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MARIANNA CANNOLETTA
Docente a contratto
Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto
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Pubblicazioni
2015
- Folate administration decreases oxidative status and blood pressure in postmenopausal women
[Articolo su rivista]
Cagnacci, Angelo; Cannoletta, Marianna; Xholli, Anjeza; Piacenti, Ilaria; Palma, Federica; Palmieri, Beniamino
abstract
The purpose of this study was to evaluate whether folate exerts antioxidant effects in postmenopausal women and whether this effect is related to folate-induced modification of 24-h ambulatory blood pressure (BP).
2015
- Relation between oxidative stress and climacteric symptoms in early postmenopausal women
[Articolo su rivista]
Cagnacci, Angelo; Cannoletta, Marianna; Palma, Federica; Bellafronte, Manuela; Romani, Cecilia; Palmieri, Beniamino
abstract
ABSTRACT Objectives: To evaluate the relation between climacteric symptoms or other risk factors for cardiovascular disease and oxidative status of postmenopausal women. Methods: Cross-sectional investigation performed at the outpatient service for the menopause at University hospital, on 50 apparently healthy women in physiological post-menopause. Whole blood free oxygen radicals (FORT), free oxygen radical defence (FORD) age, months since menopause, weight, body mass index (BMI), waist girth, waist to hip ratio (WHR), estradiol, lipids, glucose, insulin, insulin resistance (glucose/insulin and HOMA-IR), and fibrinogen were evaluated. The Greene's scale with its subscales was used to evaluate climacteric symptoms. The pulsatility index (PI), an index of downstream blood flow resistance, was determined for both the internal carotid and the brachial artery. Results: WHR (r=0.540; p<0.0001), estradiol (r=0.548; p<0.0004) and waist (r=0.345; p<0.02) were independently related to blood FORT. Score of the Greene's vasomotor sub-scale was the only parameter independently related to blood FORD (r=0.55; p<0.0001). FORT was not related to artery PI, while FORD was negatively related to the PI of both internal carotid (r=549; p<0.0001) and brachial (r=0.484; p<0.0001) artery. Discussion: In postmenopausal women, abdominal adiposity and hypoestrogenism increase oxidative stress. Climacteric symptoms, particularly vasomotor symptoms, markedly reduce antioxidant defences. Lower antioxidant defences are associated with higher resistance to blood flow of great arteries. In women early after the menopause, visceral fat, hypo-estrogenism, and climacteric symptoms may increase the risk for cardiovascular disease.
2014
- Intensity of menstrual pain and estimated angle of uterine flexion
[Articolo su rivista]
Cagnacci, Angelo; Grandi, Giovanni; Cannoletta, Marianna; Xholli, Anjeza; Piacenti, Ilaria; Volpe, Annibale
abstract
To assess the impact of ultrasound-estimated uterus position on the intensity of pelvic pain.
2014
- Modification of blood pressure in postmenopausal women: role of hormone replacement therapy
[Articolo su rivista]
Cannoletta, Marianna; Cagnacci, Angelo
abstract
The rate of hypertension increases after menopause. Whether estrogen and progesterone deficiency associated with menopause play a role in determining a worst blood pressure (BP) control is still controversial. Also, studies dealing with the administration of estrogens or hormone therapy (HT) have reported conflicting evidence. In general it seems that, despite some negative data on subgroups of later postmenopausal women obtained with oral estrogens, in particular conjugated equine estrogens (CEE), most of the data indicate neutral or beneficial effects of estrogen or HT administration on BP control of both normotensive and hypertensive women. Data obtained with ambulatory BP monitoring and with transdermal estrogens are more convincing and concordant in defining positive effect on BP control of both normotensive and hypertensive postmenopausal women. Overall progestin adjunct does not hamper the effect of estrogens. Among progestins, drospirenone, a spironolactone-derived molecule, appears to be the molecule with the best antihypertensive properties.
2014
- Seasonal trend of acute pelvic inflammatory disease
[Articolo su rivista]
Xholli, Anjeza; Cannoletta, Marianna; Cagnacci, Angelo
abstract
Many infections follow a seasonal trend. Aim of our study was to check whether acute pelvic inflammatory disease (PID) follows a seasonal progress.
