parameters were visual acuity, astigmatism changes by vector analysis, corneal thickness, endothelial cell count, and presence of flare and cells in the anterior chamber. RESULTS: The only statistically significant difference between the 2 groups was the total volume of the BSS used (P =.004) and total surgical time (P =.045). CONCLUSIONS: Both techniques were safe and effective for cataract surgery. With bimanual microphacoemulsification, significantly less BSS was used and the total surgical time was significantly shorter than with the coaxial method.

2007 - Cataratta ed emovitreo. [Altro]
Cavallini, Gian Maria; C., Masini
abstract

Si valutano le correlazioni tra cataratta ed emovitreo.

2007 - Chirurgia mininvasiva in oftalmologia [Altro]
Cavallini, Gian Maria
abstract

Chirurgia mininvasiva in oftalmologia

2007 - Evaluation of visual performance after implantation of different microincision intraocular lenses in bimanual microphacoemulsification [Abstract in Atti di Convegno]
Cavallini, Gian Maria; L., Campi; S., Pelloni; C., Masini; A., Pupino
abstract

Evaluation of visual performance after implantation of different microincision intraocular lenses in bimanual microphacoemulsification

2007 - Evaluation of visual performance after implantation of two different IOLs in biaxial microincision cataract surgery [Abstract in Atti di Convegno]
Cavallini, Gian Maria; L., Campi; S., Pelloni; C., Masini; A., Pupino
abstract

Evaluation of visual performance after implantation of two different IOLs in biaxial microincision cataract surgery

2007 - Lesioni vitreo-retiniche periferiche: indicazioni cliniche al trattamento. [Altro]
M., Borgioli; Cavallini, Gian Maria; G., Finicelli; G., Iacono; V., Volante; A., Pupino
abstract

Profilassi del distacco di retina regmatogeno traumatico: si prendono in esame le Lesioni vitreo-retiniche periferiche con indicazioni cliniche al trattamento.

2007 - Microfacoemulsificazione bimanuale nella chirurgia della cataratta [Articolo su rivista]
Cavallini, Gian Maria; Campi, L.; Lusvarghi, S.
abstract

La review presenta la nuova tecnica di microfacoemulsificazione bimanuale nella chirurgia della cataratta: studi sperimentali, studi clinici, tecnologia e tecnica chirurgica. Confronta la microfacoemulsificazione bimanuale con la facoemulsificazione tradizionale e la minifacoemulsificazione coassiale. Viene inoltre presa in considerazione l'applicazione di questa tecnica innovativa nella gestione di casi complessi come cataratta e patologia vitreoretinica, cataratte infantili, cataratte complicate.

2007 - Tecnica bimanuale nella cataratta uveitica. [Altro]
Cavallini, Gian Maria; L., Campi; C., Masini; V., Volante; S., Pelloni
abstract

Descrizione della tecnica bimanuale nella cataratta uveitica.

2007 - Visual recovery after scleral buckling for macula-off retinal detachments: An optical coherence tomography study [Articolo su rivista]
Cavallini, Gian Maria; Masini, C.; Volante, V.; Pupino, A.; Campi, L.; Pelloni, S.
abstract

PURPOSE. To assess the postoperative macular reattachment through OCT3 in eyes treated with episcleral surgery due to macula-off rhegmatogenous retinal detachment, as well as to verify if there is a statistically relevant relation between the persistence of a subfoveal detachment and poor postoperative functional recovery. METHODS. Twelve eyes of 12 patients who underwent episcleral surgery due to macula-off rhegmatogenous retinal detachment were enrolled and examined in a prospective study. Exclusion criteria were the following: traumatic retinal detachments, detachment relapses, macular holes, amblyopia, and grade B proliferative vitreoretinopathy or higher The time period from the onset of subjective symptoms of retinal detachment to retinal surgery ranged from 3 to 7 days. All patients were evaluated in the preoperative and the postoperative period (after 1, 3, and 6 months) through measurement of visual acuity by ETDRS charts, fundus photographs, and macular tomography with OCT3. The postoperative tomography outcomes and the visual acuity were statistically examined using the Mann-Whitney U-test. RESULTS. One month after surgery, despite the macular reattachment assessable ophthalmoscopically and through fundus photographs, the OCT examination showed macular subretinal fluid persistence in 66.6% of cases. After 3 and 6 months, the persistence of such foveal detachment was respectively observed in 41.6% and in 33.3% of cases. Moreover, the macular subretinal fluid persistence in the postoperative period showed a statistically significant relation with poor functional recovery. CONCLUSIONS. Delayed or incomplete visual recovery after episcleral surgery for macula-off retinal detachment may be related to macular subretinal fluid persistence, assessable with tomography and not visible ophthalmoscopically.

2006 - Bottle-cork injury to the eye: a review of 26 cases [Altro]
Cavallini, Gian Maria; A., Martini; L., Campi; N., Lugli
abstract

Bottle-cork injury to the eye: a review of 26 cases

2006 - Chirurgia combinata: microfacoemulsificazione bimanuale e vitrectomia [Altro]
Cavallini, Gian Maria; C., Masini; S., Pelloni
abstract

Chirurgia combinata: microfacoemulsificazione bimanuale e vitrectomia

2006 - La retina. [Capitolo/Saggio]
Cavallini, Gian Maria
abstract

2006 - La stadiazione del difetto glaucomatoso: esterman score monoculare soppesato sulla.soglia, reading efficiency index e glaucoma staging system a confronto [Abstract in Atti di Convegno]
Brombin, A; Delvecchio, G; Zambelli, C; Cavallini, Gm.
abstract

La stadiazione del difetto glaucomatoso: esterman score monoculare soppesato sulla.soglia, reading efficiency index e glaucoma staging system a confronto

2006 - MACULOPATIA ATTINICA DA ECLISSI PARZIALE DI SOLE: STUDIO DI 3 CASI MEDIANTE OCT-3 [Poster]
G. L., Maini; A., Pupino; A., Lazzerini; L., Campi; Cavallini, Gian Maria
abstract

Scopo: valutare le caratteristiche e l’evoluzione della lesione retinica in pazienti esposti a luce solare diretta durante un’eclissi parziale di sole attraverso la tomografia retinica a coerenza ottica. Materiali e metodi: 3 pazienti, emmetropi e senza precedenti patologie oculari, afferenti al nostro pronto soccorso oculistico, per calo del visus e metamorfopsie dopo aver osservato l’eclissi parziale di sole del 29 marzo 2006, sono stati sottoposti ad attenta misurazione dell’acuità visiva e della refrazione, biomicroscopia ed oftalmoscopia; è stato inoltre eseguito un OCT dopo 1, 15, 30 giorni. Risultati: l’acuità visiva era di 4/10 in due pazienti con riferita esposizione monoculare di pochi minuti, mentre il terzo, con un visus di 2/10, ha riferito un esposizione binoculare di circa due ore e lamentava scotoma positivo. La biomicroscopia era negativa, all’oftalmoscopia si apprezzava un’alterazione aspecifica del riflesso foveale di colore giallognolo. In tutti i pazienti al 1° giorno, l’OCT mostrava una lesione iperreflettete in sede subfoveale senza modificazioni del profilo maculare. La terapia adottata è stata di Indometacina cpr 50 mg/die e coll x4/die e Luteinacpr x1/die. La capacità visiva, nei primi due pazienti, è migliorata di 2-3 linee al primo controllo fino a normalizzarsi dopo 30 giorni, nel terzo il recupero è stato più lento con 5-6/10 dopo 30 giorni. La lesione OCT al 15° giorno si presentava come un piccola area iporeflettente subfoveale che scompariva al 30° giorno nei primi due pazienti, persistendo invece nel terzo. Conclusioni: l’OCT-3 si è dimostrato un valido strumento per diagnosticare e monitorare una lesione come la retinite attinica di difficile discriminazione al solo esame oftalmoscopico.

2006 - MICROFACOEMULSIFICAZIONE BIMANUALE NELLA CHIRURGIA DELLA CATARATTA: UP TO DATE [Altro]
Cavallini, Gian Maria; L., Campi; C., Chiesi; Del Vecchio, G.; A., Franchini; P., Giardini; A., Lazzerini; E., Martini; G., Neri; A., Pupino; D., Tognetto
abstract

La tecnica di microfacoemulsificazione bimanuale per la chirurgia della cataratta èdiventata una tecnica di routine fra i chirurghi grazie alle sue elevate potenzialità. Ilcorso aggiornerà i partecipanti sulla tecnica di microfacoemulsificazione nella chirurgiadella cataratta; saranno precisate le indicazioni, le novità di strumentazione, lemodalità di approccio, le esperienze cliniche e le varie tecniche da utilizzare nellediverse tipologie di cataratta. Al termine del corso i partecipanti avranno le informazioniaggiornate per una precisa indicazione e per utilizzare nella loro pratica clinicaquesta tecnica.

2006 - MICROPHACO: COASSIALE O BIMANUALE? [Altro]
A., Franchini; A., Caporossi; Cavallini, Gian Maria; P., Giardini; D., Tognetto
abstract

CORSO 102 - Sinossi: il corso illustra le più moderne tecniche chirurgiche per eseguire l’interventodi cataratta attraverso un microincisione.Obiettivo: attraverso filmati e risultati clinici viene discusso se la microfacoemulsificazionemanuale ha ancora ragione di esistere oggi che è possibile eseguire unamicroincisione con tecnica coassiale.

2006 - Maculopatia attinica da eclissi parziale di sole: studio di 3 casi mediante OCT-3 [Altro]
Gl, Maini; A., Pupino; A., Lazzerini; L., Campi; Cavallini, Gian Maria
abstract

Maculopatia attinica da eclissi parziale di sole: studio di 3 casi mediante OCT-3

2006 - Microfacoemulsificazione bimanuale con impianto di lente Acri.Smart 46S combinata alla chirurgia vitreoretinica [Altro]
A., Pupino; L., Campi; C., Masini; S., Pelloni; Cavallini, Gian Maria
abstract

Scopo: valutare l’efficacia e la sicurezza di questa nuova tecnica chirurgica combinata a vitrectomia in occhi con cataratta clinicamente evidente e una patologia vitreoretinica.Materiali e metodi: in 16 pazienti con cataratta clinicamente rilevante da sottoporre ad intervento di vitrectomia è stata eseguita una microfacoemulsificazione bimanuale con impianto di Acrismart 46S nel sacco capsulare contestualmente a una vitrectomia standard a 3 vie. La patologia vitreoretinica prevalente è stata il DR regmatogeno o trazionale.Risultati: l’impianto della IOL è avvenuto nel sacco capsulare integro, senza complicanzeintraoperatorie. I controlli successivi a 1 settimana, 1 mese e 3 mesi hanno mostrato un recupero visivo significativo in tutti i casi. La perdita endoteliale media è stata del 10,10%.Conclusioni: la tecnica di microfacoemulsificazione bimanuale si è dimostrata efficace e sicura anche in combinazione con l’intervento di vitrectomia. La Acrismart 46S permette un’ottima visibilità del fondo durante la vitrectomia e una grande manovrabilità, senza glare o bagliori fastidiosi al chirurgo.

2006 - Microfacoemulsificazione bimanuale nei casi complicati. [Capitolo/Saggio]
Cavallini, Gian Maria; Masini, C.
abstract

2006 - Microfacoemulsificazione bimanuale nella chirurgia della cataratta infantile. [Capitolo/Saggio]
Chiesi, Carlo; Cavallini, Gian Maria
abstract

2006 - Microfacoemulsificazione bimanuale. Basi tecnologiche. [Capitolo/Saggio]
Pupino, A; Cavallini, Gian Maria; Pelloni, S.
abstract

2006 - Microfacoemulsificazione bimanuale. Esperienza clinica. [Capitolo/Saggio]
Lugli, N; Campi, L; Cavallini, Gian Maria
abstract

2006 - Microfacoemulsificazione bimanuale. Origine e Definizione. [Capitolo/Saggio]
Cavallini, Gian Maria; Masini, C.
abstract

2006 - Microfacoemulsificazione bimanuale. Tecnica bimanuale. [Capitolo/Saggio]
Cavallini, Gian Maria
abstract

2006 - Microfacoemulsificazione con iniezione intravitreale di triamcinolone in pazienti con cataratta ed edema maculare diabetico [Altro]
G., Neri; V., Volante; C., Masini; S., Pelloni; A., Mascia; B., Moretti; Cavallini, Gian Maria
abstract

Obiettivo: valutare l’efficacia della microfacoemulsificazione con iniezione intravitreale ditriamcinolone (ivTA) in diabetici con cataratta ed edema maculare clinicamente significativo(CSMO). Tipo di studio: serie prospettica di casi. Materiali e metodi: 15 pazienti sottopostia microfacoemulsificazione della cataratta con impianto di IOL ed iniezione di 4 mg diivTA. I pazienti sono stati sottoposti ad 1, 3 e 6 mesi a misurazione della acuità visiva e misurazione dello spessore maculare centrale (CMT) con l’OCT. Risultati: 15 pazienti mostravano,dopo 6 mesi, un miglioramento della acuità visiva di 2 o più linee. A tutti controlli lo spessoremaculare si dimostrava ridotto rispetto al preoperatorio. Non si è verificata nessunacomplicanza. Conclusioni: la microfacoemulsificazione con iniezione intravitreale di triamcinolonesi è dimostrata una tecnica sicura ed efficace nella gestione del paziente diabeticocon cataratta ed edema maculare.

2006 - Nuove multifocali refrattive e diffrattive: come combinarle (MIX&MATCH), quale paziente per quale IOL? [Altro]
G., Ravalico; G., Alessio; G., Beltrame; Cavallini, Gian Maria; S., Cillino; P., Giardini; N., Hauranieh; R., Mencucci; S., Rossi; P., Vinciguerra
abstract

CORSO 109 - Sinossi: Il corso tratterà le novità sulle lenti multifocali soprattutto riguardo la scelta della IOL appropriata per ogni paziente.Obiettivo: Fornire le caratteristiche tecniche delle nuove IOL multifocali refrattive e diffrattive, il loro principio di funzionamento e la scelta delle lenti opportune in base a: esigenze lavorative e di vita quotidiana, pupilla, vizio refrattiva preesistente. Fornire principi e suggerimenti per la combinazione di IOL diverse.

2006 - Ocular involvement as first sign of isolated CNS relapse in diffuse large B-cell lymphoma [Articolo su rivista]
A., Ferrari; Luppi, Mario; A., Lazzerini; Potenza, Leonardo; Cavallini, Gian Maria; Torelli, Giuseppe
abstract

A 52-year-old man was diagnosed with stage IVB non-Hodgkin lymphoma of diffuse large B-cell lymphoma subtype that involved the bone marrow and liver. Analysis of serum samples showed a raised concentration of lactate dehydrogenase, suggesting a high–intermediate risk of non-Hodgkin lymphoma according to the international prognostic index, but no HIV-1. The patient received six cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) plus rituximab, and achieved complete remission. 6 months after diagnosis and 2 months after complete remission was achieved, the patient was admitted to hospital because of loss of vision. In the early phase of the examination, a fluorescein angiogram of the right eye (figure A) showed two large hyperfluorescent infiltrates with granularity (arrows) with small regions of retinal pigment epithelial detachments (arrowheads). In the late phase of the study, the left eye (figure B) showed a diffuse retinal pigment epithelial detachment that remained densely hypofluorescent (arrows), suggesting presence of lymphoma. However, bone-marrow biopsy and a CT scan of the neck, chest, and abdomen showed no relapse of lymphoma. 6 days later, the patient became somnolent and agitated, and developed confusion and lethargy. A CT scan (not shown) and an MRI of the brain (figure C) showed multifocal intraparenchymal lesions. Histological and immunohistochemical analysis of a stereotactic biopsy sample of one of the frontal lesions showed presence of B-lymphocyte antigen CD20-positive diffuse large B-cell lymphoma, and no presence of Epstein-Barr virus. The patient was given high-dose methotrexate followed by whole-brain radiotherapy. The patient died 1 month after CNS relapse because of disease progression.

