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MARIA PIA LUPPI

Docente a contratto
Dipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell'Adulto

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Pubblicazioni

2021 - Surgical rehabilitation of swallowing with polydimethylsiloxane injections after open partial horizontal laryngectomy: Long-term functional results and quality of life [Articolo su rivista]
Mattioli, F.; Fernandez, I. J.; Bassano, E.; Luppi, M. P.; Bonali, M.; Ghidini, A.; Trebbi, M.; Bergamini, G.; Presutti, L.; Botti, C.
abstract

Background: Swallowing disorders are common problems after partial laryngectomy. The aim of this study is to illustrate the long-term functional results of rehabilitation of swallowing by polydimethylsiloxane (PDMS) injection. Methods: Twenty-eight patients with dysphagia after partial laryngectomy who underwent injection of PDMS for rehabilitation of swallowing were included in the study. Impairment of swallowing and quality of life (QoL) were investigated with questionnaires: M. D. Anderson Dysphagia Inventory (MDADI) and Performance Status Scale for Head and Neck Cancer (PSS-HNC). Functional results at fiberoptic endoscopic evaluation of swallowing (FEES) were analyzed using a modified penetration-aspiration scale. Results: Mean follow-up was 8.5 years. Twenty-six patients showed an improvement at questionnaires (p < 0.001). Median improvement was 6 (p < 0.001) in the modified penetration-aspiration scale. Total laryngectomy was required in one patient. Conclusions: PDMS injection is a good option for rehabilitation of swallowing in case of dysphagia after partial laryngectomy. It improves QoL and the results persist after a long follow-up period.

2017 - Polydimethylsiloxane Injection Laryngoplasty for Unilateral Vocal Fold Paralysis: Long-Term Results [Articolo su rivista]
Mattioli, Francesco; Bettini, Margherita; Botti, Cecilia; Busi, Giulia; Tassi, Sauro; Malagoli, Andrea; Molteni, Gabriele; Trebbi, Marco; Luppi, Maria Pia; Bergamini, Giuseppe; Presutti, Livio
abstract

Objectives To analyze the long-term objective, perceptive, and subjective outcomes after endoscopic polydimethylsiloxane (PDMS) injection laryngoplasty in unilateral vocal fold paralysis. Study design A retrospective study carried out between January 2008 and January 2012. Setting Head and Neck Department, University Hospital of Modena, Modena, Italy. Methods This was a retrospective analysis of 26 patients with unilateral vocal fold paralysis who underwent endoscopic injection of PDMS under general anesthesia. A voice evaluation protocol was performed for all patients, which included videolaryngostroboscopy, maximum phonation time, fundamental frequency, analysis of the harmonic structure of the vowel /a/ and the word /aiuole/, Grade of Dysphonia, Instability, Roughness, Breathiness, Asthenia, and Strain scale, and Voice Handicap Index. The protocol was performed before surgery, in the immediate postoperative period, and at least 3 years after surgery. The mean follow-up period was 73 months (range 39–119 months). Results The statistical analysis showed a significant improvement (P < 0.01) for all of the objective, perceptive, and subjective parameters by comparison between the preoperative and long-term follow-up data; moreover, no statistically significant difference was found between the postoperative and long-term follow-up data. This indicates that injection laryngoplasty with PDMS guarantees long-lasting effects over time. No complications were reported in our series. Conclusion Injection laryngoplasty with PDMS can be considered to be a minimally invasive and safe technique for the treatment of unilateral vocal fold paralysis. Moreover, it allows very good and stable results to be obtained over time, avoiding repeated treatments and improving the quality of life of the patients.

2015 - Results of Early Versus Intermediate or Delayed Voice Therapy in Patients With Unilateral Vocal Fold Paralysis: Our Experience in 171 Patients [Articolo su rivista]
Mattioli, F; Menichetti, M; Bergamini, G; Molteni, G; Alberici, M P; Luppi, M P; Nizzoli, F; Presutti, L
abstract

Vocal fold paralysis can have an important impact on a patient's quality of life. The goal of this study was to compare, in terms of vocal improvement and motility recovery, the post-vocal treatment results of our patients with unilateral vocal fold paralysis (UVFP) when treatment was started early (within 4 weeks from injury) versus intermediate (from 4 to 8 weeks) or delayed (at least 8 weeks after injury) treatment.

2014 - Corrigendum to "Rapid eye movement sleep behavior disorder: Devising controlled active treatment studies for symptomatic and neuroprotective therapy-a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group" [Sleep Med 14(8) (2013) 795-806] [Articolo su rivista]
Schenck, C. H.; Montplaisir, J. Y.; Frauscher, B.; Hogl, B.; Gagnon, J. -F.; Postuma, R.; Sonka, K.; Jennum, P.; Partinen, M.; Arnulf, I.; de Cock, V. C.; Dauvilliers, Y.; Luppi, P. -H.; Heidbreder, A.; Mayer, G.; Sixel-Doring, F.; Trenkwalder, C.; Unger, M.; Young, P.; Wing, Y. K.; Ferini-Strambi, L.; Ferri, R.; Plazzi, G.; Zucconi, M.; Inoue, Y.; Iranzo, A.; Santamaria, J.; Bassetti, C.; Moller, J. C.; Boeve, B. F.; Lai, Y. Y.; Pavlova, M.; Saper, C.; Schmidt, P.; Siegel, J. M.; Singer, C.; St Louis, E.; Videnovic, A.; Oertel, W.
abstract