2013
- Intermenstrual pelvic pain, quality of life and mood
[Articolo su rivista]
Grandi, Giovanni; Xholli, Anjeza; Ferrari, Serena; Cannoletta, Marianna; Volpe, Annibale; Cagnacci, Angelo
abstract
BACKGROUND/AIMS:
To investigate the independent importance of different types of pelvic pain on quality of life and depressive symptoms.
METHODS:
A cross-sectional study was performed on patients with pelvic pain. A 10-cm visual-analogue scale (VAS) was used to investigate intensity of intermenstrual pelvic pain, dysmenorrhea or deep dyspareunia. The SF-36 form and the Zung Self-Rating Scale for Depression (SDS) were used to investigate quality of life and depressive symptoms, respectively.
RESULTS:
The final study group consisted of 248 patients, 175/248 (70.6%) with intermenstrual pelvic pain, 46/248 (18.5%) with dysmenorrhea and 27/248 (10.9%) with deep dyspareunia associated or not with dysmenorrhea. Mean VAS score for dysmenorrhea was higher than that for deep dyspareunia (p < 0.003) and intermenstrual pelvic pain (p < 0.0001). Women with intermenstrual pelvic pain had the worst SF-36 (p < 0.0001) and SDS (p < 0.002) scores. SF-36 was independently and inversely related to intermenstrual pelvic pain (CR -1.522; 95% CI -2.188 to -0.856; p < 0.0001), and less strongly to dysmenorrhea (CR -0.729; 95% CI -1.487 to 0.030; p = 0.06). Indeed, only the physical component summary of SF-36 was independently related to dysmenorrhea (CR -0.956; 95% CI -1.783 to -0.129; p = 0.024). The SDS score was independently related only to intermenstrual pelvic pain (CR 0.573; 95% CI 0.241-0.904; p = 0.0008).
CONCLUSIONS:
Patients with intermenstrual pelvic pain have the worst SF-36 and SDS scores. Intermenstrual pelvic pain seems to be more strongly associated with a reduced quality of life and depressive mood.
2013
- Ipertensione e Terapia Ormonale Sostitutiva
[Articolo su rivista]
Cannoletta, Marianna; Cagnacci, Angelo
abstract
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2010
- Folati. Implicazioni nella patogenesi e nella prevenzione dei disturbi dell'invecchiamento della donna
[Articolo su rivista]
Cagnacci, Angelo; Cannoletta, Marianna
abstract
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2009
- Effetti precoci e tardivi della menopausa
[Altro]
Cagnacci, Angelo; Romani, Cecilia; Cazzato, L; Cannoletta, Marianna; Volpe, Annibale
abstract
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2009
- High-dose short-term folate administration modifies ambulatory blood pressure in postmenopausal women. A placebo-controlled study.
[Articolo su rivista]
Cagnacci, Angelo; Cannoletta, Marianna; Volpe, Annibale
abstract
In humans low intake or low levels of folate are related to elevated homocysteine (Hcy) or blood pressure (BP). This study was performed to test whether in healthy postmenopausal women a 3-week administration of folate (5-methyltetrahydrofolate: 5-MTHF) at the dose of 15 mg/day (n=15), was, in comparison to placebo (n=15), capable of modifying 24-h ambulatory BP, along with Hcy and insulin metabolism. Placebo did not modify any parameter. 5-MTHF significantly decreased nocturnal systolic (-4.48+/-1.8 mm Hg; P=0.029), diastolic (-5.33+/-1.3 mm Hg; P=0.001) and mean (-5.10+/-1.1 mm Hg; P=0.005) BP, in a way that was significantly different from that observed during placebo. 5-MTHF also reduced Hcy (11.77+/-1.15 vs 8.71+/-0.50 micromol/l; P=0.03), and insulin resistance, evaluated by HOMA-IR (2.58+/-0.04 vs 2.03+/-0.04; P=0.01). Whether maintained in the long term, 5-MTHF's cardiovascular and metabolic effect may contribute to primary cardiovascular prevention of postmenopausal women.