2006 - Orbital actinomycosis associated with painful ophthalmoplegia - Actinomycosis of the orbit [Articolo su rivista]
Pagliani, L; Campi, L; Cavallini, Gian Maria
abstract

Purpose:To evaluate a case of orbital actinomycosis presenting as Tolosa-Hunt syndrome in a patient with a history of carcinomas of the kidney and breast. Methods: A woman with ingravescent painful ophthalmoplegia was brought to our observation. Brain and orbital and total body CT scans showed the presence of two orbital neoformations and a miliary pattern of dissemination in the lung. The initial diagnosis, which pointed to secondary localisations of the previous kidney and breast tumours, was changed to orbital and pulmonary actinomycosis following microbiological analysis of lung biopsy samples. Results: Prolonged antibiotic therapy with synthetic penicillin completely resolved the case. Conclusions: Actinomycosis is a very rare infection that may also affect the orbit and its association with a pulmonary dissemination is highly unusual. It is important to consider this type of infection among the causes of painful ophthalmoplegia. Copyright

2006 - Post-traumatic intraocular lenses dislocation [Altro]
Cavallini, Gian Maria; L., Campi; V., Volante; A., Pupino; S., Pelloni
abstract

Post-traumatic intraocular lenses dislocation

2006 - STUDIO PROSPETTICO COMPARATIVO FRA MICROFACOEMULSIFICAZIONE BIMANUALE E FACOEMULSIFICAZIONE MINICOASSIALE NELLA CHIRURGIA DELLA CATARATTA [Poster]
S., Pelloni; L., Campi; C., Masini; A., Pupino; Cavallini, Gian Maria
abstract

Obiettivo: valutare i parametri intraoperatori, ed i risultati clinici postoperatori in pazienti operati di cataratta mediante microfacoemulsificazione bimanuale in un occhio e mediante facoemulsificazione minicoassiale nell’occhio adelfo. Materiali e metodi: 50 pazienti sono stati sottoposti a microfacoemulsificazione di cataratta, con tecnica bimanuale in un occhio e con tecnica coassiale nell’occhio adelfo. Intraoperariamente sono stati valutati: EPT, power, U/S time ed il tempo operatorio, il consumo di BSS. Postoperatoriamente sono stati valutati il visus, l’astigmatismo indotto, la conta endoteliale e lo spessore corneale e le eventuali complicanze a 1, 7, 30, 90 giorni. Risultati: i parametri intraoperatori non hanno rilevato differenze significative, salvo che per il consumo di BSS, che è minore nella tecnica bimanuale. I risultati clinici non hanno dimostrato differenze significative per quanto riguarda il visus, l’astigmatismo indotto, la perdita endoteliale e lo spessore corneale. Conclusioni: non esistono differenze significative fra la tecnica bimanuale e quella coassiale, sebbene l’impressione clinica soggettiva è quella di un recupero funzionale leggermente più rapido nella microfacoemulsificazione bimanuale.

2006 - Sindrome di Posner- Schlossman e distrofia endoteliale guttata: case report [Altro]
Am, Martini; E., Martini; L., Campi; Cavallini, Gian Maria
abstract

Obiettivo: valutare un caso di crisi di ipertono oculare monolaterale recidivante da 20 anni, cheratopatia bollosa intermittente ma simultanea alla crisi, distrofia endoteliale guttata. Case report: una donna di 63 anni sofferente di attacchi di glaucoma da circa 20 anni era trattata ad ogni attacco con farmaci topici inibitori della produzione di umor-acqueo per 10 giorni con normalizzazione del quadro. La campimetria computerizzata cinetica non evidenziava alterazioni della sensibilità. Una microscopia endoteliale eseguita alla risoluzione dell’ultimo attacco evidenziava nell’occhio interessato una densità endoteliale ridotta con presenza di grosse guttae endoteliali limitatamente all’occhio colpito. Conclusioni: dalla revisione della letteratura nessun articolo riporta una associazione con alterazioni endoteliali permanenti nonostante la presenza di fini precipitati endoteliali. La particolarità del case report risiede nella osservazione della distrofia endoteliale guttata nell’occhio colpito e la normalità dell’endotelio corneale nell’occhio controlaterale. Questo riscontro potrebbe indurre a ritenere che le crisi di ipertono possano indurre alterazioni endoteliali permanenti.

2006 - Stenosi congenita del dotto naso-lacrimale: indicazioni e timing terapeutico [Altro]
C., Chiesi; D., Palmieri; R., Pignatti Morano; G., Guaraldi; Cavallini, Gian Maria
abstract

Obiettivo: scopo del lavoro è quello di meglio definire i criteri diagnostici e le strategie terapeutiche in caso di ostruzione congenita del dotto nasolacrimale. Materiale e metodi: sono stati retrospettivamente valutati 2992 pazienti trattati presso il nostro Ambulatorio di Oftalmologia Pediatrica dal 1990 al 2005. Età media al primo controllo 5,3 mesi. È stata sempre eseguita terapia antibiotica topica, associata o meno, a seconda dei sintomi e dell’età, a sondaggio della via lacrimale, con o senza ausilio di anestesia generale. Risultati: il 38,6% dei pazienti è guarito con l’uso della sola terapia antibiotica locale, mentre un timing adeguato del sondaggio ambulatoriale ha ridotto la percentuale di sondaggi in anestesia generale (dal 49% al 23,5%). Dal 1994 usiamo una tecnica anestesiologica basata sull’uso di Ketamina e Midazolam senza necessità d’intubazione oro-tracheale, che è risultata sicura e vantaggiosa. I dati mostrano un rapporto diretto tra età d’intervento e rischio d’insuccesso al primo tentativo. Conclusioni: i migliori risultati si ottengono con una stretta collaborazione tra oculista, pediatra ed anestesista, al fine di poter modulare al meglio nel tempo le varie possibilità terapeutiche.

2006 - Studio prospettico comparativo fra microfacoemulsificazione bimanuale e facoemulsificazione minicoassiale nella chirurgia della cataratta [Altro]
S., Pelloni; L., Campi; C., Masini; A., Pupino; Cavallini, Gian Maria
abstract

Studio prospettico comparativo fra microfacoemulsificazione bimanuale e facoemulsificazione minicoassiale nella chirurgia della cataratta

2006 - TRATTAMENTO DI DUE CASI DI METASTASI BILATERALE DA CARCINOMA DELLA MAMMELLA CON CHEMIOTERAPIA [Poster]
Lazzerini, A.; Pelloni, S.; Delvecchio, G.; Pupino, A.; Cavallini, Gian Maria
abstract

Introduzione: il carcinoma della mammella è la neoplasia che dà più frequentemente metastasi bulbari a livello coroideale nel sesso femminile, la seconda in assoluto dopo il carcinoma del polmone. Materiali e metodi: una paziente di 46 anni, era stata trattata con quadrantectomia alla mammella destra per carcinoma e successivamente sottoposta a cicli di chemioterapia. Tre anni dopo, nel 2004, le furono diagnosticate metastasi coroideali in OD\OS con calo del visus e presenza di scotomi, trattate con chemioterapia con cicli di Carboplatino e Taxolo in una prima fase e Taxolosuccessivamente. Risultati: dopo trattamento con chemioterapia, si è evidenziata una netta regressione oftalmoscopica, fluorangiografica ed ecografica delle lesioni fino alla completa cicatrizzazione con un recupero del visus pari a 20\20 in OD\OS. Conclusioni: la chemioterapia in casi specifici appare essere un efficace trattamento nella terapia delle metastasi coroideali da carcinoma della mammella in alternativa o in affiancamento alla radioterapia.

2006 - Terapia fotodinamica (PDT) e triamcinolone acetonide intravitreale (TA) in pazienti affetti da neovascolarizzazione sottoretinica (CNV) [Altro]
S., Lusvarghi; L., Campi; S., Pelloni; G., Guaraldi; C., Zambelli; Cavallini, Gian Maria
abstract

Obiettivo: valutare l’efficacia del trattamento con PDT e TA in pazienti con CNV. Materialie metodi: 30 pazienti con CNV, di cui 15 trattati con PDT (gruppo 1) e 15 trattati con TA ePDT (gruppo 2). Di ogni paziente si considera: visus preoperatorio, a 7, 30, e 90 giorni; tonopreoperatorio a 24 ore, a 7, 30 e 90 giorni; fluorangiografia e OCT a 90 giorni per valutareeventuale necessità di ritrattamento. Risultati: miglioramento del visus nel gruppo 2 rispettoal gruppo 1 nel primo mese; non differenze significative tra i due gruppi dopo 3 mesi.Aumento della pressione intraoculare media nel gruppo 2 rispetto al gruppo 1 dopo 1 settimana;non significative differenze di tono tra i due gruppi dopo 3 mesi. Conclusioni: il triamcinoloneintravitreale sembra aumentare l’efficacia del trattamento fotodinamico nei pazientiaffetti da CNV, anche se temporaneamente.

2006 - Trattamento con iniezione di triamcinolone intravitreale e con laser a diodi micropulsato in due gruppi di pazienti affetti da edema maculare diabetico [Altro]
A., Lazzerini; A., Pupino; E., Martini; P., Ducange; Cavallini, Gian Maria
abstract

Introduzione: il trattamento con TA intravitreale e il laser a diodi micropulsato costituiscono un presidio proposto nella terapia dell’edema maculare diabetico. Materiali e metodi: due gruppi di 20 pazienti con RD già sottoposti a fotocoagulazione Argon laser con edema maculare, furono trattati con TA (gruppo 1) e laser a diodi micropulsato (gruppo 2). Nei due gruppi furono eseguite: visita oculistica completa ed OCT preoperatoriamente a 1, 3 e 6 mesi.Risultati: nei 2 gruppi si è rilevata una diminuzione dello spessore retinico ed un incremento della BCVA più evidente fino al 1°/3° mese con una regressione fino al 6° mese senza però ritorno ai valori di partenza. I ritrattamenti sono stati: 3 nel gruppo 1 e 2 nel gruppo 2. Conclusioni: il laser a diodi micropulsato costituisce un’alternativa valida al TA nel trattamento dell’edema maculare pur con una tendenza alla regressione, come già osservato anche per il TA.

2006 - Trattamento di due casi di metastasi bilaterale da carcinoma della mammella con chemioterapia [Altro]
Lazzerini, A.; Pelloni, S.; Delvecchio, G.; Pupino, A.; Cavallini, Gian Maria
abstract

Trattamento di due casi di metastasi bilaterale da carcinoma della mammella con chemioterapia

2006 - Valutazione tomografica maculare (OCT3 Stratus) dopo trattamento di edema retinico con laser a diodo micropulsato [Altro]
A., Lazzerini; E., Martini; G., Neri; A., Pupino; Cavallini, Gian Maria
abstract

Obiettivo: valutare le variazioni di spessore e di volume della regione maculare con OCT3dopo trattamento con laser a diodo micropulsato in pazienti con edema maculare cronico.Materiali e metodi: trenta occhi con edema maculare cistoide da retinopatia diabetica,occlusione venosa centrale e di branca e da sindrome di Irvine-Gass. Le misurazioni dellospessore e del volume maculare sono state eseguite prima e 15-30-90 e 180 giorni dopo iltrattamento. Risultati: lo spessore foveale prima del trattamento era 450 ± 20 μ, il volume9,32 ± 15 mm3. Essi dimostrano una variazione significativa a 90 e 180 giorni con valori di380 ± 15 μ e di 8,60 ± 15 mm3. Il visus era 3,4/10 pretrattamento e 3,8/10 a 6 mesi, convariazione statisticamente non significativa. Conclusioni: il laser a diodo micropulsato consenteun tipo di trattamento che non determina effetti collaterali sulla retina e presenta isuoi effetti di riduzione del volume al 3°-6° mese di follow-up.

2005 - Descrizione di un caso di neuropatia ottica in una paziente sottoposta a trattamento con citosina arabinoside (ARA-C) [Altro]
A., Lazzerini; G., Neri; A., Frassoldati; P., Ducange; Cavallini, Gian Maria
abstract

Descrizione di un caso di neuropatia ottica in una paziente sottoposta a trattamento con citosina arabinoside (ARA-C)

2005 - Drug-Induced Optic Atrophy [Capitolo/Saggio]
Guerra, R; Cavallini, Gian Maria
abstract

2005 - Efficacia a lungo termine della ciclofotocoagulazione con laser a diodi in pazienti affetti da glaucoma refrattario [Abstract in Atti di Convegno]
Lazzerini, A; Martini, E; Neri, G; Delvecchio, G; Cavallini, Gm
abstract

Efficacia a lungo termine della ciclofotocoagulazione con laser a diodi in pazienti affetti da glaucoma refrattario

2005 - FACOEMULSIFICAZIONE COMBINATA ALLA SCLERECTOMIA PROFONDA: TONO E CAMPO VISIVO A 5 ANNI DALL’INTERVENTO [Altro]
E., Martini; P., Ducange; L., Campi; P., Calasso; Cavallini, Gian Maria
abstract

Obiettivo: valutare l’efficacia a 5 anni della facoemulsificazione combinata alla sclerectomia profonda sul tono oculare e sul campo visivo con uno studio prospettico. Materiali e metodi: 30 pazienti con cataratta e glaucoma ad angolo aperto scompensato sono stati sottoposti a facoemulsificazione con impianto di IOL con incisione temporale ed a sclerectomia profonda nel settore superiore. Sono stati valutati il tono oculare, il campo visivo, la percentuale di progressione.Risultati: il tono medio era preoperatoriamente 23,8 mmHg, a 1 anno 15,2 mmHg, a 2 anni 15,3 mmHg, a 3 anni 15,6, at 5 anni 15,1 mmHg. A 5 anni tutti gli occhi erano sotto 19 mmHg: 14 occhi (46,6%) con terapia. MD media a 5 anni era significativamente migliore (-15,95 vs -18,81 dB, p = 0,0003), PSD media era maggiore ma non significativa (7,84 vs 7,26, p = 0,07). 2 occhi (6,6%) hanno mostrato una progressione del danno perimetrico (> 5 dB) e sono stati ulteriormente trattati. Conclusioni: la facoemulsificazione combinata alla sclerectomia profonda e molto efficace neicasi di cataratta e di glaucoma avanzato o scompensato. Il tono a 5 anni e molto soddisfacente e il campo visivo mostra un persistente incremento medio di MD.

2005 - Gestione Chirurgica delle IOL dislocate in camera vitrea vitrectomia: e fissazione sclerale. [Poster]
V., Volante; A., Lazzerini; L., Campi; S., Pelloni; Cavallini, Gian Maria
abstract

Struttura Complessa di Oftalmologia, Universita di ModenaObiettivo: valutare l’incidenza di complicanze dell’intervento chirurgico di rimozione della IOL dislocata in camera vitrea e sua sostituzione con una IOL a fissazione sclerale. Materiali e metodi: 18 occhi, che presentavano una dislocazione in camera vitrea della IOL per rottura della capsula posteriore o disinsersione della zonula, sono stati sottoposti a vitrectomia via pars plana ed estrazione della IOL con ausilio di perfluorocarbonato ed a impianto di IOL a fissazione sclerale mediante tecnica di Lewis modificata. I pazienti sono stati sottoposti a misurazione dell’acuita visiva, ad esame oftalmoscopico ed a microscopia endoteliale dopo 1, 3 e 6 mesi dall’intervento. Risultati: intraoperatoriamente si sono verificati 2 casi di sanguinamento vitreale. Le complicanze postoperatorie sono state 2 casi di ipertono (risoltosi con terapia), 4 di edema corneale, 2 casi di edema maculare cistoide e 1 distacco di retina. Conclusioni: la rimozione della IOL dislocata dalla camera vitrea e la sua sostituzione con una IOL a fissazione sclerale con tecnica di Lewis modificata si e dimostrata un intervento chirurgico sicuro considerando la relativa incidenza di gravi complicanze.

2005 - Gestione chirurgica dell IOL dislocate in camera vitrea: vitrectomia e fissazione sclerale [Altro]
V., Volante; A., Lazzerini; L., Campi; S., Pelloni; Cavallini, Gian Maria
abstract

Gestione chirurgica dell IOL dislocate in camera vitrea: vitrectomia e fissazione sclerale

2005 - L'attendibilità dell'FDT nell'analisi di screening del campo visivo in età pediatrica [Altro]
C., Chiesi; L., Casari; Cavallini, Gian Maria
abstract

L'attendibilità dell'FDT nell'analisi di screening del campo visivo in età pediatrica

2005 - Laser a diodo micropulsato sottosoglia nel trattamento delle maculopatie edematose: studio prospettico controllato randomizzato [Altro]
E., Martini; A., Pupino; L., Campi; Cavallini, Gian Maria
abstract

Laser a diodo micropulsato sottosoglia nel trattamento delle maculopatie edematose: studio prospettico controllato randomizzato

2005 - Manifestazioni metastatiche oculari e cerebrali multifocali in caso di recidiva di linfoma diffuso a cellule di tipo B [Altro]
A., Lazzerini; G., Neri; M., Luppi; A., Ferrari; Cavallini, Gian Maria
abstract

Scopo: il Linfoma e una malattia che puo dare interessamento secondario bulbare coroideale. Descriviamo un caso nelquale tale riscontro e stato associato ad un interessamenti cerebrale metastatico multifocale. Materiali e metodi: uomo di 52 anni con diagnosi di Linfoma diffuso a grandi cellule B allo stadio IV B con coinvolgimento osseo ed epatico. Il test HIV era negativo, LDH superiore ai limiti di normalita. Trattato presso il Reparto di Ematologia con 6 cicli dichemioterapia CHOP RITUXIMAB e completa remissione del quadro. Sei mesi dopo fu ricoverato presso la Struttura Complessa di Oftalmologia per calo del visus bilaterale. Risultati: all’esame del fundus oculi OD erano evidenti due localizzazioni secondarie della malattia di base mentre in OS era presente una vasta emorragia al polo posteriore con essudati. La TAC metteva in evidenza diffuse localizzazioni cerebrali multifocali oltre ai segni di interessamento oculare; eseguiti FAG ed ecografia a e b scan. Fu eseguita craniotomia per biopsia delle lesioni frontali che rilevarono unlinfoma a cellule B diffuso CD 20 + EBTR. Nonostante la terapia con metothrexate ad alte dosi il paziente e deceduto dopo un mese dalla diagnosi di recidiva. Conclusioni: il linfoma NH da, in una certa percentuale di casi, metastasi coroideali, ma tale reperto e associato in una percentuale molto bassa di casi a localizzazione cerebrale multifocale che costituisce di per se un segno sfavorevole per l’evoluzione della malattia e per la prognosi quoad vitam.