2013 - Voice and swallowing after partial laryngectomy: Factors influencing outcome [Articolo su rivista]
ALICANDRI CIUFELLI, Matteo; Piccinini, Alessia; Grammatica, Alberto; Chiesi, Andrea; Bergamini, Giuseppe; Luppi, Maria Pia; Nizzoli, Federica; Ghidini, Angelo; Tassi, Sauro; Presutti, Livio
abstract

Background The purpose of this study was to assess the factors influencing swallowing and phonatory results after partial laryngectomy. Methods We carried out a medical chart review of patients who underwent partial laryngectomies between June 2003 and November 2010, focusing on functional outcomes. Results Thirty-two patients were enrolled. No statistically significant difference was found in the comparison of phonatory outcomes of patients with preservation of both arytenoids; the results of the Yanagihara classification were significantly different (p =.015) in patients with an atypical neoglottis; radiotherapy statistically significantly influenced only the mean fundamental frequency (p =.035). The type of partial laryngectomy does not seem to affect the deglutition results; radiotherapy statistically significantly affected the dysphagia score (DS; p =.03), penetration aspiration (p =.02), and MD Anderson Dysphagia Inventory (MDADI; p =.02). Conclusion Horizontal supraglottic laryngectomy and supracricoid partial laryngectomy give the same swallowing results. The presence of both arytenoids does not influence the final outcome compared to patients in whom only 1 arytenoid is preserved. Postoperative radiotherapy only influences the swallowing function. © 2012 Wiley Periodicals, Inc.

2011 - The role of early voice therapy in the incidence of motility recovery in unilateral vocal fold paralysis [Articolo su rivista]
Mattioli, Francesco; Bergamini, Giuseppe; ALICANDRI CIUFELLI, Matteo; Molteni, Gabriele; Luppi, Maria Pia; Nizzoli, Federica; Grammatica, Alberto; Presutti, Livio
abstract

OBJECTIVES. Vocal fold paralysis can have a significant impact on a patient's quality of life. The aim of this study was to analyze, in terms of vocal improvement and motility recovery, the post-vocal treatment results of patients with unilateral vocal fold paralysis (UVFP) who underwent early voice therapy. Study design. A 7 years prospective study of patients with an UVFP who underwent our multidimensional diagnostic-therapeutic assessment. MATERIAL AND METHODS. Seventy-four patients with UVFP were included in the study. All patients underwent a voice therapy based on forcible exercises supplemented by manipulations and maneuvers. A pre and post-treatment objective voice evaluation and self-assessment was made.

2010 - Auto-crosslinked hyaluronan gel injections in phonosurgery [Articolo su rivista]
Molteni, Gabriele; Bergamini, Giuseppe; Ricci Maccarini, Andrea; Marchese, Caterina; Ghidini, Angelo; ALICANDRI CIUFELLI, Matteo; Luppi, Maria Pia; Presutti, Livio
abstract

To evaluate the clinical performance of an auto-crosslinked gel obtained from hyaluronic acid (ACP-based gel) as an anti-adhesive agent and/or augmentative agent in vocal cord surgery for the treatment of vocal fold (VF) atrophy, sulcus vocalis, and postsurgery scarring as well as its tolerability at short- and long-term follow-up.

2009 - Quality of life in patients treated with PDMS injection for swallowing disorders [Articolo su rivista]
Molteni, Gabriele; Ghidini, Angelo; Bergamini, Giuseppe; ALICANDRI CIUFELLI, Matteo; Mattioli, Francesco; Luppi, Maria Pia; Presutti, Livio
abstract

To document the efficacy of polydimethylsiloxane (PDMS) injections in patients with swallowing disorders after partial supracricoid laryngectomy; to assess the importance of quality-of-life (QOL) outcome in oncologic patients.

2009 - Rehabilitation of swallowing with polydimethylsiloxane injections in patients who underwent partial laryngectomy [Articolo su rivista]
Bergamini, G.; Alicandri-Ciufelli, M.; Molteni, G.; De Siati, D. R.; Luppi, M. P.; Marchioni, D.; Presutti, L.
abstract

Background. We conducted this longitudinal prospective study to illustrate a surgical technique for swallowing rehabilitation of patients after partial laryngectomy. Methods. Nine patients with persistent swallowing impairment after partial laryngectomy were included in the study. Evaluation of swallowing was performed by fiberoptic endoscopic evaluation of swallowing (FEES), and was quantified using 2 scales: a dysphagia score and a modified penetrationaspiration scale. The site of bolus inhalation was identified. Polydimethylsiloxane (PDMS) was injected into the neoglottis to fill these passages, and to obtain a certain continence of the organ. Results. Mean follow-up was 25 months (range, 5-39). All patients showed an improvement both in the dysphagia score and in the modified penetration-aspiration scale. Average improvement was 2.6 points in the dysphagia score (p = .0042) and 2.1 points in the modified penetration-aspiration scale (p = .0043). Conclusion. PDMS injection can be considered as an option in surgical rehabilitation of swallowing in patients who underwent partial laryngectomy. © 2009 Wiley Periodicals, Inc.