2009
- Menopausa Chirurgica vs. Fisiologica. Sessualità, Qualità di Vita e Patologie
[Articolo su rivista]
Cagnacci, Angelo; Serenella, Arangino; Zanin, Renata; Cannoletta, Marianna; Alberto Bacchi, Modena; Francesco Saverio, Pansini; Gioacchino, Mollica; Gloria, Bonaccorsi; Nunzio, Giullini; Volpe, Annibale
abstract
Surgical menopause, in particular ovariectomy, is often assimilated to physiological menopause, although the endocrine environmentis different in the two conditions. Ovariectomy in premenopause induces a greater risk for osteoporotic fractures, for cardiovasculardiseases, but also for anxiety, depression, reduced libido, reduced verbal memory and possibly cerebral degenerative diseases. Ovariectomyafter the menopause may also be associated with a higher risk of cardiovascular diseases. Thus, consequences of ovariectomyshould be taken into account when proposing preventive ovariectomy for estrogen related diseases but mainly when proposed for theprevention of future ovarian neoplasm in non at risk women undergoing surgery for benign uterine diseases. In hysterectomized womenthe possibility to administer estrogens without progestins, furnishes advantages on mood, on the risk of breast cancer, and likelyon cardiovascular risk. Estrogen therapy is efficacious in preventing osteoporotic fractures and in decreasing the risk of cardiovasculardiseases. Androgen co-administration may be useful for reduced libido. Prior to perform an ovariectomy woman should be accuratelycounselled about the long term risk of the procedure and the possibility to perform an adequate prevention of these risks by estrogenand eventual androgen administration.Key words: menopause; ovariectomy
2009
- Supplementazione di folati in menopausa
[Altro]
Cagnacci, Angelo; Cazzato, L; Cannoletta, Marianna; Volpe, Annibale
abstract
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2008
- Correlazione tra i livelli di omocisteina e densità minerale ossea in donne in postmenopausa. Uno studio longitudinale
[Altro]
Petrella, E.; Ventura, Paolo; Caretto, S.; Cannoletta, Marianna; Zanin, R.; Generali, M.; Xholli, Anjeza; Volpe, Annibale; Cagnacci, Angelo
abstract
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2008
- Folates and Osteoporosis
[Relazione in Atti di Convegno]
Cagnacci, Angelo; Petrella, Elisabetta; Xholli, Anjeza; Cannoletta, Marianna
abstract
I livelli di follati più che quelli di omocisteina sonno correlati in maniera diretta alla densità minerale ossea delle vertebre lombari di donne in postmenopausa
2008
- Folati e osteoporosi
[Articolo su rivista]
Cagnacci, Angelo; Petrella, E; Xholli, Anjeza; Cannoletta, Marianna
abstract
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2008
- Incremento Ponderale e Modificazioni del Metabolismo Glucidico
[Articolo su rivista]
Cagnacci, Angelo; Zanin, Renata; Simona, Caretto; Anna De, Toni; Cannoletta, Marianna; Volpe, Annibale
abstract
The perimenopause is characterized by hormonal modifications, such as decreased/absent levels of progesterone associated with high/normal levels ofestrogens. Estrogen levels become very low after the menopause. The progesterone deficit is probably associated with a reduced energy expenditure,and therefore to an accumulation of energy as fat store. Very high or very low levels of estrogens may, by contrast, reduce insulin sensitivity and favourfat disposition in the abdomen. Hormonal variations of the perimenopausal period can be implicated in the modification of body composition thatcan represent risk factors for the development of chronic pathologies in postmenopausal women.
2008
- La stagionalità come uno dei fattori di rischio della PID acuta
[Altro]
Xholli, Anjeza; Cannoletta, Marianna; Caretto, S.; Zanin, Renata; Volpe, Annibale; Cagnacci, Angelo
abstract
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2008
- Postmenopausal osteoporosis: relation with folates, vitamin B12 and Homocysteine
[Abstract in Rivista]
Cagnacci, Angelo; Bagni, B; Petrella, Elisabetta; Xholly, A; Generali, Matteo; Zanin, Renata; Cannoletta, Marianna; Volpe, Annibale
abstract
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2008
- Supplementazione di folati e protezione cardiovascolare nella donna in postmenopausa
[Abstract in Rivista]
Cagnacci, Angelo; Cannoletta, Marianna; Arangino, S; Ferrari, Serena; Caretto, S; Petrella, Elisabetta; Zanin, Renata; Volpe, Annibale
abstract
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2007
- Correlazione positiva tra body mass index e vasodilatazione endotelio-dipendente in donne sane in postmenopausa
[Altro]
Cannoletta, Marianna; Cagnacci, Angelo; Zanin, Renata; Ferrari, Serena; Generali, Matteo; Volpe, Annibale
abstract
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2007
- Drospirenone: dati di sicurezza a lungo termine
[Altro]
Cagnacci, Angelo; Ferrari, Serena; Cannoletta, Marianna; Generali, Matteo; Tirelli, A; Alessandrini, Chiara; Petrella, Elisabetta; Xholli, Anjeza; Volpe, Annibale
abstract
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2007
- La sindrome metabolica in perimenopausa
[Altro]
Cagnacci, Angelo; Zanin, Renata; Caretto, Simona; DE TONI, Anna; Cannoletta, Marianna
abstract
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2007
- Modificazioni della secrezione surrenalica in menopausa ed implicazioni cliniche.