2005 - Microfacoemulsificazione bimanuale nella chirurgia della cataratta [Altro]
Cavallini, Gian Maria; Campi, L.; Chiesi, C.; Delvecchio, G.; Lazzerini, A.; Lugli, N.; Martini, E.; Neri, G.; Pupino, A.
abstract

CORSO 143 - La tecnica di microfacoemulsificazione bimanuale per la chirurgia della cataratta sta riscuotendosempre maggior interesse fra i chirurghi grazie alle sue elevate potenzialita. Il corso introdurra ipartecipanti all’uso della microfacoemulsificazione nella chirurgia della cataratta; saranno precisatele indicazioni, le caratteristiche di strumentazione, le modalita di approccio, le esperienze cliniche ele varie tecniche da utilizzare nelle diverse tipologie di cataratta. Al termine del corso i partecipantiavranno le informazioni adeguate per un precisa indicazione e per utilizzare nella loro praticaclinica questa tecnica.

2005 - Microfacoemulsificazione bimanuale nella chirurgia della cataratta senile [Altro]
N., Lugli; L., Campi; S., Lusvarghi; C., Zambelli; Cavallini, Gian Maria
abstract

Microfacoemulsificazione bimanuale nella chirurgia della cataratta senile

2005 - Neurite ottica retrobulbare in un paziente affetto da psoriasi in terapia con infliximab [Altro]
V., Volante; L., Campi; S., Lusvarghi; Cavallini, Gian Maria
abstract

Neurite ottica retrobulbare in un paziente affetto da psoriasi in terapia con infliximab

2005 - OCT ed acuità visiva in pazienti sottoposti a chirurgia episclerale per distacco di retina [Altro]
C., Masini; V., Volante; A., Pupino; L., Campi; Cavallini, Gian Maria
abstract

Obiettivo: valutare la correlazione tra visus ed OCT dopo intervento chirurgico episcerale per distacco retinico coinvolgente l’area maculare. Materiali e metodi: 24 pazienti che presentavano un distacco retinico coinvolgente la macula sono stati sottoposti ad intervento chirurgico episclerale con evacuazione del liquido sottoretinico. La valutazione dell’acuita visiva (ETDRS), la foto del fondo oculare e l’OCT sono stati condotti ad 1, 3 e 6 mesi dall’intervento chirurgico. Sono stati esclusi le miopie elevate, i fori maculari, le recidive di distacco di retina ed i distacchi di retina traumatici. Risultati: ad un mese dall’intervento, nonostante il riaccollamento retinico dell’area maculare valutabile oftalmoscopicamente e con foto del fondo, l’esame OCT evidenzia nel 62,5% dei pazienti la presenza di residuo fluido sottoretinico in sede maculare. La persistenza a 3 mesi di questo fluido si e osservata nel 37,5% dei pazienti ed nel 29,2% pazienti a 6 mesi, e si e associata ad un incompleto recupero visivo. Conclusioni: un ritardato o incompleto recupero visivo dopo un intervento chirurgico episclerale per distacco di retina puo essere correlato alla persistenza di fluidosottoretinico valutabile con OCT e non visibile oftalmoscopicamente.

2005 - Ocular blood flow evaluation in injured and healthy fellow eyes [Articolo su rivista]
Martini, Emilio; M., Guiducci; L., Campi; Cavallini, Gian Maria
abstract

PURPOSE. To assess if injured eyes develop ocular blood flow disturbances that may contribute to development of traumatic glaucoma. METHODS. Twenty-five eyes of 25 patients hospitalized from January 1997 to July 1999 for blunt (15) or penetrating (10) eye injury and elevated intraocular pressure (IOP) (> 23 mm Hg) were controlled at least 24 months after the trauma and underwent visual field examination, pulsatile ocular blood flow (pOBF), and color Doppler imaging (CDI) analysis of ophthalmic artery, central retinal artery, nasal and temporal short posterior ciliary arteries. Uninjured healthy eye was used as control. RESULTS. IOP was significantly higher in injured eyes (15.1 +/- 3.3 vs 13.0 2.7 mmHg; p < 0.01), but only 2 eyes (8%) were under medical treatment. pOBF values were significantly lower in injured eyes: 11.25 +/- 6.56 muL/sec in the trauma eyes and 15.40 +/- 7.29 in fellow eyes (p = 0.002). Resistivity index of all investigated retrobulbar vessels was very significantly higher in injured eyes than in fellow eyes (p < 0.0001). There is no significant correlation between IOP and ocular blood flow disturbance. CONCLUSIONS. Long-term follow-up (mean 39 +/- 12 months) of injured eyes shows, besides a slight but significant increase of IOP, a very significant impairment of ocular blood supply to injured eyes compared to healthy fellow eyes with reduction of pulsatile ocular blood flow and marked increase of resistance to flow in all retrobulbar vessels. These anomalies may be considered an independent risk factor to develop traumatic glaucoma.

2005 - Reading efficiency index: un nuovo score per la valutazione del campo visivo utile nelle attività visive per vicino [Abstract in Atti di Convegno]
Brombin, A; Delvecchio, G; Bussolari, L; Cavallini, Gm
abstract

Obiettivo: valutare un nuovo parametro campimetrico correlabile con l’abilita nella lettura per vicino in soggetti con estesi difetti campimetrici centrali e paracentrali di differente natura. Materiali e metodi: 40 occhi affetti da difetti campimetrici centrali e paracentrali di varia natura sono stati sottoposti ad esame campimetrico computerizzato ed a valutazione della velocita di lettura. Per ciascun occhio e stato ricavato il punteggio campimetrico di efficienza nella lettura (“Reading Efficiency Index”) ed e stato correlato con i risultati del test di lettura. Risultati: esiste una correlazione direttamente proporzionale tra visus, velocita di lettura e “Reading Efficiency Index” campimetrico fino a valori di quest’ultimo pari al 60%. Per valori superiori al 60% dell’indice campimetrico si osserva che, a parita di velocita di lettura, il visus ed il campo visivo sono in rapporto complementare l’uno con l’altro. Conclusioni: il “Reading EfficiencyIndex” si e dimostrato utile nel valutare l’effettivo peso del campo visivo residuale nel determinismo dell’efficienza nella lettura di un occhio con importanti difetti campimetrici centrali e paracentrali.

2005 - Smaller incision, better vision? [Altro]
A., Franchini; A., Caporossi; R., Mencucci; P., Giardini; Cavallini, Gian Maria; F., Passani
abstract

CORSO 106 - Il corso si propone di presentare agli oculisti che intendono avvicinarsi alla chirurgia della catarattacon microincisione le caratteristiche delle macchine piu idonee, le metodiche chirurgiche piuadeguate e i nuovi micro strumenti chirurgici. Vengono quindi confrontati i risultati ottenuti in ungruppo di pazienti operati con questa nuova tecnica con quelli ottenuti in un gruppo di pazientisottoposti a facoemulsificazione coassiale cercando di rispondere alla domanda: Smaller incision,better vision?

2005 - Studio dell'astigmatismo indotto dalla chirurgia della cataratta con tecnica di microfacoemulsificazione bimanuale [Altro]
L., Campi; N., Lugli; C., Zambelli; A., Pupino; Cavallini, Gian Maria
abstract

Studio dell'astigmatismo indotto dalla chirurgia della cataratta con tecnica di microfacoemulsificazione bimanuale

2005 - Studio dell'elettroretinogramma da pattern multifocale in soggetti affetti da glaucoma ed ipertono oculare [Altro]
Delvecchio, G.; Brombin, A.; Bussolari, L.; Guaraldi, G.; Cavallini, Gian Maria
abstract

Studio dell'elettroretinogramma da pattern multifocale in soggetti affetti da glaucoma ed ipertono oculare

2005 - TRATTAMENTO DEL GLAUCOMA AD ANGOLO APERTO MEDIANTE TRABECULOPLASTICA LASER SELETTIVA (SLT): RISULTATI A 1 ANNO DI 25 CASI [Altro]
L., Campi; E., Martini; P., Ducange; S., Pelloni; Cavallini, Gian Maria
abstract

Obiettivo: valutare la sicurezza e l’efficacia della trabeculoplastica laser selettiva nel glaucoma ad angolo aperto.Materiali e metodi: 25 occhi con diverse forme di glaucoma ad angolo aperto sono stati sottoposti a SLT. Il laser e stato eseguito per 180-250 gradi. E stata eseguita una terapia con brimonidina e desametasone 5 giorni dopo il trattamento. Il follow-up era a 7 e a 15 giorni, a 1, 2, 3, 6 e 12 mesi. Sono stati rilevati il tono oculare, il numero di farmaci usati ele complicanze. Risultati: il tono medio a un anno e diminuito da 19,0 mmHg a 14,9 (p = 0,002) con una riduzione del 21,6%. Il numero medio di farmaci usati e passato da 2,4 a 1,7 (p < 0,0001). La sola complicanza significativa e stata una reazione infiammatoria con un picco ipertensivo oculare in un paziente con eterocromia di Fuchs. Conclusioni: SLT e uno strumento sicuro ed efficace nel ridurre il tono potendo essere utilizzato in associazione ai farmaci o come singola procedura, e inoltre ripetibile se l’efficacia diminuisce nel tempo.

2005 - Valutazione dello spessore e del volume maculare in due gruppi di pazienti sottoposti ad intervento di cataratta senile con due tecniche: microfacoemulsificazione e facoemulsificazione coassiale [Altro]
G., Neri; A., Lazzerini; G., Maini; Cavallini, Gian Maria
abstract

Scopo: valutare i cambiamenti postoperatori indotti nello spessore e nel volume maculare valutati con tomografia a coerenza ottica (OCT3) in due gruppi di pazienti sottoposti ad intervento di cataratta senile mediante microfacoemulsificazione e facoemulsificazione coassiale. Materiali e metodi: due gruppi 50 pazienti, omogenei per eta e visus preoperatorio, sono stati sottoposti ad intervento chirurgico per cataratta senile mediante tecnica di microfacoemulsificazione (gruppo 1) e tecnica di facoemulsificazione coassiale (gruppo 2). Tutti i pazienti sono stati sottoposti a visita oculistica completa e ad OCT3 preoperatoriamente ed a 1, 7, 30, 60, 90 giorni dall’intervento. Risultati: nei due gruppi non si sono rilevate complessivamente differenze statisticamente significative nella valutazione dello spessore e del volume maculare rispetto ai valori preoperatori. Spessore medio gruppo 1: 165 ± 23 μ preoperatorio, 174 ± 26 μ postoperatorio;gruppo 2168 ± 23 μ preoperatorio, 178 ± 36 μ postoperatorio. Conclusioni: la microfacoemulsificazione si e dimostratanel una tecnica sicura e capace di dare, in mani esperte, variazioni di spessore e volume maculare retinico postoperatorio quanto meno paragonabili a quelle indotte dalla facoemulsificazione coassiale.

2005 - Vitrectomy for intraocular lens dilocation into de vitreous. [Altro]
Cavallini, Gian Maria; V., Volante; L., Campi; A., Pupino
abstract

Indication for vitrectomy in case of intraocular lens dilocation into de vitreous. Explanation of clinical results.

2004 - Impact of preoperative testing on ophthalmologic and systemic outcomes in cataract surgery [Articolo su rivista]
Cavallini, Gian Maria; P., Saccarola; D'Amico, Roberto; A., Gasparin; L., Campi
abstract

PURPOSE. To evaluate the incidence of ophthalmologic and systemic complications in patients who undergo cataract surgery without preoperative tests compared to subjects undergoing cataract surgery preceded by preoperative tests. METHODS. The randomized controlled study included 1276 consecutive patients admitted to the Institute of Ophthalmology of the University of Modena and Reggio Emilia for cataract surgery. The patients were randomly divided into two groups: 638 were assigned not to undergo preoperative evaluation based on routine medical tests and electrocardiograms; the other 638 underwent preoperative evaluation based on said tests. Ophthalmologic and systemic complications were assessed intraoperatively and 1 month after surgery. RESULTS. Eleven intraoperative complications occurred in the group without preoperative tests and eight in the group with preoperative tests; at 1 month six complications were recorded in the group without tests and five in the group with tests. Systemic adverse events occurred intra operatively in four patients, whereas no systemic adverse event was recorded at 1 month in either group. No statistically significant differences were observed between the two groups. CONCLUSIONS. The findings of this study have broad applicability, because the sample is representative of the population existing in numerous social and healthcare settings; they are of value for administrative purposes, because they may be taken as reference in resource allocation plans; and they have medicolegal implications, as the resulting conduct of healthcare providers is supported by a rigorous scientific study.

2004 - MALToma oculare in età pediatrica: case report. [Poster]
L., Pagliani; L., Campi; A., Baur; F. L., Munier; Cavallini, Gian Maria
abstract

Il tessuto linfatico associato alla mucosa (MALT) è un normale componente dell'organo linfatico e può andare incontro a trasformazione neoplastica definito come MALT linfoma che è un raro linfoma B non Hodgkin a basso grado di malignità. I linfomi degli annessi oculari possono coinvolgere le palpebre, la congiuntiva, il tessuto connettivo orbitario o l'apparato lacrimale. Qui noi riportiamo il primo caso di MALToma in un bambino. La diagnosi della patologia è basata su un esame bioptico e sulla colorazione immunoistochimica o sulla analisi di genetica molecolare. L'appartenenza ai linfomi B è testimoniata dalla presenza di catene di restrizione.CASE REPORT - Il paziente di anni 10, è stato sottoposto alla nostra osservazione per un MALT linfoma coinvolgente il fornice e la congiuntiva bulbare dell'occhio sinistro. E' stata eseguita un'ampia resezione chirurgica seguita contemporaneamente da trapianto di membrana amniotica per ricostruire la congiuntiva asportata. La membrana amniotica è stata prelevata e conservata come descritto da Prabhasawat. Il primo pezzo di membrana amniotica è stato rivolto con la parte stromale verso la lesione congiuntivale bulbare ed assicurato con punti staccati in nylon 10-0 e il secondo pezzo sempre con la parte stromale è stato rivolto verso la congiuntiva tarsale allo stesso modo. Approssimativamente otto mesi dopo, durante una visita di controllo, un MALT linfoma è stato identificato nella congiuntiva bulbare e tarsale superiore dell'adelfo. Il paziente è stato sottoposto allo stesso tipo di intervento chirurgico eseguito nell'occhio sinistro. Le neoformazioni asportate sono state sottoposte ad analisi di genetica molecolare e a colorazione immunoistochimica, che hanno confermato la diagnosi di MALToma.

2004 - Maltoma oculare in età pediatrica: case report [Altro]
L., Pagliani; F., Munier; A., Baur; L., Campi; Cavallini, Gian Maria
abstract

Maltoma oculare in età pediatrica: case report

2004 - Scleral fixation of a posterior chamber intraocular lens in a patient with two dislocated lens implants [Articolo su rivista]
Cavallini, Gian Maria; L., Pagliani; L., Campi; N., Lugli; P., Saccarola; V., Volante
abstract

PURPOSE. To report the clinical findings and management of a case of two consecutive intraocular lenses (IOLs) dislocated into the vitreous cavity after complicated cataract surgery. METHODS. Review of clinical findings and treatment. RESULTS. A 69-year-old man sought treatment for posterior chamber IOL dislocation. The patient reported a significant loss of visual acuity in the right eye for 4 months (best-corrected visual acuity (BCVA) 20/200 in the affected eye). In the vitreous cavity two dislocated IOLs were found, complicated by a cystoid macula edema. Surgery was planned and the two IOLs were removed from the vitreous cavity. Aphakia was then corrected by means of a scleral fixated posterior chamber lens. Three months after surgery, BCVA was 20/40. CONCLUSIONS. In the absence of randomized controlled clinical trials evaluating treatment options, preoperative patient work-up should be as accurate as possible in order to reduce the risk of intraoperative and postoperative complications. In this patient, removing the two IOLs and placing a sutured-fixated posterior chamber IOL allowed resolution of the cystoid macular edema. (Eur J Ophthalmol 2004; 14: 149-52)

2004 - Tamponamento con olio di silicone pesante (Oxane HD) nell chirurgia vitreoretinica: nostra esperienza [Altro]
A., Pupino; V., Volante; L., Campi; A., Gasparin; Cavallini, Gian Maria
abstract

Tamponamento con olio di silicone pesante (Oxane HD) nell chirurgia vitreoretinica: nostra esperienza

2004 - Terapia iperbarica nella otticopatia ischemica: case report [Altro]
L., Campi; V., Volante; N., Lugli; G., Vezzani; Cavallini, Gian Maria
abstract

Terapia iperbarica nella otticopatia ischemica: case report

2004 - Terapia iperbarica nella otticopatia ischemica: case report. [Poster]
L., Campi; V., Volante; N., Lugli; G., Vezzani; Cavallini, Gian Maria
abstract

La terapia iperbarica è utilizzata nella malattia da decompressione, nelle intossicazioni da monossido di carbonio, nella gangrea gassosa, nelle infezioni necrotizzanti, nelle ostemieliti refrattarie ed in alcune emergenze neurologiche, come danni ischemici cerebrali e paralisi spinali. In letteratura è stato segnalato l'uso di tale terapia anche in casi di otticopatia ischemica. CASE REPORT - Un uomo di 70 anni, monocolo funzionale per un otticopatia ischemica controlaterale del 1998, si è presentato lamentando una riduzione del campo visivo periferico in occhio sinistro nel settembre 2003. Il paziente è stato sottoposto a fluorangiografia, studio del campo visivo, consulenza neurologica, ecodoppler dei tronchi sovraortici ed a TAC encefalo orbite con studio particolare del canale ottico con esito negativo. E' stata instaurata una terapia con antiaggreganti e corticosteroidi (75 mg di prednisone al giorno) per 2 mesi. La progressiva riduzione del campo visivo, controllato settimanalmente, ci ha indotto ad aggiungere alla terapia anche cicli di terapia iperbarica. La terapia è stata eseguita in camera iperbarica multiposto compressa in aria, con respirazione di ossigeno al 100% mediante maschera facciale. Sono stati eseguiti un primo ciclo di 18 (novembre 2003), un secondo di 15 (gennaio 2004) ed un terzo di 10 trattamenti (marzo 2004). La pressione terapeutica scelta è stata di 2.5 atmosfere assolute ed il tempo di esposizione è stato di trenta minuti, metà del tempo usualmente adottato per altre patologie per il rischio di sviluppare lesioni retiniche da iperossia iperbarica. Il campo visivo, peggiorato fino al termine del primo ciclo di terapia iperbarica, sembra aver arrestato il peggioramento nei successivi controlli, ed attualmente il paziente vede 10/10. Sono in programma ulteriori 3-4 cicli di terapia iperbarica il prossimo anno di durata più breve (5 sedute ognuno).

2004 - Valutazione OCT dei parametri foveali in due gruppi di pazienti sottoposti ad intervento di cataratta trattati e non con FANS per via topica: studio prospettico randomizzato [Abstract in Atti di Convegno]
Lazzerini, A; Delvecchio, G; Bussolari, L; Ducange, P; Guaraldi, G; Cavallini, Gm
abstract

Valutazione OCT dei parametri foveali in due gruppi di pazienti sottoposti ad intervento di cataratta trattati e non con FANS per via topica: studio prospettico randomizzato

2004 - Visita ispettiva per l'accreditamento in sanità pubblica: esperienza in una struttura compessa di oftalmologia [Altro]
L., Campi; B., Travisani; G., Pieroni; A., Campagna; Cavallini, Gian Maria
abstract

Visita ispettiva per l'accreditamento in sanità pubblica: esperienza in una struttura compessa di oftalmologia

2003 - Attendibilità su base clinica routinaria del campo visivo in età pediatrica. FDT versus perimetria automatizzata convenzionale. [Altro]
P., Saccarola; C., Chiesi; L., Casari; E., Martini; D., Palmieri; Cavallini, Gian Maria
abstract

Valutazione dell' attendibilità su base clinica routinaria del campo visivo in età pediatrica: FDT versus perimetria automatizzata convenzionale.

2003 - Bottle-cork injury to the eye: a review of 13 cases [Articolo su rivista]
Cavallini, Gian Maria; Lugli, N; Campi, L; Pagliani, L; Saccarola, P.
abstract

PURPOSE. To analyze the anatomic and functional consequences of wine-cork injury to the eye in relation to the patient's age and them type of cork and wine. METHODS. We retrospectively studied 13 patients, six Women and seven men, presenting to our department with-bottle-cork injury to the eye between January 1999 and June 2001. RESULTS. All patients presented with closed-globe injury according to Kuhn et al's classification. All the cases were injured by bottle corks from sparkling wine: white in ten cases and red in three. Mean visual acuity at admission was 201100 (range, hand motion to 20120). The most frequent early injury was anterior chamber hyphema (84.6%), followed by corneal injury (62.2%), ocular hypertension (46.1%), lens subluxation (30.8%), traumatic cataract (23.1%), and post-traumatic retinal edema (23.1%). Mean final visual acuity was 20125; the follow-up ranged from 3 to 29 months, averaging 16.1 months. Late complications were as follows: pupil motility anomalies (38.5%), traumatic cataract (30.8%), iridodialysis (15.4%), traumatic optic neuropathy (7.7%), post-traumatic glaucoma (7.7%), and traumatic maculopathy (15.4%). Surgical treatment was necessary in two cases (15.4%). CONCLUSIONS. Bottle-cork eye injuries account for 10.8% of post-traumatic hospital admissions to our department. Most of them are due to sparkling white wine served at room temperature. There is no correlation between ocular injury and the eye-bottle distance or the type of cork.

2003 - Confronto dei risultati refrattivi e dell'errore postoperatorio ottenuti con biometria ad ultrasuoni e con interferometria a coerenza parziale nel calcolo preoperatorio della IOL [Altro]
A., Lazzerini; Cavallini, Gian Maria; G., Neri; C., Raisi; G., Guaraldi
abstract

Confronto dei risultati refrattivi e dell'errore postoperatorio ottenuti con biometria ad ultrasuoni e con interferometria a coerenza parziale nel calcolo preoperatorio della IOL

2003 - Doppio tamponamento con perfluorohesylottano (F6H8) ed olio di silicone nelle recidive dei distacchi di retina: esperienza clinica. [Altro]
V., Volante; P., Saccarola; N., Lugli; Cavallini, Gian Maria
abstract

Valutazione dell'esperienza clinica del doppio tamponamento con perfluorohesylottano (F6H8) ed olio di silicone nelle recidive dei distacchi di retina.

2003 - Ferite penetranti e perforanti: patogenesi e modelli sperimentali. [Altro]
Cavallini, Gian Maria; P., Saccarola
abstract

Si descrive la patogenesi delle ferite penetranti e perforanti e si illustrano alcuni modelli sperimentali.

2003 - Le nuove IOL acriliche idrofiliche "AKREOS" ADAPT e DISC: follow-up di un anno [Altro]
E., Martini; G., Scarale; P., Molinari; Cavallini, Gian Maria
abstract

Le nuove IOL acriliche idrofiliche "AKREOS" ADAPT e DISC: follow-up di un anno

2003 - Modelli sperimentali dei traumi oculari: ferite penetranti. [Relazione in Atti di Convegno]
Cavallini, Gian Maria; P., Saccarola
abstract

Modelli sperimentali dei traumi oculari: ferite penetranti.

2003 - Sindrome di Tolosa-Hunt da actinomicosi orbitaria [Altro]
L., Pagliani; L., Campi; L., Mavilla; Cavallini, Gian Maria
abstract

Sindrome di Tolosa-Hunt da actinomicosi orbitaria.

2003 - Studio clinico randomizzato per la valutazione dell'utilità degli esami preoperatori nella chirurgia della cataratta [Altro]
Cavallini, Gian Maria; A., Liberati; P., Saccarola; L., Campi; A., Gasparin; V., Volante
abstract

Studio clinico randomizzato per la valutazione dell'utilità degli esami preoperatori nella chirurgia della cataratta

2003 - Tumore fibroso solitario orbitario: casi clinici. [Altro]
Pagliani, L.; Campi, L.; Delvecchio, G.; Cavallini, Gian Maria
abstract

Esposizione di casi clinici di pazienti con tumore fibroso solitario orbitario.

2003 - Valutazione dell'incidenza dell'edema maculare microcistico post-operatorio valutato con tomografia retinica a coerenza ottica in due gruppi di pazienti sottoposti ad intervento di cataratta privo di complicanze trattati e non con FANS per via topica [Altro]
A., Lazzerini; Cavallini, Gian Maria; G., Guaraldi; L., Pagliani
abstract

Valuatzione dell'incidenza dell'edema maculare microcistico post-operatorio valutato con tomografia retinica a coerenza ottica in due gruppi di pazienti sottoposti ad intervento di cataratta privo di complicanze trattati e non con FANS per via topica

2003 - Valutazione dello spessore delle fibre ganglionari peripapillari mediante OCT3 e GDX: correlazione ed effetto dell'interferenza corneale [Abstract in Atti di Convegno]
Martini, E; Cavallini, Gm; Pupino, A; Gasparin, A; Delvecchio, G.
abstract

Valutazione dello spessore delle fibre ganglionari peripapillari mediante OCT3 e GDX: correlazione ed effetto dell'interferenza corneale

2003 - Varici orbitarie intraconiche: casi clinici. [Altro]
L., Pagliani; L., Campi; F., Cavalleri; A., Lazzerini; Cavallini, Gian Maria
abstract

Esposizione di casi clinici di pazienti con varici orbitarie intraconiche.

2003 - Vitrectomia transcongiuntivale eseguita con il sistema TSV25tm: prime esperienze chirurgiche. [Altro]
Cavallini, Gian Maria; P., Saccarola; V., Volante; L., Pagliani; R., Guerra
abstract

Valutazione delle prime esperienze chirurgiche della Vitrectomia transcongiuntivale eseguita con il sistema TSV25tm.

2002 - Comparison of the clinical performance of Healon 5 and Healon in phacoemulsification [Articolo su rivista]
Cavallini, Gian Maria; Campi, L; Delvecchio, Giancarlo; Lazzerini, A; Longanesi, L.
abstract

PURPOSE, Healon 5 is a high-molecular-mass fraction of sodium hyaluronate. Its density endows it with a number of viscoelastic characteristics. In this prospective, randomised clinical study we compared the performance of Healon 5 and Healon in phacoemulsification. SETTING. Institute of Ophthalmology, University of Modena and Reggio Emilia, Italy. METHODS. Two groups of patients underwent phacoemulsification and intraocular tens (IOL) implantation. In the first 27 patients Heaton 5 was used as viscoelastic substance during surgery, and in the second 27 Heaton was used. The surgeons subjective comments on the performance of these viscoelastic agents were recorded at the different steps of surgery: injection, capsulorhexis, phacoemulsification, IOL implantation, removal of viscoelastic agent and trasparency throughout the operation. The surgeon's overall impression of the viscoelastics during the whole operation was noted. Tonometry and endothelial cell count were performed in all patients before and after operation. RESULTS. There was no statistical difference between the two groups as regards visual acuity, ocular pressure and endothelial damage. Heaton 5 showed excellent ability to maintain the anterior chamber during capsulorhexis, phacoemulsification and IOL implantation. Removal time with Healon 5 was not appreciably longer than Heaton. CONCLUSIONS. Healon 5 emerges as a very interesting viscoelastic substance. Visibility is better if the anterior chamber is filled completely, Removal is easier if it is aspirated while moving the irrigation aspiration tip with circular movements over the top and around the border of the IOL.

2002 - Confronto dei risultati refrattivi ottenuti con la biometria ad ultrasuoni e con interferometria a coerenza parziale nel calcolo preoperatorio della IOL [Altro]
A., Lazzerini; Cavallini, Gian Maria; G., Neri; G. Scarale R., Guerra
abstract

Confronto dei risultati refrattivi ottenuti con la biometria ad ultrasuoni e con interferometria a coerenza parziale nel calcolo preoperatorio della IOL

2002 - Correlazioni tra le ampiezze differenziali al PERG e "l'indice di efficienza" perimetrico nei pazienti glaucomatosi, ipertesi oculari e nei controlli normali. [Altro]
Delvecchio, G.; Cavallini, Gian Maria; Saccarola, P.; Guerra, R.
abstract

Correlazioni tra le ampiezze differenziali al PERG e "l'indice di efficienza" perimetrico nei pazienti glaucomatosi, ipertesi oculari e nei controlli normali.

2002 - Efficacia della ciclofotocoagulazione transclerale in casi di glaucoma neovascolare. [Altro]
A., Lazzerini; Cavallini, Gian Maria; E., Martini; G., Scarale; L., Pagliani
abstract

Valutazione dell'efficacia della ciclofotocoagulazione transclerale in casi di glaucoma neovascolare.

2002 - Evaluation of IOL power calculation in cataract surgery and refractive results obtained with partial coherence interferometry and ultrasound biometry. [Abstract in Atti di Convegno]
A., Lazzerini; Cavallini, Gian Maria; G., Neri; R., Guerra
abstract

Evaluation of IOL power calculation in cataract surgery and refractive results obtained with partial coherence interferometry and ultrasound biometry.

2002 - Implementazione del sistema qualità ISO 9000 all'interrno di una Clinica Oculistica universitaria. [Altro]
A., Lazzerini; Cavallini, Gian Maria; G. F., Baraghini; B., Trevisani; L., Pagliani
abstract

Implementazione del sistema qualità ISO 9000 all'interrno di una Clinica Oculistica universitaria.

2002 - Intervento combinato di sclerectomia profonda e facoemulsificazione con impianto di IOL pieghevole. [Altro]
E., Martini; Cavallini, Gian Maria; G., Neri; G., Lombardo
abstract

Valutazione dei risultati clinici dell'intervento combinato di sclerectomia profonda e facoemulsificazione con impianto di IOL pieghevole.

2002 - La funzione visiva nei pazienti sottoposti ad intervento chirurgico per distacco di retina [Abstract in Atti di Convegno]
Lucchese, A; Cavallini, Gm; Delvecchio, G; Neri, G.
abstract

La funzione visiva nei pazienti sottoposti ad intervento chirurgico per distacco di retina

2002 - Lidocaine versus ropivacaine for topical anesthesia in cataract surgery [Articolo su rivista]
Martini, E.; Cavallini, Gian Maria; Campi, L.; Lugli, N.; Neri, G.; Molinari, P.
abstract

Purpose: To assess the anesthetic efficacy and safety of topical ropivacaine versus topical lidocaine in cataract surgery. Setting: Institute of Ophthalmology, University of Modena and Reggio Emilia, Modena, Italy. Methods: This prospective controlled randomized double-blind study comprised 64 patients scheduled for planned routine cataract extraction. Patients were randomized into 2 groups; 1 received topical ropivacaine 1% and the other, topical lidocaine 4%. The duration of surgery, intraoperative and early postoperative complications, and the need for supplemental intracameral anesthesia were recorded. Intraoperative and postoperative subjective pain was quantified by patients using a scale from 1 to 10. An endothelial cell count was performed preoperatively and 2 months after surgery. Results: The mean endothelial cell density decreased from 2334 cells/mm(2) +/- 496 (SD) to 2016 +/- 674 cells/mm(2) in the ropivacaine group and from 2519 +/- 404 cells/mm(2) to 1847 +/- 607 cells/mm(2) in the lidocaine group. The difference in cell density between groups was not significant before (P = .154) or after surgery (P = .329); however, the difference in mean cell loss between groups was statistically significant (P = .031). The duration of surgery and intraoperative complications were the same in both groups. Four patients in the ropivacaine group and 5 in the lidocaine group required supplemental anesthesia (P > .05). The mean subjective analog pain score was slightly higher in the lidocaine group (P > .05). The day after surgery, 12 eyes in the ropivacaine group and 6 in the lidocaine group had transient corneal edema (P = .150). Conclusions: Topical ropivacaine performed at least as well as topical lidocaine in efficacy and safety in cataract surgery. It provided sufficient and long-lasting analgesia without the need for supplemental intracameral anesthesia in most cases.

2002 - Linfoma del tessuto linfatico associato alla mucosa (MALToma): presentazione di casi clinici. [Altro]
L., Pagliani; Cavallini, Gian Maria; L., Campi; A., Lazzerini
abstract

Linfoma del tessuto linfatico associato alla mucosa (MALToma): presentazione di casi clinici.

2002 - Sensibilità e specificità della perimetria a duplicazione di frequenza. Confronto e correlazione con la perimetria acromatica SITA Fast [Altro]
Martini, E.; Cavallini, Gian Maria; Delvecchio, G.; Scarale, G.
abstract

Sensibilità e specificità della perimetria a duplicazione di frequenza. Confronto e correlazione con la perimetria acromatica SITA Fast

2002 - Traumi oculari da tappo di bottiglia: studio clinico ed epidemiologico [Altro]
Cavallini, Gian Maria; N., Lugli; L., Campi; P., Saccarola; P., Pagliani
abstract

Valutazione clinico-epidemiologica dei traumi oculari da tappo di bottiglia.

2002 - Two-sites combined procedure: phacoemulsification and deep sclerectomy. 2 years follow-up of 40 eyes. [Abstract in Atti di Convegno]
E., Martini; Cavallini, Gian Maria; G., Lombardo; G., Neri
abstract

Two-sites combined procedure: phacoemulsification and deep sclerectomy. 2 years follow-up of 40 eyes.

2002 - Valutazione del flusso ematico oculare in occhi traumatizzati e negli occhi adelfi sani. [Altro]
Cavallini, Gian Maria; E., Martini; L., Campi; M., Guiducci; P., Molinari
abstract

Confrontare il flusso ematico oculare in occhi traumatizzati e negli occhi adelfi sani.

2001 - Phacoemulsification and foldable IOL implant with deep sclerectomy: our experience with 12 months follow-up. [Altro]
E., Martini; Cavallini, Gian Maria; P. L., Neri; G., Lombardo
abstract

Evalution of clinical results in 12 months follow-up in patients treated with phacoemulsification and foldable IOL implant with deep sclerectomy.

2000 - Le infezioni nosocomiali in chirurgia oculare: proposta di un protocollo operativo e valutazione di metodologie diagnostiche rapide. [Altro]
R., Guerra; L., Longanesi; Cavallini, Gian Maria; G., Fabio; U., Fabio
abstract

Proposta di un protocollo operativo e valutazione di metodologie diagnostiche rapide per le infezioni nosocomiali in chirurgia oculare.

2000 - Substitution with latanoprost monotherapy or additional with dorzolamide and timolol treated patients. A randomized, multicentre study in Italy. [Altro]
D., Spinelli; E., Faraoni; N., Orzalesi; F., Nizzola; E., Gandolfo; L., Quaranta; L., Bonomi; S., Perfetti; P., Brusini; P., Barea; R., Guerra; Cavallini, Gian Maria
abstract

A randomized, multicentre study in Italy to evaluate the outcome of substitution with latanoprost monotherapy or additional with dorzolamide in patients treated with timolol.