[Altro]
Cagnacci, Angelo; Caretto, S; Petrella, Elisabetta; Xholli, Anjeza; Cannoletta, Marianna; Zanin, Renata; Volpe, Annibale
abstract
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2007
- Ritmicità circannuale in Ostetricia: Impatto sugli esiti riproduttivi
[Abstract in Atti di Convegno]
Cagnacci, Angelo; Cannoletta, Marianna; Zanin, Renata; Petrella, Elisabetta; Caretto, S; Xholli, Anjeza; Generali, Matteo; Volpe, Annibale
abstract
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2007
- Ruolo per i folati in Menopausa
[Altro]
Cagnacci, Angelo; Xholli, Anjeza; Petrella, Elisabetta; Cannoletta, Marianna; Caretto, S; Generali, Matteo; Zanin, Renata; Ferrari, Serena; Volpe, Annibale
abstract
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2007
- Supplementazione di folati e protezione cardiovascolare nella donna in menopausa
[Abstract in Atti di Convegno]
Cagnacci, Angelo; Cannoletta, Marianna; Ferrari, Serena; Generali, Matteo; Caretto, Simona; Zanin, Renata; Putrella, E; Xholli, Anjeza; Volpe, Annibale
abstract
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2006
- Antiche sfide e nuove frontiere per la menopausa:risposta alla sfida con tibolone
[Abstract in Atti di Convegno]
Cagnacci, Angelo; Generali, Matteo; Cannoletta, Marianna; Zanin, Renata; Zini, A; Volpe, Annibale
abstract
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2006
- Effetti della menopaus e della somministrazione di estrogeni e progestinici sul peso e sui parametri antropometrici
[Abstract in Atti di Convegno]
Zanin, Renata; Cannoletta, Marianna; Generali, Matteo; Baldassari, Francesco Vincenzo M.; Caretto, Simona; DE TONI, Anna; Volpe, Annibale; Cagnacci, Angelo
abstract
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2006
- Interactions between Melatonin and Estrogen in the regulation of blood pressare
[Abstract in Rivista]
Cagnacci, Angelo; Cannoletta, Marianna
abstract
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2006
- La pressione arteriosa notturna nelle donne in peri o postmenopausa diminuisce in seguito alla somministrazione prolungata di melatonina
[Abstract in Atti di Convegno]
Cannoletta, Marianna; Generali, Matteo; Zanin, Renata; Zini, A; Caretto, S; Arangino, S; Volpe, Annibale; Cagnacci, Angelo
abstract
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2006
- Reply to: Interactions between melatonin and estrogen in the regulation of blood pressure
[Articolo su rivista]
Cagnacci, Angelo; Cannoletta, Marianna
abstract
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2006
- Terapia ormonale sostitutiva ad alto e basso dosaggio e livelli di omocisteina a digiuno e dopo carico di metionina
[Abstract in Atti di Convegno]
Generali, Matteo; Pirillo, D; Ferrari, Serena; Caretto, Simona; Cannoletta, Marianna; Baldassari, Francesco Vincenzo M.; Volpe, Annibale; Cagnacci, Angelo
abstract
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2006
- Tibolone and estradiol plus norethisterone acetate similarly influence endothelium-dependent vasodilatation in healthy postmenopausal women
[Articolo su rivista]
Cagnacci, Angelo; Renzi, A; Cannoletta, Marianna; Pirillo, D; Arangino, S; Volpe, Annibale
abstract
In healthy postmenopausal women, E-2 plus norethisterone acetate (1 mg + 0.5 mg) or tibolone (2.5 mg) similarly modify flow-mediated endothelium-dependent vasodilatation. The effect is dependent on baseline vasodilator reserve, with low values being augmented by either treatment.