2000 - Surgical management of dislocated crystalline lens or IOL into the vitreous cavity: clinical result. [Abstract in Atti di Convegno]
Cavallini, Gian Maria; L., Campi; N., Lugli; A., Lazzerini
abstract

Evaluation of clinical result of surgical management of dislocated crystalline lens or IOL into the vitreous cavity.

2000 - Topical anesthesia in cataract surgery: lidocaine versus ropivacaine. [Abstract in Atti di Convegno]
E., Martini; Cavallini, Gian Maria; L., Campi; N., Lugli; G., Neri
abstract

Topical anesthesia in cataract surgery: lidocaine versus ropivacaine.

1999 - Comparison of clinical performances between Healon 5 and Healon in phacoemulsification. [Abstract in Atti di Convegno]
Cavallini, Gian Maria; L., Campi; L., Longanesi; E., Conte; R., Guerra
abstract

Healon 5 emerges as a very interesting viscoelastic substance. Visibility is better if the anterior chamber is filled completely. Removal is easier if it is aspirated while moving the irrigation aspiration tip with circular movements over the top and around the border of the IOL.

1999 - Evaluation of life quality in bilateral IOL implantation: multifocal versus monofocal [Abstract in Atti di Convegno]
Cavallini, Gian Maria; L., Campi; A., Lazzerini; R., Moretti; P., Vizzardelli
abstract

Evaluation of life quality in bilateral IOL implantation: multifocal versus monofocal

1999 - Profilassi delle endoftalmiti post-chirurgiche [Altro]
L., Longanesi; Cavallini, Gian Maria; L., Pagliani; R., Guerra
abstract

Trattazione riguardante la profilassi delle endoftalmiti post-chirurgiche.

1999 - Protocollo di studio dei viscomateriali: confronto delle Healon 5 con Healon nella chirurgia della cataratta. [Articolo su rivista]
Cavallini, Gian Maria; L., Campi
abstract

Protocollo di studio dei viscomateriali: confronto delle Healon 5 con Healon nella chirurgia della cataratta.

1999 - The effect of vancomycin intracameral injection in cataract surgery. [Abstract in Atti di Convegno]
Longanesi, L.; Cavallini, Gian Maria; Campi, L.; Martini, E.; Tsioumas, N.; Delvecchio, G.
abstract

Evalutaion of the effect of vancomycin intracameral injection in cataract surgery.

1998 - ABSTRACT - Study of the surfece of IOLs after contact with tamponade agents for vitreoretinal surgery. [Abstract in Atti di Convegno]
Cavallini, Gian Maria; L., Campi; A., Lazzerini; P. L., Fabbri
abstract

Study of the surfece of IOLs after contact with tamponade agents for vitreoretinal surgery.

1998 - Acetazolamide a bassi dosaggi nel trattamento del glaucoma ad angolo aperto. [Altro]
R., Guerra; Cavallini, Gian Maria
abstract

Valutazione del trattamento con acetazolamide a bassi dosaggi in pazienti affetti da glaucoma ad angola aperto.

1998 - Anestesia nel trapianto di cornea. [Altro]
Cavallini, Gian Maria; L., Campi; G., Scarale
abstract

Dissertazione sul tema dell'anestesia nei pazienti che si devono sottoporre a trapianto di cornea.

1998 - Long-term evaluation of diffractive bifocal lenses compared with monofocal lenses: objective and subjective analysis. [Abstract in Atti di Convegno]
L., Campi; Cavallini, Gian Maria; R., Moretti; A., Lazzerini; L., Longanesi
abstract

Long-term evaluation of diffractive bifocal lenses compared with monofocal lenses: objective and subjective analysis

1998 - Metodo di calcolo per l’assegnazione di un punteggio al campo visivo computerizzato in soglia [Articolo su rivista]
Delvecchio, Giancarlo; Brombin, A.; Cavallini, Gian Maria; Bussolari, L.
abstract

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1998 - Review of 89 cases of intraocular lens implantation with scleral fixation. [Abstract in Atti di Convegno]
A., Lazzerini; Cavallini, Gian Maria; L., Campi; F., Birattari; C., Mazza
abstract

Review of 89 cases of intraocular lens implantation with scleral fixation.

1998 - Studio anatomo-patologico di due diversi impianti di lente nello stesso paziente. [Altro]
L., Palmieri; Cavallini, Gian Maria; P., Lippi; D., Palmieri
abstract

Valutazione delle variazioni anatomo-patologiche confrontando 2 occhi dello stesso paziente in cui sono state impiantate due lenti diverse.

1998 - Study of the surface of IOLs after contact with tamponade agents for vitreoretinal surgery. [Poster]
Cavallini, Gian Maria; L., Campi; A., Lazzerini; P. L., Fabbri
abstract

We asses the interactions between the different biomaterials used in intraocular lenses (IOL) and the tamponade agents used in vitreoretinal surgery. Morphological analysis was carried out macro-filming with a telecamera coupled to an image analysis system and with a scannig electron microscope. The contact between the silicone oil and the silicone lenses causes numerous bubbles visible under the optical microscope as a result of the biophysical contact. The electron scanning microscope revealed a thin layer of silicone covering the whole surface the optic disc, while on the loops the silicone oil deposits in a charateristic spindlelike pattern. On the multifocal IOLs the silicone oil forms a surface film that masks the characteristic pattern of concentric rings. Silicone oil can distort the optical characteristics of IOLs in direct proportion to their hydrophobicity. To conclude, hydrophilic lens implants are to be prefferred in cataract patients when risk factors due to detached retina are present.

1998 - Ultrastructural localization of gelsolin in lattice corneal dystrophy type I [Articolo su rivista]
L., Longanesi; Cavallini, Gian Maria; A., Iammarino; F., Vaccina; Guerra, Roberto; DE POL, Anto
abstract

In the light of recent studies into lattice corneal dystrophies, with particular reference to gelsolin immunoreactivity, the authors set out to determine the ultrastructural localization of gelsolin molecules in lattice corneal dystrophy type I. Immunoelectron microscopy with a monoclonal antibody against the COOH-tenminal of the native gelsolin molecule (clone GS-2C4) was used to compare antigelsolin reactivity in normal and dystrophic corneas. A gelsolin-like protein was observed at the level of the rough endoplasmic reticulum in both epithelial and endothelial cells, together with mild positive staining in stromal keratocytes of normal corneas, increased keratocytic immunoreactivity with positive staining within and/or around corneal amyloid deposits was revealed in dystrophic corneas. Observed intra- and extracellular immunoreactivity suggests that amyloid deposition may induce gelsolin synthesis; this actin-related protein could be involved in the rearrangement of corneal stroma in lattice corneal dystrophy.

1997 - ABSTRACT - Surgically induced astigmatism after three different procedures of cataract extraction. [Abstract in Atti di Convegno]
Cavallini, Gian Maria; L., Campi; N., Lugli; A., Lazzerini; L., Longanesi
abstract

Surgically induced astigmatism after three different procedures of cataract extraction.

1997 - Analisi morfologica della superficie delle lenti intraoculari dopo contatto con sostanze tamponanti usate in chirurgia vitreoretinica. [Altro]
Cavallini, Gian Maria; L., Campi; A., Lazzerini; P. L., Fabbri
abstract

Analisi morfologica della superficie delle lenti intraoculari dopo contatto con sostanze tamponanti usate in chirurgia vitreoretinica.

1997 - Comparative analysis between diffractive bifocal lenses and monofocal lenses. [Altro]
Cavallini, Gian Maria; Tsioumas, N.; L. Campi, R. Guerra
abstract

Comparative analysis between diffractive bifocal lenses and monofocal lenses.

1997 - Comparative analysis between diffractive bifocal lenses and monofocal lenses. [Abstract in Atti di Convegno]
Cavallini, Gian Maria; L., Campi; R., Moretti; M., Sirellini
abstract

Comparative analysis between diffractive bifocal lenses and monofocal lenses.

1997 - Comparison between diffractive bifocal lenses and monofocal lenses. [Abstract in Rivista]
Cavallini, Gian Maria; G., LA Rocca; L., Campi; A., Lazzerini; R., Guerra
abstract

Comparative analysis between diffractive bifocal lenses and monofocal lenses.

1997 - Dacriocystorhinostomie endonasale par voie endoscopique. Notre experience. [Articolo su rivista]
Neri, P. L.; Lazzerini, A.; Guerra, Roberto; Cavallini, Gian Maria; Campi, L.
abstract

Dacriocystorhinostomie endonasale par voie endoscopique. Notre experience.

1997 - Giudelines for clinical use of local anaesthetics in minor ambulatory surgery with no anaesthetic's care [Articolo su rivista]
G., Bettelli; E., Dall'Olmi; A., Buttazzi; E., Cantoni; Cavallini, Gian Maria; A., Cimitan; G., Cristiani; G., Dallari; L., Marchetti; L., Morselli; M., Monteleone; A., Segre; Silingardi, Enrico; R., Simonazzi; F., Tavoni; E., Torcia; Volpe, Annibale
abstract

The authors illustrates the giudelines on local anaesthetic's use in ambulatory surgery

1997 - Morphological analysis of the surface of intraocular lenses after contact with tamponade substances used in vitreretinal surgery. [Abstract in Atti di Convegno]
Cavallini, Gian Maria; L., Campi; A., Lazzerini; P. L., Fabbri
abstract

Morphological analysis of the surface of intraocular lenses after contact with tamponade substances used in vitreretinal surgery.

1997 - Ophthalmometry in IOL power calculations, videokeratographic versus Javal ophthalmometric data. [Abstract in Atti di Convegno]
A., Lazzerini; Cavallini, Gian Maria; L., Campi; F., Birattari; C., Mazza
abstract

Ophthalmometry in IOL power calculations, videokeratographic versus Javal ophthalmometric data.

1996 - Anestesia in Oftalmochirurgia [Monografia/Trattato scientifico]
G., Bellucci; Cavallini, Gian Maria
abstract

La monografia è strutturata per un esame approfondito della tematica partendo dalla basi anatomiche e farmacologiche per addentrarsi nella pratica clinica e nella scelta delle diverse metodiche a seconda del tipo di procedura chirurgica oftalmica.

1996 - Chirurgia della cataratta in day surgery: esperienza in sanità pubblica [Altro]
Cavallini, Gian Maria; L., Campi; A. M., Pietrantonio; A., Cavina
abstract

Si descrive l'esperienza in sanità pubblica relativa alla chirurgia della catratta in day surgery

1996 - Fungal keratitis [Altro]
R., Guerra; L., Longanesi; Cavallini, Gian Maria
abstract

Fungal keratitis

1996 - Postoperative chronic choroidal detachment tratment. A description of two cases. [Altro]
Lazzerini, A.; Guerra, R.; Cavallini, Gian Maria; Delvecchio, G.; Campi, L.
abstract

Postoperative chronic choroidal detachment tratment. A description of two cases.

1996 - Postoperative chronic choroidal detachment treatement. A description of two cases [Abstract in Atti di Convegno]
Lazzerini, A.; Guerra, R.; Cavallini, Gian Maria; Delvecchio, G.; Campi, L.
abstract

This study is about post-operative complications: in particular two cases of chronic choroidal detachment have been analyzed and the article focuses on the treatement of these patients.

1996 - Postoperative chronic coroidal detachment treatment. A description of two cases. [Articolo su rivista]
Lazzerini, A.; Guerra, R.; Cavallini, Gian Maria; Delvecchio, Giancarlo; Campi, L.
abstract

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1996 - Quantitative clinical anatomy of the human cornea in vivo - A morphometric study by ultrasonic pachymetry and computer-assisted topographic videokeratoscopy [Articolo su rivista]
Longanesi, L; Cavallini, Gian Maria; Toni, R.
abstract

The cornea is the most important refractive element in the human ocular system, providing approximately two thirds of the eye's refractive power in the nonaccommodative state. The methods of description and analysis of the corneal anatomy in vivo continue to be refined thanks to the increased interest aroused by the advent of corneal refractive surgery, which aims to modify the dioptric power of the ocular system by altering the thickness and the radius of curvature of the cornea. In the present study we report quantitative morphometric data of corneal thickness and the radius of curvature of the anterior surface of the cornea obtained in vivo from normal human subjects using ultrasonic pachymetry and computer-assisted topographic videokeratoscopy. We found a highly significant statistical correlation in the distribution of corneal thickness and the radius of curvature of the anterior surface of the cornea along the principal corneal meridians (horizontal and vertical meridians) and within three different concentric zones of the cornea, 2, 4 and 6 mm, respectively, from the geometric center along the principal meridians. Correlation was also found for the same morphometric parameters between the right and the left eye. By contrast, no correlation was found between corneal thickness and the radius of curvature of the anterior surface of the cornea. These findings suggest that the adult human cornea is a structure characterized by a highly ordered tridimensional architecture and symmetry and that a specific distribution of corneal thickness and the radius of curvature of the anterior corneal surface along the principal meridians may be essential for the refractive function of the human corneal diopter in vivo.

1996 - Surgically induced astigmatism after manual extracapsular cataract extraction or after phacoemulsification procedure. [Articolo su rivista]
Cavallini, Gian Maria; Lugli, N; Campi, L; Lazzerini, A; Longanesi, L.
abstract

Astigmatic changes in three series of cataract surgical procedures were compared. The first two series comprised eyes having a manual extracapsular cataract extraction (ECCE) through a 12.0 mm or 8.0 mm incision and implant of a PMMA posterior chamber lens. The third series comprised eyes having phacoemulsification through a scleral pocket and implant of a PMMA posterior chamber lens. Preoperative keratometry measurements and corneal topography maps were compared with those obtained two days, one week, one, three and six months postoperatively. The keratometry measurements, obtained with computerized videokeratography, revealed: on day 2, 4.89 D (1st series), 3.95 D (2nd series), 2.66 D (3rd series); one week, respectively 4.46 D, 3.51 D and 2.14 D; one month, 0.65 D, 0.53 D and 0.05; three months, 1.44 D, 0.35 D and 0.36 D; six months, 1.36 D, 0.42 D and 0.48 D. The surgically-induced cylinder at three months was four times greater in the manual ECCE 12.0 mm incision series than in the phacoemulsification series. However, by six months all differences were markedly reduced. The results add to the growing evidence that the phacoemulsification procedure produces less astigmatism and more rapid visual rehabilitation than the manual ECCE procedure. Topographic analysis showed much less corneal steepening after phacoemulsification than after manual ECCE. However, all three surgical procedures offered satisfactory clinical results.

1995 - Analisi degli effetti collaterali della fluoroangiografia. Descrizione di due reazioni gravi alla somministrazione endovenosa di fluoresceina. [Articolo su rivista]
Lazzerini, A; Gaspari, M; Cavallini, Gian Maria; Longanesi, L; Mazza, C.
abstract

Si prendono in considerazione gli effetti collaterali della fluorangiografia, in particolare due reazioni gravi alla fluoresceina somministrata per via endovenosa

1995 - Anomalia di Axenfeld in due gemelle monozigoti [Articolo su rivista]
Longanesi, L; Cavallini, Gian Maria; Chiesi, C; Vocino, C.
abstract

Si descrive un caso di due gemelle omozigoti affette da anomalia di Axenfeld

1995 - Ciclosporina A: Esperienze cliniche ed indicazioni sul trattamento sistemico e locale in Oftalmologia. Bollettino di Aggiornamento in farmacologia oculare. [Articolo su rivista]
Cavallini, Gian Maria
abstract

Si descrive l'uso della ciclosporina A in oftalmologia, da un punto di vista sistemico e locale

1995 - Clinical and biologic features of adenomatosis coli in Northern Italy [Articolo su rivista]
S., DE PIETRI; R., Sassatelli; Roncucci, Luca; G., Bertoni; P., Landi; G., Sabadini; P., Tansini; Cavallini, Gian Maria; E., Cantoni; C., Mareni; M., Montera; PONZ DE LEON, Maurizio; L., Varesco; V., Gismondi; C., Davighi
abstract

Background: Familial adenomatous polyposis (FAP) is a hereditary disease characterized by more than 100 adenomas scattered in the large bowel and by various extracolonic manifestations. We proposed a) to establish the frequency of the disorder in Northern Italy, b) to describe the most relevant clinical findings, and c) in a subgroup of 21 patients (from 8 families), to evaluate the spectrum of mutations of the APC gene. Methods and Results: Patients with FAP diagnosed between 1961 and 1991 were referred to our Study Group from surgery and gastroenterology units of the region Emilia-Romagna. The incidence of FAP was in the order of 1 in 16,500, with about a third of patients being 'single' cases. Colorectal malignancies were present in 75.6% of symptomatic patients but absent in most (93.75%) of the asymptomatic family members ('call-up' individuals). Gastric, duodenal, and jejunal adenomas were found in 8.2%, 30.6% and 53.3% of the investigated patients, respectively. Congenital hypertrophy of the retinal pigment epithelium and occult jaw lesions were seen in 64.7% and 39.5% of FAP patients but only in 0.5% and 2.5% of a matched, by age and sex, control population. These two clinical markers had a specificity of 99% and 97%, although their sensitivity was 64% and 39%. Finally, mutations of the APC gene were detected in 6 families (16 affected individuals) of the 8 families (21 affected individuals) tested; no correlation could be found between genotype and phenotype. Conclusions: This study confirms that early diagnosis is essential for an appropriate management of FAP patients, although this aim remains elusive in single cases. High-risk individuals are ideal candidates for APC gene mutation analysis, which should be offered to all first-degree relatives of affected patients.

1995 - Cytologic findings in secondary cataract. [Articolo su rivista]
L., Longanesi; Cavallini, Gian Maria; F., Rivasi
abstract

Amorphus material with ferning or cristallin patterns was largely spread among cellular elements. Posterior capsular opacification seems to be due to the presence of remnants or regenerated lens epithelial cells. The clinico-pathologic correlations are discussed.

1995 - Effect of PVP (Polyvinylpyrrolidone-iodine) on the conjunctival bacterial flora in cataract surgery: a comparison of two different ways of application [Abstract in Rivista]
Cavallini, G. M.; De Iaco, A.; Delvecchio, G.; Bondi, M.; Messi, P.
abstract

To minimize the conjunctival bacterial flora before cataract surfery, it is recommended the use of PVP-I as a disinfectant on the skin and in the conjunctival sac.

1995 - Granuloma eosinofilo: caso clinico [Articolo su rivista]
Longanesi, L; Montinari, M; Lazzerini, A; Cavallini, Gian Maria
abstract

Si descrive il caso clinico di un paziente con granuloma eosinofilo

1995 - Impianto di lente intraoculare in camera posteriore senza supporto capsulare: rassegna di 43 casi. [Altro]
C., Mazza; A., Lazzerini; Cavallini, Gian Maria; R., Guerra
abstract

Dimostrazione dei risultati dell'impianto di lente intraoculare in camera posteriore senza supporto capsulare in un gruppo di 43 casi.

1995 - LONG-TERM CORNEAL ENDOTHELIAL DAMAGE AFTER CATARACT-EXTRACTION AND INTRAOCULAR-LENS IMPLANTATION [Abstract in Atti di Convegno]
L., Longanesi; Cavallini, Gian Maria; R., Derrico; F., Birattari; C., Mazza
abstract

THE STUDY IS ABOUT THE EVALUATION OF LONG-TERM CORNEAL ENDOTHELIAL DAMAGE IN PATIENTS THAT UNDERWENT CATARACT EXTRACTION AND INTRAOCULAR-LENS IMPLANTATION

1995 - Long term corneal endothelial damage after catarcat extraction and intraocular lens implantation [Altro]
L., Longanesi; Cavallini, Gian Maria; R., D'Errico; F., Birattari; C., Mazza
abstract

Long term corneal endothelial damage after catarcat extraction and intraocular lens implantation.

1995 - Megalocornea X-linked: contributo clinico. [Altro]
L., Longanesi; Cavallini, Gian Maria; A., Lazzerini; R., Guerra
abstract

Megalocornea X-linked: contributo clinico.

1995 - Metodo di calcolo per l'assegnazione di un punteggio al campo visivo computerizzato in soglia [Altro]
Delvecchio, G.; Brombin, A.; Cavallini, Gian Maria; Bussolari, L.
abstract

Proposta di un metodo di calcolo per l'assegnazione di un punteggio al campo visivo computerizzato in soglia.

1995 - Morophometric Analysis in normal and keratoconus corneas. [Abstract in Rivista]
L., Longanesi; Cavallini, Gian Maria; M., Gaspari; C., Vocino
abstract

Study on correlations between corneal thickness and curvature and morphometric changes typical of keratoconus.

1995 - New findings in optical performance of IOLs [Altro]
Cavallini, Gian Maria; R., Guerra
abstract

New findings in optical performance of IOLs

1995 - Ophthalmometry in IOL power calculation: videokeratographic versus Javal ophthalmometric data. [Altro]
A., Lazzerini; Cavallini, Gian Maria; L., Campi; N., Lugli
abstract

Ophthalmometry in IOL power calculation: videokeratographic versus Javal ophthalmometric data.

1995 - Posteoperative IOL power calculation using corneal map versus javal ophthalmometric data. [Abstract in Rivista]
A., Lazzerini; Cavallini, Gian Maria; N., Lugli; L., Campi; C., Vocino
abstract

Posteoperative IOL power calculation in a gropu of 38 patients using corneal map versus javal ophthalmometric data. The analysis of results reveals that the errors spread is less evaluating IOL power calculation with videokeratoscope, but the difference is not significative in comparison with Javal.

1995 - Psycolgical test before and after cataract surgery. [Altro]
G. C., Delvecchio; Cavallini, Gian Maria; A., Brombin; L., Bussolari
abstract

Psycolgical test before and after cataract surgery.

1995 - Psycological test before and after cataract surgery. [Abstract in Atti di Convegno]
Delvecchio, G; Cavallini, Gm; Brombin, A; Bussolari, L
abstract

Psycological test before and after cataract surgery.

1995 - Qualitative and quantitative evaluation of corneal endothelium after cataract surgery [Altro]
Cavallini, Gian Maria; L., Campi; N., Lugli; L., Longanesi; R., Guerra
abstract

Qualitative and quantitative evaluation of corneal endothelium after cataract surgery.

1995 - Role de la radio-immunoscintigraphie dans le diagnostic des neoformations de l'uvee [Articolo su rivista]
Lazzerini, A; Guerra, R; Cavallini, Gian Maria; Campi, L; Lugli, N; Pantusa, M; Longanesi, L; Gaspari, M.
abstract

Si descrive il ruolo della radioimmunoscintigrafia nel percorso diagnostico delle neoformazioni dell'uvea.

1995 - Surgical induced astigmatism after planned extracapsular cataract extraction versus astigmatism after phacoemulsification procedures. [Abstract in Rivista]
Cavallini, Gian Maria; A., Lazzerini; N., Lugli; L., Campi; L., Longanesi
abstract

Phacomelusification procedures produce less astigmatism and more rapid visual rehabilitation than ECCE procedures.

1995 - Surgically induced astigmatism in cataract extraction: comparison between three techniques. [Altro]
Cavallini, Gian Maria; N., Lugli; L., Campi; A., Lazzerini
abstract

Surgically induced astigmatism in cataract extraction: comparison between three techniques.

1995 - Topographic analysis of early changes in corneal astigmatism after phacoemulsification and planned extracapsular cataract extraction. [Altro]
Cavallini, Gian Maria; L., Campi; N., Lugli; L., Longanesi
abstract

Topographic analysis of early changes in corneal astigmatism after phacoemulsification and planned extracapsular cataract extraction.

1995 - Visual Acuity and contrast sensitivity in patients with a new diffractive bifocal intraocular lens versus patients with monofocal intraocular lens. [Relazione in Atti di Convegno]
Cavallini, Gm; Delvecchio, G; Basenghi, Mc; Lazzerini, A
abstract

Evaluation of visual acuity and contrast sensitivity in patients with a new diffractive bifocal intraocular lens versus patients with monofocal intraocular lens.

1994 - Anestesia oculare loco-regionale (acinesia e retrobulbare) versus anestesia peribulbare nella chirurgia della cataratta [Articolo su rivista]
Cavallini, Gian Maria; Gaspari, M.; Bergamaschi, M.; Delvecchio, Giancarlo
abstract

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1994 - Considerazioni sulla cheratite da Acanthamoeba, Microbiologica medica [Altro]
U., Fabio; R., Guerra; C., Casolari; Cavallini, Gian Maria; L., Longanesi
abstract

Si prende in considerazione la cheratite da Acanthamoeba

1994 - Cornea plana: studio clinico ed istopatologico [Articolo su rivista]
Longanesi, L; Cavallini, Gian Maria; Lazzerini, A.
abstract

Si esegue uno studio clinico ed istopatologico su cornea plana

1994 - Histopathological findings in Keratoconus. [Altro]
L., Longanesi; Cavallini, Gian Maria; F., Rivasi; R., Guerra
abstract

Histopathological findings in Keratoconus.

1994 - Histopathological findings in keratoconus [Poster]
L., Longanesi; Cavallini, Gian Maria; F., Rivasi; R., Guerra
abstract

Keratoconus is a bilateral thinning disorder of the cornea often associated with heterogeneous clinical conditions. Progression is marked by a slow deformation of the cornea the origin, pathogenesis and biochemistry of keratoconus are unknown, probabily because the histopathological features of this corneal disease may be related to a multifactorial etiology. The purpouse of this study was to evalue the histopathological findings in a large group of patients with different extraocular condition.

1994 - Histopatological findings in keratoconus. [Articolo su rivista]
Fabio, U.; Guerra, Roberto; Casolari, C.; Cavallini, Gian Maria; Longanesi, L.
abstract

Histopatological findings in keratoconus.

1994 - Impianto di lenti intraoculari in camera posteriore senza supporto capsulare: rassegna di 43 casi. [Relazione in Atti di Convegno]
Mazza, C.; Lazzerini, A.; Cavallini, G. M.; Campi, L.; Delvecchio, G
abstract

Impianto di lenti intraoculari in camera posteriore senza supporto capsulare: rassegna di 43 casi.

1994 - La radioimmunoscintigrafia nella diagnosi e nella gestione delle neoformazioni uveali [Abstract in Atti di Convegno]
Lazzerini, A.; Cavallini, G. M.; Pantusa, M.; Campi, L.; Marchini, G.; Lugli, Nadia; Delvecchio, G
abstract

La radioimmunoscintigrafia nella diagnosi e nella gestione delle neoformazioni uveali

1994 - La radioimmunoscintigrafia nella diagnosi e nella gestione delle neoformazioni uveali- Atti Società Oftalmologica Lombarda [Altro]
A., Lazzerini; Cavallini, Gian Maria; M., Pantusa; L., Campi; G., Marchini; N., Lugli; G. C., Del Vecchio; L., Bonomi; C., Mazza
abstract

Si studia l'uso della radioimmunoscintigrafia nella diagnosi e nella gestione delle neoformazioni uveali

1994 - Role of Radioimmunoscintigraophy in uveal neoformation diagnosis ad managment [Altro]
A., Lazzerini; Cavallini, Gian Maria; L., Lugli; Pantusa, M.; Guerra, L. L. o. n. g. a. n. e. s. i. M. G. a. s. p. a. r. i. R.
abstract

Role of Radioimmunoscintigraophy in uveal neoformation diagnosis ad managment

1994 - Studio della funzione visiva prima e dopo l'intervento di cataratta con impianto di lente intraoculare- Atti Società Oftalmologica Lombarda [Altro]
G. C., Del Vecchio; A., Brombin; L., Bussolari; A., Lazzerini; L., Longanesi; Cavallini, Gian Maria
abstract

Si studia la funzione visiva prima e dopo l'intervento di cataratta con impianto di lente intraoculare

1994 - Studio della funzione visiva prima e dopo l'intervento di cataratta con impianto di lenti intraoculare [Relazione in Atti di Convegno]
Delvecchio, G.; Brombin, A.; Bussolari, L.; Lazzerini, A.; Longanesi, L.; Cavallini, Gm
abstract

Studio della funzione visiva prima e dopo l'intervento di cataratta con impianto di lenti intraoculare

1994 - Valutazione dei difetti perimetrici glaucomatosi mediante perimetria automatica con programma soglia C/30-2 e programma Esterman [Relazione in Atti di Convegno]
Delvecchio, G.; Cavallini, G. M.; Brombin, A.; Bussolari, L.; Lazzerini, A.; Mazza, C
abstract

Valutazione dei difetti perimetrici glaucomatosi mediante perimetria automatica con programma soglia C/30-2 e programma Esterman

1994 - Valutazione dei difetti perimetrici glaucomatosi mediante perimetria automatica con programma soglia C/30-2 e programma Esterman- Atti Società Oftalmologica Lombarda [Altro]
G. C., Del Vecchio; Cavallini, Gian Maria; L., Bussolari; A., Brombin; A., Lazzerini; C., Mazza
abstract

Si valutano i difetti perimetrici glaucomatosi mediante perimetria automatica con programma soglia C/30-2 e programma Esterman

1993 - Acuità visiva elettrofisiologica in casi di cataratta con grave ipovisione [Articolo su rivista]
Pensiero, S; Cavallini, Gian Maria; Perissutti, P; Guerra, R.
abstract

Si studia l'acuità visiva elettrofisiologica in pazienti affetti da cataratta con grave ipovisione

1993 - Cataratta in glaucoma: indicazioni per l'impianto di IOL a superficie modificata con eparina [Altro]
Cavallini, Gian Maria; L., Longanesi; A., Lazzerini; R., Guerra
abstract

Si studiano le indicazioni per l'impianto di IOL a superficie modificata con eparina in casi di cataratta in glaucoma

1993 - Cheratomicosi ad eziologia rara: Rhodotorula Glutinis e Cladosporium Carrionii. [Relazione in Atti di Convegno]
Cavallini, Gian Maria; L., Longanesi; A., Lazzerini; F., Rivasi; A., Fabio; R., Guerra
abstract

Le cheratomicosi sono infezioni causate dalla penetrazione di funghi nello stroma corneale in seguito a traumi da corpi estranei contaminati. Più raramente l'infezione può essere determinata da miceti opportunisti in presenza di alterazioni epiteliali preesistenti. Più di 80 generi di funghi sono stati descritti come agenti eziologici di malattie oculari. La classificazione tassonomica dei funghi è particolarmente complessa, ma può essere semplificata e ricondotta a 3 principali categorie: muffe, lieviti e funghi difasici. I funghi responsabili delle cheratomicosi sono microorganismi ubiquitari patogeni per le piante o presenti nel suolo. Riportiamo 2 casi di cheratiti dovute ad agenti raramente isolati dagli annessi oculari ed inediti in patologia corneale. Il primo caso riguarda una cheratite causata da cladosporium carrionii, un fungo filamentoso della famiglia delle dermatiaceae, segnalato come agente patogeno oculare solo nei paesi tropicali. Il secondo caso si riferisce ad un'infezione da rhodotorula glutinis, un lievito presente nell'ambiente come saprofita.

1993 - Cheratouveite da Acanthameba SPP: descrizione di un caso. [Altro]
R., Guerra; C., Casolari; F., Rivasi; L., Longanesi; Cavallini, Gian Maria; G., Bertoli; G., Pierini; U., Fabio
abstract

Descrizione di un caso clinico di un paziente affetto da cheratouveite da Acanthameba SPP, diagnosi e terapia.

1993 - Confronto fra due tipi di lenti intraoculari bifocali mediante lo studio della sensibilità al contrasto [Capitolo/Saggio]
Cavallini, Gm; Longanesi, L; Delvecchio, G; Tartoni, Pl
abstract

Confronto fra due tipi di lenti intraoculari bifocali mediante lo studio della sensibilità al contrasto

1993 - Confronto tra due tipi di lenti intraoculari bifocali mediante lo studio della sensibilità al contrasto [Articolo su rivista]
Cavallini, Gian Maria; Longanesi, L; Del Vecchio, Gc; Tartoni, Pl
abstract

Si confrontano due tipi di lenti intraoculari bifocali, attraverso lo studio della sensibilità al contrasto

1993 - Considerazioni in margine ai primi casi di cheratite da Acanthamoeba segnalati in Italia. [Altro]
U., Fabio; R., Guerra; C., Casolari; Cavallini, Gian Maria; L., Longanesi
abstract

Si studiano i primi casi di cheratite da Acanthamoeba segnalati in Italia

1993 - Effetti collaterali dei farmaci somministrati per via topica [Altro]
Cavallini, Gian Maria
abstract

Descrizione dei principali effetti collaterali dei farmaci somministrati per via topica.

1993 - Endoscopic intranasal dacryocystorhinostomy. Report of three cases. [Abstract in Atti di Convegno]
Neri, P. L.; Lazzerini, A.; Cavallini, G. M.; Vincenzi, A.; Delvecchio, G.; Guerra, R
abstract

Endoscopic intranasal dacryocystorhinostomy. Report of three cases.

1993 - Flurbiprofen versus Piroxicam: Attività antinfiammatoria e mantenimento della midriasi intraoperatoria nella chirurgia della cataratta. [Altro]
Cavallini, Gian Maria; L., Longanesi; M., Gaspari
abstract

Si confronta l'attività di due farmaci: Flurbiprofen versus Piroxicam. In particolare si studiano l'attività antinfiammatoria ed il mantenimento della midriasi intraoperatoria nella chirurgia della cataratta.

1993 - Fungal infection of the cornea: clinical and histopathological features. [Altro]
L., Longanesi; Cavallini, Gian Maria; R., Guerra
abstract

Evaluation of the main characteristic of fungal corneal infection considering clinical and histopathological correlations.

1993 - I nuovi antibiotici in oftalmologia. [Altro]
R., Guerra; Cavallini, Gian Maria; L., Longanesi
abstract

I nuovi antibiotici in Oftalmologia.

1993 - Il PVP-I nella prevenzione delle infezioni postoperatorie intraoculari. [Altro]
M., Bondi; Messi, Patrizia; Cavallini, Gian Maria; P., Caruso; A., De Iaco
abstract

Valutazione dell'utilizzo del PVP-I nella prevenzione delle infezioni postoperatorie intraoculari.

1993 - Iridociclectomia con conservazione del forame pupillare.In: Balestrazzi E, Blasi MA, Iorio P, Spadea L: I tumori dell'iride e del corpo ciliare. Atti del III Congresso della Società Italiana di Oncologia Oculare. L'Aquila, 28-29 febbraio 1992 [Altro]
R., Guerra; Cavallini, Gian Maria; P. L., Neri; L., Longanesi
abstract

Si studia l'intervento di iridocicletomia con conservazione del forame pupillare.