2006
- Una folata in menopausa
[Abstract in Atti di Convegno]
Cagnacci, Angelo; Cannoletta, Marianna; Zanin, Renata; Generali, Matteo; Ferrari, Serena; Zini, A; Volpe, Annibale
abstract
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2005
- Effetto di una terapia ormonale sostitutiva combinata continua contenente noretisterone acetato e del tibolone sulla pressione arteriosa delle 24 h ore
[Abstract in Atti di Convegno]
Pirillo, D; Baldassari, F; Cannoletta, Marianna; Generali, Matteo; Volpe, Annibale; Cagnacci, Angelo
abstract
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2005
- Il tibolone, ma non la terapia combinata continua con estradiolo e noretisterone acetato migliora la dilatazione endotelio-dipendente nelle donne sane in postmenopausa
[Abstract in Atti di Convegno]
Cannoletta, Marianna; Renzi, A; Generali, Matteo; Pirillo, D; Volpe, Annibale; Cagnacci, Angelo
abstract
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2005
- La sindrome dismetabolica in perimenopausa
[Articolo su rivista]
Cagnacci, Angelo; De Toni, A; Caretto, S; Cannoletta, Marianna; Volpe, Annibale
abstract
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2005
- Melatonina ed apparato cardiovascolare
[Abstract in Atti di Convegno]
Cagnacci, Angelo; Cannoletta, Marianna; Renzi, A; Generali, Matteo
abstract
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2005
- Messaggi condivisi e controversi sull’HERS e WHI
[Capitolo/Saggio]
Volpe, Annibale; Generali, Matteo; Cannoletta, Marianna; DE TONI, Anna; Caretto, S; Cagnacci, Angelo
abstract
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2005
- Prolonged melatonin administration decreases nocturnal blood pressure in women
[Articolo su rivista]
Cagnacci, Angelo; Cannoletta, Marianna; Renzi, A; Baldassari, F; Arangino, S; Volpe, Annibale
abstract
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2004
- Fattori implicati nel determinismo del sesso del nascituro
[Articolo su rivista]
Cagnacci, Angelo; Cannoletta, Marianna; Pirillo, D; Alessandrini, C; Volpe, Annibale
abstract
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2004
- La contraccezione Ormonale in un anello: profilo clinico
[Abstract in Atti di Convegno]
Cagnacci, Angelo; Tirelli, A; Cannoletta, Marianna; Pirillo, D; Volpe, Annibale
abstract
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2004
- La contraccezione ormonale vaginale
[Altro]
Cagnacci, Angelo; Tirelli, A; Cannoletta, Marianna; Pirillo, Debora; Volpe, Annibale
abstract
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2004
- Meccanismi naturali implicati nella regolazione giornaliera della riproduzione
[Articolo su rivista]
Cagnacci, Angelo; Alessandrini, C; Caretto, S; Cannoletta, Marianna; Volpe, Annibale
abstract
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2004
- Melatonin and blood pressure control in postmenopausal women.
[Altro]
Cagnacci, Angelo; Cannoletta, Marianna; Arangino, S; Renzi, A.
abstract
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2004
- Osteoporosi postmenopausale e folati
[Articolo su rivista]
Cagnacci, Angelo; Baldassari, Francesco Vincenzo M.; Cannoletta, Marianna; Renzi, A; Caretto, S; Pirillo, D; Volpe, Annibale
abstract
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2003
- Effetti dell’ HRT e SERM sulla pressione arteriosa
[Capitolo/Saggio]
Cagnacci, Angelo; Alessandrini, Chiara; Pirillo, D; Cannoletta, Marianna; Caretto, Simona; Baldassari, Francesco Vincenzo M.; Renzi, A; Zanni, Al; Volpe, Annibale
abstract
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2003
- La scelta della pillola nel bilancio del rischio vascolare
[Altro]
Cagnacci, Angelo; Tirelli, A; Pirillo, D; Cannoletta, Marianna; Volpe, Annibale
abstract
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