1993 - Keratomileusis and Epikeratophakia: histopathologic and ultrastructural study. [Altro]
Cavallini, Gian Maria; L., Longanesi; R., Guerra
abstract

Keratomileusis and Epikeratophakia: histopathologic and ultrastructural study.

1993 - La morte improvvisa in corso di anestesia. [Altro]
G., Bellucci; Cavallini, Gian Maria
abstract

Si prendono in esame casi di morte improvvisa in corso di anestesia.

1993 - La pressione intraoculare valutata con tonometro non contact [Articolo su rivista]
Pensiero, S; Da Pozzo, S; Cavallini, Gian Maria; Perissutti, P; Guerra, R.
abstract

Si studia il valore della pressione intraoculare, in caso di valutazione con tonometro non contact

1993 - Lenti intraoculare a superficie modificata con eparina in casi ad alto rischio. Studio controllato. [Altro]
R., Guerra; Cavallini, Gian Maria; L., Longanesi; A., Lazzerini; M., Gaspari
abstract

Si esegue uno studio controllato prendendo in considerazione lenti intraoculari a superficie modificata con eparina in casi ad alto rischio

1993 - Macular corneal dystrophy: hystopathological study [Articolo su rivista]
Longanesi, L; Cavallini, Gian Maria; Guerra, R; Rivasi, F; Fano, Ra
abstract

A hystopathological study of a macular corneal dystrophy

1993 - Patologia infettiva della congiuntiva e dell'apparato lacrimale. [Altro]
Cavallini, Gian Maria
abstract

Descrizione delle principali caratteristiche della patologia infettiva della congiuntiva e dell'apparato lacrimale.

1993 - Risultati clinico-funzionali di 110 impianti nel sacco di IOL modello Heliolens [Articolo su rivista]
Lazzerini, A; Cavallini, Gian Maria; Gaspari, M; Del Vecchio, Gc
abstract

Si valutano i risultati clinico-funzionali di 110 impianti nel sacco di lenti intraoculari, modello Heliolens

1993 - Risultati refrattivi ottenuti con modifica della formula SRK II di bulbi minori di mm 22. Confronto con la formula SRK II [Altro]
Lazzerini, A.; Cavallini, G. M.; Gaspari, Mattia; Delvecchio, G
abstract

Risultati refrattivi ottenuti con modifica della formula SRK II di bulbi minori di mm 22. Confronto con la formula SRK II

1993 - Risultati refrattivi ottenuti con una modifica della formula SRK II in bulbi minori di 22 mm. Confronto con la formula SRK II [Articolo su rivista]
Lazzerini, A; Cavallini, Gian Maria; Gaspari, M; Del Vecchio, Gc
abstract

Si mette a confronto la formula SRK II con una modifica della stessa, applicata in bulbi di lunghezza inferiore ai 22 mm e si valutano i risdultati refrattivi ottenuti

1993 - Sclerostomia con laser ad Olmio. Risultati a lungo termine [Holmium laser sclerostomy long-term results] [Articolo su rivista]
C., Mazza; A., Lazzerini; C., Benassi; Cavallini, Gian Maria
abstract

Si studiano i risultati a lungo termine della Sclerostomia con laser ad Olmio.

1993 - Titolazione pos-mortem degli anticorpi ANTI HIV, ANTI HCV, HBSAG nei fluidi endoculari. [Altro]
R., Guerra; L., Longanesi; Cavallini, Gian Maria; G., Popoli; S., Pelosi; F., Fregni; C., Vecchi; M., De Palma; E., Baldini
abstract

Si studia la titolazione post-mortem degli anticorpi anti HIV, anti HCV, HBSAG nei fluidi endoculari.

1993 - Ultrastructural localizzation of gelsolin related protein in lattice corneal distrophy. [Altro]
L., Longanesi; Cavallini, Gian Maria; R., Guerra
abstract

Ultrastructural localizzation of gelsolin related protein in lattice corneal distrophy.

1993 - Valutazione clinica di una associazione Tobramicina 0.3% e Desametazone 0.1% in collirio nel trattamento delle flogosi oculari post-intervento di cataratta con tecnica di facoemulsificazione. [Altro]
Cavallini, Gian Maria; M., Gaspari; C., Mazza
abstract

Si valuta una associazione Tobramicina 0.3% e Desametazone 0.1% in collirio nel trattamento delle flogosi oculari post-intervento di cataratta con tecnica di facoemulsificazione.

1992 - Atrofia ottica dominante: studio genetico clinico [Relazione in Atti di Convegno]
Longanesi, L.; Cavallini, G. M.; Santucci, Annalisa; Delvecchio, G.; Forabosco, A.; Guerra, R.
abstract

Atrofia ottica dominante: studio genetico clinico

1992 - Atrofia ottica dominante: studio genetico-clinico. Atti della Società Oftalmologica Lombarda [Altro]
L., Longanesi; Cavallini, Gian Maria; A., Santucci; G. C., Del Vecchio; A., Forabosco; R., Guerra
abstract

Si esegue uno studio genetico-clinico dell' atrofia ottica dominante

1992 - CYTOLOGY OF ALLERGIC CONJUNCTIVITIS - PRESENCE OF AIRBORNE, NONHUMAN ELEMENTS [Articolo su rivista]
F., Rivasi; Cavallini, Gian Maria; L., Longanesi
abstract

Two groups of patients suffering from allergic conjunctivitis (32 atopic, 33 nonatopic) were studied. Their conjunctival secretions were subjected to cytologic examination involving morphologic and semiquantitative evaluation. Account was taken of noncellular and nonhuman elements in the smears; they included mucus, Charcot-Layden crystals, pollen grains, vegetal fragments and fungi. In 12 cases scanning electron microscopy was used in conjunction with x-ray microanalysis to identify material of noncellular origin. Similar quantities of inflammatory cells were present in both groups, while epithelial cells, particularly goblet cells, were more numerous in the atopic than in the nonatopic group (21.8% versus 6 %). Pollen grains, vegetal fragments and fungi were present in 18%, 55% and 12% of cases, respectively. Exfoliative cytology emerges as a valuable tool for the diagnosis of allergic conjunctivitis, while the presence of noncellular elements is of particular diagnostic significance.

1992 - Epikeratophakia - Histopathological And Cultural-Study [Articolo su rivista]
Cavallini, Gian Maria; L., Longanesi; DE POL, Anto; E. C., Campos; R., Guerra
abstract

Three epikeratoplasty buttons (one aphakic and two myopic) prepared by the freeze technique were removed two to nineteen months after surgery. A complete morphological and immunohistochemical study was performed on these buttons in order to gain insight into the reasons for epikeratophakia failure. Histopathological studies with light microscopy and scanning and transmission electron microscopy were performed. All three cases showed an anomalous process of re-epithelialization: in the first, the epithelium over the donor cap was almost completely absent, with many abnormalities; in the second, the epithelium was irregular, with a varying number of cell layers and poor adhesion between cells; in the third, the development of an epithelial cyst between the tissue lens and the cornea of the host caused the failure of the epikeratoplasty. The specimens were cultured 'in vitro' and the cells grown typed for HLA antigens. The antigen panel was the same as that of the host. Immunohistochemistry showed CD3- and CD8-positive cells in the stroma, proving the activity of T-suppressor lymphocytes in a cell-mediated immunoreaction.

1992 - KERATOMYCOSIS WITH AN UNUSUAL ETIOLOGY (RHODOTORULA-GLUTINIS) - A CASE-REPORT [Articolo su rivista]
Casolari, Chiara; Nanetti, A; Cavallini, Gian Maria; Rivasi, Francesco; Fabio, U; Mazzoni, A.
abstract

A case of deep keratomycosis with isolation of Rhodotorula glutinis is discussed. Keratoplasty, done immediately, prevented panophtalmitis and cured the patient. The etiology and pathogenesis of fungal keratitis is examined.

1992 - Macula corneal distrophy: histopathological study. [Altro]
R., Guerra; Cavallini, Gian Maria; L., Longanesi; F., Rivasi
abstract

Macula corneal distrophy: histopathological study.

1992 - Normal intraocular pressure in children [Articolo su rivista]
Pensiero, S; Da Pozzo, S; Perissutti, P; Cavallini, Gian Maria; Guerra, R.
abstract

The age-related trend values and the normal intraocular pressure (IOP) increase curve from birth through the 16th year of life were studied in 460 subjects with a noncontact tonometer (Keeler Pulsair, Keeler, Ltd, Windsor, Berks, UK). Much lower values than in adults were recorded in subjects up to the age of 3 or 4 years. This finding leads us to believe that in the treatment of infantile glaucoma IOP should be kept within the age physiologic levels, in an attempt to prevent visual field loss and optic atrophy.

1992 - Pemfigoide cicatriziale ad IgA lineari: caso clinico con interessamento oculare. [Altro]
L., Longanesi; Cavallini, Gian Maria; A., Lazzerini; R., Guerra
abstract

Si valuta un caso clinico di pemfigoide cicatriziale ad IgA lineari

1992 - Post-keratoplasty astigmatism after a singol running suture removal. In Scuderi G. Lim ASM, Picardo V. 3rd International Symposium-Ocular Microsurgery, Singapore 15-17 marzo 1990. Ghedini Ed. [Altro]
R., Guerra; Cavallini, Gian Maria; M., Corsi; L., Lazzerini; L., Longanesi
abstract

Evaluation of a Post-keratoplasty astigmatism after a singol running suture removal.

1992 - Preservation of the pupillary foramen in iridocyclectomy [Relazione in Atti di Convegno]
R., Guerra; Cavallini, Gian Maria; L., Lazzerini
abstract

evaluation of the conservation of pupillary foramen, performing iridocyclectomy

1992 - RHODOTORULA-GLUTINIS KERATITIS [Articolo su rivista]
Guerra, R; Cavallini, Gian Maria; Longanesi, L; Casolari, Chiara; Bertoli, G; Rivasi, Francesco; Fabio, U.
abstract

The authors report a case of deep keratomycosis, revealed by penetrating keratoplasty to be due to Rhodotorula glutinis.

1992 - Studio delle lesioni retiniche in pazienti con poliposi familiare del colon- Atti della Società Oftalmologica Lombarda [Altro]
Cavallini, Gian Maria; G. C., Del Vecchio; L., Longanesi; A., Mazzioli; R., Sassatelli; PONZ DE LEON, Maurizio
abstract

Si studiano le lesioni retiniche in pazienti con poliposi familiare del colon

1992 - Studio delle lesioni retiniche in pazienti con poliposi famigliare del colon [Relazione in Atti di Convegno]
Cavallini, G. M.; Delvecchio, G.; Longanesi, L.; Mazzoli, Alessandra; Sassatelli, A.; Ponz de Leon, M.
abstract

Studio delle lesioni retiniche in pazienti con poliposi famigliare del colon

1992 - Studio mediante perimetria computerizzata degli effetti degli oligomeri procianidolici da vitis vinifera sulla sensibilità retinica nei soggetti miopi [Articolo su rivista]
Delvecchio, Giancarlo; Cavallini, Gian Maria; Brombin, A.
abstract

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1992 - Studio sull’efficacia del Diclofenac in collirio allo 0,1% nel mantenimento della midriasi farmacologica, durante chirurgia extracapsulare di cataratta [Articolo su rivista]
Cavallini, Gian Maria; Delvecchio, Giancarlo; Longanesi, L.; Vocino, C.
abstract

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1992 - Trattamento medico con Imipenem nelle infezioni post-chirurgiche [Altro]
R., Guerra; Cavallini, Gian Maria; L., Longanesi; C., Vocino
abstract

Trattamento medico con Imipenem nelle infezioni post-chirurgiche

1992 - Triplice procedura in esiti di ferita perforante [Altro]
R., Guerra; Cavallini, Gian Maria; L., Longanesi; M., Gaspari
abstract

Triplice procedura in esiti di ferita perforante

1991 - Adverse reaction to intravenous administration of sodium fluorescein. Our experience. [Altro]
A., Lazzerini; Cavallini, Gian Maria; P., Benedetti
abstract

Study on adverse reactions to intravenous administration of sodium fluorescein

1991 - Azione del Cyanoside cloruro sulla sensibuilità al contrasto in soggetti miopi valutata con Vistech VCTS 6500 [Altro]
Cavallini, Gian Maria; K., Petropulacos; M., Gaspari; R., Bolzani
abstract

Si valuta l'azione del Cyanoside cloruro sulla sensibuilità al contrasto in soggetti miopi valutata con Vistech VCTS 6500

1991 - Cheratomicosi: indicazioni per la cheratoplastica perforante [Altro]
Cavallini, Gian Maria; L., Longanesi; G. C., Delvecchio
abstract

Si valutano le indicazioni per la cheratoplastica perforante in caso di cheratomicosi

1991 - Cultural and histological studies on epikeratoplasty buttons [Altro]
Cavallini, Gian Maria; L., Longanesi; R., Guerra; A., Iammarino; E., Dal Fiume; L., Benassi; V., Manca
abstract

Evaluation of cultural and histological studies on epikeratoplasty buttons

1991 - Function findings in early chloquine retinopathy [Altro]
Delvecchio, G.; Cavallini, Gian Maria; Brombin, A.
abstract

Description of functional findings in early chloroquine retinopathy

1991 - Il Levobunololo: effetti clinici. Risultati di una sperimentazione policentrica [Altro]
Cavallini, Gian Maria
abstract

Sperimentazione policentrica sugli effetti clinici del Levobunololo.

1991 - La pressione intraoculare normale nel primo anno di vita [Altro]
S., Pensiero; Cavallini, Gian Maria; S., Da Pozzo; S., Perissutti; R., Guerra
abstract

Si studia la pressione intraoculare normale nel primo anno di vita

1991 - Laurocerasus berries induced optic neuritis: report of a case [Altro]
Cavallini, Gian Maria; Delvecchio, G.; Lazzerini, A.
abstract

Case report on a Laurocerasus berries induced optic neuritis.

1991 - Muco-cutaneous diseases induced by drugs [Altro]
L., Longanesi; Cavallini, Gian Maria; M., Gaspari; R., Guerra
abstract

Description of Muco-cutaneous diseases induced by drugs

1991 - Nuovi farmaci antinfiammatori non steroidei per uso topico in oftalmologia [Altro]
Cavallini, Gian Maria; Gc, Delvecchio; M., Gaspari; R., Guerra
abstract

Si descrive l'uso di nuovi farmaci antinfiammatori non steroidei per uso topico in oftalmologia

1991 - Nuovi farmaci infiammatori non steroidei per uso topico in oftalmologia [Abstract in Atti di Convegno]
Cavallini, G. M.; Delvecchio, G.; Gaspari, M.; Guerra, R.
abstract

Nuovi farmaci infiammatori non steroidei per uso topico in oftalmologia

1991 - Silicone oil keratopathy [Altro]
Cavallini, Gian Maria; L., Longanesi; F., Rivasi; A., Iammarino; R., Guerra
abstract

Study on a silicone oil keratopathy.

1991 - Valutazione della sensibilità al contrasto a lungo termine dopo impianto di IOL multifocale in PMMA [Altro]
Cavallini, Gian Maria; L., Longanesi; A., Lazzerini
abstract

Valutazione della sensibilità al contrasto a lungo termine dopo impianto di IOL multifocale in PMMA

1990 - Antibiotico terapia in oftalmologia. Il fenomeno della resistenza: ampiezza e risvolti pratici [Altro]
U., Fabio; R., Guerra; Cavallini, Gian Maria; C., Casolari
abstract

Si prende in esame la antibiotico terapia in oftalmologia. Il fenomeno della resistenza: ampiezza e risvolti pratici

1990 - Citologia congiuntivale nelle flogosi non infettive [Altro]
F., Rivasi; Cavallini, Gian Maria; G., Cristini; L., Longanesi; M. V., Montinari
abstract

Analisi citologica della congiuntiva nelle flogosi non infettive

1990 - Granuloma eosinofilo: caso clinico. [Poster]
L., Longanesi; M., Montinari; A., Lazzerini; Cavallini, Gian Maria
abstract

Descritto per la prima volta da Lichtenstein nel 1940, il granuloma eosinofilo osseo fa parte delle istiocitosi X. Nel 1953 Lichtenstein raggruppò patologie caratterizzate dall'anomala proliferazione di un particolare tipo di cellule del sistema macrofagico tessutale, le cellule di Langherans, sotto il termine di istiocitosi X. Questa terminologia è stata adottata per evocare l'origine incerta di questo gruppo di entità cliniche, ma attualmente al termine "istiocitosi X" alcuni autori preferiscono la definizione "granulomatosi eosinofila delle cellule di Langherans". Le diverse forme cliniche vengono distinte in:Forme disseminate -Acute e Subacute (M. di Letterer-Siwe, la forma più aggressiva con diffuso interessamento dei tessuto molli e degli organi viscerali) -Croniche: Granuloma eosinofilo multifocale (M. di Hand-Shuller-Christian, caratterizzato dalla triade esoftalmo, difetti ossei del cranio, diabete insipido)Forme localizzate -Polmonari: Istiocitosi X polmonare -Osse: granuloma eosinofilo unifocale

1990 - L'uso della ciclosporina A nelle uveiti: contributo clinico [Altro]
C., Vocino; Cavallini, Gian Maria; L., Longanesi; R., Guerra
abstract

L'uso in clinica della ciclosporina A nei pazienti affetti da uveite

1990 - Manifestazioni oculari in pazienti sieropositivi con o senza AIDS [Altro]
Cavallini, Gian Maria; AF Penna, Caroppi; Em, Mazzilli; G., Carito; R., Guerra; B., De Rienzo et; A., L.
abstract

Si esaminano le manifestazioni oculari in pazienti sieropositivi con o senza AIDS

1989 - Cheratite micotica: descrizione di un caso [Altro]
G., Bertoli; Cavallini, Gian Maria; L., Longanesi; F., Rivasi; C., Casolari
abstract

Cheratite micotica: descrizione multidisciplinare di un caso clinico

1989 - Further evidence for the role of proprioception in space perception. [Articolo su rivista]
Campos, Ec; Bolzani, R; Schiavi, C; Fanti, Mr; Cavallini, Gian Maria
abstract

In this paper results are presented of errors in spatial localization found after encircling procedures for retinal detachment both in the operated and in the normal eye. Also changes in spatial localization were found in strabismus patients in which a stretch on the operated muscle was exerted after an adjustable recession. In both groups of patients a manipulation of the eye muscle was performed without inducing an eye muscle imbalance in the retinal detachment patients and without modifying the eye position in the strabismus patients in which a stretch was exerted. These data provide further evidence in favour of the role of proprioceptive information in space perception.

1989 - Le infezioni chirurgiche in oftalmologia. Aspetti epidemiologici [Altro]
R., Guerra; Cavallini, Gian Maria
abstract

Le infezioni chirurgiche in oftalmologia. Aspetti epidemiologici

1989 - Long-standing amblyopia in strabismus weakens the suppression mechanism [Articolo su rivista]
Ec, Campos; Cavallini, Gian Maria; R., Codeluppi
abstract

Evaluation of long-standing amblyopia in strabismus weakens the suppression mechanism

1989 - Otticopatie da farmaci [Altro]
R., Guerra; Cavallini, Gian Maria
abstract

Si prendono in esame le otticopatie da farmaci

1988 - Beta-blocking agents: adverse reaction [Altro]
Cavallini, Gian Maria; Corsi, M.; Delvecchio, G.; Guerra, R.
abstract

Evaluation of adverse reactions in Beta-blocking agents.

1988 - Complicanze tardive nelle IOL da camera posteriore. [Altro]
R., Guerra; Cavallini, Gian Maria
abstract

Complicanze tardive nelle IOL da camera posteriore.

1988 - Dischi corneo-sclarali: Studio in microscopia elettronica a scansione [Altro]
Cavallini, Gian Maria; L., Longanesi; R., De Fazio; R., Guerra
abstract

Si studiano i dischi corneo-sclerali in microscopia elettronica a scansione.

1988 - Disturbi oculari nell'insufficienza cerebrovascolare. [Altro]
E. C., Campos; Cavallini, Gian Maria
abstract

Valutazione dei disturbi oculari in pazienti affetti da disturbi cerebrovascolari.

1988 - Diuretici nel trattamento del glaucoma. [Altro]
Cavallini, Gian Maria; L., Longanesi; D., Palmieri; R., Guerra
abstract

Si esamina l'uso dei diuretici nel trattamento del glaucoma.

1988 - Fattori ambliogenici nel neonato. [Altro]
Cavallini, Gian Maria; E., Campos; R., Guerra
abstract

Studio dei principali fattori ambliogenici nel neonato.

1988 - Impianti oculari di 108 impianti di lenti intraoculari. [Altro]
Cavallini, Gian Maria; A., Penna Caroppi; Del Vecchio, G.; P., Neri
abstract

Follow-up di 108 impianti intraoculari.

1988 - Indicazioni e scelta della tecnica chirurgica per l'asportazione della cataratta con impianto. [Altro]
R., Guerra; Cavallini, Gian Maria
abstract

Indicazioni e scelta della tecnica chirurgica per l'asportazione della cataratta con impianto.

1988 - La pressione intraoculare nei primi mesi di vita. [Altro]
S., Pensiero; Cavallini, Gian Maria; P., Perissutti; R., Guerra
abstract

Si prende in esame la pressione intraoculare nei primi mesi di vita.

1988 - La sindrome da erosione iridea. [Altro]
R., Guerra; Cavallini, Gian Maria; G., Carito
abstract

Studio delle principali caratteristiche della sindrome da erosione iridea.

1988 - Reattività congiuntivale alle infezioni. [Altro]
R., Guerra; Cavallini, Gian Maria
abstract

Valutazione della reattività congiuntivale alle infezioni.

1988 - Risposta pupillare all'azione di differenti midriatici nel prematuro e nel bambino nato a termine. [Altro]
Cavallini, Gian Maria; A., Lazzerini; L., Longanesi
abstract

Valutazione dell risposta a diversi midriatici nel neonato.

1988 - Risultati a lungo termine dell'iridectomia Argon-laser nel Glaucoma ad angolo chiuso. [Altro]
C., Mazza; Cavallini, Gian Maria; A., Vinciguerra
abstract

Si studiano i risultati a lungo termine dell'iridectomia Argon-laser nel glaucoma ad angolo chiuso.

1988 - Studio clinico sugli effetti dell'applicazione topica del Levobunololo e del Timololo nel glaucoma cronico ad angolo aperto. [Altro]
Cavallini, Gian Maria; P. L., Neri; G., Carito; A., Lazzerini; S., Cascione; R., Guerra
abstract

Si esegue uno studio clinico sugli effetti dell'applicazione topica del Levobunololo e del Timololo nel glaucoma cronico ad angolo aperto.

1988 - Weakness of antidiplopic mechanism favours post-operative diplopia in adult with strabismus and amblyopia [Altro]
E. C., Campos; Cavallini, Gian Maria; R., Codeluppi
abstract

Weakness of antidiplopic mechanism favours post-operative diplopia in adult with strabismus and amblyopia

1987 - Antivirali. [Altro]
R., Guerra; Cavallini, Gian Maria; G., Carito; A., Lazzerini; S., Cascione
abstract

Valutazione della terapia con antivirali in oftalmologia.

1987 - Immunologia e clinica. [Altro]
R., Guerra; Cavallini, Gian Maria
abstract

Immunologia e clinica

1987 - Lateral approach to orbital lesions involing optic nerve or medial orbita. [Altro]
Cavallini, Gian Maria; R., Guerra
abstract

Lateral approach to orbital lesions involing optic nerve or medial orbita

1987 - Ocular syndromes associated with congenital and devolpment cataracats. [Altro]
E., Campos; Cavallini, Gian Maria
abstract

Ocular syndromes associated with congenital and devolpment cataracats.

1987 - Semeiotica clinica e strumentale della ROP. [Altro]
P., Perissutti; S., Pensiero; Cavallini, Gian Maria; L., Borzaghini
abstract

Semeiotica clinica e strumentale della ROP.

1987 - Studio dell'attività del mesoglicano sulla patologia vascolare retinica attraverso lo studio del tempo di circolo con l'uso del sincrofluoroscopio. [Altro]
R., Guerra; Cavallini, Gian Maria; G., Carito; A., Lazzerini; S., Cascione
abstract

Studio dell'attività del mesoglicano sulla patologia vascolare retinica attraverso lo studio del tempo di circolo con l'uso del sincrofluoroscopio.

1987 - Terapia a lungo a termine delle vasculopatie retinihe con somministrazione orale di alti dosaggi di 0-(beta-idrossietil-rutosidea). [Articolo su rivista]
G., Agolini; Cavallini, Gian Maria
abstract

Terapia a lungo a termine delle vasculopatie retinihe con somministrazione orale di alti dosaggi di 0-(beta-idrossietil-rutosidea).

1986 - Ciclectomy: a variation of technique to preserve a round pupil. [Altro]
R., Guerra; Cavallini, Gian Maria; G., Ravalico
abstract

Ciclectomy: a variation of technique to preserve a round pupil.

1986 - Importance of HLA-sampling in penetrating keratoplasty. [Articolo su rivista]
R., Guerra; Cavallini, Gian Maria; A. R., Pilia; T., Zacchi; A., Centonaze
abstract

Importance of HLA-sampling in penetrating keratoplasty.

1986 - Keratoplasty in pure prognosis [Altro]
R., Guerra; Cavallini, Gian Maria
abstract

Evaluation of Keratoplasty in pure prognosis

1986 - Lateral approach to orbital lesion involving optic nerve or medial orbit. [Altro]
R., Guerra; Cavallini, Gian Maria; A., Centonze
abstract

Lateral approach to orbital lesion involving optic nerve or medial orbit.

1986 - Le congiuntiviti infettivi. [Altro]
R., Guerra; Cavallini, Gian Maria
abstract

Le congiuntiviti infettive.

1986 - Local excision of uveal melanoma technique - puzzles. [Altro]
R., Guerra; Cavallini, Gian Maria; A., Bianco
abstract

Local excision of uveal melanoma technique - puzzles.

1986 - T-Cell-subsets in the periferal blood of B27 positive patients with uveitis. [Altro]
A. R., Pilia; Cavallini, Gian Maria; R., Guerra
abstract

T-Cell-subsets in the periferal blood of B27 positive patients with uveitis.

1986 - T-cell subsets in the peripheral blood of patients with uveitis. [Capitolo/Saggio]
A. R., Pilia; Cavallini, Gian Maria; R., Guerra
abstract

The study was about peripheral blood subset in a group of known patients with uveitis, in particular the T-cells subset has been analyzed.

1986 - Terapia medica. [Altro]
R., Guerra; Cavallini, Gian Maria; G., Agolini; A., Bianco
abstract

Valutazione della terapia medica nella patologia corneale.

1986 - Variations of arm-retina circulation time in vasculopathies treated with mesoglycan [VARIAZIONE DEL TEMPO DI CIRCOLO BRACCIO-RETINA NELLE VASCULOPATIE TRATTATE CON MESOGLICANO] [Articolo su rivista]
R., Guerra; G., Agolini; Cavallini, Gian Maria
abstract

Variazioni del tempo di circolo braccio-retina nelle vasculopatie trattate con mesoglicano.

1985 - Binocular tests in sensorial diagnosis in concomital squint. [Altro]
G., Ravalico; Cavallini, Gian Maria
abstract

Binocular tests in sensorial diagnosis in concomital squint.

1985 - Cristallino artificiale, visione binoculare e stereopsi. [Altro]
R., Guerra; L., Casu; Cavallini, Gian Maria; A., Deiana; M., Demartis; A., Pilia
abstract

Valutazione della visione binoculare e della stereopsi in pazienti dopo impianto di cristallino artificiale.

1985 - Early and late complication in posterior chamber intraocular lenses. [Altro]
R., Guerra; Cavallini, Gian Maria
abstract

Evaluation of early and late complications in posterior chamber intraocular lenses.

1985 - Istopatologia delle IOL. Studio preliminare. [Altro]
F., Mahnic; Cavallini, Gian Maria; F., Baccara
abstract

Istopatologia delle IOL. Studio preliminare.

1985 - May refractive surgery be useful in preventing amblyopia? [Altro]
R., Guerra; G., Ravalico; Cavallini, Gian Maria
abstract

May refractive surgery be useful in preventing amblyopia?

1985 - Risultati a distanza di una serie di IOL da camera posteriore. [Altro]
Cavallini, Gian Maria; A., Centonaze; C., Michelone
abstract

Valutazione dei risultati a distanza di una serie di IOL da camera posteriore.

1985 - Sindrome da erosione iridea nelle IOL da camera posteriore. [Altro]
R., Guerra; Cavallini, Gian Maria; G., Agolini
abstract

Sindrome da erosione iridea nelle IOL da camera posteriore.

1984 - Adattamento alla luce dopo fotocoagulazione panretinica. [Altro]
G., Ravalico; F., De Bigontina; Cavallini, Gian Maria
abstract

Valutazione dell'adattamento alla luce in pazienti in seguito a trattamento fotocoagulativo panretinico.

1984 - Anestesie generali di più giorni di durata nel trattamento della grave insufficienza respiratoria di origine polmonare. [Altro]
G., Damia; L., Giuliani; Cavallini, Gian Maria
abstract

Valutazione anestesie generali di più giorni di durata nel trattamento della grave insufficienza respiratoria di origine polmonare.

1984 - Coca e Cocaina [Altro]
G., Bellucci; Cavallini, Gian Maria; M., Ciriaco
abstract

Coca e cocaina

1984 - Congiuntivite giganto-papillare secondaria a suture esposte in monofilamento. [Articolo su rivista]
R., Guerra; L., Casu; Cavallini, Gian Maria; A. R., Pilia
abstract

Studio della congiuntivite giganto-papillare secondaria a suture esposte in monofilamento.

1984 - Il trattamento dei comi da overdose da sostanze di abuso. [Altro]
T., Cavallini; Cavallini, Gian Maria; P., Di Sibio; F., Toracca
abstract

Il trattamento dei comi da overdose da sostanze di abuso.

1984 - Infezioni tardive delle bozze filtranti nelle fistolizzanti esterne e nelle fistolizzanti protette. [Articolo su rivista]
R., Guerra; L., Casu; G., Sanna; Cavallini, Gian Maria; E., Pitzorno
abstract

Valutazione delle infezioni tardive delle bozze filtranti nelle fistolizzanti esterne e nelle fistolizzanti protette.

1984 - L' anestesia ed il trattamento del dolore nell'anziano. [Altro]
Cavallini, Gian Maria; P., Di Sibio
abstract

Valutazione dell' anestesia del trattamento del dolore nell'anziano.

1984 - La droga nei secoli [Altro]
G., Bellucci; Cavallini, Gian Maria
abstract

La droga nei secoli

1984 - La radiografia del torace in rianimazione. [Articolo su rivista]
G., Damia; A., Pelizzola; Cavallini, Gian Maria
abstract

Valutazione della radiografia del torace in rianimazione.

1984 - Pressione positiva di fine espirazione ottenuta con valvole ad acqua: modifiche e suggerimenti. [Articolo su rivista]
G., Damia; A., Pedizzola; M., Solca; M., Cigada; Cavallini, Gian Maria
abstract

Pressione positiva di fine espirazione ottenuta con valvole ad acqua: modifiche e suggerimenti.

1984 - Riabilitazione visiva dopo impianto di IOL. [Altro]
G., Ravalico; A., Sparavier; C., Michelone; F., Barosco; Cavallini, Gian Maria
abstract

Valutazione degli outcome visivi in pazienti trattati con impianto di IOL.

1984 - Rilievi sul blocco del plesso lombare per via anteriore secondo Wynnie. [Altro]
A., Di Massa; M., Baldi; G., Cofelice; Cavallini, Gian Maria
abstract

Rilievi sul blocco del plesso lombare per via anteriore secondo Wynnie.

1984 - Value of the stereoscopic tests in the detection of sensorimotor anomalies in children [Articolo su rivista]
Casu, L; Demartis, M; Pilia, Ar; Cavallini, Gian Maria
abstract

Limitations and advantages of the stereotests are briefly discussed. In this trial, two stereotests (TNO and Frisby) have been tested in 3 groups of patients: group 1 was composed of 180 cases with normal binocular vision; group 2 of 312 patients with known ocular motility disorders: group 3 of 186 patients with unknown sensorimotor status. The utility of the two stereotests in detecting ocular motility disorders and/or amblyopia is uncertain when used alone. Because of a high number of false positives and false negatives the tests are best used in conjunction with other clinical tests of ocular sensorimotor function.

1983 - Il rendimento della ventilazione in rapporto agli scambi gassosi. La protesi ideale. [Altro]
G., Damia; Cavallini, Gian Maria
abstract

Il rendimento della ventilazione in rapporto agli scambi gassosi. La protesi ideale.

1983 - Importanza dei flussi gassosi e delle resistenze in un circuito di CPAP (sistema di monitoraggio). [Articolo su rivista]
A., Pelizzola; G., Damia; L., Bettala; Cavallini, Gian Maria; M., Cigada
abstract

Valutazione dell' importanza dei flussi gassosi e delle resistenze in un circuito di CPAP (sistema di monitoraggio).

1983 - Un caso di infezione orbitaria da Dirofilaria. [Altro]
R., Guerra; L., Casu; Cavallini, Gian Maria
abstract

Un caso di infezione orbitaria da Dirofilaria.

1982 - Considerazioni pratiche sulla CPAP. [Altro]
G., Damia; Cavallini, Gian Maria
abstract

Considerazioni pratiche sulla CPAP.

1982 - I test stereoscopici sono veramente utili nel depistage delle anomalie sensorio-motorie dell'età infantile? [Articolo su rivista]
L., Casu; M., Demartis; A. R., Pilia; Cavallini, Gian Maria
abstract

Valutazione dell'efficacia dei test stereoscopici nel depistage delle anomalie sensorio-motorie dell'età infantile.

1982 - Proposta di modifica della tecnica di blocco del plesso lombare per via inguinale (blocco 3 in 1 di Winnie). [Altro]
R., Toracca; Cavallini, Gian Maria
abstract

Si propone una modifica della tecnica di blocco del plesso lombare per via inguinale (blocco 3 in 1 di Winnie).

1982 - Trattamento della cheratite erpetica umana con Trifluorotimidina. [Articolo su rivista]
R., Guerra; L., Casu; Cavallini, Gian Maria; A. R., Pilia; M., Demartis
abstract

Trattamento della cheratite erpetica umana con Trifluorotimidina.

Università degli studi di Modena e Reggio Emilia

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